LLPS-Hos-2647
PSEN2

▼ OVERVIEW

Status: Reviewed
Protein Name: Presenilin-2
Gene Name: PSEN2, AD4, PS2, PSNL2, STM2
Ensembl Gene: ENSG00000143801.16
Ensembl Protein: ENSP00000429682.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A9298903, 11053237

▼ FUNCTION

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLAGTVRFAR  HCLKFFPAQK  PACVDFGASR  GRAMLTFMAS  DSEEEVCDER  TSLMSAESPT  60
61    PRSCQEGRQG  PEDGENTAQW  RSQENEEDGE  EDPDRYVCSG  VPGRPPGLEE  ELTLKYGAKH  120
121   VIMLFVPVTL  CMIVVVATIK  SVRFYTEKNG  QLIYTPFTED  TPSVGQRLLN  SVLNTLIMIS  180
181   VIVVMTIFLV  VLYKYRCYKF  IHGWLIMSSL  MLLFLFTYIY  LGEVLKTYNV  AMDYPTLLLT  240
241   VWNFGAVGMV  CIHWKGPLVL  QQAYLIMISA  LMALVFIKYL  PEWSAWVILG  AISVYDLVAV  300
301   LCPKGPLRML  VETAQERNEP  IFPALIYSSA  MVWTVGMAKL  DPSSQGALQL  PYDPEMEEDS  360
361   YDSFGEPSYP  EVFEPPLTGY  PGEELEEEEE  RGVKLGLGDF  IFYSVLVGKA  AATGSGDWNT  420
421   TLACFVAILI  GLCLTLLLLA  VFKKALPALP  ISITFGLIFY  FSTDNLVRPF  MDTLASHQLY  480
481   I  481
Nucleotide CDS Sequence (FASTA)
1     ATGCTCACAT  TCATGGCCTC  TGACAGCGAG  GAAGAAGTGT  GTGATGAGCG  GACGTCCCTA  60
61    ATGTCGGCTG  AGAGCCCCAC  GCCGCGCTCC  TGCCAGGAGG  GCAGGCAGGG  CCCAGAGGAT  120
121   GGAGAGAACA  CTGCCCAGTG  GAGAAGCCAG  GAGAACGAGG  AGGACGGTGA  GGAGGACCCT  180
181   GACCGCTATG  TCTGTAGTGG  GGTTCCCGGG  CGGCCGCCAG  GCCTGGAGGA  AGAGCTGACC  240
241   CTCAAATACG  GAGCGAAGCA  CGTGATCATG  CTGTTTGTGC  CTGTCACTCT  GTGCATGATC  300
301   GTGGTGGTAG  CCACCATCAA  GTCTGTGCGC  TTCTACACAG  AGAAGAATGG  ACAGCTCATC  360
361   TACACGCCAT  TCACTGAGGA  CACACCCTCG  GTGGGCCAGC  GCCTCCTCAA  CTCCGTGCTG  420
421   AACACCCTCA  TCATGATCAG  CGTCATCGTG  GTTATGACCA  TCTTCTTGGT  GGTGCTCTAC  480
481   AAGTACCGCT  GCTACAAGTT  CATCCATGGC  TGGTTGATCA  TGTCTTCACT  GATGCTGCTG  540
541   TTCCTCTTCA  CCTATATCTA  CCTTGGGGAA  GTGCTCAAGA  CCTACAATGT  GGCCATGGAC  600
601   TACCCCACCC  TCTTGCTGAC  TGTCTGGAAC  TTCGGGGCAG  TGGGCATGGT  GTGCATCCAC  660
661   TGGAAGGGCC  CTCTGGTGCT  GCAGCAGGCC  TACCTCATCA  TGATCAGTGC  GCTCATGGCC  720
721   CTAGTGTTCA  TCAAGTACCT  CCCAGAGTGG  TCCGCGTGGG  TCATCCTGGG  CGCCATCTCT  780
781   GTGTATGATC  TCGTGGCTGT  GCTGTGTCCC  AAAGGGCCTC  TGAGAATGCT  GGTAGAAACT  840
841   GCCCAGGAGA  GAAATGAGCC  CATATTCCCT  GCCCTGATAT  ACTCATCTGC  CATGGTGTGG  900
901   ACGGTTGGCA  TGGCGAAGCT  GGACCCCTCC  TCTCAGGGTG  CCCTCCAGCT  CCCCTACGAC  960
961   CCGGAGATGG  AAGACTCCTA  TGACAGTTTT  GGGGAGCCTT  CATACCCCGA  AGTCTTTGAG  1020
1021  CCTCCCTTGA  CTGGCTACCC  AGGGGAGGAG  CTGGAGGAAG  AGGAGGAAAG  GGGCGTGAAG  1080
1081  CTTGGCCTCG  GGGACTTCAT  CTTCTACAGT  GTGCTGGTGG  GCAAGGCGGC  TGCCACGGGC  1140
1141  AGCGGGGACT  GGAATACCAC  GCTGGCCTGC  TTCGTGGCCA  TCCTCATTGG  CTTGTGTCTG  1200
1201  ACCCTCCTGC  TGCTTGCTGT  GTTCAAGAAG  GCGCTGCCCG  CCCTCCCCAT  CTCCATCACG  1260
1261  TTCGGGCTCA  TCTTTTACTT  CTCCACGGAC  AACCTGGTGC  GGCCGTTCAT  GGACACCCTG  1320
1321  GCCTCCCATC  AGCTCTACAT  CTGA  1344

▼ KEYWORD

ID
Family
Alternative splicing
Alzheimer disease
Amyloidosis
Cardiomyopathy
Complete proteome
Disease mutation
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Neurodegeneration
Notch signaling pathway
Phosphoprotein
Protease
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Cell cortex
Cellular Component
Centrosome
Cellular Component
Early endosome
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Golgi apparatus
Cellular Component
Golgi membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Integral component of presynaptic membrane
Cellular Component
Kinetochore
Cellular Component
Membrane
Cellular Component
Neuronal cell body
Cellular Component
Nuclear inner membrane
Cellular Component
Nucleus
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Plasma membrane
Cellular Component
Protein-containing complex
Cellular Component
Synaptic vesicle
Cellular Component
Z disc
Molecular Function
Aspartic endopeptidase activity, intramembrane cleaving
Molecular Function
Aspartic-type endopeptidase activity
Molecular Function
Endopeptidase activity
Biological Process
Amyloid precursor protein catabolic process
Biological Process
Amyloid-beta metabolic process
Biological Process
Calcium ion transport
Biological Process
Intracellular signal transduction
Biological Process
Membrane protein ectodomain proteolysis
Biological Process
Mitochondrion-endoplasmic reticulum membrane tethering
Biological Process
Notch receptor processing
Biological Process
Notch receptor processing, ligand-dependent
Biological Process
Positive regulation of catalytic activity
Biological Process
Protein processing
Biological Process
Regulation of calcium import into the mitochondrion
Biological Process
Response to hypoxia

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-2271Nomascus leucogenys100.00.0 792
LLPS-Gog-3717Gorilla gorilla99.790.0 847
LLPS-Chs-2964Chlorocebus sabaeus99.780.0 776
LLPS-Poa-1921Pongo abelii99.780.0 776
LLPS-Mam-2078Macaca mulatta98.130.0 828
LLPS-Paa-4200Papio anubis97.920.0 825
LLPS-Mal-1415Mandrillus leucophaeus97.920.0 825
LLPS-Maf-0682Macaca fascicularis97.920.0 825
LLPS-Cea-4034Cercocebus atys97.920.0 825
LLPS-Rhb-0845Rhinopithecus bieti97.920.0 827
LLPS-Man-4688Macaca nemestrina97.920.0 825
LLPS-Caj-3286Callithrix jacchus97.710.0 819
LLPS-Aon-3673Aotus nancymaae97.510.0 811
LLPS-Ict-4240Ictidomys tridecemlineatus97.320.0 754
LLPS-Bot-4517Bos taurus96.660.0 728
LLPS-Sus-3914Sus scrofa96.520.0 765
LLPS-Eqc-3247Equus caballus96.460.0 648
LLPS-Mum-4859Mus musculus95.980.0 747
LLPS-Caf-3645Canis familiaris95.980.0 740
LLPS-Mea-3808Mesocricetus auratus95.760.0 748
LLPS-Ova-3993Ovis aries95.550.0 711
LLPS-Mup-0978Mustela putorius furo95.540.0 738
LLPS-Cap-1399Cavia porcellus95.540.0 739
LLPS-Ran-2773Rattus norvegicus95.310.0 747
LLPS-Fud-2182Fukomys damarensis95.090.0 735
LLPS-Cas-0771Carlito syrichta94.920.0 766
LLPS-Orc-1096Oryctolagus cuniculus94.730.0 746
LLPS-Pap-3651Pan paniscus93.840.0 775
LLPS-Pat-2264Pan troglodytes93.840.0 775
LLPS-Dio-2002Dipodomys ordii91.740.0 707
LLPS-Loa-0392Loxodonta africana91.350.0 718
LLPS-Fec-0910Felis catus90.420.0 733
LLPS-Icp-4236Ictalurus punctatus90.364e-22 102
LLPS-Asm-2522Astyanax mexicanus89.163e-22 103
LLPS-Dar-2676Danio rerio89.164e-22 102
LLPS-Orn-2186Oreochromis niloticus87.954e-21 100
LLPS-Aim-4141Ailuropoda melanoleuca87.020.0 677
LLPS-Gaa-3184Gasterosteus aculeatus86.753e-2097.1
LLPS-Pof-2375Poecilia formosa86.754e-2199.8
LLPS-Xim-0343Xiphophorus maculatus85.546e-2199.4
LLPS-Ten-1255Tetraodon nigroviridis85.549e-2095.9
LLPS-Lac-1374Latimeria chalumnae83.874e-0859.7
LLPS-Myl-3423Myotis lucifugus83.050.0 531
LLPS-Mod-2422Monodelphis domestica80.790.0 587
LLPS-Sah-2117Sarcophilus harrisii79.740.0 576
LLPS-Gaga-3281Gallus gallus77.730.0 563
LLPS-Pes-2229Pelodiscus sinensis77.11e-162 473
LLPS-Tag-0659Taeniopygia guttata76.960.0 565
LLPS-Fia-0507Ficedula albicollis76.090.0 561
LLPS-Anc-4027Anolis carolinensis75.650.0 556
LLPS-Ora-1962Ornithorhynchus anatinus75.565e-180 518
LLPS-Anp-1862Anas platyrhynchos75.530.0 561
LLPS-Meg-1688Meleagris gallopavo75.480.0 550
LLPS-Scf-1984Scleropages formosus73.730.0 530
LLPS-Drm-1443Drosophila melanogaster72.296e-1272.0
LLPS-Xet-3910Xenopus tropicalis71.80.0 544
LLPS-Scm-1073Scophthalmus maximus68.612e-141 422
LLPS-Tar-3362Takifugu rubripes68.56e-162 473
LLPS-Ere-0423Erinaceus europaeus67.327e-94 294
LLPS-Sei-1031Setaria italica52.057e-1374.3
LLPS-Chc-0955Chondrus crispus42.481e-28 122
LLPS-Orb-2200Oryza barthii41.126e-1889.7
LLPS-Abg-1272Absidia glauca39.337e-27 117
LLPS-Osl-1471Ostreococcus lucimarinus38.181e-35 140
LLPS-Hov-0889Hordeum vulgare37.913e-2095.5
LLPS-Orni-1970Oryza nivara37.432e-25 111
LLPS-Orr-1673Oryza rufipogon37.432e-25 111
LLPS-Ors-0876Oryza sativa37.431e-25 112
LLPS-Orp-2362Oryza punctata37.435e-25 110
LLPS-Orgl-1676Oryza glumaepatula36.874e-25 110
LLPS-Prp-1993Prunus persica35.914e-25 111
LLPS-Orbr-1011Oryza brachyantha35.751e-24 110
LLPS-Vir-2043Vigna radiata35.03e-25 110
LLPS-Thc-1713Theobroma cacao35.02e-24 108
LLPS-Tra-1419Triticum aestivum34.913e-26 114
LLPS-Gor-2618Gossypium raimondii34.813e-23 105
LLPS-Mae-0556Manihot esculenta34.391e-26 115
LLPS-Viv-1899Vitis vinifera34.348e-25 110
LLPS-Tru-1880Triticum urartu34.298e-24 107
LLPS-Sem-1837Selaginella moellendorffii34.256e-22 101
LLPS-Brd-1691Brachypodium distachyon34.134e-28 120
LLPS-Lep-0962Leersia perrieri33.959e-23 104
LLPS-Phv-2258Phaseolus vulgaris33.644e-26 113
LLPS-Sot-0293Solanum tuberosum33.338e-28 118
LLPS-Coc-1807Corchorus capsularis33.332e-25 111
LLPS-Orm-1243Oryza meridionalis33.332e-26 115
LLPS-Bro-2033Brassica oleracea33.081e-25 112
LLPS-Ori-1544Oryza indica33.046e-26 114
LLPS-Sob-0943Sorghum bicolor32.672e-28 120
LLPS-Org-0827Oryza glaberrima32.68e-26 113
LLPS-Pot-1757Populus trichocarpa32.583e-27 117
LLPS-Zem-0185Zea mays32.53e-27 117
LLPS-Met-2504Medicago truncatula32.311e-26 115
LLPS-Hea-0901Helianthus annuus32.275e-25 110
LLPS-Via-2394Vigna angularis32.161e-26 115
LLPS-Nia-1020Nicotiana attenuata32.118e-26 113
LLPS-Sol-2327Solanum lycopersicum31.864e-28 119
LLPS-Cae-0700Caenorhabditis elegans31.726e-32 129
LLPS-Dac-1535Daucus carota31.471e-21 100
LLPS-Amt-1824Amborella trichopoda31.424e-25 111
LLPS-Art-2993Arabidopsis thaliana31.162e-23 106
LLPS-Glm-2366Glycine max30.672e-24 108
LLPS-Brn-0480Brassica napus30.297e-22 101
LLPS-Brr-2369Brassica rapa30.291e-21 100
LLPS-Arl-0226Arabidopsis lyrata29.776e-23 105
LLPS-Cus-0346Cucumis sativus29.759e-24 107