LLPS-Drm-1540
und

▼ OVERVIEW

Status: Unreviewed
Protein Name: Methionine aminopeptidase 2
Gene Name: und, DMAP2, Dmel\CG4008, MAP2, p67, CG4008, Dmel_CG4008
Ensembl Gene: FBgn0283478
Ensembl Protein: FBpp0079462
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSATETLNVE  AATPEIGEEV  KKQKKPKPNN  KKLRQEAAAK  IASGEGGDEE  LTTNGDAKPA  60
61    TPAAQPAKKK  GNKGKKSGQT  DPPTIPIAKL  YPDGNFPEGE  IVEHPTPKDM  PDDRTAKDRF  120
121   TSEEKRALDR  INTDIYQELR  QAAEAHRQTR  QYMQRYIKPG  MTMIQICEEL  ENTARRLIGE  180
181   NGLEAGLAFP  TGCSLNHCAA  HYTPNAGDPT  VLQYDDVCKI  DFGTHIKGRI  IDCAFTLTFN  240
241   NKYDKLLQAV  KEATNTGIRE  AGIDVRLCDI  GAAIQEVMES  YEIELDGKTY  PIKAIRNLNG  300
301   HSISPYRIHA  GKTVPIVKGG  ESTRMEEDEF  YAIETFGSTG  RGLVHDDMDC  SHYMKNFDLP  360
361   FVPLRLQSSK  QLLGTINKNF  GTLAFCKRWL  DRAGATKYQM  ALKDLCDKGI  VEAYPPLCDI  420
421   KGCYTAQYEH  TIMLRPTCKE  VVSRGDDY  448
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGCAA  CCGAGACTCT  GAATGTGGAG  GCGGCAACGC  CCGAGATCGG  CGAGGAGGTC  60
61    AAGAAACAAA  AGAAGCCCAA  GCCGAACAAC  AAGAAGCTCC  GCCAAGAAGC  GGCAGCCAAA  120
121   ATAGCCTCCG  GAGAAGGCGG  CGACGAGGAG  CTGACCACAA  ACGGAGATGC  CAAACCGGCA  180
181   ACACCGGCCG  CTCAGCCGGC  AAAGAAGAAG  GGGAACAAGG  GCAAGAAAAG  CGGTCAGACT  240
241   GATCCGCCCA  CCATACCCAT  TGCTAAGCTT  TATCCGGACG  GCAACTTCCC  CGAGGGCGAG  300
301   ATCGTGGAGC  ACCCCACGCC  CAAGGATATG  CCCGACGATC  GTACGGCCAA  GGACCGATTC  360
361   ACATCGGAGG  AGAAGCGTGC  TCTGGACCGT  ATCAACACGG  ACATCTACCA  GGAATTGCGC  420
421   CAGGCGGCTG  AGGCCCATCG  TCAGACGCGT  CAGTATATGC  AGCGCTACAT  TAAGCCGGGC  480
481   ATGACCATGA  TCCAAATCTG  CGAGGAGCTG  GAGAACACTG  CTCGGCGCCT  GATCGGCGAA  540
541   AATGGTCTGG  AGGCTGGTTT  GGCCTTCCCG  ACTGGTTGCT  CTCTTAACCA  TTGCGCCGCC  600
601   CACTACACGC  CCAATGCCGG  AGACCCCACT  GTACTGCAGT  ACGACGATGT  GTGCAAGATT  660
661   GATTTTGGTA  CCCATATCAA  GGGGCGGATC  ATTGATTGCG  CCTTCACCCT  GACCTTCAAC  720
721   AACAAGTACG  ACAAGTTGCT  GCAGGCCGTC  AAGGAGGCCA  CCAACACGGG  CATCAGAGAG  780
781   GCGGGCATCG  ATGTGCGCCT  ATGCGACATC  GGCGCCGCTA  TCCAGGAGGT  CATGGAGTCG  840
841   TACGAGATCG  AGTTGGACGG  CAAAACATAT  CCCATCAAGG  CGATTCGCAA  CTTAAATGGA  900
901   CACTCCATCA  GCCCGTACCG  CATTCATGCT  GGAAAAACGG  TGCCCATTGT  GAAAGGCGGA  960
961   GAGTCCACTC  GCATGGAGGA  GGATGAATTC  TACGCCATTG  AGACGTTCGG  CTCGACGGGT  1020
1021  CGCGGTCTGG  TCCATGACGA  TATGGACTGC  TCGCATTACA  TGAAGAACTT  TGATCTGCCG  1080
1081  TTTGTGCCGC  TGCGCCTGCA  GTCATCCAAG  CAGCTGCTTG  GCACCATCAA  CAAAAACTTC  1140
1141  GGCACCCTGG  CCTTCTGCAA  GCGTTGGCTG  GACCGCGCCG  GTGCCACGAA  GTACCAGATG  1200
1201  GCTCTCAAGG  ATCTGTGCGA  CAAGGGCATT  GTGGAGGCTT  ATCCGCCGTT  GTGCGACATT  1260
1261  AAGGGCTGCT  ACACGGCTCA  GTACGAACAC  ACAATTATGC  TGCGACCCAC  CTGCAAAGAA  1320
1321  GTCGTTTCCC  GTGGCGACGA  CTAC  1344

▼ KEYWORD

ID
Family
Aminopeptidase
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Protease
Proteomics identification
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Metal ion binding
Molecular Function
Metalloaminopeptidase activity
Biological Process
Protein initiator methionine removal

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Physicochemical
AAindex
Function
PIRSF
Localization
COMPARTMENTS
Element
RAID

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-1896Pelodiscus sinensis81.230.0 516
LLPS-Mam-3627Macaca mulatta76.850.0 561
LLPS-Nol-1806Nomascus leucogenys76.720.0 558
LLPS-Tar-3299Takifugu rubripes75.680.0 603
LLPS-Anc-3235Anolis carolinensis75.140.0 599
LLPS-Sah-0877Sarcophilus harrisii74.860.0 596
LLPS-Xim-2080Xiphophorus maculatus74.860.0 601
LLPS-Scf-0970Scleropages formosus74.860.0 597
LLPS-Xet-3470Xenopus tropicalis74.860.0 600
LLPS-Tag-2976Taeniopygia guttata74.860.0 594
LLPS-Anp-1036Anas platyrhynchos74.660.0 594
LLPS-Mum-3099Mus musculus74.590.0 594
LLPS-Sus-2648Sus scrofa74.590.0 594
LLPS-Aim-1965Ailuropoda melanoleuca74.590.0 594
LLPS-Mup-2168Mustela putorius furo74.590.0 594
LLPS-Ova-0459Ovis aries74.590.0 593
LLPS-Myl-1479Myotis lucifugus74.590.0 595
LLPS-Bot-3755Bos taurus74.590.0 595
LLPS-Orn-0809Oreochromis niloticus74.590.0 597
LLPS-Fia-1306Ficedula albicollis74.590.0 593
LLPS-Orc-2119Oryctolagus cuniculus74.590.0 594
LLPS-Fec-2275Felis catus74.590.0 594
LLPS-Urm-2624Ursus maritimus74.590.0 594
LLPS-Dar-3061Danio rerio74.590.0 598
LLPS-Loa-2443Loxodonta africana74.590.0 595
LLPS-Ict-3096Ictidomys tridecemlineatus74.590.0 596
LLPS-Eqc-3814Equus caballus74.590.0 595
LLPS-Cap-0800Cavia porcellus74.590.0 595
LLPS-Caf-3192Canis familiaris74.590.0 595
LLPS-Gog-4136Gorilla gorilla74.320.0 592
LLPS-Caj-2622Callithrix jacchus74.320.0 592
LLPS-Asm-1574Astyanax mexicanus74.320.0 594
LLPS-Chs-4138Chlorocebus sabaeus74.320.0 592
LLPS-Ora-0965Ornithorhynchus anatinus74.320.0 590
LLPS-Maf-1964Macaca fascicularis74.320.0 592
LLPS-Aon-2125Aotus nancymaae74.320.0 592
LLPS-Cea-1023Cercocebus atys74.320.0 592
LLPS-Orl-2629Oryzias latipes74.320.0 599
LLPS-Mal-0914Mandrillus leucophaeus74.320.0 592
LLPS-Paa-1906Papio anubis74.320.0 592
LLPS-Dio-0527Dipodomys ordii74.320.0 593
LLPS-Mod-0935Monodelphis domestica74.320.0 595
LLPS-Pat-0957Pan troglodytes74.320.0 592
LLPS-Pap-2478Pan paniscus74.320.0 592
LLPS-Hos-0267Homo sapiens74.320.0 593
LLPS-Man-3185Macaca nemestrina74.320.0 592
LLPS-Poa-0781Pongo abelii74.320.0 592
LLPS-Fud-0843Fukomys damarensis74.050.0 592
LLPS-Scm-1244Scophthalmus maximus74.050.0 596
LLPS-Gaga-1057Gallus gallus74.050.0 590
LLPS-Meg-1216Meleagris gallopavo73.850.0 586
LLPS-Cas-3492Carlito syrichta73.510.0 589
LLPS-Icp-1096Ictalurus punctatus73.240.0 587
LLPS-Tut-0263Tursiops truncatus73.240.0 570
LLPS-Ten-2503Tetraodon nigroviridis73.240.0 588
LLPS-Gaa-3805Gasterosteus aculeatus73.050.0 578
LLPS-Ran-1984Rattus norvegicus72.850.0 565
LLPS-Leo-2764Lepisosteus oculatus72.390.0 579
LLPS-Pof-0892Poecilia formosa72.370.0 585
LLPS-Cis-1734Ciona savignyi72.310.0 575
LLPS-Via-1916Vigna angularis71.771e-61 202
LLPS-Cii-2283Ciona intestinalis70.970.0 573
LLPS-Lac-0393Latimeria chalumnae70.390.0 580
LLPS-Brn-2492Brassica napus70.270.0 559
LLPS-Brr-3062Brassica rapa70.00.0 557
LLPS-Bro-1313Brassica oleracea70.00.0 559
LLPS-Dac-1645Daucus carota69.730.0 543
LLPS-Sei-0480Setaria italica69.730.0 560
LLPS-Cae-0841Caenorhabditis elegans69.590.0 547
LLPS-Sem-1152Selaginella moellendorffii69.460.0 538
LLPS-Arl-1907Arabidopsis lyrata69.460.0 536
LLPS-Sot-1511Solanum tuberosum69.190.0 538
LLPS-Art-0404Arabidopsis thaliana69.190.0 552
LLPS-Hea-0020Helianthus annuus69.020.0 552
LLPS-Sol-1543Solanum lycopersicum68.920.0 533
LLPS-Gor-0754Gossypium raimondii68.920.0 549
LLPS-Sob-0293Sorghum bicolor68.650.0 554
LLPS-Otg-2950Otolemur garnettii68.450.0 541
LLPS-Ori-1165Oryza indica68.110.0 552
LLPS-Brd-2039Brachypodium distachyon68.110.0 556
LLPS-Cus-1888Cucumis sativus68.110.0 527
LLPS-Met-0403Medicago truncatula68.110.0 543
LLPS-Orbr-0781Oryza brachyantha68.110.0 552
LLPS-Ors-0164Oryza sativa68.110.0 552
LLPS-Orp-0913Oryza punctata68.110.0 552
LLPS-Org-0576Oryza glaberrima68.110.0 552
LLPS-Orr-1416Oryza rufipogon68.110.0 552
LLPS-Tra-0129Triticum aestivum67.840.0 553
LLPS-Hov-0316Hordeum vulgare67.840.0 551
LLPS-Vir-0061Vigna radiata67.840.0 546
LLPS-Mae-0126Manihot esculenta67.840.0 530
LLPS-Pot-1287Populus trichocarpa67.840.0 549
LLPS-Tru-1611Triticum urartu67.840.0 551
LLPS-Coc-1079Corchorus capsularis67.840.0 530
LLPS-Lep-2275Leersia perrieri67.570.0 538
LLPS-Nia-2348Nicotiana attenuata67.30.0 526
LLPS-Viv-1516Vitis vinifera67.30.0 531
LLPS-Orni-0338Oryza nivara67.030.0 537
LLPS-Orgl-2117Oryza glumaepatula67.030.0 537
LLPS-Thc-1568Theobroma cacao66.760.0 524
LLPS-Mua-1192Musa acuminata66.760.0 546
LLPS-Glm-0306Glycine max66.760.0 540
LLPS-Phv-1458Phaseolus vulgaris66.760.0 540
LLPS-Prp-0776Prunus persica65.950.0 535
LLPS-Put-0170Puccinia triticina65.844e-109 335
LLPS-Orb-0524Oryza barthii65.360.0 543
LLPS-Chr-0401Chlamydomonas reinhardtii65.141e-180 522
LLPS-Gas-0008Galdieria sulphuraria64.323e-173 499
LLPS-Abg-0767Absidia glauca64.158e-170 491
LLPS-Rhb-0061Rhinopithecus bieti64.056e-166 483
LLPS-Chc-1100Chondrus crispus63.445e-174 503
LLPS-Osl-0653Ostreococcus lucimarinus63.072e-164 477
LLPS-Zem-0961Zea mays62.870.0 538
LLPS-Mea-4266Mesocricetus auratus62.72e-49 171
LLPS-Orm-1742Oryza meridionalis62.674e-168 491
LLPS-Php-1829Physcomitrella patens62.140.0 545
LLPS-Nef-0018Neosartorya fischeri61.442e-168 488
LLPS-Scj-0669Schizosaccharomyces japonicus61.083e-165 479
LLPS-Scp-0507Schizosaccharomyces pombe60.811e-164 478
LLPS-Asn-0391Aspergillus nidulans60.692e-165 481
LLPS-Asf-0832Aspergillus flavus60.647e-163 474
LLPS-Asc-0394Aspergillus clavatus60.454e-155 454
LLPS-Kop-0038Komagataella pastoris60.381e-155 456
LLPS-Asni-0120Aspergillus niger60.371e-162 473
LLPS-Lem-1112Leptosphaeria maculans60.371e-161 471
LLPS-Amt-1869Amborella trichopoda60.278e-161 469
LLPS-Cym-0742Cyanidioschyzon merolae60.221e-158 464
LLPS-Dos-0711Dothistroma septosporum60.166e-162 473
LLPS-Ast-0814Aspergillus terreus60.112e-164 478
LLPS-Pyt-0677Pyrenophora teres59.841e-161 471
LLPS-Fus-0810Fusarium solani59.848e-163 474
LLPS-Pytr-0486Pyrenophora triticirepentis59.842e-161 471
LLPS-Mel-0742Melampsora laricipopulina59.523e-153 450
LLPS-Pug-0627Puccinia graminis59.521e-159 466
LLPS-Miv-1309Microbotryum violaceum59.163e-159 465
LLPS-Mao-1254Magnaporthe oryzae59.044e-164 477
LLPS-Fuv-0788Fusarium verticillioides59.048e-162 471
LLPS-Fuo-0163Fusarium oxysporum59.048e-162 471
LLPS-Trr-1246Trichoderma reesei58.972e-155 452
LLPS-Phn-0291Phaeosphaeria nodorum58.947e-151 443
LLPS-Scc-0617Schizosaccharomyces cryophilus58.651e-157 460
LLPS-Gag-0741Gaeumannomyces graminis57.981e-159 466
LLPS-Beb-1007Beauveria bassiana57.946e-159 464
LLPS-Trv-0635Trichoderma virens57.711e-157 461
LLPS-Asfu-0160Aspergillus fumigatus57.541e-160 471
LLPS-Ved-0285Verticillium dahliae57.451e-154 453
LLPS-Yal-0788Yarrowia lipolytica57.328e-156 457
LLPS-Nec-0478Neurospora crassa57.181e-158 463
LLPS-Zyt-0428Zymoseptoria tritici56.995e-157 460
LLPS-Coo-1266Colletotrichum orbiculare56.911e-150 443
LLPS-Cog-0564Colletotrichum gloeosporioides56.913e-150 442
LLPS-Blg-1368Blumeria graminis56.763e-149 439
LLPS-Map-0081Magnaporthe poae56.542e-153 451
LLPS-Cogr-0752Colletotrichum graminicola56.389e-152 446
LLPS-Usm-0536Ustilago maydis55.969e-140 412
LLPS-Spr-0684Sporisorium reilianum55.651e-143 426
LLPS-Asg-0220Ashbya gossypii55.592e-128 383
LLPS-Tum-0089Tuber melanosporum55.326e-146 430
LLPS-Crn-0326Cryptococcus neoformans54.157e-139 413
LLPS-Sac-1569Saccharomyces cerevisiae53.642e-132 395
LLPS-Aso-0738Aspergillus oryzae48.569e-125 378