• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ved-0635
VDAG_04280

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase
Gene Name: VDAG_04280
Ensembl Gene: VDAG_04280
Ensembl Protein: EGY22842
Organism: Verticillium dahliae
Taxa ID: 498257
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEGY22842EGY22842
UniProtG2X1V6, G2X1V6_VERDV
GeneBankDS572701EGY22842.1
RefSeqXM_009650727.1XP_009649022.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTINVILGAQ  WGDEGKGKLV  DIQAREAQLC  CRAAGGSNAG  HLIKVDGVSY  SFHLLPSGLM  60
61    NPRCMNFIGS  GVVFHIPTFF  SELKELEEKG  LTAVHDRILV  SDRVNVLLDM  HMAVDGLEEQ  120
121   ELGDAAIGTT  RRGIGPCYQT  SRARNGIKLT  DIFHPELFEK  KVQRLADGYQ  KRFGDLFKYD  180
181   IKAELARFEE  YRETMRKYVV  DGVAFMTSAQ  QSDTKIVVEG  ANALMLDVDY  GSYPFVTSSS  240
241   TTLAGIIGGL  TLNPKNITET  VGVVKAYTTR  VGWGAFKTED  TEEYGWQQTS  GNWTRMDLVV  300
301   VKYSNSINYY  TSLNLTKLDV  LDTFETIKIA  IAYKVDGQEL  DSYPADLDIL  ERAEVVYHEM  360
361   PGWQTPTTNA  KTYVDLPKKA  RDYVEYIEKF  VGVEIKYIGT  GPEREAMIRR  S  411
Nucleotide CDS Sequence (FASTA)
1     ATGACTATCA  ATGTCATTCT  CGGGGCCCAA  TGGGGTGACG  AAGGCAAGGG  AAAGCTGGTT  60
61    GACATCCAGG  CCCGGGAGGC  GCAACTTTGT  TGCCGAGCTG  CTGGCGGATC  CAATGCAGGT  120
121   CACTTAATCA  AGGTGGATGG  AGTCTCCTAC  AGCTTCCACC  TCTTGCCCTC  CGGCCTCATG  180
181   AACCCGCGCT  GCATGAACTT  CATCGGGTCC  GGTGTGGTCT  TTCATATCCC  AACCTTCTTC  240
241   AGCGAGCTCA  AGGAGCTTGA  AGAGAAGGGC  CTGACCGCGG  TGCATGATCG  AATCCTTGTT  300
301   TCTGATAGGG  TCAATGTCCT  CTTGGACATG  CACATGGCAG  TCGATGGTCT  CGAGGAGCAG  360
361   GAGCTTGGAG  ACGCAGCCAT  CGGAACAACA  AGACGCGGCA  TTGGTCCATG  CTACCAAACA  420
421   AGCAGGGCGC  GTAACGGCAT  CAAACTGACT  GACATCTTCC  ATCCTGAACT  TTTCGAGAAG  480
481   AAGGTGCAGC  GCCTCGCTGA  TGGTTATCAA  AAGCGCTTTG  GAGATCTCTT  CAAGTACGAC  540
541   ATCAAAGCCG  AGCTTGCTCG  TTTTGAAGAA  TACAGGGAGA  CGATGAGGAA  ATACGTCGTG  600
601   GACGGTGTGG  CCTTCATGAC  ATCCGCGCAA  CAGAGCGACA  CCAAGATTGT  GGTCGAAGGC  660
661   GCAAACGCAC  TCATGCTCGA  TGTCGATTAT  GGCTCGTACC  CATTCGTTAC  CTCGTCAAGT  720
721   ACCACGCTTG  CTGGCATCAT  TGGTGGACTT  ACCCTTAACC  CGAAGAACAT  TACAGAGACG  780
781   GTTGGAGTCG  TCAAGGCTTA  CACTACCCGT  GTCGGCTGGG  GCGCCTTCAA  GACGGAAGAT  840
841   ACGGAAGAGT  ACGGTTGGCA  ACAAACTTCA  GGAAATTGGA  CGCGAATGGA  CCTTGTTGTT  900
901   GTCAAGTACA  GCAACTCCAT  CAACTACTAC  ACCAGCCTGA  ATCTGACAAA  GCTCGACGTT  960
961   TTGGACACTT  TCGAAACGAT  CAAGATCGCG  ATCGCTTACA  AGGTCGACGG  ACAGGAACTG  1020
1021  GACTCTTACC  CTGCGGATCT  TGACATCTTG  GAACGAGCTG  AGGTGGTGTA  CCACGAGATG  1080
1081  CCGGGGTGGC  AGACACCGAC  TACGAACGCG  AAGACCTACG  TCGATCTGCC  CAAGAAGGCT  1140
1141  CGCGACTACG  TCGAGTACAT  CGAGAAATTT  GTGGGAGTCG  AGATCAAGTA  CATCGGCACC  1200
1201  GGTCCCGAGC  GCGAGGCCAT  GATCCGGCGC  TCCTGA  1236

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Biological Process
'de novo' AMP biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fuo-1421Fusarium oxysporum69.670.0 621
LLPS-Fuv-1299Fusarium verticillioides69.030.0 617
LLPS-Fus-0180Fusarium solani64.150.0 538
LLPS-Trr-0139Trichoderma reesei63.790.0 542
LLPS-Trv-0769Trichoderma virens63.410.0 531
LLPS-Nec-0687Neurospora crassa62.860.0 545
LLPS-Mao-0966Magnaporthe oryzae61.190.0 532
LLPS-Gag-0205Gaeumannomyces graminis60.00.0 521
LLPS-Map-1244Magnaporthe poae59.760.0 520
LLPS-Coo-1286Colletotrichum orbiculare58.160.0 519
LLPS-Beb-0207Beauveria bassiana57.722e-169 489
LLPS-Cogr-1261Colletotrichum graminicola56.973e-176 506
LLPS-Lem-0930Leptosphaeria maculans56.242e-173 499
LLPS-Tum-1600Tuber melanosporum56.225e-170 490
LLPS-Cog-0788Colletotrichum gloeosporioides55.448e-143 422
LLPS-Phn-1421Phaeosphaeria nodorum55.088e-172 495
LLPS-Pyt-1575Pyrenophora teres54.141e-160 484
LLPS-Pytr-1614Pyrenophora triticirepentis54.143e-166 481
LLPS-Zyt-1548Zymoseptoria tritici53.219e-155 451
LLPS-Dos-0332Dothistroma septosporum52.722e-154 451
LLPS-Scp-1463Schizosaccharomyces pombe52.151e-153 449
LLPS-Blg-0813Blumeria graminis52.137e-143 421
LLPS-Scs-1031Sclerotinia sclerotiorum52.137e-102 313
LLPS-Asc-1389Aspergillus clavatus51.766e-152 444
LLPS-Nef-1284Neosartorya fischeri51.762e-153 447
LLPS-Miv-1011Microbotryum violaceum51.762e-148 436
LLPS-Asfu-1448Aspergillus fumigatus51.531e-152 446
LLPS-Crn-0994Cryptococcus neoformans50.959e-148 434
LLPS-Spr-0335Sporisorium reilianum50.946e-153 447
LLPS-Asf-0713Aspergillus flavus50.821e-147 433
LLPS-Aso-0613Aspergillus oryzae50.821e-147 433
LLPS-Asn-1158Aspergillus nidulans50.352e-147 432
LLPS-Asni-0729Aspergillus niger50.352e-147 433
LLPS-Ast-0159Aspergillus terreus50.356e-149 437
LLPS-Scj-1492Schizosaccharomyces japonicus50.241e-145 428
LLPS-Usm-0054Ustilago maydis50.245e-151 442
LLPS-Scc-0109Schizosaccharomyces cryophilus50.02e-147 433
LLPS-Asg-0922Ashbya gossypii49.075e-136 404
LLPS-Mel-0588Melampsora laricipopulina48.857e-143 422
LLPS-Pug-0609Puccinia graminis48.742e-141 418
LLPS-Sac-1612Saccharomyces cerevisiae48.67e-142 419
LLPS-Abg-1763Absidia glauca48.574e-143 422
LLPS-Put-1310Puccinia triticina48.514e-143 422
LLPS-Chc-0747Chondrus crispus47.627e-123 370
LLPS-Kop-0984Komagataella pastoris47.545e-134 399
LLPS-Yal-0927Yarrowia lipolytica47.541e-139 413
LLPS-Leo-2410Lepisosteus oculatus47.187e-134 399
LLPS-Pes-2532Pelodiscus sinensis47.178e-134 399
LLPS-Tag-2953Taeniopygia guttata46.951e-127 383
LLPS-Anc-2966Anolis carolinensis46.938e-135 401
LLPS-Lac-1985Latimeria chalumnae46.933e-133 397
LLPS-Dac-1813Daucus carota46.811e-125 379
LLPS-Gaga-1964Gallus gallus46.76e-133 397
LLPS-Fia-2442Ficedula albicollis46.463e-131 395
LLPS-Chr-1273Chlamydomonas reinhardtii46.457e-128 384
LLPS-Orb-2409Oryza barthii46.435e-126 380
LLPS-Ors-1970Oryza sativa46.437e-126 380
LLPS-Gor-2149Gossypium raimondii46.346e-124 375
LLPS-Viv-2237Vitis vinifera46.343e-123 373
LLPS-Org-1697Oryza glaberrima46.211e-126 380
LLPS-Hea-2379Helianthus annuus46.11e-124 377
LLPS-Scf-0454Scleropages formosus46.011e-130 390
LLPS-Lep-2353Leersia perrieri45.972e-123 374
LLPS-Orp-0898Oryza punctata45.978e-125 377
LLPS-Pot-2036Populus trichocarpa45.867e-123 372
LLPS-Cap-0471Cavia porcellus45.751e-128 386
LLPS-Tra-2903Triticum aestivum45.712e-121 369
LLPS-Brd-2360Brachypodium distachyon45.717e-120 365
LLPS-Met-2355Medicago truncatula45.634e-121 367
LLPS-Mae-0815Manihot esculenta45.631e-120 366
LLPS-Meg-2327Meleagris gallopavo45.574e-117 354
LLPS-Brn-2145Brassica napus45.543e-120 365
LLPS-Anp-3143Anas platyrhynchos45.451e-114 348
LLPS-Bro-1915Brassica oleracea45.413e-121 368
LLPS-Brr-1112Brassica rapa45.414e-120 365
LLPS-Vir-1620Vigna radiata45.392e-122 371
LLPS-Sei-2295Setaria italica45.396e-123 372
LLPS-Glm-0680Glycine max45.395e-122 370
LLPS-Eqc-3422Equus caballus45.313e-125 378
LLPS-Bot-3997Bos taurus45.281e-129 389
LLPS-Mod-3700Monodelphis domestica45.285e-129 387
LLPS-Sob-1512Sorghum bicolor45.246e-122 370
LLPS-Sot-0966Solanum tuberosum45.157e-122 370
LLPS-Via-1972Vigna angularis45.152e-121 368
LLPS-Coc-1423Corchorus capsularis45.156e-120 365
LLPS-Myl-3796Myotis lucifugus45.094e-125 377
LLPS-Gaa-1243Gasterosteus aculeatus45.073e-125 377
LLPS-Ict-0614Ictidomys tridecemlineatus45.071e-126 380
LLPS-Scm-2202Scophthalmus maximus45.074e-126 380
LLPS-Sus-1919Sus scrofa45.053e-128 385
LLPS-Maf-4153Macaca fascicularis44.944e-118 359
LLPS-Mam-4127Macaca mulatta44.944e-118 359
LLPS-Man-1930Macaca nemestrina44.944e-118 359
LLPS-Nia-2586Nicotiana attenuata44.921e-121 370
LLPS-Orbr-0602Oryza brachyantha44.922e-121 368
LLPS-Tar-1307Takifugu rubripes44.844e-125 377
LLPS-Icp-0440Ictalurus punctatus44.842e-130 390
LLPS-Aon-4655Aotus nancymaae44.849e-126 379
LLPS-Orl-3833Oryzias latipes44.842e-125 378
LLPS-Mum-3906Mus musculus44.845e-126 379
LLPS-Caf-0754Canis familiaris44.844e-126 379
LLPS-Orn-2937Oreochromis niloticus44.847e-127 381
LLPS-Dar-0993Danio rerio44.842e-127 382
LLPS-Mup-3445Mustela putorius furo44.813e-128 385
LLPS-Ran-1046Rattus norvegicus44.812e-127 382
LLPS-Cea-1553Cercocebus atys44.813e-127 382
LLPS-Chs-4116Chlorocebus sabaeus44.814e-127 382
LLPS-Mea-0780Mesocricetus auratus44.819e-127 381
LLPS-Prp-1925Prunus persica44.792e-118 361
LLPS-Zem-0333Zea mays44.761e-120 367
LLPS-Arl-0264Arabidopsis lyrata44.714e-117 357
LLPS-Cus-1099Cucumis sativus44.686e-121 367
LLPS-Thc-1009Theobroma cacao44.682e-118 361
LLPS-Xet-2209Xenopus tropicalis44.688e-130 389
LLPS-Ova-0495Ovis aries44.634e-124 374
LLPS-Mal-3025Mandrillus leucophaeus44.61e-124 375
LLPS-Paa-0183Papio anubis44.61e-124 375
LLPS-Tut-1107Tursiops truncatus44.69e-126 378
LLPS-Caj-2039Callithrix jacchus44.65e-125 377
LLPS-Sah-2724Sarcophilus harrisii44.61e-126 380
LLPS-Hos-3127Homo sapiens44.69e-125 376
LLPS-Pap-2800Pan paniscus44.68e-125 376
LLPS-Pat-2324Pan troglodytes44.68e-125 376
LLPS-Nol-0675Nomascus leucogenys44.584e-127 382
LLPS-Cas-1462Carlito syrichta44.582e-126 380
LLPS-Poa-3715Pongo abelii44.585e-127 382
LLPS-Sol-2459Solanum lycopersicum44.523e-113 362
LLPS-Cis-2011Ciona savignyi44.59e-119 360
LLPS-Sem-0453Selaginella moellendorffii44.59e-120 364
LLPS-Orni-1991Oryza nivara44.441e-121 369
LLPS-Phv-0405Phaseolus vulgaris44.442e-120 366
LLPS-Ten-3754Tetraodon nigroviridis44.372e-124 375
LLPS-Otg-0311Otolemur garnettii44.346e-126 379
LLPS-Fec-3598Felis catus44.341e-127 383
LLPS-Orc-3994Oryctolagus cuniculus44.311e-120 366
LLPS-Aim-0685Ailuropoda melanoleuca44.244e-127 382
LLPS-Art-1169Arabidopsis thaliana44.241e-115 354
LLPS-Orgl-2078Oryza glumaepatula44.219e-121 367
LLPS-Orr-0955Oryza rufipogon44.219e-121 367
LLPS-Osl-0169Ostreococcus lucimarinus44.122e-120 364
LLPS-Pof-4180Poecilia formosa44.061e-119 362
LLPS-Cym-0464Cyanidioschyzon merolae44.012e-117 357
LLPS-Ora-0414Ornithorhynchus anatinus43.914e-110 336
LLPS-Xim-2450Xiphophorus maculatus43.99e-121 365
LLPS-Hov-1464Hordeum vulgare43.879e-121 367
LLPS-Amt-2199Amborella trichopoda43.812e-114 351
LLPS-Php-1841Physcomitrella patens43.744e-118 360
LLPS-Rhb-1010Rhinopithecus bieti43.693e-123 372
LLPS-Fud-1741Fukomys damarensis43.662e-119 362
LLPS-Dio-1426Dipodomys ordii43.42e-108 332
LLPS-Gog-2368Gorilla gorilla43.374e-111 342
LLPS-Loa-4079Loxodonta africana43.276e-124 375
LLPS-Cae-1517Caenorhabditis elegans43.264e-112 343
LLPS-Mua-0127Musa acuminata42.896e-112 345
LLPS-Ori-0464Oryza indica42.767e-117 357
LLPS-Asm-1457Astyanax mexicanus42.625e-120 363
LLPS-Drm-2081Drosophila melanogaster42.423e-123 372
LLPS-Gas-1383Galdieria sulphuraria41.818e-111 339
LLPS-Urm-3150Ursus maritimus39.174e-98 307
LLPS-Cii-2325Ciona intestinalis38.632e-96 302