• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scp-1463
ade2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase
Gene Name: ade2, SPAC144.03
Ensembl Gene: SPAC144.03
Ensembl Protein: SPAC144.03.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASVRETGVN  VSNDGITVVL  GSQWGDEGKG  KLVDILCDNV  DVCARCQGGN  NAGHTIVANG  60
61    VTYDFHILPS  GLVNPKCQNL  IGSGVVVYLP  AFFSELEKLE  QKGLKCRDRI  FISDRAHLVF  120
121   DYHQRADALN  EAELGKQSIG  TTGKGIGPAY  STKATRSGIR  VHHLYHWAEF  EARYRKNVAD  180
181   LQKRYGAFEY  DVEAELIRYK  ELAQRLKPFV  IDAVAFMYEA  LQSKKRILVE  GANALMLDLD  240
241   FGTYPFVTSS  NTTVGGVCTG  LGVPPQRIAN  SIGVVKAYTT  RVGAGPFPTE  QLNEIGDHLQ  300
301   SVGREVGVTT  GRKRRCGWLD  LVVVKYSTMI  NGYTSLNLTK  LDILDALDEI  KVAVAYIING  360
361   KRIETFPADL  DSLEEAEIVY  ETFPGWKVPT  TGITHWDQMP  ENAKKYIEFI  EKFVGVPITF  420
421   IGVGPGRDEM  LVKE  434
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTCAG  TGCGAGAAAC  TGGTGTAAAT  GTTTCCAATG  ATGGAATAAC  CGTCGTCCTT  60
61    GGCAGTCAAT  GGGGTGACGA  AGGAAAGGGT  AAACTTGTTG  ATATCCTTTG  CGATAATGTT  120
121   GATGTCTGTG  CTCGCTGTCA  GGGTGGTAAC  AATGCTGGTC  ATACCATTGT  TGCTAATGGT  180
181   GTCACTTACG  ATTTTCACAT  TCTTCCTTCA  GGACTCGTAA  ATCCTAAATG  CCAGAACTTG  240
241   ATTGGTTCTG  GTGTTGTCGT  CTATTTACCT  GCTTTTTTTA  GTGAGTTAGA  GAAACTTGAG  300
301   CAAAAGGGTT  TGAAATGTAG  AGATCGTATT  TTCATTTCTG  ATCGCGCTCA  TCTAGTATTT  360
361   GACTACCATC  AACGTGCAGA  TGCTTTAAAC  GAGGCAGAGC  TCGGAAAACA  AAGCATCGGA  420
421   ACAACCGGAA  AGGGTATTGG  TCCTGCTTAT  TCCACCAAGG  CTACTCGCAG  CGGTATTCGT  480
481   GTTCATCACT  TGTATCATTG  GGCTGAATTT  GAAGCTCGTT  ACCGTAAGAA  CGTTGCTGAC  540
541   TTGCAGAAAC  GTTATGGTGC  TTTCGAGTAT  GATGTTGAAG  CTGAACTCAT  TCGTTATAAG  600
601   GAATTGGCTC  AAAGACTTAA  GCCATTTGTC  ATTGATGCTG  TTGCGTTCAT  GTATGAAGCT  660
661   TTACAAAGCA  AGAAACGTAT  CCTTGTCGAA  GGTGCTAACG  CTTTGATGCT  TGATTTGGAC  720
721   TTTGGAACTT  ATCCATTCGT  TACCAGCTCT  AACACTACTG  TTGGTGGTGT  TTGCACTGGT  780
781   TTGGGTGTTC  CTCCTCAGCG  CATTGCTAAC  TCCATCGGTG  TAGTGAAAGC  TTATACAACT  840
841   CGTGTAGGCG  CTGGTCCTTT  CCCAACGGAA  CAGCTCAACG  AAATTGGTGA  CCATCTTCAA  900
901   AGTGTTGGAA  GAGAAGTTGG  TGTTACCACC  GGTCGTAAAC  GCCGCTGCGG  CTGGCTTGAT  960
961   TTGGTCGTTG  TCAAATACTC  TACTATGATC  AATGGTTACA  CTTCTTTGAA  CCTTACCAAG  1020
1021  CTTGACATTT  TGGATGCCTT  GGATGAGATC  AAAGTTGCTG  TTGCCTACAT  TATTAACGGT  1080
1081  AAACGCATTG  AAACTTTTCC  TGCTGATCTT  GATTCTCTTG  AAGAAGCCGA  GATTGTATAC  1140
1141  GAAACTTTCC  CTGGTTGGAA  AGTTCCTACA  ACAGGTATCA  CTCATTGGGA  TCAGATGCCT  1200
1201  GAGAATGCCA  AGAAATACAT  AGAGTTCATT  GAAAAGTTTG  TTGGTGTTCC  CATCACTTTC  1260
1261  ATCGGTGTTG  GTCCTGGTCG  TGATGAGATG  TTGGTTAAGG  AGTAA  1305

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Molecular Function
Sulfinylpropanyl adenylate synthase
Biological Process
'de novo' AMP biosynthetic process
Biological Process
Adenosine biosynthetic process
Biological Process
Cellular response to cadmium ion
Biological Process
Fumarate metabolic process
Biological Process
IMP metabolic process
Biological Process
Purine nucleotide biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0109Schizosaccharomyces cryophilus85.020.0 753
LLPS-Scj-1492Schizosaccharomyces japonicus84.790.0 744
LLPS-Yal-0927Yarrowia lipolytica70.450.0 607
LLPS-Abg-1763Absidia glauca69.280.0 600
LLPS-Tum-1600Tuber melanosporum68.420.0 584
LLPS-Miv-1011Microbotryum violaceum66.670.0 564
LLPS-Kop-0984Komagataella pastoris66.430.0 582
LLPS-Sac-1612Saccharomyces cerevisiae64.190.0 561
LLPS-Asg-0922Ashbya gossypii64.190.0 551
LLPS-Lem-0930Leptosphaeria maculans63.480.0 536
LLPS-Pyt-1575Pyrenophora teres63.331e-179 534
LLPS-Pytr-1614Pyrenophora triticirepentis63.010.0 529
LLPS-Phn-1421Phaeosphaeria nodorum62.290.0 528
LLPS-Mel-0588Melampsora laricipopulina61.40.0 526
LLPS-Crn-0994Cryptococcus neoformans61.270.0 532
LLPS-Spr-0335Sporisorium reilianum61.150.0 553
LLPS-Usm-0054Ustilago maydis61.150.0 552
LLPS-Bot-3997Bos taurus60.663e-172 498
LLPS-Aim-0685Ailuropoda melanoleuca60.523e-170 493
LLPS-Mup-3445Mustela putorius furo60.435e-172 498
LLPS-Pug-0609Puccinia graminis60.378e-177 509
LLPS-Sus-1919Sus scrofa60.192e-170 493
LLPS-Nec-0687Neurospora crassa59.955e-177 509
LLPS-Tar-1307Takifugu rubripes59.952e-169 491
LLPS-Put-1310Puccinia triticina59.916e-177 509
LLPS-Fec-3598Felis catus59.722e-170 493
LLPS-Scm-2202Scophthalmus maximus59.726e-171 495
LLPS-Orn-2937Oreochromis niloticus59.582e-172 499
LLPS-Leo-2410Lepisosteus oculatus59.487e-171 494
LLPS-Orl-3833Oryzias latipes59.158e-170 492
LLPS-Mao-0966Magnaporthe oryzae59.148e-175 503
LLPS-Gaa-1243Gasterosteus aculeatus58.887e-170 492
LLPS-Fia-2442Ficedula albicollis58.776e-166 485
LLPS-Blg-0813Blumeria graminis58.591e-153 449
LLPS-Mea-0780Mesocricetus auratus58.533e-168 488
LLPS-Nol-0675Nomascus leucogenys58.537e-168 487
LLPS-Gaga-1964Gallus gallus58.535e-167 485
LLPS-Poa-3715Pongo abelii58.539e-168 487
LLPS-Cap-0471Cavia porcellus58.532e-167 486
LLPS-Beb-0207Beauveria bassiana58.532e-168 487
LLPS-Lac-1985Latimeria chalumnae58.533e-168 488
LLPS-Asc-1389Aspergillus clavatus58.497e-170 491
LLPS-Nef-1284Neosartorya fischeri58.491e-171 495
LLPS-Dar-0993Danio rerio58.412e-168 488
LLPS-Ran-1046Rattus norvegicus58.292e-167 486
LLPS-Cea-1553Cercocebus atys58.291e-167 486
LLPS-Asfu-1448Aspergillus fumigatus58.251e-170 493
LLPS-Chs-4116Chlorocebus sabaeus58.062e-166 483
LLPS-Anc-2966Anolis carolinensis58.065e-166 482
LLPS-Mod-3700Monodelphis domestica58.063e-166 483
LLPS-Xim-2450Xiphophorus maculatus57.944e-165 480
LLPS-Meg-2327Meleagris gallopavo57.932e-151 443
LLPS-Scf-0454Scleropages formosus57.894e-168 487
LLPS-Cas-1462Carlito syrichta57.828e-167 484
LLPS-Fus-0180Fusarium solani57.741e-160 467
LLPS-Asn-1158Aspergillus nidulans57.686e-165 478
LLPS-Xet-2209Xenopus tropicalis57.583e-165 480
LLPS-Otg-0311Otolemur garnettii57.583e-166 483
LLPS-Pes-2532Pelodiscus sinensis57.581e-164 479
LLPS-Pof-4180Poecilia formosa57.588e-163 474
LLPS-Asni-0729Aspergillus niger57.553e-168 487
LLPS-Gog-2368Gorilla gorilla57.542e-147 436
LLPS-Icp-0440Ictalurus punctatus57.513e-168 488
LLPS-Fuv-1299Fusarium verticillioides57.423e-172 497
LLPS-Scs-1031Sclerotinia sclerotiorum57.42e-109 333
LLPS-Drm-2081Drosophila melanogaster57.286e-167 484
LLPS-Zyt-1548Zymoseptoria tritici57.241e-169 490
LLPS-Anp-3143Anas platyrhynchos57.227e-149 436
LLPS-Asf-0713Aspergillus flavus57.081e-166 482
LLPS-Aso-0613Aspergillus oryzae57.081e-166 482
LLPS-Gag-0205Gaeumannomyces graminis57.012e-170 492
LLPS-Dos-0332Dothistroma septosporum56.971e-169 490
LLPS-Ast-0159Aspergillus terreus56.842e-166 482
LLPS-Fuo-1421Fusarium oxysporum56.73e-170 491
LLPS-Asm-1457Astyanax mexicanus56.542e-157 460
LLPS-Cogr-1261Colletotrichum graminicola56.42e-163 474
LLPS-Map-1244Magnaporthe poae56.293e-169 489
LLPS-Ict-0614Ictidomys tridecemlineatus55.662e-153 450
LLPS-Tag-2953Taeniopygia guttata55.662e-153 450
LLPS-Eqc-3422Equus caballus55.664e-153 450
LLPS-Maf-4153Macaca fascicularis55.618e-147 434
LLPS-Mam-4127Macaca mulatta55.618e-147 434
LLPS-Man-1930Macaca nemestrina55.618e-147 434
LLPS-Loa-4079Loxodonta africana55.433e-162 473
LLPS-Tut-1107Tursiops truncatus55.428e-154 451
LLPS-Mum-3906Mus musculus55.421e-153 451
LLPS-Mal-3025Mandrillus leucophaeus55.199e-153 448
LLPS-Paa-0183Papio anubis55.199e-153 448
LLPS-Sah-2724Sarcophilus harrisii55.192e-153 450
LLPS-Ova-0495Ovis aries55.163e-151 445
LLPS-Osl-0169Ostreococcus lucimarinus55.167e-161 468
LLPS-Coo-1286Colletotrichum orbiculare54.985e-161 468
LLPS-Caj-2039Callithrix jacchus54.953e-152 447
LLPS-Aon-4655Aotus nancymaae54.952e-151 445
LLPS-Pap-2800Pan paniscus54.953e-152 447
LLPS-Hos-3127Homo sapiens54.955e-152 446
LLPS-Caf-0754Canis familiaris54.862e-154 452
LLPS-Pat-2324Pan troglodytes54.722e-151 445
LLPS-Ora-0414Ornithorhynchus anatinus54.713e-135 401
LLPS-Orc-3994Oryctolagus cuniculus54.522e-144 428
LLPS-Myl-3796Myotis lucifugus54.462e-149 439
LLPS-Rhb-1010Rhinopithecus bieti54.462e-151 445
LLPS-Trv-0769Trichoderma virens54.392e-151 443
LLPS-Gor-2149Gossypium raimondii54.374e-154 453
LLPS-Chc-0747Chondrus crispus54.271e-147 434
LLPS-Fud-1741Fukomys damarensis54.253e-145 429
LLPS-Dio-1426Dipodomys ordii54.23e-135 402
LLPS-Mae-0815Manihot esculenta54.143e-152 448
LLPS-Cis-2011Ciona savignyi54.123e-147 434
LLPS-Brd-2360Brachypodium distachyon54.057e-155 456
LLPS-Tra-2903Triticum aestivum54.052e-157 461
LLPS-Hea-2379Helianthus annuus53.99e-155 455
LLPS-Brr-1112Brassica rapa53.94e-153 450
LLPS-Lep-2353Leersia perrieri53.815e-157 461
LLPS-Sob-1512Sorghum bicolor53.813e-156 459
LLPS-Orp-0898Oryza punctata53.811e-157 462
LLPS-Zem-0333Zea mays53.662e-155 456
LLPS-Pot-2036Populus trichocarpa53.669e-154 452
LLPS-Viv-2237Vitis vinifera53.669e-157 460
LLPS-Sei-2295Setaria italica53.435e-156 458
LLPS-Cus-1099Cucumis sativus53.432e-151 446
LLPS-Thc-1009Theobroma cacao53.431e-152 449
LLPS-Glm-0680Glycine max53.431e-151 447
LLPS-Ors-1970Oryza sativa53.338e-156 457
LLPS-Chr-1273Chlamydomonas reinhardtii53.31e-158 464
LLPS-Bro-1915Brassica oleracea53.198e-153 450
LLPS-Orb-2409Oryza barthii53.14e-155 456
LLPS-Org-1697Oryza glaberrima53.18e-156 456
LLPS-Amt-2199Amborella trichopoda53.14e-150 443
LLPS-Brn-2145Brassica napus53.073e-151 446
LLPS-Vir-1620Vigna radiata52.964e-151 445
LLPS-Met-2355Medicago truncatula52.969e-149 439
LLPS-Coc-1423Corchorus capsularis52.966e-150 442
LLPS-Nia-2586Nicotiana attenuata52.961e-152 450
LLPS-Ten-3754Tetraodon nigroviridis52.821e-151 446
LLPS-Cae-1517Caenorhabditis elegans52.781e-149 440
LLPS-Cym-0464Cyanidioschyzon merolae52.768e-148 435
LLPS-Arl-0264Arabidopsis lyrata52.723e-151 446
LLPS-Dac-1813Daucus carota52.728e-153 449
LLPS-Via-1972Vigna angularis52.485e-149 440
LLPS-Prp-1925Prunus persica52.481e-149 442
LLPS-Urm-3150Ursus maritimus52.314e-135 404
LLPS-Gas-1383Galdieria sulphuraria52.271e-150 442
LLPS-Phv-0405Phaseolus vulgaris52.253e-149 441
LLPS-Art-1169Arabidopsis thaliana52.256e-150 442
LLPS-Ved-0635Verticillium dahliae52.153e-148 435
LLPS-Sem-0453Selaginella moellendorffii52.124e-150 443
LLPS-Orgl-2078Oryza glumaepatula52.011e-150 444
LLPS-Orni-1991Oryza nivara52.012e-150 444
LLPS-Orr-0955Oryza rufipogon52.014e-151 446
LLPS-Orbr-0602Oryza brachyantha52.016e-150 442
LLPS-Hov-1464Hordeum vulgare51.894e-151 445
LLPS-Php-1841Physcomitrella patens51.652e-149 442
LLPS-Sot-0966Solanum tuberosum51.498e-150 442
LLPS-Mua-0127Musa acuminata51.486e-147 436
LLPS-Trr-0139Trichoderma reesei51.22e-134 400
LLPS-Cog-0788Colletotrichum gloeosporioides51.047e-122 370
LLPS-Sol-2459Solanum lycopersicum50.332e-143 443
LLPS-Ori-0464Oryza indica49.772e-145 431
LLPS-Cii-2325Ciona intestinalis48.818e-124 374