DrLLPS - Data resource of LLPS

LLPS-Vir-2043
LOC106753789

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Presenilin
Gene Name:	LOC106753789
Ensembl Gene:	vigra.VC1973A.gnm6.ann1.Vradi0007s00580
Ensembl Protein:	vigra.VC1973A.gnm6.ann1.Vradi0007s00580.1
Organism:	Vigna radiata
Taxa ID:	3916
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Centrosome/Spindle pole body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0229	P49768	Client	Centrosome/Spindle pole body	38.44	2e-37	146

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	vigra.VC1973A.gnm6.ann1.Vradi0007s00580.1	vigra.VC1973A.gnm6.ann1.Vradi0007s00580.1
UniProt		A0A1S3TBJ8, A0A1S3TBJ8_VIGRR
RefSeq	, XM_014635644.1	, XP_014491130.1, XP_014491130.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MFLVVLLVYA LSSPSSSAAT ITTAANLVYA ENPADSPAEK FEGALLNAVV FVGLIALVTF 60 61 LLVLLYYYNC TAFLRHYTRF SAFFVLASMG GSILLSLLQR FSIPLDAVSS LLLLFNFTVV 120 121 GVLSVFAGGI PIILRQAYMV CLGIIVAAWF TKLPEWTTWT LLVALALYDL VAVLAPGGPL 180 181 KLLVDLASTR NEELPALVYE ARPTVATRTP AALGFVVAGV SDSEASRIEL QVVSRDNVSN 240 241 NDDDDDDIDA NHGGSDEGER SPLVGGMRFG DVVINEEMSP LVEMSGMGDG EDAERVMREI 300 301 GGERGIKLGL GDFVFYSVLV GRAAMYDLMT VYACYLAIIS GLGCTLILLS VCRQALPALP 360 361 ISIALGVLFY FLTRLLMEPF IVGTATNLMM F 391

Protein Sequence (FASTA)

1     MFLVVLLVYA  LSSPSSSAAT  ITTAANLVYA  ENPADSPAEK  FEGALLNAVV  FVGLIALVTF  60
61    LLVLLYYYNC  TAFLRHYTRF  SAFFVLASMG  GSILLSLLQR  FSIPLDAVSS  LLLLFNFTVV  120
121   GVLSVFAGGI  PIILRQAYMV  CLGIIVAAWF  TKLPEWTTWT  LLVALALYDL  VAVLAPGGPL  180
181   KLLVDLASTR  NEELPALVYE  ARPTVATRTP  AALGFVVAGV  SDSEASRIEL  QVVSRDNVSN  240
241   NDDDDDDIDA  NHGGSDEGER  SPLVGGMRFG  DVVINEEMSP  LVEMSGMGDG  EDAERVMREI  300
301   GGERGIKLGL  GDFVFYSVLV  GRAAMYDLMT  VYACYLAIIS  GLGCTLILLS  VCRQALPALP  360
361   ISIALGVLFY  FLTRLLMEPF  IVGTATNLMM  F  391

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0256	Endoplasmic reticulum
KW-0333	Golgi apparatus
KW-0378	Hydrolase
KW-0472	Membrane
KW-0914	Notch signaling pathway
KW-0645	Protease
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005789	Cellular Component	Endoplasmic reticulum membrane
GO:0000139	Cellular Component	Golgi membrane
GO:0016021	Cellular Component	Integral component of membrane
GO:0004190	Molecular Function	Aspartic-type endopeptidase activity
GO:0007219	Biological Process	Notch signaling pathway
GO:0016485	Biological Process	Protein processing

▼ KEGG

vra:106753789

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Via-2394	Vigna angularis	99.18	0.0	587
LLPS-Phv-2258	Phaseolus vulgaris	92.05	0.0	557
LLPS-Tra-1419	Triticum aestivum	89.77	1e-44	165
LLPS-Sei-1031	Setaria italica	75.86	6e-34	135
LLPS-Arl-0226	Arabidopsis lyrata	72.25	2e-60	208
LLPS-Met-2504	Medicago truncatula	71.73	4e-139	410
LLPS-Orni-1970	Oryza nivara	67.65	1e-45	168
LLPS-Orb-2200	Oryza barthii	67.65	5e-46	168
LLPS-Ori-1544	Oryza indica	67.65	2e-45	168
LLPS-Orgl-1676	Oryza glumaepatula	67.65	1e-45	168
LLPS-Ors-0876	Oryza sativa	67.65	1e-45	168
LLPS-Org-0827	Oryza glaberrima	67.65	2e-45	168
LLPS-Orr-1673	Oryza rufipogon	67.65	1e-45	168
LLPS-Sob-0943	Sorghum bicolor	67.63	7e-47	172
LLPS-Orbr-1011	Oryza brachyantha	67.63	4e-46	171
LLPS-Zem-0185	Zea mays	67.05	2e-44	166
LLPS-Thc-1713	Theobroma cacao	67.0	6e-139	411
LLPS-Orm-1243	Oryza meridionalis	66.47	5e-46	170
LLPS-Orp-2362	Oryza punctata	66.18	2e-45	167
LLPS-Glm-2366	Glycine max	65.77	1e-35	140
LLPS-Coc-1807	Corchorus capsularis	65.25	3e-139	412
LLPS-Prp-1993	Prunus persica	64.88	1e-133	398
LLPS-Dac-1535	Daucus carota	64.81	3e-126	378
LLPS-Gor-2618	Gossypium raimondii	64.66	2e-136	405
LLPS-Viv-1899	Vitis vinifera	63.7	8e-131	390
LLPS-Mae-0556	Manihot esculenta	62.97	3e-128	384
LLPS-Pot-1757	Populus trichocarpa	62.59	6e-126	378
LLPS-Nia-1020	Nicotiana attenuata	62.53	9e-121	365
LLPS-Hea-0901	Helianthus annuus	62.24	1e-116	353
LLPS-Brn-0480	Brassica napus	61.82	6e-120	361
LLPS-Sot-0293	Solanum tuberosum	61.5	1e-115	350
LLPS-Nol-2271	Nomascus leucogenys	60.87	1e-06	54.7
LLPS-Brr-2369	Brassica rapa	60.78	2e-119	360
LLPS-Art-2993	Arabidopsis thaliana	60.25	4e-123	370
LLPS-Drm-1443	Drosophila melanogaster	60.0	8e-16	83.2
LLPS-Amt-1824	Amborella trichopoda	58.72	3e-115	351
LLPS-Xim-0809	Xiphophorus maculatus	57.65	4e-15	80.5
LLPS-Myl-3423	Myotis lucifugus	57.47	9e-16	82.4
LLPS-Dio-2002	Dipodomys ordii	57.47	2e-15	81.6
LLPS-Sol-2327	Solanum lycopersicum	56.45	2e-86	275
LLPS-Gog-3717	Gorilla gorilla	56.32	4e-15	80.9
LLPS-Fud-2182	Fukomys damarensis	56.32	7e-15	79.7
LLPS-Caj-3286	Callithrix jacchus	56.32	4e-15	80.9
LLPS-Mum-4859	Mus musculus	56.32	2e-15	81.3
LLPS-Maf-0682	Macaca fascicularis	56.32	4e-15	80.9
LLPS-Chs-2964	Chlorocebus sabaeus	56.32	3e-15	80.9
LLPS-Sus-3914	Sus scrofa	56.32	4e-15	80.9
LLPS-Aon-3673	Aotus nancymaae	56.32	5e-15	80.5
LLPS-Cea-4034	Cercocebus atys	56.32	4e-15	80.5
LLPS-Sah-2117	Sarcophilus harrisii	56.32	2e-15	81.6
LLPS-Mal-1415	Mandrillus leucophaeus	56.32	4e-15	80.9
LLPS-Paa-4200	Papio anubis	56.32	4e-15	80.9
LLPS-Ova-3993	Ovis aries	56.32	4e-15	80.5
LLPS-Aim-4141	Ailuropoda melanoleuca	56.32	4e-15	80.9
LLPS-Mup-0978	Mustela putorius furo	56.32	3e-15	80.9
LLPS-Bot-4517	Bos taurus	56.32	4e-15	80.5
LLPS-Orc-1096	Oryctolagus cuniculus	56.32	4e-15	80.9
LLPS-Rhb-0845	Rhinopithecus bieti	56.32	5e-15	80.5
LLPS-Meg-1688	Meleagris gallopavo	56.32	2e-15	81.6
LLPS-Hos-2647	Homo sapiens	56.32	4e-15	80.9
LLPS-Pap-3651	Pan paniscus	56.32	6e-15	80.5
LLPS-Pat-2264	Pan troglodytes	56.32	6e-15	80.5
LLPS-Mod-2422	Monodelphis domestica	56.32	2e-15	81.3
LLPS-Man-4688	Macaca nemestrina	56.32	4e-15	80.9
LLPS-Cas-0771	Carlito syrichta	56.32	4e-15	80.9
LLPS-Ict-4240	Ictidomys tridecemlineatus	56.32	3e-15	80.9
LLPS-Caf-3645	Canis familiaris	56.32	3e-15	80.9
LLPS-Poa-1921	Pongo abelii	56.32	3e-15	80.9
LLPS-Cap-1399	Cavia porcellus	56.32	4e-15	80.9
LLPS-Mam-2078	Macaca mulatta	56.32	4e-15	80.9
LLPS-Mea-3808	Mesocricetus auratus	55.29	1e-13	76.3
LLPS-Ran-2773	Rattus norvegicus	55.29	7e-14	77.0
LLPS-Osl-1471	Ostreococcus lucimarinus	54.26	7e-15	79.3
LLPS-Tar-3362	Takifugu rubripes	53.85	3e-15	80.9
LLPS-Lep-0962	Leersia perrieri	52.44	6e-92	290
LLPS-Brd-1691	Brachypodium distachyon	52.2	1e-94	298
LLPS-Tru-1880	Triticum urartu	51.9	4e-89	282
LLPS-Hov-0889	Hordeum vulgare	51.0	7e-84	266
LLPS-Bro-2033	Brassica oleracea	50.55	5e-83	265
LLPS-Sem-1837	Selaginella moellendorffii	48.91	9e-77	249
LLPS-Cus-0346	Cucumis sativus	46.79	1e-74	245
LLPS-Chc-0955	Chondrus crispus	44.95	3e-20	96.3
LLPS-Ere-0423	Erinaceus europaeus	38.31	3e-29	120
LLPS-Ora-2366	Ornithorhynchus anatinus	37.24	4e-28	117
LLPS-Loa-0888	Loxodonta africana	36.83	5e-28	118
LLPS-Fec-3228	Felis catus	36.78	3e-31	128
LLPS-Tag-3175	Taeniopygia guttata	36.31	8e-33	130
LLPS-Fia-3431	Ficedula albicollis	36.02	1e-31	129
LLPS-Eqc-1974	Equus caballus	35.91	3e-32	130
LLPS-Anc-3329	Anolis carolinensis	35.84	1e-29	123
LLPS-Pes-3073	Pelodiscus sinensis	35.53	4e-32	130
LLPS-Anp-2593	Anas platyrhynchos	35.14	2e-29	122
LLPS-Xet-1426	Xenopus tropicalis	34.82	3e-29	122
LLPS-Dar-3285	Danio rerio	34.44	5e-33	133
LLPS-Gaga-1189	Gallus gallus	34.36	8e-31	126
LLPS-Pof-2375	Poecilia formosa	34.27	5e-29	121
LLPS-Gaa-3841	Gasterosteus aculeatus	34.06	7e-30	124
LLPS-Icp-4236	Ictalurus punctatus	33.52	8e-25	108
LLPS-Asm-2522	Astyanax mexicanus	33.24	5e-23	103
LLPS-Orn-2186	Oreochromis niloticus	32.78	3e-28	119
LLPS-Scf-1951	Scleropages formosus	32.4	2e-23	105
LLPS-Ten-2205	Tetraodon nigroviridis	32.16	4e-23	103
LLPS-Scm-1073	Scophthalmus maximus	31.3	4e-24	107
LLPS-Abg-1272	Absidia glauca	30.6	4e-25	111
LLPS-Cae-0700	Caenorhabditis elegans	29.88	3e-13	74.3
LLPS-Lac-1374	Latimeria chalumnae	29.48	3e-14	78.2

LLPS-Vir-2043LOC106753789

Protein Sequence

Nucleotide Sequence

LLPS-Vir-2043
LOC106753789