• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Php-1841
PURA

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase, chloroplastic
Gene Name: PURA, PHYPA_013113
Ensembl Gene: Pp3c9_24250
Ensembl Protein: Pp3c9_24250V3.1
Organism: Physcomitrella patens
Taxa ID: 3218
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAMAAAAAVA  SQGLLATSSQ  QQKKSSAKLI  CNAATFFSGK  RLLWVKSCNN  GAVGLRASGV  60
61    RCEAQAIERE  AVKADAGNSR  EEDAFSGLKQ  VCAVLGTQWG  DEGKGKLVDI  LAQRFDVVAR  120
121   CQGGANAGHT  IYNDKGEKFA  LHLVPSGILN  EKTTCVVGNG  VVIHLPGFFK  EIDNLESKGV  180
181   NTNGRLLVSD  RAHLLFNLHQ  EVDGLREAEL  AGQMIGTTKR  GIGPCYASKA  IRNGIRVSDL  240
241   RHLDTFREKL  DILYRDAAAR  FKDFEYSSDE  VNAEMEKYVK  YAERLEPYIV  DTVDYVNAAI  300
301   AEGKRILIEG  GQATMLDIDF  GTYPFVTSSN  PSVGGICTGL  GVAPNRLGDI  VGVAKAYTSR  360
361   VGSGPYPTEL  FGEEGDELRK  AGFEWGTTTG  RPRRCGWLDI  VALNFVCTIN  GFTAINLTKL  420
421   DVLSGLPEVK  LGIAYKTPSG  EKLRAFPADL  SILEQVEVEY  EILEGWKEDI  TKVRSYDELP  480
481   AAAQRYVERI  EELIGLPCQY  IGVGPGRDAL  IVKQ  514
Nucleotide CDS Sequence (FASTA)
1     ATGGCTATGG  CAGCTGCCGC  AGCTGTGGCC  TCCCAGGGTC  TGTTAGCTAC  ATCTTCTCAG  60
61    CAGCAGAAGA  AATCTTCCGC  CAAACTCATT  TGCAATGCTG  CCACATTCTT  TTCGGGGAAG  120
121   AGATTGCTCT  GGGTGAAGAG  CTGTAACAAC  GGCGCTGTAG  GGCTGCGCGC  GAGTGGGGTG  180
181   CGTTGCGAGG  CGCAGGCGAT  TGAGAGGGAG  GCAGTGAAAG  CGGATGCCGG  GAATAGTCGC  240
241   GAGGAGGATG  CATTCAGTGG  GTTGAAGCAG  GTGTGTGCTG  TGTTGGGTAC  GCAATGGGGT  300
301   GACGAGGGGA  AGGGCAAGCT  CGTCGACATA  TTGGCCCAGC  GCTTTGACGT  CGTTGCTCGC  360
361   TGCCAGGGAG  GTGCAAATGC  CGGCCACACT  ATCTATAACG  ATAAGGGCGA  AAAGTTTGCA  420
421   CTTCATTTGG  TACCTTCTGG  GATCCTCAAT  GAGAAGACCA  CGTGCGTTGT  TGGCAATGGA  480
481   GTAGTGATTC  ATCTTCCAGG  ATTCTTCAAA  GAGATAGATA  ACCTAGAGTC  GAAGGGTGTC  540
541   AACACCAACG  GTCGTCTGCT  AGTGTCCGAC  CGTGCCCATC  TGCTCTTCAA  CTTGCACCAA  600
601   GAGGTCGATG  GTTTACGTGA  AGCCGAGCTG  GCAGGACAAA  TGATTGGGAC  AACGAAGCGT  660
661   GGCATTGGTC  CTTGCTACGC  CAGTAAGGCC  ATTCGCAATG  GTATTAGAGT  GAGCGACCTC  720
721   CGCCACCTGG  ATACATTCCG  GGAGAAATTG  GACATTCTTT  ACCGTGATGC  TGCTGCCCGG  780
781   TTCAAGGATT  TTGAGTACTC  CTCCGATGAA  GTAAATGCTG  AGATGGAAAA  GTATGTCAAG  840
841   TATGCGGAGA  GACTGGAACC  CTACATCGTT  GATACTGTAG  ACTACGTAAA  TGCTGCTATT  900
901   GCTGAAGGCA  AACGCATATT  GATTGAGGGA  GGCCAGGCCA  CCATGCTCGA  CATTGATTTT  960
961   GGAACGTATC  CTTTTGTCAC  GTCTTCAAAT  CCTTCTGTTG  GAGGAATCTG  TACTGGTTTG  1020
1021  GGAGTAGCAC  CCAACCGTCT  CGGTGACATC  GTTGGTGTTG  CTAAGGCGTA  CACAAGCCGT  1080
1081  GTTGGCTCAG  GCCCATATCC  CACAGAGCTC  TTCGGTGAGG  AAGGAGACGA  GCTTCGTAAG  1140
1141  GCTGGGTTTG  AGTGGGGAAC  CACTACAGGC  AGGCCTCGTC  GCTGTGGCTG  GCTGGACATA  1200
1201  GTCGCCCTAA  ACTTCGTCTG  TACCATCAAT  GGTTTCACCG  CTATCAACCT  CACTAAACTT  1260
1261  GATGTCCTCT  CTGGACTGCC  TGAGGTGAAA  CTAGGAATTG  CTTACAAAAC  CCCATCCGGC  1320
1321  GAGAAGCTTA  GAGCGTTCCC  TGCTGATCTG  TCTATCCTCG  AGCAAGTTGA  GGTGGAGTAT  1380
1381  GAAATCTTGG  AAGGGTGGAA  AGAGGACATC  ACTAAAGTTA  GATCGTATGA  CGAGCTACCA  1440
1441  GCTGCTGCAC  AAAGGTATGT  GGAGAGGATA  GAGGAGCTTA  TTGGGTTACC  CTGTCAGTAT  1500
1501  ATTGGTGTGG  GTCCTGGTCG  AGATGCTTTG  ATTGTGAAGC  AATAG  1545

▼ KEYWORD

ID
Family
Chloroplast
Complete proteome
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Plastid
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Biological Process
'de novo' AMP biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orni-1991Oryza nivara74.010.0 689
LLPS-Orgl-2078Oryza glumaepatula73.780.0 685
LLPS-Orr-0955Oryza rufipogon73.780.0 686
LLPS-Sei-2295Setaria italica73.470.0 671
LLPS-Prp-1925Prunus persica72.770.0 657
LLPS-Tra-2903Triticum aestivum72.540.0 661
LLPS-Sob-1512Sorghum bicolor72.540.0 665
LLPS-Zem-0333Zea mays72.540.0 662
LLPS-Hov-1464Hordeum vulgare72.220.0 666
LLPS-Lep-2353Leersia perrieri71.830.0 663
LLPS-Mae-0815Manihot esculenta71.830.0 658
LLPS-Viv-2237Vitis vinifera71.60.0 651
LLPS-Org-1697Oryza glaberrima71.60.0 662
LLPS-Brd-2360Brachypodium distachyon71.360.0 653
LLPS-Orbr-0602Oryza brachyantha71.330.0 684
LLPS-Cus-1099Cucumis sativus71.130.0 656
LLPS-Ori-0464Oryza indica70.670.0 676
LLPS-Gor-2149Gossypium raimondii70.660.0 645
LLPS-Coc-1423Corchorus capsularis70.230.0 663
LLPS-Ors-1970Oryza sativa69.730.0 663
LLPS-Pot-2036Populus trichocarpa69.720.0 648
LLPS-Thc-1009Theobroma cacao69.550.0 657
LLPS-Orb-2409Oryza barthii69.510.0 662
LLPS-Bro-1915Brassica oleracea69.140.0 654
LLPS-Sot-0966Solanum tuberosum69.110.0 666
LLPS-Orp-0898Oryza punctata69.040.0 663
LLPS-Brn-2145Brassica napus68.920.0 654
LLPS-Brr-1112Brassica rapa68.670.0 638
LLPS-Met-2355Medicago truncatula68.060.0 636
LLPS-Nia-2586Nicotiana attenuata68.050.0 668
LLPS-Arl-0264Arabidopsis lyrata67.970.0 653
LLPS-Glm-0680Glycine max67.830.0 651
LLPS-Mua-0127Musa acuminata67.790.0 642
LLPS-Hea-2379Helianthus annuus67.760.0 657
LLPS-Art-1169Arabidopsis thaliana67.760.0 657
LLPS-Dac-1813Daucus carota67.690.0 661
LLPS-Sem-0453Selaginella moellendorffii67.40.0 645
LLPS-Sol-2459Solanum lycopersicum66.880.0 658
LLPS-Osl-0169Ostreococcus lucimarinus65.950.0 592
LLPS-Amt-2199Amborella trichopoda65.050.0 636
LLPS-Vir-1620Vigna radiata64.460.0 655
LLPS-Via-1972Vigna angularis64.260.0 650
LLPS-Phv-0405Phaseolus vulgaris64.260.0 650
LLPS-Chr-1273Chlamydomonas reinhardtii62.370.0 582
LLPS-Cym-0464Cyanidioschyzon merolae54.523e-154 454
LLPS-Gas-1383Galdieria sulphuraria54.356e-165 481
LLPS-Miv-1011Microbotryum violaceum53.051e-155 458
LLPS-Chc-0747Chondrus crispus52.939e-146 432
LLPS-Scm-2202Scophthalmus maximus52.642e-146 436
LLPS-Mel-0588Melampsora laricipopulina52.522e-156 460
LLPS-Crn-0994Cryptococcus neoformans52.355e-155 456
LLPS-Pof-4180Poecilia formosa52.284e-144 429
LLPS-Orn-2937Oreochromis niloticus51.957e-146 434
LLPS-Drm-2081Drosophila melanogaster51.891e-155 459
LLPS-Orl-3833Oryzias latipes51.662e-147 437
LLPS-Scp-1463Schizosaccharomyces pombe51.657e-159 466
LLPS-Abg-1763Absidia glauca51.656e-158 464
LLPS-Tar-1307Takifugu rubripes51.645e-146 434
LLPS-Scc-0109Schizosaccharomyces cryophilus51.531e-160 471
LLPS-Scf-0454Scleropages formosus51.41e-147 438
LLPS-Tag-2953Taeniopygia guttata51.45e-146 434
LLPS-Leo-2410Lepisosteus oculatus51.171e-146 436
LLPS-Dar-0993Danio rerio51.175e-146 434
LLPS-Gaa-1243Gasterosteus aculeatus51.135e-147 437
LLPS-Tum-1600Tuber melanosporum51.062e-153 452
LLPS-Spr-0335Sporisorium reilianum51.031e-160 471
LLPS-Yal-0927Yarrowia lipolytica50.934e-149 441
LLPS-Icp-0440Ictalurus punctatus50.72e-144 430
LLPS-Kop-0984Komagataella pastoris50.75e-154 454
LLPS-Put-1310Puccinia triticina50.686e-147 436
LLPS-Pes-2532Pelodiscus sinensis50.587e-147 436
LLPS-Anc-2966Anolis carolinensis50.583e-146 435
LLPS-Usm-0054Ustilago maydis50.575e-160 469
LLPS-Pug-0609Puccinia graminis50.461e-147 437
LLPS-Mea-0780Mesocricetus auratus50.344e-148 439
LLPS-Sus-1919Sus scrofa50.343e-148 440
LLPS-Sac-1612Saccharomyces cerevisiae50.231e-152 450
LLPS-Blg-0813Blumeria graminis50.236e-132 397
LLPS-Lac-1985Latimeria chalumnae50.238e-145 431
LLPS-Ran-1046Rattus norvegicus50.114e-147 437
LLPS-Mup-3445Mustela putorius furo50.112e-148 441
LLPS-Xim-2450Xiphophorus maculatus50.113e-145 432
LLPS-Fia-2442Ficedula albicollis50.04e-147 440
LLPS-Ten-3754Tetraodon nigroviridis50.05e-144 429
LLPS-Asg-0922Ashbya gossypii49.894e-145 431
LLPS-Bot-3997Bos taurus49.896e-148 439
LLPS-Cap-0471Cavia porcellus49.892e-147 438
LLPS-Scj-1492Schizosaccharomyces japonicus49.761e-156 460
LLPS-Meg-2327Meleagris gallopavo49.755e-133 399
LLPS-Mod-3700Monodelphis domestica49.665e-146 434
LLPS-Sah-2724Sarcophilus harrisii49.536e-141 421
LLPS-Xet-2209Xenopus tropicalis49.534e-144 429
LLPS-Phn-1421Phaeosphaeria nodorum49.534e-144 428
LLPS-Mum-3906Mus musculus49.442e-143 428
LLPS-Aon-4655Aotus nancymaae49.443e-142 424
LLPS-Ova-0495Ovis aries49.443e-140 419
LLPS-Tut-1107Tursiops truncatus49.443e-142 425
LLPS-Otg-0311Otolemur garnettii49.434e-147 437
LLPS-Cas-1462Carlito syrichta49.433e-147 437
LLPS-Caj-2039Callithrix jacchus49.217e-141 421
LLPS-Chs-4116Chlorocebus sabaeus49.216e-146 434
LLPS-Cea-1553Cercocebus atys49.214e-146 434
LLPS-Paa-0183Papio anubis49.216e-141 421
LLPS-Mal-3025Mandrillus leucophaeus49.216e-141 421
LLPS-Aim-0685Ailuropoda melanoleuca49.214e-146 435
LLPS-Pat-2324Pan troglodytes49.216e-141 421
LLPS-Pap-2800Pan paniscus49.214e-141 422
LLPS-Fec-3598Felis catus49.211e-146 436
LLPS-Ict-0614Ictidomys tridecemlineatus49.215e-141 421
LLPS-Caf-0754Canis familiaris49.211e-141 423
LLPS-Eqc-3422Equus caballus49.213e-140 421
LLPS-Maf-4153Macaca fascicularis49.081e-135 408
LLPS-Man-1930Macaca nemestrina49.081e-135 408
LLPS-Mam-4127Macaca mulatta49.081e-135 408
LLPS-Coo-1286Colletotrichum orbiculare49.077e-140 417
LLPS-Anp-3143Anas platyrhynchos49.02e-130 392
LLPS-Gaga-1964Gallus gallus49.05e-148 439
LLPS-Hos-3127Homo sapiens48.992e-140 420
LLPS-Nol-0675Nomascus leucogenys48.987e-146 434
LLPS-Poa-3715Pongo abelii48.987e-146 434
LLPS-Cis-2011Ciona savignyi48.961e-136 410
LLPS-Zyt-1548Zymoseptoria tritici48.824e-139 416
LLPS-Asm-1457Astyanax mexicanus48.789e-140 418
LLPS-Orc-3994Oryctolagus cuniculus48.712e-132 400
LLPS-Mao-0966Magnaporthe oryzae48.71e-136 409
LLPS-Myl-3796Myotis lucifugus48.693e-141 422
LLPS-Gog-2368Gorilla gorilla48.481e-126 386
LLPS-Cogr-1261Colletotrichum graminicola48.362e-141 421
LLPS-Rhb-1010Rhinopithecus bieti48.327e-139 416
LLPS-Pyt-1575Pyrenophora teres48.243e-133 417
LLPS-Lem-0930Leptosphaeria maculans48.244e-138 413
LLPS-Pytr-1614Pyrenophora triticirepentis48.124e-138 413
LLPS-Nec-0687Neurospora crassa48.112e-138 414
LLPS-Ora-0414Ornithorhynchus anatinus47.992e-124 377
LLPS-Fud-1741Fukomys damarensis47.878e-134 402
LLPS-Dos-0332Dothistroma septosporum47.763e-138 413
LLPS-Fuv-1299Fusarium verticillioides47.753e-131 395
LLPS-Dio-1426Dipodomys ordii47.744e-124 376
LLPS-Loa-4079Loxodonta africana47.738e-143 427
LLPS-Scs-1031Sclerotinia sclerotiorum47.693e-91 289
LLPS-Map-1244Magnaporthe poae47.526e-134 402
LLPS-Asni-0729Aspergillus niger47.438e-133 399
LLPS-Asc-1389Aspergillus clavatus47.313e-135 405
LLPS-Fuo-1421Fusarium oxysporum47.281e-129 391
LLPS-Beb-0207Beauveria bassiana47.045e-135 405
LLPS-Gag-0205Gaeumannomyces graminis46.811e-132 399
LLPS-Asf-0713Aspergillus flavus46.67e-132 397
LLPS-Aso-0613Aspergillus oryzae46.67e-132 397
LLPS-Cae-1517Caenorhabditis elegans46.583e-129 391
LLPS-Fus-0180Fusarium solani46.472e-126 382
LLPS-Nef-1284Neosartorya fischeri45.97e-133 399
LLPS-Ast-0159Aspergillus terreus45.92e-128 388
LLPS-Asn-1158Aspergillus nidulans45.672e-131 395
LLPS-Cii-2325Ciona intestinalis45.672e-119 365
LLPS-Asfu-1448Aspergillus fumigatus45.679e-132 397
LLPS-Cog-0788Colletotrichum gloeosporioides44.997e-107 334
LLPS-Trv-0769Trichoderma virens44.312e-124 377
LLPS-Ved-0635Verticillium dahliae43.746e-118 360
LLPS-Urm-3150Ursus maritimus43.492e-116 358
LLPS-Trr-0139Trichoderma reesei40.377e-106 330