LLPS-Dar-2676
psen1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Presenilin-1
Gene Name: psen1
Ensembl Gene: ENSDARG00000004870.12
Ensembl Protein: ENSDARP00000136264.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10521267). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADLVQNAAN  NVLNDGMDTS  RHTSSTAAPP  SRNEVELNGQ  PPTAPPPQVV  TDSEEDEDEE  60
61    LTLKYGAKHV  IMLFIPVTLC  MVVVVATIKS  VSFYTQKDGQ  QLIYTPFRED  TETVGQRALH  120
121   SMLNAIIMIS  VIVVMTLVLV  VLYKYRCYKV  IQAWLFFSNL  LLLFFFSLIY  LGEVFKTYNV  180
181   AMDYFTLALI  IWNFGVVGMI  CIHWKGPLRL  QQAYLIMISA  LMALVFIKYL  PEWTAWLILA  240
241   AISVYDLLAV  LCPKGPLRIL  VETAQERNEA  IFPALIYSST  MVWLFNMADS  AETRNNSSHP  300
301   VPQQENQVVA  MAPTAQPEDD  GGFTPAWVDH  QQHQLGPMQS  TEESRRQIQE  MPSARPPPPA  360
361   DDDEERGVKL  GLGDFIFYSM  LVGKASATAS  GDWNTTLACF  VAILIGLCLT  LLLLAIFKKA  420
421   LPALPISITF  GLVFYFATDN  LVRPFMDQLA  VHQFYI  456
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGATT  TAGTGCAGAA  TGCTGCCAAT  AATGTGCTAA  ATGATGGGAT  GGACACCAGC  60
61    CGGCACACAA  GCAGCACCGC  GGCGCCGCCC  AGCCGTAATG  AGGTGGAGCT  GAACGGGCAG  120
121   CCGCCCACCG  CTCCGCCCCC  GCAGGTGGTC  ACAGACAGTG  AGGAAGACGA  GGACGAGGAG  180
181   CTCACTCTCA  AATATGGGGC  GAAGCACGTC  ATCATGCTGT  TCATTCCCGT  CACGCTCTGC  240
241   ATGGTGGTGG  TGGTGGCGAC  CATCAAATCT  GTCAGCTTCT  ACACACAGAA  GGACGGACAG  300
301   CAGCTGATCT  ACACCCCGTT  TCGTGAGGAC  ACGGAGACGG  TGGGTCAGCG  AGCTCTGCAC  360
361   TCCATGCTCA  ACGCCATCAT  CATGATCAGT  GTGATCGTGG  TCATGACCCT  GGTGCTGGTG  420
421   GTGCTCTACA  AGTACAGATG  CTACAAGGTG  ATTCAAGCCT  GGCTGTTCTT  CTCCAACCTC  480
481   CTCCTGCTCT  TCTTTTTCTC  CTTAATTTAT  TTGGGGGAAG  TGTTCAAGAC  GTATAACGTG  540
541   GCGATGGATT  ACTTCACGCT  GGCGTTGATC  ATCTGGAACT  TCGGTGTGGT  GGGAATGATC  600
601   TGCATCCACT  GGAAGGGGCC  GCTGCGGCTC  CAGCAGGCCT  ATCTGATCAT  GATCAGCGCT  660
661   CTCATGGCTC  TGGTCTTCAT  CAAGTATCTC  CCCGAGTGGA  CCGCATGGCT  CATCCTCGCT  720
721   GCTATTTCAG  TCTACGATCT  TCTGGCAGTG  TTGTGTCCGA  AAGGCCCTCT  GCGAATCCTT  780
781   GTGGAAACAG  CTCAAGAGAG  GAATGAGGCC  ATTTTCCCAG  CGCTCATCTA  CTCCTCTACG  840
841   ATGGTGTGGC  TCTTCAATAT  GGCGGACAGT  GCTGAAACCA  GGAATAATTC  CAGTCATCCA  900
901   GTCCCTCAGC  AGGAGAACCA  GGTAGTTGCG  ATGGCTCCCA  CAGCTCAGCC  GGAGGACGAT  960
961   GGCGGCTTCA  CTCCGGCGTG  GGTGGATCAT  CAGCAGCATC  AGCTCGGACC  CATGCAGTCC  1020
1021  ACGGAGGAGA  GCAGACGACA  GATCCAGGAG  ATGCCCAGCG  CTCGGCCACC  ACCACCAGCA  1080
1081  GATGATGACG  AAGAGCGGGG  TGTGAAGCTG  GGTTTGGGAG  ATTTCATCTT  TTACAGTATG  1140
1141  CTGGTGGGTA  AAGCATCAGC  TACAGCCAGC  GGTGACTGGA  ACACGACGTT  AGCCTGCTTC  1200
1201  GTGGCCATTC  TCATTGGTTT  ATGTCTGACT  CTCCTCCTGC  TGGCCATCTT  CAAGAAGGCT  1260
1261  CTTCCCGCAC  TCCCCATCTC  CATAACCTTC  GGCCTGGTGT  TTTACTTTGC  CACTGATAAC  1320
1321  CTCGTGCGGC  CGTTCATGGA  CCAGCTGGCC  GTCCATCAGT  TCTACATATA  G  1371

▼ KEYWORD

ID
Family
Cell junction
Cell membrane
Cell projection
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Notch signaling pathway
Protease
Reference proteome
Synapse
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cell junction
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Gamma-secretase complex
Cellular Component
Golgi apparatus
Cellular Component
Golgi membrane
Cellular Component
Integral component of membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Intrinsic component of membrane
Cellular Component
Mitochondrion
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Synapse
Molecular Function
Aspartic endopeptidase activity, intramembrane cleaving
Molecular Function
Endopeptidase activity
Biological Process
Amyloid-beta formation
Biological Process
Brain development
Biological Process
Canonical Wnt signaling pathway
Biological Process
Lymphangiogenesis
Biological Process
Melanocyte differentiation
Biological Process
Membrane protein ectodomain proteolysis
Biological Process
Notch signaling pathway
Biological Process
Optomotor response
Biological Process
Positive regulation of catalytic activity
Biological Process
Protein processing
Biological Process
Regulation of canonical Wnt signaling pathway
Biological Process
Regulation of endopeptidase activity
Biological Process
Response to hypoxia
Biological Process
Somite development
Biological Process
Swimming behavior

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
MIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-0809Xiphophorus maculatus86.674e-25 109
LLPS-Asm-2522Astyanax mexicanus84.720.0 587
LLPS-Scm-1073Scophthalmus maximus83.80.0 551
LLPS-Orn-2186Oreochromis niloticus83.50.0 556
LLPS-Icp-4236Ictalurus punctatus82.580.0 609
LLPS-Tar-2870Takifugu rubripes82.580.0 545
LLPS-Pof-2375Poecilia formosa82.00.0 549
LLPS-Scf-1951Scleropages formosus81.50.0 567
LLPS-Eqc-3247Equus caballus80.71e-104 330
LLPS-Cas-1188Carlito syrichta79.44e-176 509
LLPS-Man-3948Macaca nemestrina79.152e-175 507
LLPS-Pap-2693Pan paniscus79.152e-175 507
LLPS-Pat-4016Pan troglodytes79.152e-175 507
LLPS-Hos-0229Homo sapiens79.152e-175 507
LLPS-Mam-4610Macaca mulatta79.152e-175 507
LLPS-Poa-3349Pongo abelii79.152e-175 507
LLPS-Nol-3807Nomascus leucogenys79.152e-175 507
LLPS-Aon-1680Aotus nancymaae79.152e-175 507
LLPS-Cea-2734Cercocebus atys79.152e-175 507
LLPS-Maf-1756Macaca fascicularis79.152e-175 507
LLPS-Chs-2329Chlorocebus sabaeus79.153e-175 507
LLPS-Fud-3331Fukomys damarensis79.157e-177 511
LLPS-Mal-4659Mandrillus leucophaeus79.152e-175 507
LLPS-Cap-3353Cavia porcellus78.88e-176 508
LLPS-Caj-4180Callithrix jacchus78.83e-175 507
LLPS-Fec-3228Felis catus78.72e-176 510
LLPS-Orc-2311Oryctolagus cuniculus78.71e-174 509
LLPS-Ict-1589Ictidomys tridecemlineatus78.641e-174 505
LLPS-Myl-1194Myotis lucifugus78.642e-175 508
LLPS-Dio-4331Dipodomys ordii78.556e-177 511
LLPS-Caf-0916Canis familiaris78.452e-175 507
LLPS-Mup-1992Mustela putorius furo78.452e-175 507
LLPS-Mea-2209Mesocricetus auratus78.399e-175 506
LLPS-Sus-4218Sus scrofa78.341e-173 503
LLPS-Ran-3649Rattus norvegicus78.25e-175 506
LLPS-Anc-3329Anolis carolinensis78.146e-178 514
LLPS-Mum-3451Mus musculus78.145e-174 504
LLPS-Paa-0012Papio anubis77.692e-165 481
LLPS-Loa-0888Loxodonta africana77.195e-161 470
LLPS-Ova-3225Ovis aries77.191e-174 505
LLPS-Xet-1426Xenopus tropicalis77.176e-171 496
LLPS-Ten-1255Tetraodon nigroviridis76.635e-175 506
LLPS-Gog-1553Gorilla gorilla76.615e-133 396
LLPS-Bot-3381Bos taurus75.983e-174 505
LLPS-Tag-3175Taeniopygia guttata75.881e-138 409
LLPS-Ora-2366Ornithorhynchus anatinus75.793e-131 390
LLPS-Aim-1010Ailuropoda melanoleuca75.24e-147 431
LLPS-Gaa-3184Gasterosteus aculeatus74.950.0 523
LLPS-Pes-2229Pelodiscus sinensis74.97e-109 334
LLPS-Sah-3412Sarcophilus harrisii74.122e-178 515
LLPS-Ere-0423Erinaceus europaeus73.872e-126 376
LLPS-Fia-3431Ficedula albicollis73.722e-177 512
LLPS-Mod-2110Monodelphis domestica72.737e-177 511
LLPS-Gaga-1189Gallus gallus72.375e-177 511
LLPS-Anp-2593Anas platyrhynchos71.655e-174 504
LLPS-Rhb-3189Rhinopithecus bieti71.612e-144 427
LLPS-Meg-0821Meleagris gallopavo71.555e-176 509
LLPS-Lac-1374Latimeria chalumnae67.591e-153 452
LLPS-Chc-0955Chondrus crispus59.765e-0756.2
LLPS-Art-2993Arabidopsis thaliana58.754e-0859.3
LLPS-Arl-0226Arabidopsis lyrata58.754e-0859.7
LLPS-Tra-1419Triticum aestivum58.753e-0859.7
LLPS-Sob-0943Sorghum bicolor57.51e-0758.2
LLPS-Drm-1443Drosophila melanogaster51.564e-107 335
LLPS-Sei-1031Setaria italica36.144e-23 105
LLPS-Sem-1837Selaginella moellendorffii34.584e-35 139
LLPS-Nia-1020Nicotiana attenuata34.222e-38 150
LLPS-Vir-2043Vigna radiata33.91e-30 126
LLPS-Orb-2200Oryza barthii33.647e-27 115
LLPS-Hov-0889Hordeum vulgare33.437e-27 114
LLPS-Viv-1899Vitis vinifera33.427e-31 127
LLPS-Ors-0876Oryza sativa33.332e-29 122
LLPS-Orr-1673Oryza rufipogon33.332e-29 123
LLPS-Orgl-1676Oryza glumaepatula33.332e-29 123
LLPS-Met-2504Medicago truncatula33.255e-37 145
LLPS-Orp-2362Oryza punctata33.163e-30 125
LLPS-Sot-0293Solanum tuberosum33.092e-38 149
LLPS-Osl-1471Ostreococcus lucimarinus33.083e-34 136
LLPS-Prp-1993Prunus persica32.946e-31 127
LLPS-Dac-1535Daucus carota32.782e-30 126
LLPS-Gor-2618Gossypium raimondii32.633e-29 122
LLPS-Via-2394Vigna angularis32.64e-32 131
LLPS-Phv-2258Phaseolus vulgaris32.522e-34 137
LLPS-Thc-1713Theobroma cacao32.412e-29 123
LLPS-Zem-0185Zea mays32.092e-30 126
LLPS-Orni-1970Oryza nivara32.064e-29 122
LLPS-Bro-2033Brassica oleracea32.012e-29 122
LLPS-Abg-1272Absidia glauca31.886e-33 134
LLPS-Brr-2369Brassica rapa31.82e-29 122
LLPS-Orm-1243Oryza meridionalis31.778e-32 130
LLPS-Lep-0962Leersia perrieri31.772e-30 125
LLPS-Tru-1880Triticum urartu31.596e-27 115
LLPS-Orbr-1011Oryza brachyantha31.513e-26 115
LLPS-Cus-0346Cucumis sativus31.484e-29 122
LLPS-Org-0827Oryza glaberrima31.335e-30 125
LLPS-Pot-1757Populus trichocarpa31.152e-34 138
LLPS-Hea-0901Helianthus annuus31.127e-33 133
LLPS-Mae-0556Manihot esculenta30.824e-31 128
LLPS-Coc-1807Corchorus capsularis30.684e-31 128
LLPS-Brd-1691Brachypodium distachyon30.383e-26 114
LLPS-Brn-0480Brassica napus30.322e-30 125
LLPS-Glm-2366Glycine max30.253e-29 122
LLPS-Ori-1544Oryza indica30.229e-30 124
LLPS-Sol-2327Solanum lycopersicum30.144e-32 130
LLPS-Amt-1824Amborella trichopoda29.862e-33 135
LLPS-Cae-0700Caenorhabditis elegans29.691e-38 149