• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nec-0687
NCU09789

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase
Gene Name: NCU09789
Ensembl Gene: NCU09789
Ensembl Protein: EAA30951
Organism: Neurospora crassa
Taxa ID: 367110
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAA30951EAA30951
UniProtQ7S604, PURA_NEUCR
GeneBankCM002241EAA30951.1
RefSeqXM_955094.3XP_960187.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATLILGSQW  GDEGKGKLTD  ILCPKAQICA  RAAGGHNAGH  SIVANGVEYD  FHLLPSGLVN  60
61    PNCMNLIGSS  VVFHVPSFFS  ELSKLEEKGL  TDVHNRILVS  DRCHVNFDLH  AAVDGLEEVE  120
121   LGDRKIGTTG  RGIGPSYSTK  MARSGVRIHE  IFNEEIFERK  LRQLAAGYKK  RFGDLLKYDV  180
181   EEEIARFKEY  RVKLARYTVD  AIQYMKEAQD  RGYKILIEGA  NALMLDIDYG  TYPYVTSSNT  240
241   GLGGIITGLA  INPTKIDNII  GVVKAYTTRV  GGGPFKTEDL  EEAGTKLQEI  GREWGVSTGR  300
301   KRRCGWLDLV  VLKYSTAINN  YTALNLTKLD  ILDTFETIKV  AVAYKDPQTG  EEVEYFPADL  360
361   DILDSLEVVY  KELPGWNKPI  TDCKTYYDLP  KEARAYIEFI  EEFVGVPICY  IGTGPKREDM  420
421   IVRKTSAIKE  430
Nucleotide CDS Sequence (FASTA)
1     ATGGCCACTC  TCATTCTTGG  TTCCCAGTGG  GGTGACGAGG  GTAAAGGAAA  GCTTACCGAC  60
61    ATCCTCTGCC  CCAAGGCCCA  GATCTGCGCC  AGAGCCGCTG  GCGGCCACAA  CGCTGGTCAC  120
121   TCCATCGTCG  CCAATGGCGT  CGAGTACGAC  TTCCACCTTC  TCCCCTCCGG  TCTCGTCAAC  180
181   CCCAACTGCA  TGAACCTCAT  CGGTTCCTCT  GTCGTCTTCC  ACGTCCCCAG  CTTCTTCAGC  240
241   GAGCTCAGCA  AGCTTGAGGA  GAAGGGCCTC  ACCGATGTTC  ACAACCGCAT  CCTCGTCTCC  300
301   GACCGCTGCC  ACGTCAACTT  CGACCTTCAC  GCTGCCGTTG  ATGGTCTCGA  GGAGGTTGAG  360
361   CTCGGTGACC  GCAAGATCGG  CACCACCGGC  CGTGGTATCG  GTCCCTCTTA  CAGTACCAAG  420
421   ATGGCGAGAA  GCGGTGTCAG  AATCCACGAG  ATCTTCAACG  AGGAGATCTT  TGAGCGCAAG  480
481   CTCAGGCAAC  TCGCTGCCGG  CTACAAGAAG  AGATTTGGTG  ATCTCCTCAA  GTACGATGTC  540
541   GAGGAGGAGA  TTGCCCGCTT  CAAGGAGTAC  CGTGTCAAGC  TCGCCCGCTA  TACTGTCGAT  600
601   GCCATCCAGT  ACATGAAGGA  GGCCCAGGAC  CGCGGCTACA  AGATCCTCAT  CGAGGGTGCC  660
661   AACGCCCTCA  TGCTGGATAT  CGACTACGGC  ACCTACCCCT  ACGTCACCTC  CAGCAACACC  720
721   GGTCTTGGTG  GTATCATTAC  TGGTCTTGCC  ATTAACCCTA  CCAAGATTGA  CAACATCATT  780
781   GGTGTCGTCA  AGGCCTACAC  CACTCGTGTC  GGTGGTGGTC  CCTTCAAGAC  TGAGGACCTC  840
841   GAGGAGGCTG  GTACCAAGCT  CCAAGAGATT  GGTCGCGAAT  GGGGTGTCAG  CACTGGTCGC  900
901   AAGCGTCGTT  GCGGCTGGCT  CGATCTCGTC  GTCCTCAAGT  ACTCGACCGC  CATCAACAAC  960
961   TATACCGCCC  TCAACCTTAC  CAAGCTCGAT  ATCCTCGATA  CTTTCGAGAC  CATTAAGGTT  1020
1021  GCCGTCGCTT  ACAAGGACCC  TCAGACCGGT  GAGGAGGTCG  AGTACTTCCC  TGCCGATCTC  1080
1081  GACATCCTCG  ACAGCCTTGA  GGTTGTCTAC  AAGGAGCTTC  CCGGCTGGAA  CAAGCCCATC  1140
1141  ACTGACTGCA  AGACCTACTA  CGATCTCCCC  AAGGAGGCTC  GCGCCTACAT  TGAGTTCATT  1200
1201  GAGGAGTTCG  TCGGCGTCCC  CATTTGCTAC  ATTGGCACCG  GCCCCAAGCG  TGAGGACATG  1260
1261  ATTGTCCGCA  AGACCTCCGC  CATCAAGGAG  TAA  1293

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Biological Process
'de novo' AMP biosynthetic process
Biological Process
IMP metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mao-0966Magnaporthe oryzae78.960.0 649
LLPS-Map-1244Magnaporthe poae76.830.0 640
LLPS-Gag-0205Gaeumannomyces graminis76.360.0 638
LLPS-Fus-0180Fusarium solani73.90.0 594
LLPS-Fuv-1299Fusarium verticillioides73.40.0 609
LLPS-Beb-0207Beauveria bassiana73.110.0 604
LLPS-Fuo-1421Fusarium oxysporum72.450.0 603
LLPS-Trv-0769Trichoderma virens71.220.0 577
LLPS-Cogr-1261Colletotrichum graminicola68.570.0 566
LLPS-Coo-1286Colletotrichum orbiculare67.290.0 561
LLPS-Scs-1031Sclerotinia sclerotiorum66.772e-138 407
LLPS-Trr-0139Trichoderma reesei66.040.0 539
LLPS-Lem-0930Leptosphaeria maculans65.320.0 520
LLPS-Tum-1600Tuber melanosporum65.250.0 531
LLPS-Pytr-1614Pyrenophora triticirepentis64.542e-179 514
LLPS-Pyt-1575Pyrenophora teres63.981e-172 516
LLPS-Cog-0788Colletotrichum gloeosporioides63.212e-156 458
LLPS-Asfu-1448Aspergillus fumigatus62.885e-179 514
LLPS-Nef-1284Neosartorya fischeri62.887e-180 516
LLPS-Ved-0635Verticillium dahliae62.863e-174 501
LLPS-Phn-1421Phaeosphaeria nodorum62.479e-176 506
LLPS-Asn-1158Aspergillus nidulans62.171e-173 500
LLPS-Asc-1389Aspergillus clavatus61.71e-174 503
LLPS-Asni-0729Aspergillus niger60.762e-173 500
LLPS-Aso-0613Aspergillus oryzae60.525e-173 499
LLPS-Asf-0713Aspergillus flavus60.525e-173 499
LLPS-Ast-0159Aspergillus terreus60.286e-173 498
LLPS-Scp-1463Schizosaccharomyces pombe59.955e-170 491
LLPS-Scj-1492Schizosaccharomyces japonicus59.862e-166 482
LLPS-Blg-0813Blumeria graminis59.721e-166 483
LLPS-Zyt-1548Zymoseptoria tritici59.671e-170 493
LLPS-Miv-1011Microbotryum violaceum59.391e-159 465
LLPS-Dos-0332Dothistroma septosporum58.641e-163 475
LLPS-Kop-0984Komagataella pastoris58.413e-157 459
LLPS-Sac-1612Saccharomyces cerevisiae57.771e-160 467
LLPS-Abg-1763Absidia glauca57.522e-161 469
LLPS-Asg-0922Ashbya gossypii57.343e-158 461
LLPS-Yal-0927Yarrowia lipolytica57.274e-161 469
LLPS-Spr-0335Sporisorium reilianum56.812e-157 459
LLPS-Usm-0054Ustilago maydis56.344e-156 456
LLPS-Crn-0994Cryptococcus neoformans56.04e-153 448
LLPS-Scc-0109Schizosaccharomyces cryophilus55.925e-160 466
LLPS-Mel-0588Melampsora laricipopulina55.538e-157 458
LLPS-Pug-0609Puccinia graminis54.136e-145 427
LLPS-Put-1310Puccinia triticina53.92e-144 426
LLPS-Lac-1985Latimeria chalumnae51.643e-136 406
LLPS-Chc-0747Chondrus crispus51.187e-124 373
LLPS-Cae-1517Caenorhabditis elegans50.811e-137 410
LLPS-Gor-2149Gossypium raimondii50.597e-128 386
LLPS-Brr-1112Brassica rapa50.592e-125 379
LLPS-Drm-2081Drosophila melanogaster50.367e-137 407
LLPS-Gaga-1964Gallus gallus50.242e-134 401
LLPS-Fia-2442Ficedula albicollis50.245e-133 401
LLPS-Bot-3997Bos taurus50.02e-133 399
LLPS-Leo-2410Lepisosteus oculatus50.03e-132 396
LLPS-Cap-0471Cavia porcellus50.06e-133 397
LLPS-Ict-0614Ictidomys tridecemlineatus50.04e-128 385
LLPS-Anc-2966Anolis carolinensis50.06e-134 400
LLPS-Pes-2532Pelodiscus sinensis50.05e-132 395
LLPS-Pot-2036Populus trichocarpa49.883e-126 382
LLPS-Anp-3143Anas platyrhynchos49.877e-119 359
LLPS-Myl-3796Myotis lucifugus49.772e-125 379
LLPS-Mum-3906Mus musculus49.777e-128 385
LLPS-Caf-0754Canis familiaris49.771e-127 384
LLPS-Tag-2953Taeniopygia guttata49.774e-125 377
LLPS-Scf-0454Scleropages formosus49.767e-131 392
LLPS-Sus-1919Sus scrofa49.765e-133 398
LLPS-Brn-2145Brassica napus49.762e-124 377
LLPS-Orl-3833Oryzias latipes49.766e-129 387
LLPS-Glm-0680Glycine max49.763e-125 379
LLPS-Icp-0440Ictalurus punctatus49.766e-131 392
LLPS-Met-2355Medicago truncatula49.659e-125 377
LLPS-Coc-1423Corchorus capsularis49.652e-126 382
LLPS-Bro-1915Brassica oleracea49.653e-125 379
LLPS-Meg-2327Meleagris gallopavo49.632e-121 366
LLPS-Tut-1107Tursiops truncatus49.533e-127 383
LLPS-Via-1972Vigna angularis49.532e-125 379
LLPS-Ova-0495Ovis aries49.532e-125 379
LLPS-Vir-1620Vigna radiata49.532e-125 379
LLPS-Sah-2724Sarcophilus harrisii49.533e-128 385
LLPS-Aon-4655Aotus nancymaae49.533e-127 383
LLPS-Poa-3715Pongo abelii49.533e-131 393
LLPS-Nol-0675Nomascus leucogenys49.533e-131 393
LLPS-Cas-1462Carlito syrichta49.531e-132 397
LLPS-Fec-3598Felis catus49.531e-131 394
LLPS-Pat-2324Pan troglodytes49.532e-126 381
LLPS-Pap-2800Pan paniscus49.532e-126 381
LLPS-Hos-3127Homo sapiens49.532e-126 380
LLPS-Orn-2937Oreochromis niloticus49.531e-129 389
LLPS-Phv-0405Phaseolus vulgaris49.532e-124 377
LLPS-Arl-0264Arabidopsis lyrata49.411e-123 375
LLPS-Hea-2379Helianthus annuus49.416e-125 379
LLPS-Sob-1512Sorghum bicolor49.411e-126 382
LLPS-Ora-0414Ornithorhynchus anatinus49.372e-113 345
LLPS-Paa-0183Papio anubis49.34e-126 380
LLPS-Mal-3025Mandrillus leucophaeus49.34e-126 380
LLPS-Caj-2039Callithrix jacchus49.33e-126 380
LLPS-Eqc-3422Equus caballus49.36e-126 380
LLPS-Dar-0993Danio rerio49.33e-128 385
LLPS-Gaa-1243Gasterosteus aculeatus49.293e-128 385
LLPS-Ran-1046Rattus norvegicus49.297e-132 395
LLPS-Cea-1553Cercocebus atys49.295e-131 393
LLPS-Chs-4116Chlorocebus sabaeus49.294e-131 393
LLPS-Mea-0780Mesocricetus auratus49.296e-131 392
LLPS-Maf-4153Macaca fascicularis49.274e-120 365
LLPS-Mam-4127Macaca mulatta49.274e-120 365
LLPS-Man-1930Macaca nemestrina49.274e-120 365
LLPS-Pof-4180Poecilia formosa49.183e-123 373
LLPS-Dac-1813Daucus carota49.175e-125 378
LLPS-Orc-3994Oryctolagus cuniculus49.173e-122 370
LLPS-Chr-1273Chlamydomonas reinhardtii49.072e-133 399
LLPS-Tar-1307Takifugu rubripes49.062e-126 380
LLPS-Mup-3445Mustela putorius furo49.069e-131 392
LLPS-Scm-2202Scophthalmus maximus49.061e-127 385
LLPS-Aim-0685Ailuropoda melanoleuca48.943e-130 390
LLPS-Sei-2295Setaria italica48.945e-126 381
LLPS-Orb-2409Oryza barthii48.947e-128 386
LLPS-Thc-1009Theobroma cacao48.943e-124 376
LLPS-Org-1697Oryza glaberrima48.942e-128 385
LLPS-Art-1169Arabidopsis thaliana48.943e-123 374
LLPS-Ors-1970Oryza sativa48.948e-128 385
LLPS-Viv-2237Vitis vinifera48.941e-124 377
LLPS-Mae-0815Manihot esculenta48.945e-123 373
LLPS-Dio-1426Dipodomys ordii48.862e-112 343
LLPS-Gog-2368Gorilla gorilla48.858e-116 355
LLPS-Fud-1741Fukomys damarensis48.833e-123 372
LLPS-Tra-2903Triticum aestivum48.827e-126 380
LLPS-Orni-1991Oryza nivara48.828e-126 380
LLPS-Prp-1925Prunus persica48.822e-121 369
LLPS-Xet-2209Xenopus tropicalis48.821e-130 392
LLPS-Orbr-0602Oryza brachyantha48.828e-125 378
LLPS-Otg-0311Otolemur garnettii48.821e-130 392
LLPS-Zem-0333Zea mays48.711e-125 380
LLPS-Lep-2353Leersia perrieri48.71e-126 383
LLPS-Cus-1099Cucumis sativus48.73e-122 371
LLPS-Orp-0898Oryza punctata48.78e-127 383
LLPS-Nia-2586Nicotiana attenuata48.591e-125 380
LLPS-Orgl-2078Oryza glumaepatula48.585e-125 378
LLPS-Xim-2450Xiphophorus maculatus48.581e-124 376
LLPS-Brd-2360Brachypodium distachyon48.584e-124 377
LLPS-Orr-0955Oryza rufipogon48.583e-125 379
LLPS-Amt-2199Amborella trichopoda48.586e-122 371
LLPS-Osl-0169Ostreococcus lucimarinus48.571e-129 388
LLPS-Hov-1464Hordeum vulgare48.462e-125 379
LLPS-Cis-2011Ciona savignyi48.361e-129 389
LLPS-Rhb-1010Rhinopithecus bieti48.361e-124 376
LLPS-Mua-0127Musa acuminata48.299e-121 368
LLPS-Php-1841Physcomitrella patens48.111e-124 378
LLPS-Gas-1383Galdieria sulphuraria47.981e-122 370
LLPS-Mod-3700Monodelphis domestica47.889e-128 384
LLPS-Sot-0966Solanum tuberosum47.754e-123 374
LLPS-Sem-0453Selaginella moellendorffii47.758e-125 378
LLPS-Loa-4079Loxodonta africana47.532e-127 384
LLPS-Cym-0464Cyanidioschyzon merolae47.471e-122 371
LLPS-Asm-1457Astyanax mexicanus47.062e-120 366
LLPS-Sol-2459Solanum lycopersicum46.712e-115 369
LLPS-Ori-0464Oryza indica46.492e-120 367
LLPS-Ten-3754Tetraodon nigroviridis46.481e-119 364
LLPS-Cii-2325Ciona intestinalis44.686e-114 348
LLPS-Urm-3150Ursus maritimus42.472e-101 317