• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asf-0713
AFLA_083920

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylosuccinate synthetase
Gene Name: AFLA_083920
Ensembl Gene: AFLA_083920
Ensembl Protein: EED57695
Organism: Aspergillus flavus
Taxa ID: 332952
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEED57695EED57695
UniProtB8MZA3, PURA_ASPFN
GeneBankEQ963472EED57695.1
RefSeqXM_002373266.1XP_002373307.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGVSIVLGSQ  WGDEGKGKIT  DMLAQQATLC  CRAAGGHNAG  HTIVHGNKTY  DFHILPSGLI  60
61    SPSCINLIGA  GTVVHVPSFF  KELASLEEKG  LEGASKRIFI  SDRAHVCLQL  HSVVDGLEEA  120
121   KLGGRKVGTT  GKGIGPCYSD  KASRRGIRVG  EILDEAVFER  KLRSLDAGYR  ARFGDLEYNV  180
181   EEELAQFKEY  RKLLGPYIVD  QLAFLQKYKD  SPNTLVEGAN  ALMLDLDHGT  YPYVTSSSTG  240
241   LGGAMQALSL  NPTSIKSVIG  VVKAYTTRVG  SGPFPSEQFN  ADGDKLQSVG  REFGVTTGRR  300
301   RRCGWLDLVV  CRYSQAINHY  TALNLTKLDV  LDDFDEIKVG  VAYILPDGTR  TENTIPADAE  360
361   VLEKVKVEYV  TLPGWKSNTM  GVKKYEDLPD  NARAYIEYIE  RELGGVPVKW  IGTGPARDDM  420
421   IARE  424
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGTTT  CAATCGTTCT  GGGCAGCCAG  TGGGGTGATG  AAGGAAAGGG  CAAGATTACG  60
61    GATATGCTCG  CGCAGCAGGC  GACGCTGTGC  TGCCGTGCCG  CTGGCGGTCA  CAATGCGGGC  120
121   CATACTATTG  TCCATGGTAA  CAAGACCTAT  GATTTCCACA  TTCTTCCCTC  TGGCCTGATC  180
181   TCCCCTTCAT  GTATCAACCT  TATCGGTGCT  GGTACCGTTG  TTCACGTTCC  CAGCTTCTTC  240
241   AAGGAGTTGG  CTTCTCTTGA  GGAGAAGGGT  CTCGAGGGTG  CTAGCAAGCG  CATTTTCATC  300
301   TCCGACCGCG  CGCATGTCTG  CCTTCAATTG  CACTCCGTTG  TAGATGGCTT  GGAGGAGGCC  360
361   AAGCTGGGTG  GTCGCAAGGT  TGGTACTACT  GGTAAGGGCA  TTGGTCCTTG  CTACAGTGAT  420
421   AAGGCTTCTC  GCAGGGGTAT  CCGTGTGGGA  GAGATCCTGG  ATGAGGCGGT  TTTCGAGCGC  480
481   AAGTTACGCT  CTTTGGATGC  CGGATATCGC  GCCCGATTCG  GCGATTTGGA  ATACAACGTC  540
541   GAGGAGGAGC  TCGCGCAATT  CAAGGAATAC  CGCAAACTCC  TGGGCCCCTA  CATTGTCGAC  600
601   CAACTGGCCT  TCCTTCAAAA  ATACAAGGAC  TCGCCCAACA  CCCTGGTCGA  GGGTGCCAAC  660
661   GCTCTTATGC  TTGACTTGGA  TCATGGCACC  TACCCCTATG  TGACTTCCTC  GTCCACCGGC  720
721   CTGGGCGGTG  CTATGCAAGC  CCTGTCTCTG  AACCCCACTA  GCATCAAATC  CGTTATCGGT  780
781   GTCGTAAAAG  CCTACACTAC  CCGTGTCGGC  TCCGGACCTT  TCCCTAGCGA  ACAGTTCAAC  840
841   GCAGACGGTG  ACAAGCTGCA  GAGTGTCGGC  AGGGAGTTCG  GTGTCACTAC  CGGTCGTCGC  900
901   CGTCGCTGCG  GTTGGCTTGA  CTTGGTCGTC  TGCCGCTACT  CGCAGGCGAT  CAACCACTAC  960
961   ACAGCCCTTA  ACCTGACCAA  GCTGGACGTT  CTGGACGACT  TCGACGAGAT  CAAGGTCGGC  1020
1021  GTTGCCTACA  TTCTGCCCGA  CGGCACTCGC  ACCGAGAACA  CTATCCCTGC  CGACGCCGAA  1080
1081  GTTCTCGAGA  AGGTGAAGGT  TGAATACGTT  ACTCTCCCCG  GCTGGAAGAG  CAACACCATG  1140
1141  GGCGTCAAGA  AGTACGAGGA  TCTCCCCGAC  AATGCGCGTG  CGTACATCGA  GTACATCGAG  1200
1201  CGCGAACTGG  GTGGCGTTCC  TGTGAAATGG  ATCGGTACCG  GTCCCGCTCG  CGATGACATG  1260
1261  ATTGCCCGCG  AGTAG  1275

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Adenylosuccinate synthase activity
Molecular Function
GTP binding
Molecular Function
Magnesium ion binding
Biological Process
'de novo' AMP biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aso-0613Aspergillus oryzae100.00.0 872
LLPS-Asni-0729Aspergillus niger91.980.0 814
LLPS-Ast-0159Aspergillus terreus91.270.0 815
LLPS-Asfu-1448Aspergillus fumigatus88.210.0 785
LLPS-Nef-1284Neosartorya fischeri87.970.0 785
LLPS-Asc-1389Aspergillus clavatus87.50.0 777
LLPS-Asn-1158Aspergillus nidulans86.320.0 766
LLPS-Beb-0207Beauveria bassiana63.830.0 541
LLPS-Fus-0180Fusarium solani62.044e-176 506
LLPS-Lem-0930Leptosphaeria maculans61.880.0 536
LLPS-Map-1244Magnaporthe poae61.850.0 538
LLPS-Gag-0205Gaeumannomyces graminis61.610.0 534
LLPS-Pytr-1614Pyrenophora triticirepentis61.410.0 534
LLPS-Pyt-1575Pyrenophora teres61.271e-180 536
LLPS-Phn-1421Phaeosphaeria nodorum61.180.0 526
LLPS-Mao-0966Magnaporthe oryzae60.90.0 530
LLPS-Nec-0687Neurospora crassa60.520.0 535
LLPS-Scs-1031Sclerotinia sclerotiorum60.253e-119 358
LLPS-Fuo-1421Fusarium oxysporum59.622e-177 509
LLPS-Fuv-1299Fusarium verticillioides59.394e-178 511
LLPS-Blg-0813Blumeria graminis58.783e-162 471
LLPS-Zyt-1548Zymoseptoria tritici58.397e-177 508
LLPS-Dos-0332Dothistroma septosporum58.319e-173 498
LLPS-Scj-1492Schizosaccharomyces japonicus58.029e-175 503
LLPS-Trv-0769Trichoderma virens57.911e-163 474
LLPS-Miv-1011Microbotryum violaceum57.288e-168 485
LLPS-Tum-1600Tuber melanosporum57.111e-173 500
LLPS-Scp-1463Schizosaccharomyces pombe57.081e-170 493
LLPS-Pug-0609Puccinia graminis56.856e-165 478
LLPS-Put-1310Puccinia triticina56.622e-165 479
LLPS-Cogr-1261Colletotrichum graminicola56.262e-170 492
LLPS-Asg-0922Ashbya gossypii55.892e-165 479
LLPS-Crn-0994Cryptococcus neoformans55.879e-161 468
LLPS-Abg-1763Absidia glauca55.691e-166 483
LLPS-Coo-1286Colletotrichum orbiculare55.662e-166 482
LLPS-Usm-0054Ustilago maydis55.534e-161 469
LLPS-Spr-0335Sporisorium reilianum55.538e-163 473
LLPS-Mel-0588Melampsora laricipopulina54.822e-163 474
LLPS-Scc-0109Schizosaccharomyces cryophilus54.723e-167 484
LLPS-Trr-0139Trichoderma reesei54.442e-152 446
LLPS-Sac-1612Saccharomyces cerevisiae54.271e-167 485
LLPS-Yal-0927Yarrowia lipolytica54.12e-162 472
LLPS-Kop-0984Komagataella pastoris54.14e-162 471
LLPS-Orn-2937Oreochromis niloticus52.08e-150 441
LLPS-Orl-3833Oryzias latipes52.01e-148 437
LLPS-Sus-1919Sus scrofa51.533e-146 431
LLPS-Scf-0454Scleropages formosus51.532e-150 441
LLPS-Bot-3997Bos taurus51.292e-147 434
LLPS-Gaa-1243Gasterosteus aculeatus51.293e-145 429
LLPS-Cog-0788Colletotrichum gloeosporioides51.161e-127 384
LLPS-Lac-1985Latimeria chalumnae51.063e-149 439
LLPS-Scm-2202Scophthalmus maximus51.067e-146 431
LLPS-Pes-2532Pelodiscus sinensis51.062e-146 432
LLPS-Fia-2442Ficedula albicollis51.063e-146 434
LLPS-Icp-0440Ictalurus punctatus51.066e-148 436
LLPS-Tar-1307Takifugu rubripes51.068e-146 430
LLPS-Gaga-1964Gallus gallus50.823e-147 434
LLPS-Ved-0635Verticillium dahliae50.821e-147 433
LLPS-Tag-2953Taeniopygia guttata50.825e-140 415
LLPS-Anc-2966Anolis carolinensis50.821e-146 432
LLPS-Leo-2410Lepisosteus oculatus50.822e-146 432
LLPS-Fec-3598Felis catus50.591e-144 427
LLPS-Pat-2324Pan troglodytes50.594e-142 421
LLPS-Pap-2800Pan paniscus50.593e-142 421
LLPS-Hos-3127Homo sapiens50.594e-142 421
LLPS-Xet-2209Xenopus tropicalis50.591e-145 430
LLPS-Mum-3906Mus musculus50.596e-142 420
LLPS-Aon-4655Aotus nancymaae50.592e-142 422
LLPS-Sah-2724Sarcophilus harrisii50.591e-142 422
LLPS-Xim-2450Xiphophorus maculatus50.593e-143 424
LLPS-Aim-0685Ailuropoda melanoleuca50.598e-143 423
LLPS-Paa-0183Papio anubis50.594e-142 421
LLPS-Mal-3025Mandrillus leucophaeus50.594e-142 421
LLPS-Meg-2327Meleagris gallopavo50.513e-132 394
LLPS-Pof-4180Poecilia formosa50.473e-141 419
LLPS-Cis-2011Ciona savignyi50.473e-144 426
LLPS-Man-1930Macaca nemestrina50.371e-134 402
LLPS-Mam-4127Macaca mulatta50.371e-134 402
LLPS-Maf-4153Macaca fascicularis50.371e-134 402
LLPS-Drm-2081Drosophila melanogaster50.361e-150 442
LLPS-Dar-0993Danio rerio50.357e-145 428
LLPS-Ict-0614Ictidomys tridecemlineatus50.351e-141 419
LLPS-Caj-2039Callithrix jacchus50.359e-142 420
LLPS-Asm-1457Astyanax mexicanus50.358e-138 410
LLPS-Tut-1107Tursiops truncatus50.354e-142 421
LLPS-Mup-3445Mustela putorius furo50.354e-144 426
LLPS-Chc-0747Chondrus crispus50.352e-136 405
LLPS-Bro-1915Brassica oleracea50.236e-137 409
LLPS-Via-1972Vigna angularis50.239e-138 410
LLPS-Anp-3143Anas platyrhynchos50.132e-129 386
LLPS-Caf-0754Canis familiaris50.128e-141 417
LLPS-Brn-2145Brassica napus50.129e-137 408
LLPS-Ova-0495Ovis aries50.122e-139 414
LLPS-Brr-1112Brassica rapa50.05e-135 404
LLPS-Phv-0405Phaseolus vulgaris50.05e-137 409
LLPS-Vir-1620Vigna radiata50.07e-138 411
LLPS-Ran-1046Rattus norvegicus49.882e-143 424
LLPS-Gor-2149Gossypium raimondii49.776e-136 406
LLPS-Eqc-3422Equus caballus49.778e-141 418
LLPS-Lep-2353Leersia perrieri49.776e-139 414
LLPS-Mod-3700Monodelphis domestica49.655e-144 426
LLPS-Poa-3715Pongo abelii49.656e-142 421
LLPS-Cas-1462Carlito syrichta49.653e-143 424
LLPS-Nol-0675Nomascus leucogenys49.655e-142 421
LLPS-Mea-0780Mesocricetus auratus49.653e-142 421
LLPS-Fud-1741Fukomys damarensis49.655e-136 405
LLPS-Myl-3796Myotis lucifugus49.652e-138 411
LLPS-Cae-1517Caenorhabditis elegans49.542e-139 414
LLPS-Glm-0680Glycine max49.535e-137 409
LLPS-Rhb-1010Rhinopithecus bieti49.423e-140 416
LLPS-Otg-0311Otolemur garnettii49.411e-142 422
LLPS-Orc-3994Oryctolagus cuniculus49.416e-135 403
LLPS-Ten-3754Tetraodon nigroviridis49.415e-138 410
LLPS-Chs-4116Chlorocebus sabaeus49.411e-141 419
LLPS-Cea-1553Cercocebus atys49.419e-142 420
LLPS-Ora-0414Ornithorhynchus anatinus49.374e-125 375
LLPS-Coc-1423Corchorus capsularis49.34e-134 402
LLPS-Prp-1925Prunus persica49.36e-133 399
LLPS-Met-2355Medicago truncatula49.37e-135 403
LLPS-Cap-0471Cavia porcellus49.182e-140 417
LLPS-Sei-2295Setaria italica49.073e-136 407
LLPS-Art-1169Arabidopsis thaliana49.063e-132 397
LLPS-Ors-1970Oryza sativa49.063e-138 412
LLPS-Orp-0898Oryza punctata49.061e-137 410
LLPS-Org-1697Oryza glaberrima49.063e-139 413
LLPS-Zem-0333Zea mays49.069e-138 411
LLPS-Orb-2409Oryza barthii49.062e-138 413
LLPS-Cus-1099Cucumis sativus49.063e-134 402
LLPS-Osl-0169Ostreococcus lucimarinus49.054e-142 420
LLPS-Amt-2199Amborella trichopoda48.942e-133 400
LLPS-Gog-2368Gorilla gorilla48.853e-125 379
LLPS-Sob-1512Sorghum bicolor48.836e-137 409
LLPS-Mae-0815Manihot esculenta48.832e-131 395
LLPS-Dac-1813Daucus carota48.838e-136 405
LLPS-Brd-2360Brachypodium distachyon48.833e-134 403
LLPS-Tra-2903Triticum aestivum48.831e-136 408
LLPS-Arl-0264Arabidopsis lyrata48.832e-131 394
LLPS-Pot-2036Populus trichocarpa48.597e-133 398
LLPS-Orr-0955Oryza rufipogon48.363e-132 397
LLPS-Sem-0453Selaginella moellendorffii48.361e-136 408
LLPS-Hea-2379Helianthus annuus48.364e-133 399
LLPS-Thc-1009Theobroma cacao48.362e-130 392
LLPS-Orni-1991Oryza nivara48.367e-133 398
LLPS-Orgl-2078Oryza glumaepatula48.364e-132 396
LLPS-Dio-1426Dipodomys ordii48.266e-123 370
LLPS-Orbr-0602Oryza brachyantha48.122e-130 392
LLPS-Nia-2586Nicotiana attenuata48.123e-133 400
LLPS-Sot-0966Solanum tuberosum48.122e-133 400
LLPS-Viv-2237Vitis vinifera47.891e-131 395
LLPS-Loa-4079Loxodonta africana47.872e-138 412
LLPS-Hov-1464Hordeum vulgare47.653e-128 386
LLPS-Chr-1273Chlamydomonas reinhardtii47.652e-136 407
LLPS-Gas-1383Galdieria sulphuraria47.041e-129 387
LLPS-Cym-0464Cyanidioschyzon merolae46.911e-130 391
LLPS-Php-1841Physcomitrella patens46.63e-132 397
LLPS-Sol-2459Solanum lycopersicum46.43e-123 390
LLPS-Ori-0464Oryza indica46.072e-127 385
LLPS-Mua-0127Musa acuminata45.522e-125 380
LLPS-Cii-2325Ciona intestinalis44.682e-122 370
LLPS-Urm-3150Ursus maritimus44.61e-112 345