LLPS-Hos-0555
VBP1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Prefoldin subunit 3; HIBBJ46; von Hippel-Lindau-binding protein 1; VBP-1; VHL-binding protein 1 |
| Gene Name: | VBP1, PFDN3 |
| Ensembl Gene: | ENSG00000155959.10 |
| Ensembl Protein: | ENSP00000438694.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs." | Neural progenitor cells | 29373831 |
| Stress granule | "...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis." | Neural progenitor cells | 29373831 |
▼ FUNCTION
| Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000535916.5 | ENSP00000438694.1 |
| Ensembl | ENST00000625964.2 | ENSP00000486053.1 |
| Ensembl | ENST00000286428.5 | ENSP00000286428.5 |
| UniProt | P61758, PFD3_HUMAN, B2R8L5, B4DWR3, F5H2A7, O55228, Q15765, Q5JT81, Q86X96 | |
| GeneBank | BT019604, AK301646, BX682237, BC046094, U56833, AL356738, AK313420, U96759, Y17394 | CAI41469.1, BAG63125.1, AAV38411.1, CAA76761.1, BAG36212.1, AAC50617.1, AAH46094.1, AAC23907.1 |
| RefSeq | NM_001303543.1, NM_001303545.1, NM_003372.6 | NP_001290472.1, NP_001290474.1, NP_003363.1 |
| Entrez | 7411 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL KKLDEQYQKY 60 61 KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS METRFLLADN LYCKASVPPT 120 121 DKVCLWLGAN VMLEYDIDEA QALLEKNLST ATKNLDSLEE DLDFLRDQFT TTEVNMARVY 180 181 NWDVKRRNKD DSTKNKA 197 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCCG TTAAGGACAG TTGTGGCAAA GGAGAAATGG CCACAGGGAA TGGGCGGCGG 60 61 CTCCACCTGG GGATTCCTGA GGCCGTGTTT GTGGAAGATG TAGATTCCTT CATGAAACAG 120 121 CCTGGGAATG AGACTGCAGA TACAGTATTA AAGAAGCTGG ATGAACAGTA CCAGAAGTAT 180 181 AAGTTTATGG AACTCAACCT TGCTCAAAAG AAAAGAAGGC TAAAAGGTCA GATTCCTGAA 240 241 ATTAAACAGA CTTTGGAAAT TCTAAAATAC ATGCAGAAGA AAAAAGAGTC CACCAACTCA 300 301 ATGGAGACCA GATTCTTGCT GGCAGATAAC CTGTATTGCA AAGCTTCAGT TCCTCCTACC 360 361 GATAAAGTGT GTCTGTGGTT GGGGGCTAAT GTAATGCTTG AATATGATAT TGATGAAGCT 420 421 CAGGCATTGT TGGAAAAGAA TTTATCGACT GCCACAAAGA ATCTTGATTC CCTGGAGGAA 480 481 GACCTTGACT TTCTTCGAGA TCAATTTACT ACCACAGAAG TCAATATGGC CAGGGTTTAT 540 541 AATTGGGATG TAAAAAGAAG AAACAAGGAT GACTCTACCA AGAACAAAGC ATAA 594 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Intracellular membrane-bounded organelle | |
Cellular Component | Nucleus | |
Cellular Component | Polysome | |
Cellular Component | Prefoldin complex | |
Molecular Function | Tubulin binding | |
Biological Process | Microtubule-based process | |
Biological Process | Protein folding | |
Biological Process | Tubulin complex assembly |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CORUM | CellMarker | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nol-2834 | Nomascus leucogenys | 100.0 | 3e-144 | 407 |
| LLPS-Poa-3596 | Pongo abelii | 100.0 | 3e-144 | 407 |
| LLPS-Pat-3142 | Pan troglodytes | 100.0 | 3e-144 | 407 |
| LLPS-Pap-1643 | Pan paniscus | 100.0 | 3e-144 | 407 |
| LLPS-Gog-1861 | Gorilla gorilla | 100.0 | 3e-144 | 407 |
| LLPS-Mam-4616 | Macaca mulatta | 99.49 | 8e-144 | 406 |
| LLPS-Man-3236 | Macaca nemestrina | 99.49 | 8e-144 | 406 |
| LLPS-Paa-4142 | Papio anubis | 99.49 | 4e-143 | 406 |
| LLPS-Mal-1787 | Mandrillus leucophaeus | 99.49 | 8e-144 | 406 |
| LLPS-Maf-1328 | Macaca fascicularis | 99.49 | 8e-144 | 406 |
| LLPS-Cea-2219 | Cercocebus atys | 99.49 | 3e-143 | 406 |
| LLPS-Urm-1628 | Ursus maritimus | 98.75 | 6e-112 | 323 |
| LLPS-Caj-3724 | Callithrix jacchus | 97.97 | 4e-141 | 399 |
| LLPS-Chs-1240 | Chlorocebus sabaeus | 97.49 | 2e-140 | 399 |
| LLPS-Eqc-0808 | Equus caballus | 97.46 | 1e-140 | 398 |
| LLPS-Mum-4073 | Mus musculus | 96.95 | 3e-137 | 389 |
| LLPS-Caf-3695 | Canis familiaris | 96.45 | 6e-139 | 393 |
| LLPS-Otg-0664 | Otolemur garnettii | 96.39 | 3e-115 | 333 |
| LLPS-Loa-3569 | Loxodonta africana | 95.96 | 2e-137 | 390 |
| LLPS-Cap-2047 | Cavia porcellus | 95.94 | 9e-138 | 390 |
| LLPS-Fec-2707 | Felis catus | 95.94 | 1e-138 | 392 |
| LLPS-Mup-2383 | Mustela putorius furo | 95.94 | 2e-138 | 392 |
| LLPS-Tut-1608 | Tursiops truncatus | 95.94 | 4e-137 | 389 |
| LLPS-Sus-1203 | Sus scrofa | 95.94 | 1e-137 | 392 |
| LLPS-Cas-1705 | Carlito syrichta | 95.43 | 5e-137 | 389 |
| LLPS-Ict-3866 | Ictidomys tridecemlineatus | 95.43 | 2e-135 | 384 |
| LLPS-Ova-1562 | Ovis aries | 95.43 | 5e-137 | 389 |
| LLPS-Bot-3970 | Bos taurus | 95.43 | 5e-137 | 389 |
| LLPS-Gaga-3288 | Gallus gallus | 95.0 | 3e-108 | 314 |
| LLPS-Mea-1808 | Mesocricetus auratus | 94.92 | 2e-136 | 387 |
| LLPS-Meg-1915 | Meleagris gallopavo | 94.64 | 1e-113 | 328 |
| LLPS-Pes-3587 | Pelodiscus sinensis | 94.58 | 4e-112 | 324 |
| LLPS-Aon-4066 | Aotus nancymaae | 94.25 | 4e-116 | 335 |
| LLPS-Aim-2086 | Ailuropoda melanoleuca | 93.94 | 1e-132 | 377 |
| LLPS-Orc-3626 | Oryctolagus cuniculus | 93.91 | 4e-133 | 380 |
| LLPS-Ora-3123 | Ornithorhynchus anatinus | 93.1 | 4e-95 | 280 |
| LLPS-Fud-0979 | Fukomys damarensis | 92.89 | 3e-133 | 379 |
| LLPS-Myl-2125 | Myotis lucifugus | 92.46 | 2e-132 | 377 |
| LLPS-Fia-2828 | Ficedula albicollis | 92.18 | 6e-117 | 339 |
| LLPS-Tag-2291 | Taeniopygia guttata | 91.62 | 7e-117 | 337 |
| LLPS-Anc-3584 | Anolis carolinensis | 90.53 | 5e-124 | 355 |
| LLPS-Lac-1705 | Latimeria chalumnae | 87.36 | 1e-113 | 330 |
| LLPS-Anp-0765 | Anas platyrhynchos | 86.32 | 1e-112 | 327 |
| LLPS-Dio-3278 | Dipodomys ordii | 84.26 | 7e-115 | 332 |
| LLPS-Xet-2986 | Xenopus tropicalis | 83.25 | 3e-117 | 338 |
| LLPS-Rhb-1684 | Rhinopithecus bieti | 82.93 | 3e-87 | 261 |
| LLPS-Leo-1983 | Lepisosteus oculatus | 81.03 | 8e-114 | 330 |
| LLPS-Sah-0547 | Sarcophilus harrisii | 80.93 | 2e-114 | 332 |
| LLPS-Dar-3929 | Danio rerio | 80.54 | 6e-109 | 317 |
| LLPS-Icp-2754 | Ictalurus punctatus | 79.67 | 4e-107 | 312 |
| LLPS-Orn-0484 | Oreochromis niloticus | 79.49 | 4e-112 | 325 |
| LLPS-Ran-1786 | Rattus norvegicus | 77.35 | 2e-100 | 295 |
| LLPS-Gaa-2723 | Gasterosteus aculeatus | 77.32 | 2e-107 | 313 |
| LLPS-Orl-4003 | Oryzias latipes | 76.41 | 8e-107 | 312 |
| LLPS-Scf-2814 | Scleropages formosus | 76.29 | 1e-107 | 313 |
| LLPS-Asm-4015 | Astyanax mexicanus | 76.14 | 3e-95 | 283 |
| LLPS-Pof-2098 | Poecilia formosa | 75.0 | 3e-104 | 305 |
| LLPS-Tar-3876 | Takifugu rubripes | 65.64 | 8e-89 | 266 |
| LLPS-Abg-1477 | Absidia glauca | 62.5 | 3e-14 | 69.3 |
| LLPS-Ten-3499 | Tetraodon nigroviridis | 60.51 | 6e-78 | 238 |
| LLPS-Cii-2299 | Ciona intestinalis | 56.9 | 2e-68 | 214 |
| LLPS-Spr-1570 | Sporisorium reilianum | 52.8 | 6e-52 | 172 |
| LLPS-Drm-1995 | Drosophila melanogaster | 51.87 | 6e-64 | 202 |
| LLPS-Usm-0924 | Ustilago maydis | 51.85 | 1e-49 | 174 |
| LLPS-Asni-0269 | Aspergillus niger | 50.74 | 5e-40 | 140 |
| LLPS-Amt-1737 | Amborella trichopoda | 50.0 | 3e-50 | 167 |
| LLPS-Vir-1351 | Vigna radiata | 48.67 | 3e-33 | 123 |
| LLPS-Ved-1479 | Verticillium dahliae | 48.5 | 8e-48 | 161 |
| LLPS-Org-2046 | Oryza glaberrima | 47.45 | 1e-38 | 136 |
| LLPS-Sem-0857 | Selaginella moellendorffii | 47.4 | 9e-41 | 143 |
| LLPS-Orb-0811 | Oryza barthii | 47.06 | 1e-37 | 134 |
| LLPS-Met-0886 | Medicago truncatula | 46.95 | 5e-47 | 159 |
| LLPS-Lep-0908 | Leersia perrieri | 46.95 | 7e-47 | 159 |
| LLPS-Ori-0913 | Oryza indica | 46.92 | 4e-35 | 126 |
| LLPS-Coo-1605 | Colletotrichum orbiculare | 46.67 | 3e-49 | 165 |
| LLPS-Nec-0645 | Neurospora crassa | 46.58 | 2e-46 | 160 |
| LLPS-Php-0576 | Physcomitrella patens | 46.56 | 5e-49 | 164 |
| LLPS-Gag-0855 | Gaeumannomyces graminis | 46.55 | 1e-47 | 161 |
| LLPS-Miv-0992 | Microbotryum violaceum | 46.39 | 1e-42 | 152 |
| LLPS-Prp-1329 | Prunus persica | 46.34 | 3e-47 | 160 |
| LLPS-Cog-0986 | Colletotrichum gloeosporioides | 46.24 | 1e-48 | 164 |
| LLPS-Orr-1408 | Oryza rufipogon | 46.2 | 9e-48 | 161 |
| LLPS-Sob-2237 | Sorghum bicolor | 46.2 | 1e-48 | 163 |
| LLPS-Ors-2366 | Oryza sativa | 46.2 | 9e-48 | 161 |
| LLPS-Orp-0301 | Oryza punctata | 46.2 | 9e-48 | 161 |
| LLPS-Orni-2227 | Oryza nivara | 46.2 | 9e-48 | 161 |
| LLPS-Cogr-0992 | Colletotrichum graminicola | 45.95 | 1e-48 | 164 |
| LLPS-Orbr-1007 | Oryza brachyantha | 45.88 | 1e-47 | 160 |
| LLPS-Cus-2068 | Cucumis sativus | 45.78 | 6e-44 | 151 |
| LLPS-Pyt-1157 | Pyrenophora teres | 45.76 | 5e-49 | 164 |
| LLPS-Phv-0905 | Phaseolus vulgaris | 45.73 | 2e-45 | 155 |
| LLPS-Mae-0299 | Manihot esculenta | 45.73 | 5e-46 | 156 |
| LLPS-Via-0512 | Vigna angularis | 45.73 | 7e-46 | 156 |
| LLPS-Mua-2169 | Musa acuminata | 45.66 | 4e-49 | 164 |
| LLPS-Scc-1473 | Schizosaccharomyces cryophilus | 45.66 | 4e-38 | 135 |
| LLPS-Asn-0121 | Aspergillus nidulans | 45.61 | 6e-45 | 154 |
| LLPS-Hea-0170 | Helianthus annuus | 45.61 | 1e-45 | 155 |
| LLPS-Map-1409 | Magnaporthe poae | 45.56 | 8e-48 | 162 |
| LLPS-Phn-1075 | Phaeosphaeria nodorum | 45.51 | 5e-46 | 157 |
| LLPS-Nia-1893 | Nicotiana attenuata | 45.51 | 1e-45 | 155 |
| LLPS-Beb-1276 | Beauveria bassiana | 45.3 | 2e-47 | 160 |
| LLPS-Aso-0699 | Aspergillus oryzae | 45.29 | 3e-42 | 147 |
| LLPS-Pytr-1493 | Pyrenophora triticirepentis | 45.26 | 2e-49 | 165 |
| LLPS-Fus-0565 | Fusarium solani | 45.16 | 2e-44 | 152 |
| LLPS-Thc-2491 | Theobroma cacao | 45.12 | 2e-45 | 155 |
| LLPS-Trv-0702 | Trichoderma virens | 45.05 | 6e-48 | 162 |
| LLPS-Orgl-2052 | Oryza glumaepatula | 44.81 | 2e-39 | 139 |
| LLPS-Zem-1881 | Zea mays | 44.75 | 9e-49 | 163 |
| LLPS-Sei-1912 | Setaria italica | 44.75 | 6e-49 | 164 |
| LLPS-Kop-0010 | Komagataella pastoris | 44.71 | 3e-37 | 134 |
| LLPS-Dos-0857 | Dothistroma septosporum | 44.67 | 7e-46 | 156 |
| LLPS-Gor-2541 | Gossypium raimondii | 44.51 | 1e-44 | 153 |
| LLPS-Viv-1946 | Vitis vinifera | 44.51 | 5e-45 | 154 |
| LLPS-Hov-0114 | Hordeum vulgare | 44.51 | 9e-46 | 156 |
| LLPS-Nef-1475 | Neosartorya fischeri | 44.44 | 1e-44 | 153 |
| LLPS-Zyt-1479 | Zymoseptoria tritici | 44.31 | 2e-41 | 144 |
| LLPS-Brd-0484 | Brachypodium distachyon | 44.19 | 5e-45 | 154 |
| LLPS-Yal-1149 | Yarrowia lipolytica | 44.17 | 2e-39 | 139 |
| LLPS-Ast-0256 | Aspergillus terreus | 44.12 | 5e-42 | 146 |
| LLPS-Tra-1573 | Triticum aestivum | 44.12 | 1e-45 | 156 |
| LLPS-Fuo-1015 | Fusarium oxysporum | 44.02 | 3e-45 | 155 |
| LLPS-Trr-0547 | Trichoderma reesei | 44.02 | 4e-48 | 162 |
| LLPS-Put-1327 | Puccinia triticina | 43.98 | 4e-43 | 149 |
| LLPS-Sol-1091 | Solanum lycopersicum | 43.94 | 2e-33 | 122 |
| LLPS-Pug-0444 | Puccinia graminis | 43.9 | 8e-44 | 151 |
| LLPS-Art-2479 | Arabidopsis thaliana | 43.9 | 2e-44 | 152 |
| LLPS-Coc-0266 | Corchorus capsularis | 43.85 | 5e-46 | 157 |
| LLPS-Fuv-1435 | Fusarium verticillioides | 43.85 | 5e-46 | 157 |
| LLPS-Mao-1533 | Magnaporthe oryzae | 43.81 | 7e-50 | 167 |
| LLPS-Mel-0111 | Melampsora laricipopulina | 43.75 | 2e-43 | 150 |
| LLPS-Asg-1536 | Ashbya gossypii | 43.71 | 1e-36 | 132 |
| LLPS-Orm-0296 | Oryza meridionalis | 43.65 | 4e-44 | 152 |
| LLPS-Asc-1694 | Aspergillus clavatus | 43.65 | 1e-44 | 153 |
| LLPS-Arl-0722 | Arabidopsis lyrata | 43.29 | 3e-44 | 152 |
| LLPS-Blg-0858 | Blumeria graminis | 43.24 | 1e-43 | 150 |
| LLPS-Pot-2704 | Populus trichocarpa | 43.23 | 7e-46 | 156 |
| LLPS-Glm-1736 | Glycine max | 43.1 | 1e-45 | 155 |
| LLPS-Sac-1216 | Saccharomyces cerevisiae | 42.77 | 2e-34 | 126 |
| LLPS-Sot-1061 | Solanum tuberosum | 42.77 | 3e-45 | 155 |
| LLPS-Asfu-0489 | Aspergillus fumigatus | 42.38 | 1e-34 | 127 |
| LLPS-Scp-1429 | Schizosaccharomyces pombe | 42.37 | 2e-35 | 128 |
| LLPS-Brr-0133 | Brassica rapa | 42.07 | 3e-43 | 149 |
| LLPS-Brn-2960 | Brassica napus | 41.76 | 9e-44 | 151 |
| LLPS-Asf-0688 | Aspergillus flavus | 41.72 | 1e-30 | 119 |
| LLPS-Scj-1452 | Schizosaccharomyces japonicus | 41.71 | 7e-34 | 124 |
| LLPS-Tru-1909 | Triticum urartu | 41.67 | 2e-42 | 148 |
| LLPS-Bro-2664 | Brassica oleracea | 41.46 | 3e-42 | 147 |
| LLPS-Chc-0105 | Chondrus crispus | 40.7 | 9e-39 | 138 |
| LLPS-Cae-0436 | Caenorhabditis elegans | 40.34 | 9e-40 | 140 |
| LLPS-Crn-0936 | Cryptococcus neoformans | 40.0 | 3e-40 | 143 |
| LLPS-Gas-0783 | Galdieria sulphuraria | 39.88 | 3e-37 | 133 |
| LLPS-Chr-0693 | Chlamydomonas reinhardtii | 38.92 | 6e-37 | 133 |
| LLPS-Tum-1438 | Tuber melanosporum | 37.74 | 2e-18 | 82.4 |
| LLPS-Osl-1071 | Ostreococcus lucimarinus | 36.94 | 4e-30 | 114 |
| LLPS-Dac-1820 | Daucus carota | 35.48 | 2e-09 | 56.6 |
| LLPS-Lem-1236 | Leptosphaeria maculans | 34.62 | 3e-18 | 82.4 |
| LLPS-Cym-0780 | Cyanidioschyzon merolae | 33.13 | 3e-21 | 92.4 |