• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Man-4688
PSEN2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Presenilin
Gene Name: PSEN2
Ensembl Gene: ENSMNEG00000035904.1
Ensembl Protein: ENSMNEP00000024737.1
Organism: Macaca nemestrina
Taxa ID: 9545
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLARIVRFAR  HCLELFPARN  PACVAFGTSG  GRAMLTFMAS  DSEEEVCDER  TSLMSAESPT  60
61    PRSCQEGRQG  PEDGENIAQW  RSQENEEDGE  EDPDRYVCSG  VPGRPPGLEE  ELTLKYGAKH  120
121   VIMLFVPVTL  CMIVVVATIK  SVRFYTEKNG  QLIYTPFTED  TPSVGQRLLN  SVLNTLIMIS  180
181   VIVVMTIFLV  VLYKYRCYKF  IHGWLIMSSL  MLLFLFTYIY  LGEVLKTYNV  AMDYPTLLLT  240
241   VWNFGAVGMV  CIHWKGPLVL  QQAYLIMISA  LMALVFIKYL  PEWSAWVILG  AISVYDLVAV  300
301   LCPKGPLRML  VETAQERNEP  IFPALIYSSA  MVWTVGMAKL  DPSSQGALQL  PYDPEMEEDS  360
361   YDSFGEPSYP  EVFEPPLTGY  PGEELEEEEE  RGVKLGLGDF  IFYSVLVGKA  AATGSGDWNT  420
421   TLACFVAILI  GLCLTLLLLA  VFKKALPALP  ISITFGLIFY  FSTDNLVRPF  MDTLASHQLY  480
481   I  481
Nucleotide CDS Sequence (FASTA)
1     ATGCTCACAT  TCATGGCCTC  TGACAGCGAG  GAAGAAGTGT  GTGATGAGCG  GACATCCCTA  60
61    ATGTCGGCCG  AGAGCCCCAC  ACCGCGCTCC  TGCCAGGAGG  GCAGGCAGGG  ACCAGAGGAC  120
121   GGAGAGAACA  TTGCCCAGTG  GAGAAGCCAG  GAGAACGAGG  AGGACGGTGA  GGAGGACCCT  180
181   GACCGCTACG  TCTGTAGTGG  GGTTCCCGGG  CGGCCTCCAG  GCCTGGAGGA  AGAGCTGACC  240
241   CTCAAGTACG  GGGCAAAGCA  CGTGATCATG  CTGTTTGTGC  CGGTCACTCT  GTGCATGATC  300
301   GTGGTGGTAG  CCACCATCAA  GTCTGTGCGC  TTCTACACGG  AGAAGAATGG  ACAGCTCATC  360
361   TACACGCCAT  TCACTGAGGA  CACGCCCTCG  GTGGGCCAGC  GCCTCCTCAA  CTCTGTTCTC  420
421   AACACCCTCA  TCATGATCAG  CGTCATCGTG  GTTATGACCA  TCTTCTTGGT  GGTGCTCTAC  480
481   AAGTACCGCT  GCTACAAGTT  CATCCATGGC  TGGTTGATCA  TGTCTTCGCT  GATGCTGCTG  540
541   TTCCTCTTCA  CCTATATCTA  CCTTGGGGAA  GTGCTGAAGA  CCTACAATGT  GGCCATGGAC  600
601   TACCCCACCC  TCTTGCTGAC  TGTCTGGAAC  TTCGGGGCGG  TGGGCATGGT  GTGTATCCAC  660
661   TGGAAGGGCC  CCCTGGTGCT  GCAGCAGGCC  TACCTCATCA  TGATCAGTGC  ACTCATGGCC  720
721   TTGGTGTTCA  TCAAGTACCT  CCCAGAGTGG  TCCGCGTGGG  TCATCCTGGG  CGCCATCTCT  780
781   GTGTACGATC  TCGTGGCTGT  GCTGTGTCCC  AAAGGGCCTC  TGAGAATGCT  GGTAGAAACT  840
841   GCCCAGGAGA  GAAACGAGCC  CATATTCCCT  GCCCTGATAT  ACTCATCCGC  CATGGTGTGG  900
901   ACGGTCGGCA  TGGCGAAGCT  GGACCCCTCA  TCTCAGGGTG  CCCTCCAGCT  CCCCTATGAC  960
961   CCAGAGATGG  AAGAAGACTC  CTATGACAGT  TTTGGGGAGC  CTTCATACCC  CGAAGTCTTT  1020
1021  GAGCCTCCCC  TGACTGGCTA  CCCAGGGGAG  GAACTGGAGG  AAGAGGAGGA  AAGGGGTGTG  1080
1081  AAGCTTGGCC  TCGGGGACTT  CATCTTCTAC  AGTGTGCTGG  TGGGCAAGGC  AGCGGCCACG  1140
1141  GGCAGCGGGG  ACTGGAATAC  CACGCTGGCC  TGCTTCGTGG  CCATCCTCAT  TGGCTTGTGT  1200
1201  CTGACCCTCC  TGCTGCTTGC  TGTCTTCAAG  AAGGCGTTGC  CCGCCCTCCC  CATCTCCATC  1260
1261  ACGTTTGGGC  TCATCTTTTA  CTTCTCCACG  GACAACCTGG  TGCGACCATT  CATGGACACC  1320
1321  CTGGCCTCCC  ATCAGCTCTA  CATCTGA  1347

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Notch signaling pathway
Protease
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Golgi membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Kinetochore
Cellular Component
Nuclear inner membrane
Molecular Function
Aspartic endopeptidase activity, intramembrane cleaving
Biological Process
Amyloid precursor protein catabolic process
Biological Process
Intracellular signal transduction
Biological Process
Membrane protein ectodomain proteolysis
Biological Process
Mitochondrion-endoplasmic reticulum membrane tethering
Biological Process
Notch signaling pathway
Biological Process
Positive regulation of catalytic activity
Biological Process
Protein processing
Biological Process
Regulation of calcium import into the mitochondrion

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-2078Macaca mulatta99.790.0 844
LLPS-Mal-1415Mandrillus leucophaeus99.580.0 842
LLPS-Paa-4200Papio anubis99.580.0 842
LLPS-Maf-0682Macaca fascicularis99.580.0 841
LLPS-Poa-1921Pongo abelii99.550.0 774
LLPS-Chs-2964Chlorocebus sabaeus99.550.0 774
LLPS-Cea-4034Cercocebus atys99.170.0 834
LLPS-Rhb-0845Rhinopithecus bieti98.960.0 836
LLPS-Hos-2647Homo sapiens97.920.0 825
LLPS-Gog-3717Gorilla gorilla97.920.0 825
LLPS-Nol-2271Nomascus leucogenys97.650.0 769
LLPS-Ict-4240Ictidomys tridecemlineatus97.10.0 752
LLPS-Sus-3914Sus scrofa96.960.0 770
LLPS-Bot-4517Bos taurus96.660.0 728
LLPS-Eqc-3247Equus caballus96.460.0 648
LLPS-Caj-3286Callithrix jacchus96.260.0 802
LLPS-Aon-3673Aotus nancymaae96.050.0 794
LLPS-Caf-3645Canis familiaris95.980.0 740
LLPS-Mum-4859Mus musculus95.760.0 744
LLPS-Ova-3993Ovis aries95.550.0 710
LLPS-Cap-1399Cavia porcellus95.540.0 739
LLPS-Mup-0978Mustela putorius furo95.540.0 737
LLPS-Mea-3808Mesocricetus auratus95.540.0 746
LLPS-Ran-2773Rattus norvegicus95.090.0 746
LLPS-Fud-2182Fukomys damarensis95.090.0 734
LLPS-Orc-1096Oryctolagus cuniculus94.290.0 740
LLPS-Cas-0771Carlito syrichta93.530.0 761
LLPS-Pat-2264Pan troglodytes91.790.0 752
LLPS-Pap-3651Pan paniscus91.790.0 752
LLPS-Dio-2002Dipodomys ordii91.740.0 705
LLPS-Loa-0392Loxodonta africana91.130.0 716
LLPS-Icp-4236Ictalurus punctatus90.363e-22 102
LLPS-Fec-0910Felis catus90.00.0 728
LLPS-Dar-2676Danio rerio89.164e-22 102
LLPS-Asm-2522Astyanax mexicanus89.163e-22 103
LLPS-Orn-2186Oreochromis niloticus87.954e-21 100
LLPS-Aim-4141Ailuropoda melanoleuca86.810.0 675
LLPS-Pof-2375Poecilia formosa86.754e-21 100
LLPS-Gaa-3184Gasterosteus aculeatus86.753e-2097.4
LLPS-Ten-1255Tetraodon nigroviridis85.548e-2095.9
LLPS-Xim-0343Xiphophorus maculatus85.546e-2199.4
LLPS-Lac-1374Latimeria chalumnae83.874e-0859.7
LLPS-Myl-3423Myotis lucifugus83.050.0 531
LLPS-Mod-2422Monodelphis domestica81.00.0 590
LLPS-Sah-2117Sarcophilus harrisii79.530.0 576
LLPS-Gaga-3281Gallus gallus77.140.0 562
LLPS-Pes-2229Pelodiscus sinensis77.13e-162 472
LLPS-Tag-0659Taeniopygia guttata76.960.0 564
LLPS-Fia-0507Ficedula albicollis76.090.0 560
LLPS-Anc-4027Anolis carolinensis75.650.0 556
LLPS-Ora-1962Ornithorhynchus anatinus75.563e-180 519
LLPS-Anp-1862Anas platyrhynchos75.530.0 561
LLPS-Meg-1688Meleagris gallopavo74.890.0 548
LLPS-Scf-1984Scleropages formosus73.730.0 530
LLPS-Drm-1443Drosophila melanogaster72.295e-1272.0
LLPS-Xet-3910Xenopus tropicalis71.80.0 543
LLPS-Tar-3362Takifugu rubripes71.175e-162 473
LLPS-Scm-1073Scophthalmus maximus68.613e-141 422
LLPS-Ere-0423Erinaceus europaeus67.327e-94 293
LLPS-Sei-1031Setaria italica52.058e-1374.3
LLPS-Chc-0955Chondrus crispus42.481e-28 122
LLPS-Orb-2200Oryza barthii41.127e-1889.4
LLPS-Abg-1272Absidia glauca39.338e-27 117
LLPS-Osl-1471Ostreococcus lucimarinus38.181e-35 140
LLPS-Hov-0889Hordeum vulgare37.913e-2095.5
LLPS-Orr-1673Oryza rufipogon37.433e-25 111
LLPS-Orp-2362Oryza punctata37.435e-25 110
LLPS-Ors-0876Oryza sativa37.432e-25 112
LLPS-Orni-1970Oryza nivara37.432e-25 111
LLPS-Orgl-1676Oryza glumaepatula36.874e-25 111
LLPS-Prp-1993Prunus persica35.913e-25 111
LLPS-Orbr-1011Oryza brachyantha35.751e-24 110
LLPS-Vir-2043Vigna radiata35.03e-25 110
LLPS-Thc-1713Theobroma cacao35.02e-24 108
LLPS-Tra-1419Triticum aestivum34.913e-26 114
LLPS-Gor-2618Gossypium raimondii34.812e-23 106
LLPS-Mae-0556Manihot esculenta34.391e-26 115
LLPS-Viv-1899Vitis vinifera34.349e-25 110
LLPS-Tru-1880Triticum urartu34.299e-24 107
LLPS-Sem-1837Selaginella moellendorffii34.256e-22 101
LLPS-Brd-1691Brachypodium distachyon34.134e-28 120
LLPS-Lep-0962Leersia perrieri33.959e-23 104
LLPS-Phv-2258Phaseolus vulgaris33.643e-26 113
LLPS-Bro-2033Brassica oleracea33.511e-25 111
LLPS-Coc-1807Corchorus capsularis33.332e-25 111
LLPS-Orm-1243Oryza meridionalis33.333e-26 115
LLPS-Sot-0293Solanum tuberosum33.337e-28 119
LLPS-Ori-1544Oryza indica33.045e-26 114
LLPS-Sob-0943Sorghum bicolor32.672e-28 120
LLPS-Org-0827Oryza glaberrima32.69e-26 113
LLPS-Pot-1757Populus trichocarpa32.582e-27 117
LLPS-Zem-0185Zea mays32.53e-27 117
LLPS-Met-2504Medicago truncatula32.311e-26 115
LLPS-Hea-0901Helianthus annuus32.275e-25 110
LLPS-Via-2394Vigna angularis32.161e-26 115
LLPS-Nia-1020Nicotiana attenuata32.118e-26 113
LLPS-Sol-2327Solanum lycopersicum31.863e-28 119
LLPS-Cae-0700Caenorhabditis elegans31.726e-32 129
LLPS-Dac-1535Daucus carota31.471e-21 100
LLPS-Amt-1824Amborella trichopoda31.424e-25 111
LLPS-Art-2993Arabidopsis thaliana31.162e-23 106
LLPS-Glm-2366Glycine max30.673e-24 108
LLPS-Brr-2369Brassica rapa30.298e-22 101
LLPS-Brn-0480Brassica napus30.296e-22 101
LLPS-Arl-0226Arabidopsis lyrata29.775e-23 105
LLPS-Cus-0346Cucumis sativus29.759e-24 107