• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sob-0943
SORBI_3003G130500

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Presenilin
Gene Name: SORBI_3003G130500
Ensembl Gene: SORBI_3003G130500
Ensembl Protein: EES02765
Organism: Sorghum bicolor
Taxa ID: 4558
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEES02765EES02765
UniProtC5XH90, C5XH90_SORBI
GeneBankCM000762EES02765.1
RefSeqXM_002457600.1XP_002457645.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDPAAASPVP  ALAPAVEEPI  SAISVLDTLG  AEVLAVMSPV  SICMALVVLL  ISLLSPPSSG  60
61    SAAASPPPVT  AATLVYLESP  NDSPGQKFLG  ALLDAAVFVV  LVAAVTFVLV  ALYYYRCTGF  120
121   LKNYMRFSAF  FVIFSMGGAI  LTAVLRRLAA  PLDAPTALLL  LFNGAAVGVL  SVFASAVPIL  180
181   VRQGYMVALA  VIVAAWLSRL  PEWTTWIMLV  ALAVYDLVAV  LAPRGPLRML  VELASSRDDE  240
241   LPALVYESRP  TVGPATSSSS  YASAMGSVEM  QTMTDSGQIS  GNRYDRVEQE  EDASPAVVEM  300
301   RDLRRGRSEM  NRSRGSVLQM  ENLEREVSVT  SAELTANQGG  SSQHAVIQIE  QPGEEETSPL  360
361   VSAASTNNAA  LDEEHRQSSS  SEPLDFEMFE  STRGIKLGLG  DFVFYSVLVG  RAAMYDLMTV  420
421   YACYLAIIAG  LGCTLILLSI  CQHALPALPI  SIMLGVTFYF  LTRLLMEPFV  VGASTNLVMF  480
Nucleotide CDS Sequence (FASTA)
1     ATGGATCCCG  CCGCCGCCTC  GCCGGTGCCG  GCTCTGGCGC  CTGCCGTGGA  GGAGCCCATC  60
61    AGCGCCATCT  CCGTTCTCGA  CACCCTCGGC  GCGGAGGTGC  TGGCGGTTAT  GTCCCCGGTC  120
121   TCCATCTGCA  TGGCGCTCGT  CGTGCTCCTC  ATCTCCCTCC  TCTCGCCGCC  GTCCTCCGGC  180
181   TCCGCGGCGG  CCTCGCCCCC  GCCAGTCACC  GCTGCCACAC  TCGTCTATCT  CGAGTCCCCT  240
241   AACGACTCCC  CGGGCCAGAA  GTTCCTCGGC  GCACTCCTCG  ACGCTGCCGT  CTTCGTTGTC  300
301   CTCGTCGCCG  CTGTCACCTT  CGTCCTCGTC  GCGCTCTACT  ACTACCGCTG  CACGGGCTTC  360
361   CTCAAGAACT  ACATGCGCTT  CTCCGCCTTC  TTCGTCATCT  TCTCCATGGG  AGGCGCCATC  420
421   CTCACCGCCG  TGCTCCGCCG  CCTTGCGGCT  CCTCTCGACG  CGCCCACCGC  GCTCCTGCTC  480
481   CTCTTCAACG  GCGCCGCTGT  CGGGGTCCTC  TCTGTCTTCG  CCTCCGCTGT  CCCCATCCTC  540
541   GTCCGCCAAG  GGTACATGGT  CGCCCTCGCC  GTCATCGTCG  CCGCCTGGCT  CTCTAGGCTC  600
601   CCCGAGTGGA  CCACGTGGAT  CATGCTCGTC  GCGCTCGCCG  TGTATGACCT  CGTCGCCGTG  660
661   CTTGCACCCC  GGGGACCGCT  CAGGATGCTT  GTGGAGCTCG  CCTCCTCCAG  GGATGATGAG  720
721   CTACCAGCAC  TCGTCTATGA  GTCTCGGCCT  ACAGTCGGCC  CAGCCACAAG  CTCTTCCTCT  780
781   TATGCTTCGG  CCATGGGGTC  TGTGGAGATG  CAAACCATGA  CTGATTCTGG  TCAGATCAGT  840
841   GGCAATCGGT  ATGACCGGGT  GGAGCAGGAG  GAAGATGCCA  GCCCTGCTGT  TGTGGAAATG  900
901   AGGGATCTTA  GAAGAGGCCG  ATCAGAGATG  AACAGATCAA  GAGGTTCTGT  GCTTCAAATG  960
961   GAGAACCTTG  AAAGGGAGGT  ATCAGTGACT  TCAGCAGAGC  TCACAGCAAA  TCAAGGTGGG  1020
1021  AGTTCACAGC  ATGCTGTCAT  TCAAATTGAA  CAACCTGGCG  AAGAAGAGAC  ATCACCTTTG  1080
1081  GTATCTGCAG  CATCTACCAA  CAATGCAGCT  TTGGATGAGG  AGCATAGACA  AAGTTCATCA  1140
1141  TCAGAGCCTC  TGGATTTTGA  GATGTTTGAA  TCTACAAGGG  GCATCAAGTT  GGGCCTTGGC  1200
1201  GATTTTGTTT  TCTACAGTGT  GCTTGTTGGG  AGAGCTGCCA  TGTATGATCT  GATGACTGTG  1260
1261  TATGCATGCT  ACCTCGCCAT  CATTGCTGGG  CTTGGTTGCA  CCCTTATCTT  GCTTTCCATA  1320
1321  TGCCAGCATG  CGCTACCTGC  ACTCCCAATC  TCTATTATGC  TGGGAGTGAC  ATTCTACTTC  1380
1381  TTGACACGGT  TGCTGATGGA  GCCATTTGTG  GTTGGTGCTT  CGACAAACTT  GGTGATGTTC  1440
1441  TGA  1443

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Notch signaling pathway
Protease
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Golgi membrane
Cellular Component
Integral component of membrane
Molecular Function
Aspartic-type endopeptidase activity
Biological Process
Notch signaling pathway
Biological Process
Protein processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Zem-0185Zea mays92.260.0 639
LLPS-Sol-2327Solanum lycopersicum86.03e-1890.5
LLPS-Lep-0962Leersia perrieri83.30.0 550
LLPS-Orm-1243Oryza meridionalis82.330.0 528
LLPS-Orgl-1676Oryza glumaepatula81.868e-176 508
LLPS-Orr-1673Oryza rufipogon81.861e-175 508
LLPS-Orni-1970Oryza nivara81.629e-175 506
LLPS-Ors-0876Oryza sativa81.625e-175 505
LLPS-Orb-2200Oryza barthii81.446e-161 469
LLPS-Orp-2362Oryza punctata81.086e-173 501
LLPS-Orbr-1011Oryza brachyantha80.430.0 543
LLPS-Org-0827Oryza glaberrima79.870.0 527
LLPS-Brd-1691Brachypodium distachyon79.788e-172 499
LLPS-Ori-1544Oryza indica79.440.0 526
LLPS-Tru-1880Triticum urartu76.822e-144 427
LLPS-Hov-0889Hordeum vulgare76.111e-141 418
LLPS-Tra-1419Triticum aestivum74.941e-152 449
LLPS-Vir-2043Vigna radiata67.86e-44 164
LLPS-Via-2394Vigna angularis67.722e-44 167
LLPS-Sem-1837Selaginella moellendorffii62.619e-34 135
LLPS-Xim-0809Xiphophorus maculatus59.497e-1374.3
LLPS-Ten-2205Tetraodon nigroviridis59.493e-1375.5
LLPS-Paa-0012Papio anubis59.268e-1477.4
LLPS-Mum-3451Mus musculus59.265e-1478.2
LLPS-Dio-2002Dipodomys ordii58.026e-1477.8
LLPS-Myl-3423Myotis lucifugus58.025e-1477.8
LLPS-Sah-2117Sarcophilus harrisii58.023e-1478.6
LLPS-Tag-0659Taeniopygia guttata58.022e-1479.7
LLPS-Meg-1688Meleagris gallopavo58.022e-1479.3
LLPS-Mod-2422Monodelphis domestica58.023e-1479.0
LLPS-Orc-1096Oryctolagus cuniculus58.024e-1478.6
LLPS-Fia-0507Ficedula albicollis58.022e-1479.3
LLPS-Osl-1471Ostreococcus lucimarinus57.142e-1375.5
LLPS-Fec-0910Felis catus57.142e-1479.7
LLPS-Mea-3808Mesocricetus auratus56.961e-1273.6
LLPS-Fud-2182Fukomys damarensis56.794e-1375.5
LLPS-Prp-1993Prunus persica56.547e-112 345
LLPS-Pot-1757Populus trichocarpa55.965e-113 348
LLPS-Pof-0272Poecilia formosa55.213e-1478.6
LLPS-Phv-2258Phaseolus vulgaris54.276e-104 323
LLPS-Viv-1899Vitis vinifera54.243e-103 323
LLPS-Thc-1713Theobroma cacao54.092e-102 320
LLPS-Gaa-3841Gasterosteus aculeatus53.477e-1580.9
LLPS-Mae-0556Manihot esculenta53.435e-108 335
LLPS-Sot-0293Solanum tuberosum53.332e-103 322
LLPS-Gor-2618Gossypium raimondii53.215e-106 330
LLPS-Coc-1807Corchorus capsularis53.13e-108 336
LLPS-Asm-1181Astyanax mexicanus53.02e-1479.3
LLPS-Nia-1020Nicotiana attenuata52.921e-104 327
LLPS-Hea-0901Helianthus annuus52.82e-101 317
LLPS-Dac-1535Daucus carota52.485e-104 324
LLPS-Met-2504Medicago truncatula51.512e-106 330
LLPS-Art-2993Arabidopsis thaliana51.386e-101 317
LLPS-Scf-1951Scleropages formosus51.01e-1376.6
LLPS-Brn-0480Brassica napus51.07e-94 297
LLPS-Icp-3597Ictalurus punctatus50.914e-1581.6
LLPS-Arl-0226Arabidopsis lyrata50.731e-99 313
LLPS-Brr-2369Brassica rapa50.669e-93 295
LLPS-Amt-1824Amborella trichopoda50.422e-104 326
LLPS-Tar-3362Takifugu rubripes49.554e-1581.3
LLPS-Orn-0994Oreochromis niloticus48.761e-1583.2
LLPS-Gaga-3281Gallus gallus48.677e-1580.9
LLPS-Loa-0392Loxodonta africana48.182e-1479.0
LLPS-Mal-1415Mandrillus leucophaeus47.833e-1479.0
LLPS-Mup-0978Mustela putorius furo47.832e-1479.0
LLPS-Aim-4141Ailuropoda melanoleuca47.833e-1479.0
LLPS-Sus-3914Sus scrofa47.833e-1479.3
LLPS-Cea-4034Cercocebus atys47.833e-1479.0
LLPS-Aon-3673Aotus nancymaae47.833e-1479.0
LLPS-Maf-0682Macaca fascicularis47.833e-1479.0
LLPS-Chs-2964Chlorocebus sabaeus47.832e-1479.3
LLPS-Caj-3286Callithrix jacchus47.833e-1479.0
LLPS-Gog-3717Gorilla gorilla47.833e-1479.0
LLPS-Mam-2078Macaca mulatta47.833e-1479.0
LLPS-Caf-3645Canis familiaris47.833e-1479.0
LLPS-Poa-1921Pongo abelii47.832e-1479.3
LLPS-Ict-4240Ictidomys tridecemlineatus47.833e-1479.0
LLPS-Cas-0771Carlito syrichta47.833e-1479.0
LLPS-Man-4688Macaca nemestrina47.833e-1479.0
LLPS-Hos-2647Homo sapiens47.833e-1479.3
LLPS-Rhb-0845Rhinopithecus bieti47.833e-1479.0
LLPS-Anc-4027Anolis carolinensis47.793e-1582.0
LLPS-Bot-4517Bos taurus46.967e-1477.8
LLPS-Ova-3993Ovis aries46.967e-1477.8
LLPS-Cap-1399Cavia porcellus46.967e-1477.8
LLPS-Ran-2773Rattus norvegicus46.096e-1374.7
LLPS-Anp-1862Anas platyrhynchos46.094e-1581.6
LLPS-Cus-0346Cucumis sativus45.21e-77 256
LLPS-Glm-2366Glycine max44.897e-80 262
LLPS-Pap-3651Pan paniscus44.784e-1581.6
LLPS-Pat-2264Pan troglodytes44.784e-1581.6
LLPS-Bro-2033Brassica oleracea44.427e-71 237
LLPS-Nol-2271Nomascus leucogenys43.751e-0655.1
LLPS-Sei-1031Setaria italica42.868e-60 209
LLPS-Ora-1962Ornithorhynchus anatinus38.411e-0758.2
LLPS-Eqc-3247Equus caballus38.411e-1067.8
LLPS-Cae-0700Caenorhabditis elegans37.232e-1066.6
LLPS-Lac-3488Latimeria chalumnae36.234e-0859.3
LLPS-Pes-2229Pelodiscus sinensis36.236e-0858.9
LLPS-Drm-1443Drosophila melanogaster35.381e-31 131
LLPS-Dar-2676Danio rerio34.082e-24 109
LLPS-Xet-1426Xenopus tropicalis33.861e-25 112
LLPS-Scm-1073Scophthalmus maximus33.768e-2199.0
LLPS-Ere-0423Erinaceus europaeus32.82e-24 107
LLPS-Chc-0955Chondrus crispus30.252e-32 133
LLPS-Abg-1272Absidia glauca28.712e-2098.2