LLPS-Crn-0994
CNC04750
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Adenylosuccinate synthetase |
| Gene Name: | CNC04750 |
| Ensembl Gene: | CNC04750 |
| Ensembl Protein: | AAW42427 |
| Organism: | Cryptococcus neoformans |
| Taxa ID: | 214684 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AAW42427 | AAW42427 |
| UniProt | P0CQ34, PURA_CRYNJ, Q55W95, Q5KK02 | |
| GeneBank | AE017343 | AAW42427.1 |
| RefSeq | XM_569734.1 | XP_569734.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAPSPEGVTV VLGAQWGDEG KGKLVDILAA EADICARCAG GNNAGHTIVV RNDKGEKTSY 60 61 AFNLLPSGLI NPECTAFIGS GVVVHVPSLF NELDTLERKG LKVAGRLFVS DRAHLVMGFH 120 121 QIVDGLKEVE LGGSSIGTTR KGIGPAYSSK ASRSGLRVHH LFDPTFPAKF RKLVEGRFKR 180 181 YGHFEFDTEG EIEMYLAFAE RLRPFIVDGP TFMHNAVNSG KRVLVEGANA LMLDLDYGTY 240 241 PFVTSSSTSI GGVVSGLGIS PFAIKRVVGV IKAYTTRVGG GPFPTEDLAT VGETLQEVGA 300 301 EYGTVTGRRR RCGWLDLVVM KYSTMINGYT SLNLTKLDVL DGFDEIKVAT GYKIDGVEVE 360 361 GFPADLDRLA KVEVQYATLP GWKTDISNCK TYEEFPENAK AYIKFIEDYL GVKVQYVGVG 420 421 PGRDQNVIIF 430 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCCAT CCCCGGAGGG AGTTACTGTC GTTCTCGGAG CCCAATGGGG TGACGAGGGC 60 61 AAGGGAAAGC TTGTGGACAT CCTTGCCGCT GAGGCGGACA TTTGCGCTCG ATGTGCCGGT 120 121 GGTAACAATG CCGGTCACAC CATTGTTGTC AGAAATGATA AGGGCGAGAA AACCAGCTAT 180 181 GCCTTCAACC TTTTGCCCAG TGGGTTGATC AATCCTGAGT GCACCGCGTT CATTGGCTCT 240 241 GGTGTTGTTG TTCATGTCCC TTCGCTTTTC AATGAGCTCG ACACGCTTGA GCGAAAAGGC 300 301 CTCAAGGTTG CCGGTCGGCT CTTTGTCTCT GATAGGGCTC ATCTCGTCAT GGGTTTCCAC 360 361 CAGATCGTTG ATGGTCTCAA GGAGGTTGAG CTTGGTGGCT CGTCCATTGG CACTACCAGG 420 421 AAGGGTATCG GACCCGCTTA CTCTTCCAAG GCCTCTCGAT CTGGTCTTCG TGTCCATCAC 480 481 CTCTTCGACC CTACCTTCCC TGCCAAGTTC AGGAAACTGG TCGAGGGCAG GTTCAAACGA 540 541 TACGGCCACT TCGAGTTCGA CACTGAGGGT GAGATTGAGA TGTACTTGGC CTTTGCCGAG 600 601 CGCCTTCGAC CCTTCATCGT GGACGGACCC ACCTTCATGC ACAATGCTGT GAACTCTGGC 660 661 AAGCGAGTTC TCGTTGAGGG TGCCAACGCC CTTATGCTTG ATCTCGACTA TGGTACCTAC 720 721 CCGTTCGTTA CTTCTTCTTC CACCTCTATC GGTGGTGTCG TCAGTGGACT CGGTATCTCG 780 781 CCATTCGCTA TCAAGCGTGT CGTCGGTGTC ATCAAGGCCT ACACTACTCG AGTTGGTGGA 840 841 GGTCCTTTCC CTACCGAAGA TCTTGCTACC GTCGGTGAGA CCTTGCAAGA GGTTGGTGCC 900 901 GAGTACGGTA CCGTCACTGG CAGAAGAAGG CGATGCGGAT GGCTCGACTT GGTCGTTATG 960 961 AAGTACTCCA CCATGATCAA TGGTTACACT AGTCTCAACC TTACCAAGCT TGATGTTCTT 1020 1021 GACGGCTTCG ACGAGATCAA GGTCGCCACT GGCTACAAGA TTGATGGTGT TGAGGTTGAA 1080 1081 GGTTTCCCTG CCGATCTTGA CCGACTCGCC AAGGTTGAAG TTCAATATGC CACCCTTCCT 1140 1141 GGGTGGAAGA CTGACATCTC CAACTGCAAA ACATACGAAG AATTCCCCGA GAACGCCAAG 1200 1201 GCTTATATCA AGTTTATTGA GGACTACTTG GGCGTCAAGG TTCAATACGT CGGCGTTGGC 1260 1261 CCTGGTCGGG ACCAGAACGT TATCATTTTC TAA 1293 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Molecular Function | Adenylosuccinate synthase activity | |
Molecular Function | GTP binding | |
Molecular Function | Magnesium ion binding | |
Biological Process | 'de novo' AMP biosynthetic process | |
Biological Process | IMP metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Spr-0335 | Sporisorium reilianum | 72.14 | 0.0 | 599 |
| LLPS-Miv-1011 | Microbotryum violaceum | 72.03 | 0.0 | 605 |
| LLPS-Usm-0054 | Ustilago maydis | 71.9 | 0.0 | 597 |
| LLPS-Pug-0609 | Puccinia graminis | 64.46 | 0.0 | 533 |
| LLPS-Mel-0588 | Melampsora laricipopulina | 63.97 | 0.0 | 549 |
| LLPS-Put-1310 | Puccinia triticina | 63.1 | 0.0 | 526 |
| LLPS-Yal-0927 | Yarrowia lipolytica | 62.97 | 7e-179 | 514 |
| LLPS-Abg-1763 | Absidia glauca | 62.82 | 0.0 | 535 |
| LLPS-Asg-0922 | Ashbya gossypii | 62.09 | 1e-171 | 496 |
| LLPS-Scc-0109 | Schizosaccharomyces cryophilus | 61.97 | 0.0 | 522 |
| LLPS-Scj-1492 | Schizosaccharomyces japonicus | 61.27 | 0.0 | 521 |
| LLPS-Scp-1463 | Schizosaccharomyces pombe | 61.27 | 0.0 | 521 |
| LLPS-Sac-1612 | Saccharomyces cerevisiae | 61.16 | 1e-175 | 506 |
| LLPS-Tum-1600 | Tuber melanosporum | 60.62 | 1e-172 | 498 |
| LLPS-Kop-0984 | Komagataella pastoris | 60.61 | 1e-175 | 505 |
| LLPS-Lem-0930 | Leptosphaeria maculans | 59.0 | 3e-168 | 486 |
| LLPS-Phn-1421 | Phaeosphaeria nodorum | 58.06 | 3e-164 | 476 |
| LLPS-Fuv-1299 | Fusarium verticillioides | 57.72 | 5e-164 | 476 |
| LLPS-Pyt-1575 | Pyrenophora teres | 57.35 | 5e-155 | 471 |
| LLPS-Pytr-1614 | Pyrenophora triticirepentis | 57.35 | 3e-160 | 466 |
| LLPS-Fuo-1421 | Fusarium oxysporum | 57.24 | 1e-162 | 472 |
| LLPS-Nec-0687 | Neurospora crassa | 56.0 | 1e-155 | 455 |
| LLPS-Sus-1919 | Sus scrofa | 55.92 | 4e-154 | 452 |
| LLPS-Asf-0713 | Aspergillus flavus | 55.87 | 2e-151 | 444 |
| LLPS-Aso-0613 | Aspergillus oryzae | 55.87 | 2e-151 | 444 |
| LLPS-Orn-2937 | Oreochromis niloticus | 55.81 | 4e-152 | 447 |
| LLPS-Xim-2450 | Xiphophorus maculatus | 55.58 | 7e-148 | 436 |
| LLPS-Orl-3833 | Oryzias latipes | 55.58 | 4e-150 | 441 |
| LLPS-Lep-2353 | Leersia perrieri | 55.45 | 4e-148 | 438 |
| LLPS-Asni-0729 | Aspergillus niger | 55.4 | 2e-150 | 441 |
| LLPS-Chr-1273 | Chlamydomonas reinhardtii | 55.35 | 6e-151 | 444 |
| LLPS-Asn-1158 | Aspergillus nidulans | 55.29 | 3e-149 | 438 |
| LLPS-Sei-2295 | Setaria italica | 55.21 | 1e-146 | 434 |
| LLPS-Sob-1512 | Sorghum bicolor | 55.21 | 5e-149 | 440 |
| LLPS-Orp-0898 | Oryza punctata | 55.21 | 3e-148 | 438 |
| LLPS-Gor-2149 | Gossypium raimondii | 55.21 | 5e-148 | 437 |
| LLPS-Ors-1970 | Oryza sativa | 55.21 | 6e-148 | 437 |
| LLPS-Brr-1112 | Brassica rapa | 55.21 | 4e-146 | 432 |
| LLPS-Pof-4180 | Poecilia formosa | 55.2 | 2e-146 | 432 |
| LLPS-Ast-0159 | Aspergillus terreus | 55.16 | 7e-148 | 434 |
| LLPS-Gaa-1243 | Gasterosteus aculeatus | 55.12 | 7e-151 | 443 |
| LLPS-Tar-1307 | Takifugu rubripes | 55.12 | 1e-149 | 440 |
| LLPS-Fus-0180 | Fusarium solani | 55.1 | 3e-144 | 425 |
| LLPS-Mup-3445 | Mustela putorius furo | 54.99 | 2e-152 | 448 |
| LLPS-Bot-3997 | Bos taurus | 54.99 | 2e-153 | 450 |
| LLPS-Coo-1286 | Colletotrichum orbiculare | 54.98 | 6e-145 | 427 |
| LLPS-Orb-2409 | Oryza barthii | 54.98 | 2e-147 | 436 |
| LLPS-Org-1697 | Oryza glaberrima | 54.98 | 3e-148 | 436 |
| LLPS-Pot-2036 | Populus trichocarpa | 54.98 | 3e-145 | 430 |
| LLPS-Asfu-1448 | Aspergillus fumigatus | 54.93 | 4e-151 | 443 |
| LLPS-Gas-1383 | Galdieria sulphuraria | 54.89 | 5e-151 | 442 |
| LLPS-Dar-0993 | Danio rerio | 54.88 | 4e-151 | 444 |
| LLPS-Maf-4153 | Macaca fascicularis | 54.76 | 4e-142 | 422 |
| LLPS-Mam-4127 | Macaca mulatta | 54.76 | 4e-142 | 422 |
| LLPS-Man-1930 | Macaca nemestrina | 54.76 | 4e-142 | 421 |
| LLPS-Fec-3598 | Felis catus | 54.76 | 2e-152 | 447 |
| LLPS-Mum-3906 | Mus musculus | 54.73 | 1e-149 | 441 |
| LLPS-Tag-2953 | Taeniopygia guttata | 54.73 | 2e-147 | 434 |
| LLPS-Asc-1389 | Aspergillus clavatus | 54.69 | 5e-148 | 435 |
| LLPS-Nef-1284 | Neosartorya fischeri | 54.69 | 2e-151 | 444 |
| LLPS-Viv-2237 | Vitis vinifera | 54.69 | 3e-149 | 440 |
| LLPS-Scm-2202 | Scophthalmus maximus | 54.65 | 2e-149 | 440 |
| LLPS-Aim-0685 | Ailuropoda melanoleuca | 54.52 | 2e-152 | 447 |
| LLPS-Met-2355 | Medicago truncatula | 54.5 | 1e-143 | 426 |
| LLPS-Brd-2360 | Brachypodium distachyon | 54.5 | 1e-143 | 427 |
| LLPS-Tra-2903 | Triticum aestivum | 54.5 | 3e-146 | 432 |
| LLPS-Thc-1009 | Theobroma cacao | 54.5 | 1e-143 | 426 |
| LLPS-Zem-0333 | Zea mays | 54.5 | 7e-146 | 432 |
| LLPS-Bro-1915 | Brassica oleracea | 54.5 | 6e-145 | 429 |
| LLPS-Mae-0815 | Manihot esculenta | 54.5 | 1e-144 | 429 |
| LLPS-Cus-1099 | Cucumis sativus | 54.48 | 1e-142 | 424 |
| LLPS-Mao-0966 | Magnaporthe oryzae | 54.48 | 3e-148 | 436 |
| LLPS-Brn-2145 | Brassica napus | 54.37 | 4e-144 | 427 |
| LLPS-Icp-0440 | Ictalurus punctatus | 54.36 | 5e-153 | 449 |
| LLPS-Caf-0754 | Canis familiaris | 54.34 | 2e-149 | 440 |
| LLPS-Myl-3796 | Myotis lucifugus | 54.32 | 4e-148 | 436 |
| LLPS-Cogr-1261 | Colletotrichum graminicola | 54.27 | 6e-144 | 424 |
| LLPS-Nia-2586 | Nicotiana attenuata | 54.27 | 1e-144 | 429 |
| LLPS-Blg-0813 | Blumeria graminis | 54.23 | 3e-133 | 397 |
| LLPS-Chc-0747 | Chondrus crispus | 54.19 | 2e-135 | 403 |
| LLPS-Leo-2410 | Lepisosteus oculatus | 54.19 | 3e-150 | 442 |
| LLPS-Tut-1107 | Tursiops truncatus | 54.11 | 5e-149 | 439 |
| LLPS-Caj-2039 | Callithrix jacchus | 54.11 | 1e-148 | 437 |
| LLPS-Aon-4655 | Aotus nancymaae | 54.11 | 1e-148 | 438 |
| LLPS-Sah-2724 | Sarcophilus harrisii | 54.11 | 5e-149 | 439 |
| LLPS-Eqc-3422 | Equus caballus | 54.11 | 8e-147 | 434 |
| LLPS-Ova-0495 | Ovis aries | 54.09 | 2e-147 | 434 |
| LLPS-Ran-1046 | Rattus norvegicus | 54.06 | 6e-150 | 441 |
| LLPS-Coc-1423 | Corchorus capsularis | 54.03 | 6e-143 | 424 |
| LLPS-Art-1169 | Arabidopsis thaliana | 54.03 | 2e-144 | 428 |
| LLPS-Gag-0205 | Gaeumannomyces graminis | 54.01 | 1e-145 | 429 |
| LLPS-Ict-0614 | Ictidomys tridecemlineatus | 54.0 | 5e-149 | 439 |
| LLPS-Anc-2966 | Anolis carolinensis | 53.9 | 4e-151 | 444 |
| LLPS-Mal-3025 | Mandrillus leucophaeus | 53.88 | 4e-148 | 436 |
| LLPS-Paa-0183 | Papio anubis | 53.88 | 4e-148 | 436 |
| LLPS-Pat-2324 | Pan troglodytes | 53.88 | 4e-148 | 436 |
| LLPS-Cea-1553 | Cercocebus atys | 53.83 | 3e-148 | 437 |
| LLPS-Mea-0780 | Mesocricetus auratus | 53.83 | 8e-150 | 441 |
| LLPS-Chs-4116 | Chlorocebus sabaeus | 53.83 | 4e-148 | 436 |
| LLPS-Nol-0675 | Nomascus leucogenys | 53.83 | 2e-148 | 437 |
| LLPS-Cas-1462 | Carlito syrichta | 53.83 | 2e-150 | 442 |
| LLPS-Poa-3715 | Pongo abelii | 53.83 | 2e-148 | 437 |
| LLPS-Cap-0471 | Cavia porcellus | 53.83 | 6e-149 | 438 |
| LLPS-Osl-0169 | Ostreococcus lucimarinus | 53.81 | 6e-148 | 435 |
| LLPS-Arl-0264 | Arabidopsis lyrata | 53.79 | 6e-144 | 427 |
| LLPS-Prp-1925 | Prunus persica | 53.79 | 1e-142 | 424 |
| LLPS-Orbr-0602 | Oryza brachyantha | 53.79 | 1e-140 | 418 |
| LLPS-Sem-0453 | Selaginella moellendorffii | 53.76 | 4e-143 | 424 |
| LLPS-Pap-2800 | Pan paniscus | 53.65 | 1e-147 | 435 |
| LLPS-Hos-3127 | Homo sapiens | 53.65 | 2e-147 | 435 |
| LLPS-Hea-2379 | Helianthus annuus | 53.55 | 2e-143 | 426 |
| LLPS-Map-1244 | Magnaporthe poae | 53.54 | 3e-145 | 428 |
| LLPS-Scf-0454 | Scleropages formosus | 53.49 | 2e-149 | 439 |
| LLPS-Hov-1464 | Hordeum vulgare | 53.43 | 2e-141 | 420 |
| LLPS-Beb-0207 | Beauveria bassiana | 53.41 | 8e-142 | 419 |
| LLPS-Xet-2209 | Xenopus tropicalis | 53.36 | 1e-148 | 438 |
| LLPS-Otg-0311 | Otolemur garnettii | 53.36 | 6e-148 | 436 |
| LLPS-Sot-0966 | Solanum tuberosum | 53.32 | 8e-142 | 422 |
| LLPS-Orgl-2078 | Oryza glumaepatula | 53.32 | 2e-140 | 418 |
| LLPS-Orni-1991 | Oryza nivara | 53.32 | 1e-140 | 419 |
| LLPS-Orr-0955 | Oryza rufipogon | 53.32 | 4e-141 | 420 |
| LLPS-Lac-1985 | Latimeria chalumnae | 53.26 | 8e-149 | 438 |
| LLPS-Fia-2442 | Ficedula albicollis | 53.21 | 2e-148 | 440 |
| LLPS-Rhb-1010 | Rhinopithecus bieti | 53.18 | 2e-146 | 432 |
| LLPS-Orc-3994 | Oryctolagus cuniculus | 53.15 | 1e-140 | 418 |
| LLPS-Drm-2081 | Drosophila melanogaster | 53.08 | 4e-148 | 436 |
| LLPS-Dac-1813 | Daucus carota | 53.08 | 3e-142 | 422 |
| LLPS-Glm-0680 | Glycine max | 53.08 | 1e-143 | 426 |
| LLPS-Zyt-1548 | Zymoseptoria tritici | 53.05 | 6e-146 | 429 |
| LLPS-Trv-0769 | Trichoderma virens | 53.01 | 2e-138 | 410 |
| LLPS-Pes-2532 | Pelodiscus sinensis | 52.98 | 3e-148 | 436 |
| LLPS-Asm-1457 | Astyanax mexicanus | 52.95 | 1e-140 | 417 |
| LLPS-Vir-1620 | Vigna radiata | 52.84 | 3e-143 | 425 |
| LLPS-Amt-2199 | Amborella trichopoda | 52.84 | 2e-137 | 410 |
| LLPS-Gaga-1964 | Gallus gallus | 52.75 | 1e-148 | 438 |
| LLPS-Fud-1741 | Fukomys damarensis | 52.74 | 1e-140 | 417 |
| LLPS-Mod-3700 | Monodelphis domestica | 52.67 | 3e-147 | 434 |
| LLPS-Scs-1031 | Sclerotinia sclerotiorum | 52.66 | 1e-93 | 293 |
| LLPS-Ora-0414 | Ornithorhynchus anatinus | 52.62 | 3e-127 | 381 |
| LLPS-Via-1972 | Vigna angularis | 52.61 | 2e-142 | 423 |
| LLPS-Phv-0405 | Phaseolus vulgaris | 52.61 | 5e-142 | 422 |
| LLPS-Php-1841 | Physcomitrella patens | 52.35 | 1e-143 | 427 |
| LLPS-Ten-3754 | Tetraodon nigroviridis | 52.31 | 3e-143 | 424 |
| LLPS-Dio-1426 | Dipodomys ordii | 52.25 | 1e-128 | 385 |
| LLPS-Cis-2011 | Ciona savignyi | 52.2 | 3e-140 | 416 |
| LLPS-Gog-2368 | Gorilla gorilla | 51.63 | 9e-127 | 383 |
| LLPS-Sol-2459 | Solanum lycopersicum | 51.58 | 1e-135 | 422 |
| LLPS-Cym-0464 | Cyanidioschyzon merolae | 51.49 | 8e-138 | 409 |
| LLPS-Dos-0332 | Dothistroma septosporum | 51.42 | 2e-145 | 428 |
| LLPS-Ori-0464 | Oryza indica | 51.25 | 7e-137 | 409 |
| LLPS-Meg-2327 | Meleagris gallopavo | 51.11 | 3e-130 | 389 |
| LLPS-Ved-0635 | Verticillium dahliae | 50.95 | 5e-137 | 406 |
| LLPS-Mua-0127 | Musa acuminata | 50.9 | 4e-134 | 403 |
| LLPS-Anp-3143 | Anas platyrhynchos | 50.87 | 1e-127 | 382 |
| LLPS-Loa-4079 | Loxodonta africana | 50.87 | 6e-145 | 429 |
| LLPS-Trr-0139 | Trichoderma reesei | 49.53 | 4e-121 | 366 |
| LLPS-Cog-0788 | Colletotrichum gloeosporioides | 48.96 | 1e-102 | 320 |
| LLPS-Cii-2325 | Ciona intestinalis | 47.21 | 1e-116 | 355 |
| LLPS-Urm-3150 | Ursus maritimus | 46.92 | 2e-117 | 358 |
| LLPS-Cae-1517 | Caenorhabditis elegans | 46.12 | 8e-121 | 367 |