LLPS-Mod-2422
PSEN2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Presenilin |
| Gene Name: | PSEN2 |
| Ensembl Gene: | ENSMODG00000006114.3 |
| Ensembl Protein: | ENSMODP00000007575.2 |
| Organism: | Monodelphis domestica |
| Taxa ID: | 13616 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMODT00000007728.3 | ENSMODP00000007575.2 |
| UniProt | F7EIE5, F7EIE5_MONDO | |
| RefSeq | XM_007481504.2, XM_007481505.2, XM_007481506.2, XM_016430204.1 | XP_007481566.1, XP_007481567.1, XP_007481568.1, XP_016285690.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MITFMNSDSE EEVCNERTSL MSTESPPARS YHEGICTEER DKEIQEKRRG SPCHHGDADQ 60 61 CTPDSRGSTR SSSLEEEEEE EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVRFYTEKN 120 121 GQLIYTPFTE DTPSIGQRLL NSVLNTLIMI SVIVVMTIFL VVLYKYRCYK FIHGWLILSS 180 181 LMLLFLFTYI YLGEVLKTYN VAMDYPTLFL VIWNFGAVGM ICIHWKGPLV LQQAYLIMIS 240 241 ALMALVFIKY LPEWSAWVIL GAISVYDLVA VLCPKGPLRM LVETAQERNE PIFPALIYSS 300 301 AMVWTVGMAK VDSPTKGALP KDQEQEDDWS DTSGDHSYSE TYDSPRCTPL HVPSYAVEEL 360 361 EEEEERGVKL GLGDFIFYSV LVGKAAATAS GDWNTTLACF VAILIGLCLT LLLLAVFKKA 420 421 LPALPISITF GLIFYFSTDN LVRPFMDTLA SHQLYI 456 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATAACAT TCATGAATTC AGACAGTGAA GAGGAAGTCT GCAACGAGAG GACATCTCTG 60 61 ATGTCCACAG AGAGCCCCCC AGCGCGGTCG TATCATGAAG GAATTTGCAC GGAAGAAAGG 120 121 GATAAGGAGA TCCAAGAGAA ACGCCGCGGC AGCCCGTGTC ACCATGGTGA TGCTGACCAG 180 181 TGTACCCCTG ACAGCAGGGG CTCCACGAGA AGCAGCAGCC TGGAGGAAGA GGAAGAGGAG 240 241 GAAGAGCTGA CCCTCAAATA CGGGGCGAAG CACGTGATCA TGCTGTTTGT GCCTGTCACT 300 301 CTCTGCATGG TGGTTGTCGT GGCAACCATT AAGTCAGTCC GCTTCTACAC GGAGAAGAAT 360 361 GGACAGCTAA TCTACACGCC ATTTACGGAA GACACCCCCT CCATCGGTCA GCGCTTGCTC 420 421 AACTCGGTGC TAAACACCCT CATCATGATC AGCGTCATTG TGGTCATGAC GATATTCTTG 480 481 GTCGTGCTGT ACAAGTACCG CTGCTACAAG TTTATCCATG GCTGGTTGAT CCTGTCTTCT 540 541 CTGATGCTCC TCTTCCTCTT CACCTACATT TATCTTGGAG AAGTGCTCAA GACTTACAAT 600 601 GTGGCTATGG ATTATCCAAC CCTTTTTTTG GTCATCTGGA ACTTTGGGGC AGTGGGAATG 660 661 ATTTGCATCC ACTGGAAGGG CCCCCTGGTG CTGCAGCAGG CCTACCTCAT CATGATCAGT 720 721 GCCCTCATGG CCTTGGTTTT CATCAAGTAC CTCCCAGAAT GGTCAGCCTG GGTCATCCTG 780 781 GGAGCCATCT CTGTGTATGA TCTGGTGGCT GTGCTCTGTC CTAAGGGGCC CTTGAGGATG 840 841 CTTGTAGAAA CGGCTCAGGA AAGAAACGAA CCTATCTTTC CTGCCCTCAT ATATTCGTCC 900 901 GCCATGGTGT GGACCGTAGG CATGGCAAAG GTGGACAGTC CAACGAAGGG AGCCCTCCCC 960 961 AAGGACCAGG AGCAAGAGGA CGACTGGAGC GACACTTCTG GGGACCATTC TTACTCTGAA 1020 1021 ACCTACGACT CCCCGAGGTG CACCCCCCTC CACGTGCCTT CCTATGCCGT GGAGGAGCTG 1080 1081 GAGGAAGAGG AGGAAAGGGG CGTGAAGCTG GGCCTGGGGG ATTTCATCTT CTACAGCGTT 1140 1141 CTGGTGGGCA AGGCGGCAGC CACGGCCAGC GGGGACTGGA ACACGACCCT CGCCTGCTTT 1200 1201 GTCGCCATTC TCATTGGCCT GTGTTTGACG CTCTTGCTGC TGGCGGTGTT CAAGAAGGCT 1260 1261 TTGCCCGCCC TGCCCATCTC CATCACCTTC GGTCTCATCT TCTACTTCTC CACCGACAAC 1320 1321 CTCGTGAGGC CTTTCATGGA CACCCTGGCC TCCCACCAGC TGTACATTTA G 1371 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Cell cortex | |
Cellular Component | Centrosome | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Kinetochore | |
Cellular Component | Neuronal cell body | |
Cellular Component | Nuclear inner membrane | |
Cellular Component | Nucleus | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Z disc | |
Molecular Function | Aspartic endopeptidase activity, intramembrane cleaving | |
Molecular Function | Endopeptidase activity | |
Biological Process | Amyloid precursor protein catabolic process | |
Biological Process | Amyloid-beta metabolic process | |
Biological Process | Calcium ion transport | |
Biological Process | Intracellular signal transduction | |
Biological Process | Membrane protein ectodomain proteolysis | |
Biological Process | Mitochondrion-endoplasmic reticulum membrane tethering | |
Biological Process | Notch receptor processing | |
Biological Process | Notch signaling pathway | |
Biological Process | Positive regulation of catalytic activity | |
Biological Process | Protein processing | |
Biological Process | Regulation of calcium import into the mitochondrion |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sah-2117 | Sarcophilus harrisii | 96.32 | 0.0 | 760 |
| LLPS-Sus-3914 | Sus scrofa | 81.26 | 0.0 | 619 |
| LLPS-Man-4688 | Macaca nemestrina | 81.22 | 0.0 | 618 |
| LLPS-Mam-2078 | Macaca mulatta | 81.22 | 0.0 | 618 |
| LLPS-Aon-3673 | Aotus nancymaae | 81.22 | 0.0 | 617 |
| LLPS-Maf-0682 | Macaca fascicularis | 81.22 | 0.0 | 618 |
| LLPS-Paa-4200 | Papio anubis | 81.22 | 0.0 | 618 |
| LLPS-Mal-1415 | Mandrillus leucophaeus | 81.22 | 0.0 | 618 |
| LLPS-Hos-2647 | Homo sapiens | 81.0 | 0.0 | 616 |
| LLPS-Rhb-0845 | Rhinopithecus bieti | 81.0 | 0.0 | 617 |
| LLPS-Cas-0771 | Carlito syrichta | 81.0 | 0.0 | 619 |
| LLPS-Gog-3717 | Gorilla gorilla | 81.0 | 0.0 | 616 |
| LLPS-Cap-1399 | Cavia porcellus | 80.95 | 0.0 | 617 |
| LLPS-Ict-4240 | Ictidomys tridecemlineatus | 80.95 | 0.0 | 618 |
| LLPS-Cea-4034 | Cercocebus atys | 80.95 | 0.0 | 618 |
| LLPS-Poa-1921 | Pongo abelii | 80.74 | 0.0 | 617 |
| LLPS-Chs-2964 | Chlorocebus sabaeus | 80.74 | 0.0 | 617 |
| LLPS-Caj-3286 | Callithrix jacchus | 80.74 | 0.0 | 615 |
| LLPS-Ova-3993 | Ovis aries | 80.57 | 0.0 | 608 |
| LLPS-Mum-4859 | Mus musculus | 80.3 | 0.0 | 619 |
| LLPS-Orc-1096 | Oryctolagus cuniculus | 80.22 | 0.0 | 603 |
| LLPS-Bot-4517 | Bos taurus | 80.13 | 0.0 | 607 |
| LLPS-Mea-3808 | Mesocricetus auratus | 79.91 | 0.0 | 607 |
| LLPS-Mup-0978 | Mustela putorius furo | 79.78 | 0.0 | 621 |
| LLPS-Caf-3645 | Canis familiaris | 79.57 | 0.0 | 619 |
| LLPS-Anc-4027 | Anolis carolinensis | 79.08 | 0.0 | 603 |
| LLPS-Ran-2773 | Rattus norvegicus | 78.88 | 0.0 | 603 |
| LLPS-Fud-2182 | Fukomys damarensis | 78.82 | 0.0 | 601 |
| LLPS-Eqc-3247 | Equus caballus | 78.41 | 3e-168 | 494 |
| LLPS-Nol-2271 | Nomascus leucogenys | 78.36 | 0.0 | 560 |
| LLPS-Myl-3423 | Myotis lucifugus | 78.25 | 1e-162 | 473 |
| LLPS-Ora-1962 | Ornithorhynchus anatinus | 78.24 | 0.0 | 570 |
| LLPS-Gaga-3281 | Gallus gallus | 78.14 | 0.0 | 606 |
| LLPS-Dio-2002 | Dipodomys ordii | 78.0 | 0.0 | 588 |
| LLPS-Meg-1688 | Meleagris gallopavo | 77.75 | 0.0 | 592 |
| LLPS-Tag-0659 | Taeniopygia guttata | 77.73 | 0.0 | 602 |
| LLPS-Anp-1862 | Anas platyrhynchos | 77.71 | 0.0 | 598 |
| LLPS-Fia-0507 | Ficedula albicollis | 77.51 | 0.0 | 597 |
| LLPS-Fec-0910 | Felis catus | 77.34 | 0.0 | 602 |
| LLPS-Pap-3651 | Pan paniscus | 77.11 | 0.0 | 570 |
| LLPS-Pat-2264 | Pan troglodytes | 77.11 | 0.0 | 570 |
| LLPS-Loa-0392 | Loxodonta africana | 76.86 | 0.0 | 598 |
| LLPS-Xet-3910 | Xenopus tropicalis | 75.22 | 0.0 | 574 |
| LLPS-Aim-4141 | Ailuropoda melanoleuca | 73.7 | 0.0 | 540 |
| LLPS-Drm-1443 | Drosophila melanogaster | 73.63 | 3e-17 | 88.6 |
| LLPS-Scf-1984 | Scleropages formosus | 73.13 | 0.0 | 545 |
| LLPS-Pes-2229 | Pelodiscus sinensis | 72.77 | 7e-166 | 480 |
| LLPS-Orn-2186 | Oreochromis niloticus | 71.43 | 1e-162 | 476 |
| LLPS-Tar-3362 | Takifugu rubripes | 70.85 | 2e-175 | 506 |
| LLPS-Dar-2676 | Danio rerio | 70.47 | 2e-151 | 446 |
| LLPS-Icp-4236 | Ictalurus punctatus | 70.32 | 5e-151 | 445 |
| LLPS-Scm-1073 | Scophthalmus maximus | 70.3 | 2e-153 | 452 |
| LLPS-Asm-1181 | Astyanax mexicanus | 69.98 | 7e-177 | 510 |
| LLPS-Lac-3488 | Latimeria chalumnae | 69.49 | 0.0 | 523 |
| LLPS-Pof-2375 | Poecilia formosa | 69.42 | 5e-160 | 469 |
| LLPS-Xim-0343 | Xiphophorus maculatus | 69.17 | 2e-159 | 467 |
| LLPS-Ten-2205 | Tetraodon nigroviridis | 68.82 | 4e-157 | 459 |
| LLPS-Gaa-3184 | Gasterosteus aculeatus | 68.5 | 4e-152 | 448 |
| LLPS-Ere-0423 | Erinaceus europaeus | 68.3 | 9e-105 | 321 |
| LLPS-Brr-2369 | Brassica rapa | 61.73 | 1e-07 | 57.8 |
| LLPS-Brn-0480 | Brassica napus | 61.73 | 1e-07 | 57.8 |
| LLPS-Hea-0901 | Helianthus annuus | 61.73 | 6e-08 | 58.9 |
| LLPS-Sot-0293 | Solanum tuberosum | 61.54 | 7e-06 | 52.4 |
| LLPS-Ors-0876 | Oryza sativa | 60.49 | 3e-07 | 56.6 |
| LLPS-Art-2993 | Arabidopsis thaliana | 60.49 | 1e-07 | 57.8 |
| LLPS-Orbr-1011 | Oryza brachyantha | 60.49 | 4e-07 | 56.6 |
| LLPS-Orm-1243 | Oryza meridionalis | 60.49 | 2e-07 | 57.4 |
| LLPS-Orr-1673 | Oryza rufipogon | 60.49 | 3e-07 | 56.6 |
| LLPS-Org-0827 | Oryza glaberrima | 60.49 | 3e-07 | 57.0 |
| LLPS-Orb-2200 | Oryza barthii | 60.49 | 3e-07 | 56.6 |
| LLPS-Ori-1544 | Oryza indica | 60.49 | 3e-07 | 57.0 |
| LLPS-Orni-1970 | Oryza nivara | 60.49 | 3e-07 | 56.6 |
| LLPS-Orgl-1676 | Oryza glumaepatula | 60.49 | 3e-07 | 57.0 |
| LLPS-Arl-0226 | Arabidopsis lyrata | 60.49 | 1e-07 | 57.8 |
| LLPS-Amt-1824 | Amborella trichopoda | 59.26 | 1e-07 | 58.2 |
| LLPS-Gor-2618 | Gossypium raimondii | 58.62 | 8e-09 | 61.6 |
| LLPS-Coc-1807 | Corchorus capsularis | 58.62 | 2e-08 | 60.5 |
| LLPS-Sob-0943 | Sorghum bicolor | 58.02 | 3e-07 | 56.6 |
| LLPS-Zem-0185 | Zea mays | 58.02 | 3e-07 | 56.6 |
| LLPS-Tru-1880 | Triticum urartu | 58.02 | 2e-07 | 57.4 |
| LLPS-Hov-0889 | Hordeum vulgare | 58.02 | 1e-07 | 57.8 |
| LLPS-Tra-1419 | Triticum aestivum | 58.02 | 1e-07 | 58.2 |
| LLPS-Viv-1899 | Vitis vinifera | 57.47 | 6e-08 | 58.9 |
| LLPS-Mae-0556 | Manihot esculenta | 57.47 | 2e-07 | 57.4 |
| LLPS-Brd-1691 | Brachypodium distachyon | 56.79 | 4e-07 | 56.2 |
| LLPS-Pot-1757 | Populus trichocarpa | 56.32 | 4e-07 | 56.2 |
| LLPS-Prp-1993 | Prunus persica | 56.32 | 1e-07 | 57.8 |
| LLPS-Sei-1031 | Setaria italica | 52.05 | 4e-13 | 75.1 |
| LLPS-Lep-0962 | Leersia perrieri | 50.0 | 5e-07 | 55.8 |
| LLPS-Abg-1272 | Absidia glauca | 46.15 | 3e-27 | 118 |
| LLPS-Thc-1713 | Theobroma cacao | 42.86 | 7e-09 | 62.0 |
| LLPS-Chc-0955 | Chondrus crispus | 41.83 | 8e-28 | 119 |
| LLPS-Osl-1471 | Ostreococcus lucimarinus | 37.13 | 4e-36 | 141 |
| LLPS-Orp-2362 | Oryza punctata | 34.42 | 8e-36 | 142 |
| LLPS-Bro-2033 | Brassica oleracea | 33.94 | 2e-32 | 131 |
| LLPS-Sem-1837 | Selaginella moellendorffii | 33.91 | 2e-32 | 131 |
| LLPS-Met-2504 | Medicago truncatula | 33.57 | 3e-39 | 152 |
| LLPS-Nia-1020 | Nicotiana attenuata | 33.25 | 8e-37 | 145 |
| LLPS-Vir-2043 | Vigna radiata | 33.06 | 9e-36 | 141 |
| LLPS-Phv-2258 | Phaseolus vulgaris | 32.6 | 6e-37 | 145 |
| LLPS-Glm-2366 | Glycine max | 32.44 | 1e-25 | 112 |
| LLPS-Via-2394 | Vigna angularis | 32.27 | 2e-37 | 146 |
| LLPS-Sol-2327 | Solanum lycopersicum | 32.15 | 6e-33 | 133 |
| LLPS-Dac-1535 | Daucus carota | 32.06 | 7e-33 | 133 |
| LLPS-Cae-0700 | Caenorhabditis elegans | 31.72 | 7e-40 | 152 |
| LLPS-Cus-0346 | Cucumis sativus | 30.5 | 2e-28 | 120 |