• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sus-2648
METAP2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Methionine aminopeptidase 2
Gene Name: METAP2
Ensembl Gene: ENSSSCG00000030608.2
Ensembl Protein: ENSSSCP00000027134.2
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGVEEAASS  GSHLNGDLDP  DDREEGAAST  AEEAAKKKRR  KKKKTKGAAT  GQQEPEKESG  60
61    GSIDEVTRQL  ETQALDEKER  DDDDEDGDGD  GDGATGKKKK  KKKKKRGPKV  QTDPPSVPIC  120
121   DLYPNGVFPK  GQECEYPPTQ  DGRTAAWRTT  SEEKKALDQA  SEEIWNDFRE  AAEAHRQVRK  180
181   YVMSWIKPGM  TMIEICEKLE  DCSRKLIKEN  GLNAGLAFPT  GCSLNNCAAH  YTPNAGDTTV  240
241   LQYDDICKID  FGTHISGRII  DCAFTVTFNP  KYDTLLKAVK  DATNTGIKCA  GIDVRLCDVG  300
301   EAIQEVMESY  EVEIDGKTYQ  VKPIRNLNGH  SIGPYRIHAG  KTVPIVKGGE  ATRMEEGEVY  360
361   AIETFGSTGK  GIVHDDMECS  HYMKNFDVGH  VPIRLPRTKH  LLNVINENFG  TLAFCRRWLD  420
421   RLGESKYLMA  LKNLCDLGIV  DPYPPLCDIK  GSYTAQFEHT  ILLRPTCKEV  VSRGDDY  477
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGGCG  TGGAGGAGGC  GGCGTCCTCC  GGGAGCCACC  TGAATGGCGA  CCTGGATCCA  60
61    GACGACAGGG  AGGAGGGAGC  TGCTTCTACG  GCTGAGGAGG  CAGCTAAGAA  AAAAAGACGG  120
121   AAGAAGAAGA  AGACTAAAGG  GGCTGCCACA  GGGCAACAGG  AACCTGAAAA  GGAATCAGGA  180
181   GGCTCGATTG  ATGAGGTAAC  AAGACAGTTG  GAAACACAAG  CATTGGACGA  GAAAGAAAGA  240
241   GATGATGACG  ATGAAGATGG  AGATGGTGAT  GGAGATGGAG  CAACTGGAAA  GAAAAAGAAA  300
301   AAGAAGAAGA  AGAAGAGAGG  ACCAAAAGTT  CAAACAGACC  CTCCCTCAGT  TCCAATATGT  360
361   GACCTGTATC  CTAATGGTGT  ATTTCCCAAA  GGACAAGAAT  GCGAGTACCC  ACCCACACAA  420
421   GATGGGCGAA  CAGCTGCTTG  GAGAACTACA  AGTGAAGAAA  AGAAAGCATT  AGATCAAGCA  480
481   AGTGAAGAGA  TTTGGAATGA  TTTTCGAGAA  GCTGCAGAGG  CACATCGACA  GGTTAGAAAA  540
541   TATGTTATGA  GCTGGATCAA  GCCTGGGATG  ACAATGATAG  AAATCTGTGA  AAAGTTGGAA  600
601   GACTGTTCAC  GAAAGCTAAT  AAAAGAGAAT  GGATTAAATG  CAGGCCTGGC  ATTTCCTACT  660
661   GGGTGTTCTC  TAAATAATTG  TGCTGCCCAT  TATACTCCCA  ATGCTGGTGA  CACAACAGTA  720
721   TTGCAATATG  ATGACATCTG  TAAGATAGAC  TTTGGAACAC  ATATAAGTGG  TAGGATTATT  780
781   GACTGTGCTT  TTACTGTCAC  TTTTAATCCC  AAATATGATA  CATTATTAAA  AGCTGTAAAA  840
841   GATGCCACTA  ACACTGGAAT  AAAGTGTGCT  GGAATTGATG  TCCGTCTCTG  TGATGTTGGT  900
901   GAGGCCATCC  AAGAGGTTAT  GGAGTCCTAT  GAAGTTGAAA  TCGATGGGAA  GACATATCAA  960
961   GTGAAACCAA  TCCGTAATCT  AAATGGACAT  TCAATTGGGC  CATATAGAAT  ACATGCTGGG  1020
1021  AAAACAGTGC  CCATTGTGAA  AGGAGGAGAG  GCAACGAGAA  TGGAGGAGGG  AGAAGTATAT  1080
1081  GCCATTGAAA  CCTTTGGTAG  CACAGGCAAA  GGCATTGTTC  ATGATGATAT  GGAATGTTCA  1140
1141  CATTACATGA  AAAATTTTGA  TGTTGGACAT  GTGCCAATAA  GGCTTCCAAG  AACGAAACAC  1200
1201  TTGTTAAATG  TCATCAATGA  AAACTTTGGC  ACCCTTGCCT  TCTGTCGCAG  ATGGCTGGAT  1260
1261  CGCTTGGGAG  AAAGTAAATA  CTTGATGGCT  CTGAAGAATC  TGTGTGACTT  GGGCATTGTA  1320
1321  GATCCATATC  CACCATTATG  TGACATTAAA  GGATCATATA  CAGCACAGTT  TGAACATACC  1380
1381  ATACTTTTGC  GTCCAACATG  TAAAGAAGTT  GTCAGCAGAG  GAGATGACTA  TTAA  1434

▼ KEYWORD

ID
Family
Aminopeptidase
Complete proteome
Cytoplasm
Glycoprotein
Hydrolase
Metal-binding
Protease
Proteomics identification
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Plasma membrane
Molecular Function
Metal ion binding
Molecular Function
Metalloaminopeptidase activity
Biological Process
N-terminal protein amino acid modification
Biological Process
Peptidyl-methionine modification
Biological Process
Protein initiator methionine removal
Biological Process
Protein processing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-4266Mesocricetus auratus100.01e-87 272
LLPS-Nol-1806Nomascus leucogenys99.110.0 704
LLPS-Sah-0877Sarcophilus harrisii98.640.0 765
LLPS-Ora-0965Ornithorhynchus anatinus98.10.0 763
LLPS-Pes-1896Pelodiscus sinensis97.970.0 608
LLPS-Eqc-3814Equus caballus97.910.0 834
LLPS-Urm-2624Ursus maritimus97.90.0 838
LLPS-Ran-1984Rattus norvegicus97.780.0 748
LLPS-Aim-1965Ailuropoda melanoleuca97.70.0 833
LLPS-Mup-2168Mustela putorius furo97.70.0 835
LLPS-Fec-2275Felis catus97.490.0 834
LLPS-Bot-3755Bos taurus97.480.0 837
LLPS-Ova-0459Ovis aries97.280.0 828
LLPS-Dio-0527Dipodomys ordii96.860.0 831
LLPS-Ict-3096Ictidomys tridecemlineatus96.860.0 834
LLPS-Cas-3492Carlito syrichta96.480.0 789
LLPS-Aon-2125Aotus nancymaae96.230.0 825
LLPS-Hos-0267Homo sapiens96.230.0 828
LLPS-Pap-2478Pan paniscus96.230.0 832
LLPS-Pat-0957Pan troglodytes96.230.0 832
LLPS-Myl-1479Myotis lucifugus96.040.0 825
LLPS-Gog-4136Gorilla gorilla96.030.0 827
LLPS-Caj-2622Callithrix jacchus95.820.0 825
LLPS-Caf-3192Canis familiaris95.490.0 825
LLPS-Fud-0843Fukomys damarensis94.970.0 830
LLPS-Xet-3470Xenopus tropicalis94.820.0 747
LLPS-Cap-0800Cavia porcellus94.240.0 822
LLPS-Fia-1306Ficedula albicollis94.00.0 766
LLPS-Mal-0914Mandrillus leucophaeus93.930.0 830
LLPS-Cea-1023Cercocebus atys93.930.0 830
LLPS-Maf-1964Macaca fascicularis93.930.0 830
LLPS-Man-3185Macaca nemestrina93.930.0 830
LLPS-Paa-1906Papio anubis93.720.0 830
LLPS-Poa-0781Pongo abelii93.720.0 826
LLPS-Orc-2119Oryctolagus cuniculus93.320.0 820
LLPS-Tut-0263Tursiops truncatus93.310.0 808
LLPS-Anc-3235Anolis carolinensis92.940.0 772
LLPS-Meg-1216Meleagris gallopavo91.780.0 760
LLPS-Otg-2950Otolemur garnettii91.150.0 712
LLPS-Dar-3061Danio rerio90.810.0 727
LLPS-Orl-2629Oryzias latipes90.790.0 722
LLPS-Icp-1096Ictalurus punctatus89.160.0 716
LLPS-Scf-0970Scleropages formosus89.080.0 743
LLPS-Chs-4138Chlorocebus sabaeus88.910.0 822
LLPS-Loa-2443Loxodonta africana88.770.0 817
LLPS-Mum-3099Mus musculus88.730.0 811
LLPS-Tar-3299Takifugu rubripes88.650.0 711
LLPS-Gaa-0732Gasterosteus aculeatus88.350.0 700
LLPS-Mam-3627Macaca mulatta87.870.0 749
LLPS-Ten-2503Tetraodon nigroviridis87.470.0 701
LLPS-Anp-1036Anas platyrhynchos87.380.0 760
LLPS-Scm-1244Scophthalmus maximus86.510.0 728
LLPS-Tag-2976Taeniopygia guttata86.490.0 769
LLPS-Gaga-1057Gallus gallus86.220.0 766
LLPS-Mod-0935Monodelphis domestica86.040.0 786
LLPS-Leo-2764Lepisosteus oculatus85.890.0 721
LLPS-Orn-2497Oreochromis niloticus85.610.0 721
LLPS-Asm-1574Astyanax mexicanus85.310.0 719
LLPS-Xim-2080Xiphophorus maculatus83.610.0 722
LLPS-Lac-0393Latimeria chalumnae83.220.0 726
LLPS-Rhb-0061Rhinopithecus bieti82.440.0 688
LLPS-Via-1916Vigna angularis81.451e-70 226
LLPS-Cii-2283Ciona intestinalis80.320.0 647
LLPS-Cis-1734Ciona savignyi80.050.0 642
LLPS-Pof-0892Poecilia formosa79.590.0 706
LLPS-Drm-1540Drosophila melanogaster74.590.0 595
LLPS-Sei-0480Setaria italica73.240.0 582
LLPS-Cae-0841Caenorhabditis elegans72.80.0 567
LLPS-Art-0404Arabidopsis thaliana72.750.0 575
LLPS-Brn-2492Brassica napus72.480.0 573
LLPS-Sem-1152Selaginella moellendorffii72.480.0 559
LLPS-Brr-3062Brassica rapa72.480.0 572
LLPS-Arl-1907Arabidopsis lyrata72.210.0 559
LLPS-Hov-0316Hordeum vulgare72.210.0 575
LLPS-Cus-1888Cucumis sativus72.210.0 554
LLPS-Bro-0011Brassica oleracea72.210.0 570
LLPS-Sot-1511Solanum tuberosum72.160.0 563
LLPS-Met-0403Medicago truncatula72.160.0 568
LLPS-Brd-2039Brachypodium distachyon72.160.0 581
LLPS-Dac-1645Daucus carota72.160.0 562
LLPS-Sob-0293Sorghum bicolor72.160.0 576
LLPS-Tra-0129Triticum aestivum71.890.0 578
LLPS-Sol-1543Solanum lycopersicum71.890.0 559
LLPS-Tru-1611Triticum urartu71.890.0 575
LLPS-Gor-0754Gossypium raimondii71.890.0 575
LLPS-Ori-1165Oryza indica71.620.0 575
LLPS-Orr-1416Oryza rufipogon71.620.0 576
LLPS-Org-0576Oryza glaberrima71.620.0 575
LLPS-Orp-0913Oryza punctata71.620.0 575
LLPS-Ors-0164Oryza sativa71.620.0 576
LLPS-Orbr-0781Oryza brachyantha71.620.0 573
LLPS-Hea-0020Helianthus annuus71.510.0 566
LLPS-Pot-1287Populus trichocarpa71.390.0 572
LLPS-Mae-0126Manihot esculenta71.390.0 556
LLPS-Coc-1079Corchorus capsularis71.350.0 560
LLPS-Nia-2348Nicotiana attenuata71.350.0 560
LLPS-Vir-0061Vigna radiata71.120.0 563
LLPS-Viv-1516Vitis vinifera71.120.0 557
LLPS-Lep-2275Leersia perrieri70.810.0 560
LLPS-Orgl-2117Oryza glumaepatula70.540.0 563
LLPS-Orni-0338Oryza nivara70.540.0 563
LLPS-Thc-1568Theobroma cacao70.540.0 551
LLPS-Glm-0306Glycine max70.30.0 563
LLPS-Phv-1458Phaseolus vulgaris70.30.0 562
LLPS-Chr-0401Chlamydomonas reinhardtii70.110.0 549
LLPS-Mua-1192Musa acuminata70.00.0 570
LLPS-Prp-0776Prunus persica69.380.0 559
LLPS-Orb-0524Oryza barthii69.270.0 567
LLPS-Php-1829Physcomitrella patens68.390.0 556
LLPS-Zem-0961Zea mays66.340.0 562
LLPS-Orm-1742Oryza meridionalis66.212e-177 516
LLPS-Gas-0008Galdieria sulphuraria65.494e-178 513
LLPS-Put-0170Puccinia triticina65.439e-107 330
LLPS-Osl-0653Ostreococcus lucimarinus64.952e-167 486
LLPS-Amt-1869Amborella trichopoda64.668e-170 493
LLPS-Scj-0669Schizosaccharomyces japonicus63.516e-176 508
LLPS-Scp-0507Schizosaccharomyces pombe63.242e-178 514
LLPS-Abg-0767Absidia glauca63.177e-175 505
LLPS-Chc-1100Chondrus crispus62.95e-173 501
LLPS-Scc-0617Schizosaccharomyces cryophilus61.892e-171 496
LLPS-Kop-0038Komagataella pastoris61.715e-159 466
LLPS-Fus-0810Fusarium solani61.179e-166 483
LLPS-Lem-1112Leptosphaeria maculans61.074e-162 474
LLPS-Pug-0627Puccinia graminis61.076e-161 471
LLPS-Nef-0018Neosartorya fischeri60.73e-164 479
LLPS-Mao-1254Magnaporthe oryzae60.594e-167 486
LLPS-Ast-0814Aspergillus terreus60.432e-162 474
LLPS-Cogr-0752Colletotrichum graminicola60.377e-160 468
LLPS-Asni-0120Aspergillus niger60.272e-161 471
LLPS-Cym-0742Cyanidioschyzon merolae60.174e-162 474
LLPS-Dos-0711Dothistroma septosporum60.113e-163 477
LLPS-Zyt-0428Zymoseptoria tritici60.052e-164 480
LLPS-Pyt-0677Pyrenophora teres59.896e-159 466
LLPS-Gag-0741Gaeumannomyces graminis59.893e-164 479
LLPS-Pytr-0486Pyrenophora triticirepentis59.894e-159 466
LLPS-Beb-1007Beauveria bassiana59.843e-161 471
LLPS-Nec-0478Neurospora crassa59.792e-160 469
LLPS-Trr-1246Trichoderma reesei59.735e-157 457
LLPS-Trv-0635Trichoderma virens59.571e-161 472
LLPS-Cog-0564Colletotrichum gloeosporioides59.572e-155 456
LLPS-Asn-0391Aspergillus nidulans59.423e-162 474
LLPS-Map-0081Magnaporthe poae59.375e-159 466
LLPS-Fuv-0788Fusarium verticillioides59.319e-162 473
LLPS-Coo-1266Colletotrichum orbiculare59.313e-157 461
LLPS-Fuo-0163Fusarium oxysporum59.319e-162 473
LLPS-Ved-0285Verticillium dahliae59.314e-158 463
LLPS-Asc-0394Aspergillus clavatus59.12e-150 443
LLPS-Asf-0832Aspergillus flavus59.093e-158 464
LLPS-Phn-0291Phaeosphaeria nodorum59.051e-149 441
LLPS-Mel-0742Melampsora laricipopulina58.932e-150 444
LLPS-Asg-0220Ashbya gossypii58.822e-136 404
LLPS-Sac-1569Saccharomyces cerevisiae58.638e-142 421
LLPS-Tum-0089Tuber melanosporum57.912e-154 453
LLPS-Asfu-0160Aspergillus fumigatus57.323e-157 463
LLPS-Miv-1309Microbotryum violaceum56.731e-148 439
LLPS-Yal-0788Yarrowia lipolytica56.651e-156 460
LLPS-Blg-1368Blumeria graminis56.158e-147 434
LLPS-Usm-0536Ustilago maydis55.961e-135 403
LLPS-Spr-0684Sporisorium reilianum55.657e-140 417
LLPS-Crn-0326Cryptococcus neoformans54.831e-138 413
LLPS-Aso-0738Aspergillus oryzae52.122e-132 398