LLPS-Prp-1993
PRUPE_5G048300
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Presenilin |
| Gene Name: | PRUPE_5G048300, PRUPE_ppa005461mg |
| Ensembl Gene: | PRUPE_5G048300 |
| Ensembl Protein: | ONI06224 |
| Organism: | Prunus persica |
| Taxa ID: | 3760 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ONI06224 | ONI06224 |
| UniProt | M5WAI2, M5WAI2_PRUPE | |
| GeneBank | CM007655, KB639086 | EMJ10321.1, ONI06224.1 |
| RefSeq | XM_007209060.1 | XP_007209122.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MESSILESIG VEIIGVMSPV SICMLLVVLL VYALSPSNPF SAAASAPPIR TAANLVYLES 60 61 PSDSASQKLE GALLNALVFV VLIAIVTFLL VLLYYYNFTN FLKNYMRFSA FFVLGTMGGS 120 121 IFLSIIQHFS IPIDSITCFL LLFNFTVVGV LSVFSGGIPI FLRQAYMVCL GIIVAAWFTK 180 181 LPEWTTWVLL VALAVYDLVA VLAPGGPLKL LVELASSRDE ELPALVYEAR PTVPRNTQRR 240 241 GSGLELLVAG VSDSGSVELQ AVTRDNVNRN ENESRGNSEY SAVEFGSFGS EGHESNRDEG 300 301 ERLLSEENAR DRQSLSSDSL GYSTVIVQSD RATQFSSGAS EIINEEMSPL VEMTGLGNER 360 361 EQLRRDGSEM FSKGIKLGLG DFVFYSVLVG RAAMYDLMTV YACYLAIISG LGCTLILLSV 420 421 CHRALPALPI SITLGVVFYF LTRLLMEPFV VGTATNLVMF 460 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGTCGA GCATCCTAGA GTCGATCGGC GTTGAGATTA TCGGCGTCAT GTCGCCGGTC 60 61 TCCATCTGCA TGCTCCTCGT AGTTCTCTTA GTCTACGCTC TCTCTCCTTC CAACCCCTTT 120 121 TCCGCCGCCG CCTCCGCTCC CCCGATCCGC ACCGCCGCCA ACCTCGTCTA CCTCGAGAGC 180 181 CCCTCTGACT CCGCCTCCCA AAAGCTCGAA GGCGCTCTCC TCAACGCCTT GGTCTTCGTC 240 241 GTCCTCATCG CCATCGTCAC CTTCCTCCTC GTCCTTCTCT ACTACTACAA TTTCACCAAC 300 301 TTCTTGAAGA ACTACATGCG CTTCTCTGCC TTCTTCGTCC TCGGCACCAT GGGAGGTTCG 360 361 ATTTTCTTGT CCATAATCCA GCATTTCTCG ATACCCATTG ACTCCATCAC TTGCTTTTTG 420 421 CTGCTTTTCA ATTTCACTGT TGTGGGAGTG TTGTCTGTGT TCTCTGGTGG GATACCCATT 480 481 TTTCTACGCC AAGCTTATAT GGTTTGTTTG GGGATTATTG TGGCGGCTTG GTTTACCAAG 540 541 TTGCCCGAAT GGACAACTTG GGTTTTGCTT GTGGCTCTGG CTGTGTATGA TTTGGTGGCT 600 601 GTGCTGGCAC CCGGTGGGCC GCTTAAGCTG TTGGTGGAGT TGGCCTCTAG CCGGGATGAG 660 661 GAGCTCCCCG CTTTGGTTTA CGAGGCTCGC CCCACTGTGC CACGAAATAC TCAGCGTCGT 720 721 GGGTCCGGAT TAGAACTTTT GGTTGCTGGG GTTTCGGATT CAGGGTCAGT TGAGCTTCAG 780 781 GCAGTCACAA GGGACAATGT GAATCGAAAT GAGAATGAAA GTCGTGGTAA TTCAGAGTAC 840 841 AGTGCGGTTG AGTTTGGAAG TTTCGGGAGT GAGGGACATG AGAGTAATAG AGATGAAGGG 900 901 GAGAGGTTAC TATCAGAGGA GAATGCACGG GATAGGCAGT CGTTAAGCAG TGATTCTTTG 960 961 GGATATTCAA CTGTGATTGT TCAGTCTGAT AGAGCTACGC AATTTAGCAG TGGAGCATCT 1020 1021 GAGATTATTA ATGAGGAAAT GTCCCCTCTT GTTGAAATGA CAGGACTGGG AAATGAGAGA 1080 1081 GAGCAGTTGA GGAGGGATGG TAGCGAAATG TTCAGTAAAG GTATTAAACT TGGTCTTGGG 1140 1141 GATTTCGTGT TCTACAGTGT TCTTGTGGGC AGAGCTGCAA TGTATGACCT TATGACTGTG 1200 1201 TATGCCTGTT ATCTTGCCAT TATTTCCGGA CTTGGGTGCA CTCTTATTTT GTTGTCAGTG 1260 1261 TGCCATCGAG CTTTGCCTGC TCTGCCTATA TCGATTACAT TGGGTGTCGT TTTTTACTTC 1320 1321 TTGACTCGGT TATTAATGGA GCCTTTTGTT GTTGGGACAG CTACAAATTT AGTGATGTTC 1380 1381 TGA 1383 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Aspartic-type endopeptidase activity | |
Biological Process | Notch signaling pathway | |
Biological Process | Protein processing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tru-1880 | Triticum urartu | 90.91 | 8e-45 | 167 |
| LLPS-Brd-1691 | Brachypodium distachyon | 90.43 | 7e-46 | 171 |
| LLPS-Sol-2327 | Solanum lycopersicum | 88.0 | 2e-18 | 90.9 |
| LLPS-Gor-2618 | Gossypium raimondii | 77.39 | 0.0 | 577 |
| LLPS-Coc-1807 | Corchorus capsularis | 76.89 | 0.0 | 587 |
| LLPS-Thc-1713 | Theobroma cacao | 75.43 | 0.0 | 566 |
| LLPS-Viv-1899 | Vitis vinifera | 74.41 | 0.0 | 567 |
| LLPS-Mae-0556 | Manihot esculenta | 72.84 | 0.0 | 564 |
| LLPS-Pot-1757 | Populus trichocarpa | 72.57 | 0.0 | 562 |
| LLPS-Phv-2258 | Phaseolus vulgaris | 66.24 | 1e-174 | 504 |
| LLPS-Dac-1535 | Daucus carota | 65.38 | 1e-171 | 496 |
| LLPS-Hea-0901 | Helianthus annuus | 65.24 | 4e-167 | 485 |
| LLPS-Via-2394 | Vigna angularis | 65.16 | 1e-173 | 501 |
| LLPS-Brn-0480 | Brassica napus | 64.46 | 9e-168 | 486 |
| LLPS-Vir-2043 | Vigna radiata | 64.25 | 1e-158 | 462 |
| LLPS-Art-2993 | Arabidopsis thaliana | 63.6 | 4e-179 | 516 |
| LLPS-Arl-0226 | Arabidopsis lyrata | 63.37 | 5e-177 | 511 |
| LLPS-Brr-2369 | Brassica rapa | 63.19 | 6e-169 | 489 |
| LLPS-Met-2504 | Medicago truncatula | 63.01 | 5e-169 | 489 |
| LLPS-Nia-1020 | Nicotiana attenuata | 61.85 | 3e-164 | 479 |
| LLPS-Sot-0293 | Solanum tuberosum | 61.8 | 8e-165 | 479 |
| LLPS-Amt-1824 | Amborella trichopoda | 59.68 | 5e-172 | 498 |
| LLPS-Dio-2002 | Dipodomys ordii | 59.26 | 6e-15 | 80.9 |
| LLPS-Xet-1426 | Xenopus tropicalis | 59.26 | 5e-15 | 81.3 |
| LLPS-Nol-2271 | Nomascus leucogenys | 58.7 | 3e-06 | 53.5 |
| LLPS-Scm-1073 | Scophthalmus maximus | 57.69 | 3e-11 | 69.3 |
| LLPS-Sob-0943 | Sorghum bicolor | 56.51 | 2e-130 | 393 |
| LLPS-Ran-2773 | Rattus norvegicus | 56.47 | 3e-14 | 78.6 |
| LLPS-Mup-0978 | Mustela putorius furo | 56.32 | 4e-15 | 81.3 |
| LLPS-Aim-4141 | Ailuropoda melanoleuca | 56.32 | 5e-15 | 81.3 |
| LLPS-Ova-3993 | Ovis aries | 56.32 | 7e-15 | 80.9 |
| LLPS-Paa-0012 | Papio anubis | 56.32 | 6e-15 | 80.9 |
| LLPS-Mal-1415 | Mandrillus leucophaeus | 56.32 | 6e-15 | 80.9 |
| LLPS-Bot-4517 | Bos taurus | 56.32 | 6e-15 | 80.9 |
| LLPS-Gog-3717 | Gorilla gorilla | 56.32 | 6e-15 | 80.9 |
| LLPS-Caj-3286 | Callithrix jacchus | 56.32 | 6e-15 | 80.9 |
| LLPS-Chs-2964 | Chlorocebus sabaeus | 56.32 | 5e-15 | 81.3 |
| LLPS-Maf-0682 | Macaca fascicularis | 56.32 | 6e-15 | 80.9 |
| LLPS-Mum-4859 | Mus musculus | 56.32 | 4e-15 | 81.6 |
| LLPS-Cea-4034 | Cercocebus atys | 56.32 | 6e-15 | 80.9 |
| LLPS-Sah-2117 | Sarcophilus harrisii | 56.32 | 4e-15 | 81.6 |
| LLPS-Aon-3673 | Aotus nancymaae | 56.32 | 6e-15 | 80.9 |
| LLPS-Sus-3914 | Sus scrofa | 56.32 | 6e-15 | 81.3 |
| LLPS-Gaga-3281 | Gallus gallus | 56.32 | 2e-15 | 82.8 |
| LLPS-Cas-0771 | Carlito syrichta | 56.32 | 5e-15 | 81.3 |
| LLPS-Tag-0659 | Taeniopygia guttata | 56.32 | 2e-15 | 82.4 |
| LLPS-Ict-4240 | Ictidomys tridecemlineatus | 56.32 | 4e-15 | 81.3 |
| LLPS-Cap-1399 | Cavia porcellus | 56.32 | 6e-15 | 80.9 |
| LLPS-Poa-1921 | Pongo abelii | 56.32 | 5e-15 | 81.3 |
| LLPS-Caf-3645 | Canis familiaris | 56.32 | 5e-15 | 81.3 |
| LLPS-Mam-2078 | Macaca mulatta | 56.32 | 6e-15 | 80.9 |
| LLPS-Rhb-0845 | Rhinopithecus bieti | 56.32 | 7e-15 | 80.9 |
| LLPS-Fia-0507 | Ficedula albicollis | 56.32 | 3e-15 | 82.0 |
| LLPS-Orc-1096 | Oryctolagus cuniculus | 56.32 | 6e-15 | 81.3 |
| LLPS-Mod-2422 | Monodelphis domestica | 56.32 | 4e-15 | 81.3 |
| LLPS-Pat-2264 | Pan troglodytes | 56.32 | 9e-15 | 80.5 |
| LLPS-Pap-3651 | Pan paniscus | 56.32 | 9e-15 | 80.5 |
| LLPS-Dar-3285 | Danio rerio | 56.32 | 2e-14 | 79.3 |
| LLPS-Hos-2647 | Homo sapiens | 56.32 | 6e-15 | 80.9 |
| LLPS-Meg-1688 | Meleagris gallopavo | 56.32 | 2e-15 | 82.0 |
| LLPS-Anp-1862 | Anas platyrhynchos | 56.32 | 2e-15 | 82.4 |
| LLPS-Man-4688 | Macaca nemestrina | 56.32 | 6e-15 | 80.9 |
| LLPS-Zem-0185 | Zea mays | 55.51 | 2e-129 | 390 |
| LLPS-Xim-0809 | Xiphophorus maculatus | 55.29 | 6e-14 | 77.4 |
| LLPS-Myl-3423 | Myotis lucifugus | 55.17 | 2e-14 | 79.3 |
| LLPS-Tar-3362 | Takifugu rubripes | 55.17 | 7e-15 | 80.5 |
| LLPS-Fud-2182 | Fukomys damarensis | 55.17 | 2e-14 | 79.3 |
| LLPS-Fec-0910 | Felis catus | 54.26 | 3e-15 | 82.0 |
| LLPS-Orni-1970 | Oryza nivara | 53.36 | 1e-116 | 356 |
| LLPS-Orr-1673 | Oryza rufipogon | 53.36 | 2e-116 | 355 |
| LLPS-Orgl-1676 | Oryza glumaepatula | 53.13 | 2e-116 | 355 |
| LLPS-Lep-0962 | Leersia perrieri | 53.04 | 2e-124 | 377 |
| LLPS-Ors-0876 | Oryza sativa | 52.9 | 2e-116 | 355 |
| LLPS-Anc-4027 | Anolis carolinensis | 52.48 | 8e-16 | 83.6 |
| LLPS-Orp-2362 | Oryza punctata | 52.41 | 8e-118 | 359 |
| LLPS-Hov-0889 | Hordeum vulgare | 52.37 | 9e-96 | 299 |
| LLPS-Orm-1243 | Oryza meridionalis | 52.28 | 6e-128 | 387 |
| LLPS-Tra-1419 | Triticum aestivum | 52.02 | 1e-123 | 374 |
| LLPS-Ori-1544 | Oryza indica | 51.96 | 2e-125 | 380 |
| LLPS-Orbr-1011 | Oryza brachyantha | 51.82 | 4e-119 | 365 |
| LLPS-Org-0827 | Oryza glaberrima | 51.75 | 3e-125 | 379 |
| LLPS-Orb-2200 | Oryza barthii | 51.05 | 8e-98 | 306 |
| LLPS-Ten-1255 | Tetraodon nigroviridis | 50.96 | 9e-14 | 77.4 |
| LLPS-Asm-2522 | Astyanax mexicanus | 50.0 | 3e-14 | 78.6 |
| LLPS-Orn-2186 | Oreochromis niloticus | 49.02 | 7e-14 | 77.8 |
| LLPS-Glm-2366 | Glycine max | 46.97 | 3e-105 | 327 |
| LLPS-Cus-0346 | Cucumis sativus | 46.82 | 1e-106 | 330 |
| LLPS-Sem-1837 | Selaginella moellendorffii | 45.63 | 1e-93 | 295 |
| LLPS-Bro-2033 | Brassica oleracea | 43.44 | 9e-90 | 285 |
| LLPS-Osl-1471 | Ostreococcus lucimarinus | 42.15 | 7e-41 | 155 |
| LLPS-Gaa-3184 | Gasterosteus aculeatus | 41.67 | 5e-13 | 74.7 |
| LLPS-Sei-1031 | Setaria italica | 41.52 | 2e-75 | 250 |
| LLPS-Pof-0272 | Poecilia formosa | 39.87 | 2e-15 | 82.4 |
| LLPS-Loa-0392 | Loxodonta africana | 39.64 | 1e-16 | 85.9 |
| LLPS-Icp-3597 | Ictalurus punctatus | 39.63 | 8e-16 | 83.6 |
| LLPS-Scf-1984 | Scleropages formosus | 39.26 | 1e-15 | 82.8 |
| LLPS-Mea-3808 | Mesocricetus auratus | 36.75 | 1e-14 | 79.7 |
| LLPS-Chc-0955 | Chondrus crispus | 35.91 | 1e-23 | 107 |
| LLPS-Ere-0423 | Erinaceus europaeus | 34.88 | 8e-31 | 125 |
| LLPS-Ora-2366 | Ornithorhynchus anatinus | 34.14 | 1e-23 | 105 |
| LLPS-Eqc-3247 | Equus caballus | 33.33 | 1e-20 | 98.6 |
| LLPS-Lac-3488 | Latimeria chalumnae | 32.88 | 5e-19 | 93.6 |
| LLPS-Drm-1443 | Drosophila melanogaster | 31.66 | 1e-40 | 157 |
| LLPS-Pes-3073 | Pelodiscus sinensis | 31.17 | 7e-39 | 151 |
| LLPS-Cae-0700 | Caenorhabditis elegans | 31.03 | 3e-10 | 65.9 |
| LLPS-Abg-1272 | Absidia glauca | 30.95 | 7e-30 | 125 |