• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Otg-0311
ADSSL1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase isozyme 1
Gene Name: ADSSL1, ADSS1
Ensembl Gene: ENSOGAG00000015406.2
Ensembl Protein: ENSOGAP00000013796.2
Organism: Otolemur garnettii
Taxa ID: 30611
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     QTSETSMSGT  RASNDRPPGA  GGVKRGRQQQ  EAAATGSRVT  VVLGAQWGDE  GKGKVVDLLA  60
61    TDADIISRCQ  GGNNAGHTVV  VDGKEYDFHL  LPSGIINTKA  VSFIGNGVVI  HLPGLFEEAE  120
121   KNEKKGLKDW  EKRLIISDRA  HLVFDFHQAV  DGLQEVQRQA  QEGKNIGTTK  KGIGPTYSSK  180
181   ASRTGLRICD  LLSDFDEFSS  RFKNLAHQHQ  AMFPTLDVDI  EGQLKKLKGF  AERIRPMVRD  240
241   GVYFMYEALH  GPPKKILVEG  ANAALLDIDF  GTYPFVTSSN  CTVGGVCTGL  GIPPQNIGDV  300
301   YGVVKAYTTR  VGIGAFPTEQ  INEIGDLLQN  RGHEWGVTTG  RKRRCGWLDL  MILRYAHMVN  360
361   GFTALAFTKL  DILDVLSEIK  VGVSYKLNGK  RIPYFPANQE  ILQKVEVEYE  TLPGWKADTT  420
421   GARRWEDLPP  QAQSYVRFVE  NHVGVAVKWV  GVGKSRESMI  QLF  463
Nucleotide CDS Sequence (FASTA)
1     CAGACCAGCG  AAACAAGCAT  GTCAGGAACC  CGAGCCTCCA  ACGACCGGCC  CCCCGGCGCG  60
61    GGCGGCGTCA  AGCGGGGGCG  GCAGCAGCAG  GAGGCGGCGG  CGACGGGCTC  CCGCGTGACG  120
121   GTGGTGCTGG  GCGCGCAGTG  GGGGGACGAG  GGCAAAGGCA  AGGTGGTGGA  CCTGCTTGCC  180
181   ACGGACGCCG  ACATCATCAG  CCGCTGTCAG  GGGGGCAACA  ATGCTGGCCA  CACCGTGGTG  240
241   GTGGATGGCA  AGGAGTACGA  CTTCCACCTG  CTGCCCAGTG  GCATCATCAA  CACCAAGGCT  300
301   GTTTCCTTCA  TTGGCAACGG  GGTGGTCATT  CACCTGCCTG  GCTTGTTTGA  AGAAGCAGAG  360
361   AAGAATGAGA  AGAAAGGGCT  GAAGGATTGG  GAGAAGAGGC  TCATCATCTC  TGACAGAGCC  420
421   CACCTGGTGT  TTGATTTTCA  CCAGGCCGTT  GACGGGCTTC  AGGAAGTTCA  GCGCCAAGCA  480
481   CAAGAGGGGA  AGAACATCGG  CACCACCAAG  AAGGGGATCG  GGCCAACTTA  CTCCTCCAAG  540
541   GCTTCCCGGA  CGGGCCTCCG  CATCTGTGAC  CTCCTGTCAG  ATTTTGATGA  GTTTTCCAGC  600
601   AGGTTCAAGA  ACCTGGCTCA  CCAGCACCAG  GCCATGTTCC  CCACCCTGGA  TGTGGACATC  660
661   GAAGGGCAGC  TCAAGAAGCT  GAAGGGCTTT  GCTGAGCGGA  TCAGACCGAT  GGTCCGAGAT  720
721   GGTGTTTACT  TTATGTATGA  GGCACTCCAT  GGCCCCCCCA  AGAAAATCCT  TGTGGAAGGT  780
781   GCCAACGCAG  CCCTTCTCGA  CATTGACTTT  GGGACCTACC  CCTTTGTGAC  CTCGTCCAAC  840
841   TGCACGGTGG  GCGGTGTGTG  CACGGGCCTG  GGCATACCAC  CCCAGAACAT  AGGCGATGTG  900
901   TACGGCGTGG  TGAAGGCTTA  CACCACACGT  GTGGGCATTG  GGGCCTTCCC  CACTGAGCAG  960
961   ATCAATGAAA  TCGGAGACCT  ATTGCAGAAC  CGTGGCCATG  AGTGGGGAGT  GACCACGGGT  1020
1021  AGGAAGCGGC  GCTGCGGGTG  GCTAGACCTC  ATGATCCTGA  GATATGCTCA  CATGGTCAAC  1080
1081  GGGTTCACCG  CGCTGGCCTT  CACGAAGCTG  GACATCCTGG  ATGTTCTGAG  TGAGATTAAA  1140
1141  GTCGGCGTCT  CGTACAAGCT  GAATGGGAAA  AGGATTCCCT  ACTTTCCAGC  TAACCAGGAG  1200
1201  ATACTTCAGA  AGGTTGAAGT  TGAATATGAA  ACACTGCCAG  GATGGAAAGC  AGACACCACA  1260
1261  GGGGCCAGGA  GGTGGGAGGA  CCTACCCCCG  CAGGCCCAGA  GCTACGTCCG  CTTCGTGGAG  1320
1321  AACCACGTGG  GAGTTGCAGT  CAAGTGGGTC  GGAGTTGGCA  AGTCCAGAGA  GTCGATGATC  1380
1381  CAGCTGTTTT  AA  1392

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Biological Process
'de novo' AMP biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-3715Pongo abelii97.370.0 871
LLPS-Cea-1553Cercocebus atys97.160.0 870
LLPS-Nol-0675Nomascus leucogenys97.160.0 870
LLPS-Chs-4116Chlorocebus sabaeus96.940.0 868
LLPS-Ran-1046Rattus norvegicus96.940.0 872
LLPS-Cas-1462Carlito syrichta96.940.0 870
LLPS-Mea-0780Mesocricetus auratus96.720.0 870
LLPS-Gog-2368Gorilla gorilla96.70.0 746
LLPS-Cap-0471Cavia porcellus95.840.0 862
LLPS-Fec-3598Felis catus94.540.0 851
LLPS-Bot-3997Bos taurus93.870.0 847
LLPS-Sus-1919Sus scrofa93.650.0 848
LLPS-Mup-3445Mustela putorius furo93.490.0 853
LLPS-Aim-0685Ailuropoda melanoleuca92.260.0 815
LLPS-Mod-3700Monodelphis domestica91.250.0 825
LLPS-Anp-3143Anas platyrhynchos90.70.0 707
LLPS-Meg-2327Meleagris gallopavo90.520.0 717
LLPS-Loa-4079Loxodonta africana90.40.0 835
LLPS-Pes-2532Pelodiscus sinensis88.450.0 794
LLPS-Gaga-1964Gallus gallus88.040.0 795
LLPS-Xet-2209Xenopus tropicalis87.750.0 784
LLPS-Fia-2442Ficedula albicollis87.50.0 797
LLPS-Anc-2966Anolis carolinensis87.090.0 783
LLPS-Scf-0454Scleropages formosus85.350.0 745
LLPS-Leo-2410Lepisosteus oculatus83.510.0 756
LLPS-Lac-1985Latimeria chalumnae82.880.0 733
LLPS-Xim-2450Xiphophorus maculatus81.390.0 721
LLPS-Pof-4180Poecilia formosa81.070.0 715
LLPS-Orl-3833Oryzias latipes80.670.0 725
LLPS-Icp-0440Ictalurus punctatus80.650.0 732
LLPS-Orn-2937Oreochromis niloticus80.130.0 727
LLPS-Sah-2724Sarcophilus harrisii79.070.0 678
LLPS-Dar-0993Danio rerio79.00.0 719
LLPS-Caf-0754Canis familiaris78.840.0 678
LLPS-Scm-2202Scophthalmus maximus78.430.0 722
LLPS-Gaa-1243Gasterosteus aculeatus78.170.0 717
LLPS-Tar-1307Takifugu rubripes78.070.0 711
LLPS-Ora-0414Ornithorhynchus anatinus78.030.0 610
LLPS-Asm-1457Astyanax mexicanus77.630.0 685
LLPS-Tag-2953Taeniopygia guttata77.630.0 675
LLPS-Rhb-1010Rhinopithecus bieti77.290.0 670
LLPS-Dio-1426Dipodomys ordii76.770.0 603
LLPS-Eqc-3422Equus caballus75.990.0 678
LLPS-Urm-3150Ursus maritimus75.970.0 657
LLPS-Maf-4153Macaca fascicularis75.930.0 663
LLPS-Man-1930Macaca nemestrina75.930.0 663
LLPS-Mam-4127Macaca mulatta75.930.0 663
LLPS-Tut-1107Tursiops truncatus75.770.0 676
LLPS-Mal-3025Mandrillus leucophaeus75.770.0 676
LLPS-Paa-0183Papio anubis75.770.0 676
LLPS-Ict-0614Ictidomys tridecemlineatus75.770.0 676
LLPS-Ova-0495Ovis aries75.660.0 673
LLPS-Aon-4655Aotus nancymaae75.550.0 674
LLPS-Mum-3906Mus musculus75.550.0 676
LLPS-Caj-2039Callithrix jacchus75.550.0 676
LLPS-Pap-2800Pan paniscus75.550.0 676
LLPS-Pat-2324Pan troglodytes75.550.0 676
LLPS-Hos-3127Homo sapiens75.550.0 675
LLPS-Myl-3796Myotis lucifugus74.890.0 674
LLPS-Fud-1741Fukomys damarensis74.670.0 657
LLPS-Ten-3754Tetraodon nigroviridis74.360.0 612
LLPS-Orc-3994Oryctolagus cuniculus73.130.0 647
LLPS-Drm-2081Drosophila melanogaster61.120.0 526
LLPS-Cis-2011Ciona savignyi59.267e-173 501
LLPS-Abg-1763Absidia glauca58.636e-164 477
LLPS-Asg-0922Ashbya gossypii58.513e-157 460
LLPS-Sac-1612Saccharomyces cerevisiae57.347e-161 469
LLPS-Kop-0984Komagataella pastoris56.941e-157 461
LLPS-Scp-1463Schizosaccharomyces pombe56.724e-162 473
LLPS-Lem-0930Leptosphaeria maculans56.241e-146 433
LLPS-Phn-1421Phaeosphaeria nodorum56.242e-145 430
LLPS-Yal-0927Yarrowia lipolytica55.695e-152 447
LLPS-Pyt-1575Pyrenophora teres55.068e-138 427
LLPS-Pytr-1614Pyrenophora triticirepentis55.061e-142 422
LLPS-Scc-0109Schizosaccharomyces cryophilus54.593e-158 462
LLPS-Scj-1492Schizosaccharomyces japonicus54.486e-156 457
LLPS-Miv-1011Microbotryum violaceum54.314e-155 454
LLPS-Tum-1600Tuber melanosporum54.233e-142 421
LLPS-Spr-0335Sporisorium reilianum53.818e-158 462
LLPS-Usm-0054Ustilago maydis53.811e-156 459
LLPS-Chr-1273Chlamydomonas reinhardtii53.723e-139 415
LLPS-Viv-2237Vitis vinifera52.455e-137 410
LLPS-Brr-1112Brassica rapa52.321e-132 399
LLPS-Prp-1925Prunus persica52.322e-131 396
LLPS-Chc-0747Chondrus crispus52.237e-133 397
LLPS-Cogr-1261Colletotrichum graminicola52.218e-133 397
LLPS-Brn-2145Brassica napus52.082e-133 401
LLPS-Lep-2353Leersia perrieri52.081e-134 404
LLPS-Sot-0966Solanum tuberosum52.082e-134 404
LLPS-Cii-2325Ciona intestinalis51.876e-143 424
LLPS-Glm-0680Glycine max51.832e-131 396
LLPS-Via-1972Vigna angularis51.832e-132 399
LLPS-Vir-1620Vigna radiata51.831e-132 399
LLPS-Tra-2903Triticum aestivum51.834e-133 400
LLPS-Mae-0815Manihot esculenta51.834e-132 398
LLPS-Phv-0405Phaseolus vulgaris51.839e-132 397
LLPS-Bro-1915Brassica oleracea51.832e-131 396
LLPS-Crn-0994Cryptococcus neoformans51.712e-144 427
LLPS-Cym-0464Cyanidioschyzon merolae51.698e-136 405
LLPS-Orni-1991Oryza nivara51.592e-132 399
LLPS-Brd-2360Brachypodium distachyon51.593e-130 394
LLPS-Orp-0898Oryza punctata51.593e-134 404
LLPS-Pot-2036Populus trichocarpa51.594e-135 405
LLPS-Mel-0588Melampsora laricipopulina51.573e-151 445
LLPS-Coo-1286Colletotrichum orbiculare51.524e-130 390
LLPS-Sem-0453Selaginella moellendorffii51.471e-134 404
LLPS-Thc-1009Theobroma cacao51.346e-133 400
LLPS-Orgl-2078Oryza glumaepatula51.342e-131 396
LLPS-Sei-2295Setaria italica51.342e-133 401
LLPS-Orr-0955Oryza rufipogon51.341e-131 397
LLPS-Arl-0264Arabidopsis lyrata51.222e-129 391
LLPS-Met-2355Medicago truncatula51.24e-130 392
LLPS-Hea-2379Helianthus annuus51.082e-134 404
LLPS-Ors-1970Oryza sativa51.074e-135 405
LLPS-Put-1310Puccinia triticina50.922e-148 437
LLPS-Gor-2149Gossypium raimondii50.861e-134 404
LLPS-Coc-1423Corchorus capsularis50.864e-131 395
LLPS-Amt-2199Amborella trichopoda50.841e-127 387
LLPS-Orb-2409Oryza barthii50.832e-134 404
LLPS-Org-1697Oryza glaberrima50.835e-135 404
LLPS-Dac-1813Daucus carota50.732e-131 396
LLPS-Pug-0609Puccinia graminis50.691e-148 438
LLPS-Cus-1099Cucumis sativus50.614e-132 398
LLPS-Art-1169Arabidopsis thaliana50.612e-128 389
LLPS-Cae-1517Caenorhabditis elegans50.582e-144 428
LLPS-Asn-1158Aspergillus nidulans50.53e-129 388
LLPS-Php-1841Physcomitrella patens50.361e-133 402
LLPS-Zem-0333Zea mays50.351e-131 397
LLPS-Hov-1464Hordeum vulgare50.242e-129 391
LLPS-Sob-1512Sorghum bicolor50.233e-134 403
LLPS-Sol-2459Solanum lycopersicum50.125e-126 399
LLPS-Orbr-0602Oryza brachyantha49.771e-132 399
LLPS-Mua-0127Musa acuminata49.427e-130 393
LLPS-Ori-0464Oryza indica49.189e-128 387
LLPS-Nia-2586Nicotiana attenuata49.11e-134 405
LLPS-Asfu-1448Aspergillus fumigatus48.514e-131 393
LLPS-Zyt-1548Zymoseptoria tritici48.471e-125 379
LLPS-Cog-0788Colletotrichum gloeosporioides48.346e-97 306
LLPS-Nef-1284Neosartorya fischeri48.273e-131 393
LLPS-Mao-0966Magnaporthe oryzae48.124e-128 385
LLPS-Osl-0169Ostreococcus lucimarinus48.094e-135 403
LLPS-Asni-0729Aspergillus niger48.025e-130 390
LLPS-Gas-1383Galdieria sulphuraria47.893e-131 393
LLPS-Aso-0613Aspergillus oryzae47.772e-127 384
LLPS-Asf-0713Aspergillus flavus47.772e-127 384
LLPS-Asc-1389Aspergillus clavatus47.525e-130 390
LLPS-Ast-0159Aspergillus terreus47.521e-128 387
LLPS-Fus-0180Fusarium solani47.478e-116 353
LLPS-Nec-0687Neurospora crassa47.412e-129 389
LLPS-Gag-0205Gaeumannomyces graminis47.188e-126 379
LLPS-Fuo-1421Fusarium oxysporum47.173e-126 380
LLPS-Map-1244Magnaporthe poae46.953e-124 375
LLPS-Fuv-1299Fusarium verticillioides46.932e-126 381
LLPS-Beb-0207Beauveria bassiana46.932e-123 373
LLPS-Dos-0332Dothistroma septosporum46.847e-126 380
LLPS-Blg-0813Blumeria graminis46.262e-118 361
LLPS-Scs-1031Sclerotinia sclerotiorum45.379e-83 266
LLPS-Ved-0635Verticillium dahliae44.346e-111 341
LLPS-Trv-0769Trichoderma virens43.515e-111 341
LLPS-Trr-0139Trichoderma reesei41.114e-95 300