DrLLPS - Data resource of LLPS

LLPS-Paa-0012
PSEN1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Presenilin
Gene Name:	PSEN1
Ensembl Gene:	ENSPANG00000006859.2
Ensembl Protein:	ENSPANP00000025020.1
Organism:	Papio anubis
Taxa ID:	9555
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Centrosome/Spindle pole body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0229	P49768	Client	Centrosome/Spindle pole body	94.43	0.0	743

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSPANT00000046134.1	ENSPANP00000025020.1
Ensembl	ENSPANT00000013861.2	ENSPANP00000017209.2
Ensembl	ENSPANT00000031562.1	ENSPANP00000043435.1
UniProt		A0A2I3LNK2, A0A2I3LNK2_PAPAN
GeneBank	AHZZ02032394

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR 60 61 QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 120 121 DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI 180 181 YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY 240 241 LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE 300 301 GDPEAQRRVS KNSKYNAESH HKDHGSRNDD GGFSLKSLTP ESRAAVQELS SSILAGEDPE 360 361 ERGVKLGLGD FIFYSVLVGK ASATASGDWN TTIACFVAIL IGLCLTLLLL AIFKKALPAL 420 421 PISITFGLVF YFATDYLVQP FMDQLAFHQF YI 452
Nucleotide CDS Sequence (FASTA)
1 ATGACAGAGT TACCTGCACC GTTGTCCTAC TTCCAGAATG CACAGATGTC CGAGGACAAC 60 61 CACCTGAGCA ATACTGTACG TAGCCAGAAT GACAATAGAG AACGGCAGGA GCACAACGAC 120 121 AGGCGGAGCC TTGGCCACCC TGAGCCATTA TCTAATGGAC GACCCCAGGG TAACTCTCGG 180 181 CAGGTGGTGG AGCAAGATGA AGAAGAAGAT GAGGAGCTGA CATTGAAATA TGGCGCCAAA 240 241 CATGTGATCA TGCTCTTTGT CCCCGTGACT CTCTGCATGG TGGTGGTGGT GGCTACCATC 300 301 AAGTCAGTCA GCTTTTATAC CCGGAAGGAT GGGCAGCTAA TCTATACCCC ATTCACAGAA 360 361 GATACCGAGA CTGTGGGCCA GAGGGCCCTG CACTCAATTC TGAATGCGGC CATCATGATC 420 421 AGTGTCATTG TTGTCATGAC TATCCTCCTG GTGGTTCTGT ATAAATACAG GTGCTATAAG 480 481 GTCATCCATG CCTGGCTTAT TATATCATCT CTATTGTTGC TGTTCTTTTT TTCATTCATT 540 541 TACTTGGGGG AAGTGTTTAA AACCTATAAC GTTGCTGTGG ACTACATTAC TGTTGCACTC 600 601 CTGATCTGGA ATTTTGGTGT GGTGGGAATG ATTTCCATTC ACTGGAAAGG TCCACTTCGA 660 661 CTCCAGCAGG CATATCTCAT TATGATTAGT GCCCTCATGG CCCTGGTGTT TATCAAGTAC 720 721 CTCCCTGAAT GGACTGCGTG GCTCATCTTG GCTGTGATTT CAGTATATGA TTTAGTGGCT 780 781 GTTTTGTGTC CGAAAGGTCC ACTTCGTATG CTGGTTGAGA CAGCTCAGGA GAGAAATGAA 840 841 ACACTTTTTC CAGCTCTCAT TTACTCCTCA ACAATGGTGT GGTTGGTGAA TATGGCAGAA 900 901 GGAGACCCGG AAGCTCAAAG GAGAGTATCC AAAAATTCCA AGTATAATGC AGAAAGGGGA 960 961 GTAAAACTTG GATTGGGAGA TTTCATTTTC TACAGTGTTC TGGTTGGTAA AGCCTCAGCA 1020 1021 ACAGCCAGTG GAGACTGGAA CACAACCATA GCCTGTTTTG TAGCCATATT AATTGGTTTG 1080 1081 TGCCTTACAT TATTACTCCT CGCCATTTTC AAGAAAGCAT TGCCAGCTCT TCCAATCTCC 1140 1141 ATCACCTTTG GGCTTGTTTT CTACTTTGCC ACAGATTATC TTGTACAGCC TTTTATGGAC 1200 1201 CAATTAGCAT TCCATCAATT TTATATCTAG 1230

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0256	Endoplasmic reticulum
KW-0333	Golgi apparatus
KW-0378	Hydrolase
KW-0472	Membrane
KW-0914	Notch signaling pathway
KW-0645	Protease
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016235	Cellular Component	Aggresome
GO:0005938	Cellular Component	Cell cortex
GO:0030054	Cellular Component	Cell junction
GO:0005813	Cellular Component	Centrosome
GO:0035253	Cellular Component	Ciliary rootlet
GO:0031410	Cellular Component	Cytoplasmic vesicle
GO:0043198	Cellular Component	Dendritic shaft
GO:0005789	Cellular Component	Endoplasmic reticulum membrane
GO:0070765	Cellular Component	Gamma-secretase complex
GO:0000139	Cellular Component	Golgi membrane
GO:0030426	Cellular Component	Growth cone
GO:0005887	Cellular Component	Integral component of plasma membrane
GO:0000776	Cellular Component	Kinetochore
GO:0045121	Cellular Component	Membrane raft
GO:0005739	Cellular Component	Mitochondrion
GO:0043025	Cellular Component	Neuronal cell body
GO:0005640	Cellular Component	Nuclear outer membrane
GO:0098793	Cellular Component	Presynapse
GO:0005791	Cellular Component	Rough endoplasmic reticulum
GO:0005790	Cellular Component	Smooth endoplasmic reticulum
GO:0042500	Molecular Function	Aspartic endopeptidase activity, intramembrane cleaving
GO:0008013	Molecular Function	Beta-catenin binding
GO:0045296	Molecular Function	Cadherin binding
GO:0005262	Molecular Function	Calcium channel activity
GO:0030165	Molecular Function	PDZ domain binding
GO:0000186	Biological Process	Activation of MAPKK activity
GO:0034205	Biological Process	Amyloid-beta formation
GO:0002265	Biological Process	Astrocyte activation involved in immune response
GO:0000045	Biological Process	Autophagosome assembly
GO:0001568	Biological Process	Blood vessel development
GO:0048854	Biological Process	Brain morphogenesis
GO:0021870	Biological Process	Cajal-Retzius cell differentiation
GO:0001708	Biological Process	Cell fate specification
GO:0098609	Biological Process	Cell-cell adhesion
GO:1904646	Biological Process	Cellular response to amyloid-beta
GO:0006974	Biological Process	Cellular response to DNA damage stimulus
GO:0021795	Biological Process	Cerebral cortex cell migration
GO:0015871	Biological Process	Choline transport
GO:0021904	Biological Process	Dorsal/ventral neural tube patterning
GO:0030326	Biological Process	Embryonic limb morphogenesis
GO:0050673	Biological Process	Epithelial cell proliferation
GO:0001947	Biological Process	Heart looping
GO:0002244	Biological Process	Hematopoietic progenitor cell differentiation
GO:0035556	Biological Process	Intracellular signal transduction
GO:0006509	Biological Process	Membrane protein ectodomain proteolysis
GO:0007613	Biological Process	Memory
GO:0006839	Biological Process	Mitochondrial transport
GO:0090647	Biological Process	Modulation of age-related behavioral decline
GO:0043011	Biological Process	Myeloid dendritic cell differentiation
GO:2001234	Biological Process	Negative regulation of apoptotic signaling pathway
GO:0050771	Biological Process	Negative regulation of axonogenesis
GO:1904797	Biological Process	Negative regulation of core promoter binding
GO:0007175	Biological Process	Negative regulation of epidermal growth factor-activated receptor activity
GO:0000122	Biological Process	Negative regulation of transcription by RNA polymerase II
GO:2000059	Biological Process	Negative regulation of ubiquitin-dependent protein catabolic process
GO:0051444	Biological Process	Negative regulation of ubiquitin-protein transferase activity
GO:0051402	Biological Process	Neuron apoptotic process
GO:0048666	Biological Process	Neuron development
GO:0001764	Biological Process	Neuron migration
GO:1990535	Biological Process	Neuron projection maintenance
GO:0007220	Biological Process	Notch receptor processing
GO:0007219	Biological Process	Notch signaling pathway
GO:1905908	Biological Process	Positive regulation of amyloid fibril formation
GO:0043065	Biological Process	Positive regulation of apoptotic process
GO:0050820	Biological Process	Positive regulation of coagulation
GO:0060999	Biological Process	Positive regulation of dendritic spine development
GO:0002038	Biological Process	Positive regulation of L-glutamate import across plasma membrane
GO:0032436	Biological Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092	Biological Process	Positive regulation of protein binding
GO:0042307	Biological Process	Positive regulation of protein import into nucleus
GO:0001921	Biological Process	Positive regulation of receptor recycling
GO:0045893	Biological Process	Positive regulation of transcription, DNA-templated
GO:0009791	Biological Process	Post-embryonic development
GO:0006486	Biological Process	Protein glycosylation
GO:0016485	Biological Process	Protein processing
GO:0015031	Biological Process	Protein transport
GO:0060828	Biological Process	Regulation of canonical Wnt signaling pathway
GO:0060075	Biological Process	Regulation of resting membrane potential
GO:0048167	Biological Process	Regulation of synaptic plasticity
GO:0051966	Biological Process	Regulation of synaptic transmission, glutamatergic
GO:0006979	Biological Process	Response to oxidative stress
GO:0048705	Biological Process	Skeletal system morphogenesis
GO:0043589	Biological Process	Skin morphogenesis
GO:0051563	Biological Process	Smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756	Biological Process	Somitogenesis
GO:0050808	Biological Process	Synapse organization
GO:0016080	Biological Process	Synaptic vesicle targeting
GO:0002286	Biological Process	T cell activation involved in immune response
GO:0050852	Biological Process	T cell receptor signaling pathway
GO:0048538	Biological Process	Thymus development

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Mal-4659	Mandrillus leucophaeus	94.43	0.0	743
LLPS-Maf-1756	Macaca fascicularis	94.43	0.0	743
LLPS-Cea-2734	Cercocebus atys	94.43	0.0	743
LLPS-Mam-4610	Macaca mulatta	94.43	0.0	743
LLPS-Nol-3807	Nomascus leucogenys	94.43	0.0	743
LLPS-Hos-0229	Homo sapiens	94.43	0.0	743
LLPS-Pat-4016	Pan troglodytes	94.43	0.0	743
LLPS-Pap-2693	Pan paniscus	94.43	0.0	743
LLPS-Man-3948	Macaca nemestrina	94.43	0.0	743
LLPS-Chs-2329	Chlorocebus sabaeus	94.22	0.0	741
LLPS-Poa-3349	Pongo abelii	93.36	0.0	728
LLPS-Gog-1553	Gorilla gorilla	93.09	0.0	609
LLPS-Aon-1680	Aotus nancymaae	92.93	0.0	725
LLPS-Cas-1188	Carlito syrichta	92.51	0.0	728
LLPS-Caj-4180	Callithrix jacchus	92.49	0.0	719
LLPS-Ict-1589	Ictidomys tridecemlineatus	91.43	0.0	716
LLPS-Fud-3331	Fukomys damarensis	90.79	0.0	717
LLPS-Fec-3228	Felis catus	90.6	0.0	697
LLPS-Cap-3353	Cavia porcellus	90.58	0.0	711
LLPS-Dio-4331	Dipodomys ordii	90.36	0.0	713
LLPS-Orc-2311	Oryctolagus cuniculus	89.96	0.0	704
LLPS-Mea-2209	Mesocricetus auratus	89.94	0.0	705
LLPS-Caf-0916	Canis familiaris	89.94	0.0	698
LLPS-Mum-3451	Mus musculus	89.29	0.0	701
LLPS-Myl-1194	Myotis lucifugus	89.1	0.0	694
LLPS-Mup-1992	Mustela putorius furo	88.89	0.0	686
LLPS-Sus-4218	Sus scrofa	88.87	0.0	687
LLPS-Ran-3649	Rattus norvegicus	87.85	0.0	687
LLPS-Aim-1010	Ailuropoda melanoleuca	87.12	2e-179	514
LLPS-Ova-3225	Ovis aries	86.75	0.0	675
LLPS-Rhb-3189	Rhinopithecus bieti	86.72	0.0	648
LLPS-Eqc-1974	Equus caballus	85.96	0.0	682
LLPS-Bot-3381	Bos taurus	85.77	0.0	676
LLPS-Sah-3412	Sarcophilus harrisii	85.74	0.0	663
LLPS-Loa-0888	Loxodonta africana	85.59	0.0	595
LLPS-Ere-0423	Erinaceus europaeus	85.34	8e-153	444
LLPS-Mod-2110	Monodelphis domestica	85.14	0.0	659
LLPS-Tag-3175	Taeniopygia guttata	84.37	3e-155	451
LLPS-Ora-2366	Ornithorhynchus anatinus	82.85	2e-145	426
LLPS-Fia-3431	Ficedula albicollis	81.57	0.0	610
LLPS-Meg-0821	Meleagris gallopavo	80.93	0.0	610
LLPS-Anp-2593	Anas platyrhynchos	80.34	0.0	600
LLPS-Pes-3073	Pelodiscus sinensis	80.3	0.0	608
LLPS-Gaga-1189	Gallus gallus	79.4	0.0	595
LLPS-Anc-3329	Anolis carolinensis	78.65	0.0	610
LLPS-Dar-2676	Danio rerio	77.69	1e-169	492
LLPS-Drm-1443	Drosophila melanogaster	77.42	4e-21	99.8
LLPS-Xet-1426	Xenopus tropicalis	77.07	0.0	572
LLPS-Tar-2870	Takifugu rubripes	75.57	2e-164	479
LLPS-Scm-1073	Scophthalmus maximus	75.38	4e-158	464
LLPS-Pof-2375	Poecilia formosa	75.25	4e-165	481
LLPS-Orn-2186	Oreochromis niloticus	75.06	1e-167	488
LLPS-Scf-1984	Scleropages formosus	73.18	2e-152	447
LLPS-Xim-0343	Xiphophorus maculatus	73.02	3e-166	484
LLPS-Gaa-3841	Gasterosteus aculeatus	72.68	2e-147	436
LLPS-Icp-3597	Ictalurus punctatus	72.44	3e-148	437
LLPS-Asm-1181	Astyanax mexicanus	72.18	6e-145	428
LLPS-Ten-2205	Tetraodon nigroviridis	69.9	1e-136	407
LLPS-Lac-1374	Latimeria chalumnae	65.19	9e-170	493
LLPS-Orgl-1676	Oryza glumaepatula	61.73	1e-09	64.3
LLPS-Ori-1544	Oryza indica	61.73	1e-09	63.9
LLPS-Orb-2200	Oryza barthii	61.73	1e-09	63.9
LLPS-Orni-1970	Oryza nivara	61.73	1e-09	64.3
LLPS-Orm-1243	Oryza meridionalis	61.73	1e-09	64.7
LLPS-Orr-1673	Oryza rufipogon	61.73	1e-09	64.3
LLPS-Org-0827	Oryza glaberrima	61.73	1e-09	63.9
LLPS-Ors-0876	Oryza sativa	61.73	1e-09	63.9
LLPS-Orp-2362	Oryza punctata	61.73	1e-09	64.3
LLPS-Orbr-1011	Oryza brachyantha	61.73	1e-09	64.3
LLPS-Chc-0955	Chondrus crispus	60.98	5e-09	62.4
LLPS-Lep-0962	Leersia perrieri	60.49	3e-09	62.8
LLPS-Tra-1419	Triticum aestivum	60.49	5e-10	65.5
LLPS-Sob-0943	Sorghum bicolor	59.26	1e-09	64.3
LLPS-Arl-0226	Arabidopsis lyrata	58.82	1e-10	67.4
LLPS-Amt-1824	Amborella trichopoda	56.98	4e-10	65.9
LLPS-Brd-1691	Brachypodium distachyon	54.0	4e-10	65.9
LLPS-Sem-1837	Selaginella moellendorffii	37.97	7e-36	141
LLPS-Vir-2043	Vigna radiata	37.32	4e-37	145
LLPS-Sei-1031	Setaria italica	36.36	2e-22	103
LLPS-Osl-1471	Ostreococcus lucimarinus	35.94	5e-41	155
LLPS-Via-2394	Vigna angularis	35.75	1e-38	150
LLPS-Hov-0889	Hordeum vulgare	34.78	3e-32	130
LLPS-Phv-2258	Phaseolus vulgaris	34.66	4e-38	148
LLPS-Dac-1535	Daucus carota	34.46	1e-36	144
LLPS-Viv-1899	Vitis vinifera	34.41	2e-35	141
LLPS-Brn-0480	Brassica napus	33.98	6e-36	142
LLPS-Sot-0293	Solanum tuberosum	33.82	3e-40	154
LLPS-Brr-2369	Brassica rapa	33.74	3e-35	140
LLPS-Bro-2033	Brassica oleracea	33.6	3e-34	137
LLPS-Mae-0556	Manihot esculenta	33.49	1e-36	144
LLPS-Coc-1807	Corchorus capsularis	33.18	6e-36	142
LLPS-Gor-2618	Gossypium raimondii	33.17	3e-35	140
LLPS-Met-2504	Medicago truncatula	33.09	1e-35	141
LLPS-Abg-1272	Absidia glauca	32.91	3e-30	127
LLPS-Sol-2327	Solanum lycopersicum	32.85	2e-33	134
LLPS-Thc-1713	Theobroma cacao	32.66	6e-35	139
LLPS-Tru-1880	Triticum urartu	32.58	3e-29	122
LLPS-Nia-1020	Nicotiana attenuata	32.35	9e-39	151
LLPS-Hea-0901	Helianthus annuus	32.33	4e-33	134
LLPS-Pot-1757	Populus trichocarpa	32.05	4e-38	149
LLPS-Art-2993	Arabidopsis thaliana	31.89	2e-32	132
LLPS-Prp-1993	Prunus persica	31.84	2e-34	138
LLPS-Glm-2366	Glycine max	31.83	5e-34	137
LLPS-Cae-0700	Caenorhabditis elegans	31.52	6e-37	144
LLPS-Zem-0185	Zea mays	31.25	2e-32	132
LLPS-Cus-0346	Cucumis sativus	31.02	5e-27	115

LLPS-Paa-0012PSEN1

Protein Sequence

Nucleotide Sequence

LLPS-Paa-0012
PSEN1