• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Lac-0393
METAP2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Methionine aminopeptidase 2
Gene Name: METAP2
Ensembl Gene: ENSLACG00000002702.1
Ensembl Protein: ENSLACP00000003020.1
Organism: Latimeria chalumnae
Taxa ID: 7897
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADVLEPGGD  GTSLPDRHLN  GEAHLGDREE  LDVPEEAAKK  KKRRKKKSKS  AAAGQNEIEK  60
61    EVAAVDGVTK  RLENQALEDK  EKEDEEEEGS  SYCILMFKKK  KKKKKKKKKT  KVQTDPPSVA  120
121   ICELFSNGIF  PKGQECEYPA  AQDGRTAAWR  MTNEEKKVLD  KANEEMWSDF  RQAAEAHRQV  180
181   RKYVRSWIKP  GMTMIEICEK  LEDCSRKLIK  ENGLNAGLAF  PTGCSINNCA  AHYTPNAGDP  240
241   TVLQYDDVCK  VDFGTHINGR  IIDCAFTVTF  NPKYDKLIEA  VKDATNTGIK  CAGIDVRLCD  300
301   VGEAIQEVME  SYEVEIDGKT  YQVKPIRNLN  GHSIGQYRIH  AGKTVPIVKG  GEATRMEVNT  360
361   VCIRALTCSH  HYEGEVYAIE  TFGSTGKGVV  HDDMDCSHYM  KNFDVGHVPI  RLPRAKHLLN  420
421   VINENFGTLA  FCRRWLDRLG  ESKYLMALKN  LCDLGIVDPY  PPLCDIKGSY  TAQFEHTILM  480
481   RPTCKEVVSR  GDDY  494
Nucleotide CDS Sequence (FASTA)
1     ATGCTGGCTG  TTTTCCCAGC  ATCCTTAGGG  CACGCCTCTT  TCTCCCCCTC  CTCCCTTCTC  60
61    TCTTTCTCTC  TCTGTGAGTC  TAAGATGGCG  GATGTGTTGG  AGCCGGGCGG  CGACGGGACG  120
121   TCTCTCCCGG  ACCGGCACCT  GAACGGGGAA  GCGCACCTCG  GCGACAGGGA  GGAGCTGGAC  180
181   GTCCCCGAGG  AGGCCGCCAA  GAAGAAGAAG  AGAAGGAAGA  AGAAGAGTAA  ATCCGCGGCG  240
241   GCCGGGCAGA  ATGAAATTGA  GAAGGAGGTT  GCAGCTGTGG  ATGGTGTGAC  AAAACGGCTA  300
301   GAAAATCAAG  CCTTGGAGGA  CAAAGAAAAG  GAAGATGAAG  AAGAAGCCAA  AGTTCAAACA  360
361   GATCCTCCCT  CTGTTGCAAT  ATGTGAGCTC  TTTTCCAATG  GAATCTTTCC  GAAAGGTCAG  420
421   GAGTGCGAGT  ACCCGGCTGC  ACAAGACGGG  CGCACGGCTG  CCTGGCGCAT  GACTAATGAA  480
481   GAGAAGAAAG  TACTGGATAA  AGCCAACGAA  GAGATGTGGA  GTGACTTCAG  ACAAGCAGCT  540
541   GAGGCACATA  GACAAGTGAG  GAAATATGTC  CGAAGCTGGA  TCAAGCCTGG  AATGACCATG  600
601   ATTGAAATCT  GTGAAAAGCT  GGAAGATTGT  TCACGCAAAT  TGATTAAAGA  AAATGGCTTG  660
661   AATGCAGGTC  TTGCATTTCC  TACTGGCTGT  TCCATAAATA  ACTGTGCAGC  ACACTATACG  720
721   CCTAACGCTG  GGGACCCAAC  AGTGCTACAG  TATGACGACG  TCTGCAAAGT  TGATTTCGGA  780
781   ACACACATTA  ATGGTCGCAT  TATTGATTGT  GCTTTTACAG  TCACTTTTAA  TCCAAAGTAC  840
841   GACAAATTAA  TTGAAGCTGT  AAAAGATGCT  ACTAATACTG  GAATCAAGTG  CGCTGGAATT  900
901   GATGTTCGTC  TTTGTGATGT  TGGAGAAGCC  ATTCAAGAAG  TAATGGAATC  TTACGAAGTT  960
961   GAAATTGATG  GCAAAACTTA  TCAAGTAAAG  CCAATTCGTA  ACCTGAATGG  ACATTCTATT  1020
1021  GGGCAGTACA  GAATACATGC  TGGCAAAACT  GTTCCAATTG  TCAAAGGAGG  AGAAGCCACA  1080
1081  AGAATGGAGG  AAGGAGAGGT  TTATGCCATA  GAGACATTTG  GCAGCACAGG  AAAAGGAGTT  1140
1141  GTTCATGATG  ACATGGACTG  TTCACATTAT  ATGAAGAACT  TTGATGTTGG  TCATGTGCCA  1200
1201  ATAAGGCTTC  CAAGAGCAAA  ACACCTGCTG  AATGTAATTA  ATGAGAACTT  TGGTACCCTT  1260
1261  GCCTTCTGTC  GCAGATGGCT  AGATCGCCTG  GGAGAAAGTA  AATACCTAAT  GGCCCTGAAG  1320
1321  AACTTGTGTG  ACTTGGGTAT  AGTGGATCCA  TACCCTCCCC  TGTGTGACAT  CAAAGGCTCA  1380
1381  TATACAGCAC  AGTTTGAACA  CACCATTCTA  ATGCGCCCAA  CCTGCAAGGA  AGTTGTCAGC  1440
1441  AGGGGTGACG  ATTATTAA  1458

▼ KEYWORD

ID
Family
Aminopeptidase
Complete proteome
Cytoplasm
Glycoprotein
Hydrolase
Metal-binding
Protease
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Metal ion binding
Molecular Function
Metalloaminopeptidase activity
Biological Process
Definitive hemopoiesis
Biological Process
Hematopoietic stem cell differentiation
Biological Process
Protein initiator methionine removal
Biological Process
Wnt signaling pathway

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pes-1896Pelodiscus sinensis91.590.0 593
LLPS-Nol-1806Nomascus leucogenys90.310.0 671
LLPS-Mam-3627Macaca mulatta89.750.0 686
LLPS-Sah-0877Sarcophilus harrisii89.030.0 721
LLPS-Xet-3470Xenopus tropicalis89.010.0 724
LLPS-Ora-0965Ornithorhynchus anatinus88.770.0 720
LLPS-Anp-1036Anas platyrhynchos88.540.0 720
LLPS-Ran-1984Rattus norvegicus87.430.0 691
LLPS-Dar-2650Danio rerio87.210.0 717
LLPS-Tar-3299Takifugu rubripes86.390.0 706
LLPS-Xim-2080Xiphophorus maculatus86.390.0 713
LLPS-Mea-4266Mesocricetus auratus86.293e-74 238
LLPS-Ten-2503Tetraodon nigroviridis85.080.0 697
LLPS-Gaa-3805Gasterosteus aculeatus84.60.0 689
LLPS-Icp-1096Ictalurus punctatus84.60.0 699
LLPS-Fia-1306Ficedula albicollis84.030.0 719
LLPS-Ova-0459Ovis aries83.710.0 727
LLPS-Pof-0892Poecilia formosa83.670.0 698
LLPS-Myl-1479Myotis lucifugus83.330.0 724
LLPS-Anc-3235Anolis carolinensis83.140.0 726
LLPS-Meg-1216Meleagris gallopavo82.990.0 715
LLPS-Gaga-1057Gallus gallus82.950.0 719
LLPS-Tag-2976Taeniopygia guttata82.730.0 720
LLPS-Cas-3492Carlito syrichta82.580.0 719
LLPS-Bot-3755Bos taurus82.290.0 734
LLPS-Asm-1574Astyanax mexicanus82.00.0 711
LLPS-Otg-2950Otolemur garnettii81.140.0 660
LLPS-Orc-2119Oryctolagus cuniculus81.040.0 724
LLPS-Dio-0527Dipodomys ordii80.680.0 728
LLPS-Orn-2497Oreochromis niloticus80.610.0 728
LLPS-Via-1916Vigna angularis80.331e-68 222
LLPS-Leo-2764Lepisosteus oculatus80.290.0 714
LLPS-Scf-0970Scleropages formosus80.040.0 729
LLPS-Urm-2624Ursus maritimus79.880.0 729
LLPS-Pap-2478Pan paniscus79.680.0 735
LLPS-Pat-0957Pan troglodytes79.680.0 735
LLPS-Mum-3099Mus musculus79.60.0 721
LLPS-Sus-2648Sus scrofa79.480.0 728
LLPS-Fud-0843Fukomys damarensis79.280.0 730
LLPS-Scm-1244Scophthalmus maximus79.230.0 721
LLPS-Tut-0263Tursiops truncatus79.00.0 701
LLPS-Aon-2125Aotus nancymaae78.920.0 731
LLPS-Fec-2275Felis catus78.710.0 730
LLPS-Mod-0935Monodelphis domestica78.570.0 726
LLPS-Orl-2629Oryzias latipes78.560.0 721
LLPS-Mup-2168Mustela putorius furo78.510.0 729
LLPS-Caj-2622Callithrix jacchus78.510.0 729
LLPS-Cii-2283Ciona intestinalis78.390.0 642
LLPS-Cis-1734Ciona savignyi78.390.0 640
LLPS-Eqc-3814Equus caballus78.310.0 728
LLPS-Poa-0781Pongo abelii78.310.0 725
LLPS-Hos-0267Homo sapiens78.310.0 732
LLPS-Man-3185Macaca nemestrina78.310.0 728
LLPS-Aim-1965Ailuropoda melanoleuca78.310.0 727
LLPS-Paa-1906Papio anubis78.310.0 728
LLPS-Mal-0914Mandrillus leucophaeus78.310.0 728
LLPS-Gog-4136Gorilla gorilla78.310.0 732
LLPS-Maf-1964Macaca fascicularis78.310.0 728
LLPS-Cea-1023Cercocebus atys78.310.0 728
LLPS-Ict-3096Ictidomys tridecemlineatus78.110.0 732
LLPS-Loa-2443Loxodonta africana77.640.0 723
LLPS-Cap-0800Cavia porcellus77.080.0 729
LLPS-Chs-4138Chlorocebus sabaeus76.310.0 725
LLPS-Caf-3192Canis familiaris75.00.0 722
LLPS-Drm-1540Drosophila melanogaster70.390.0 581
LLPS-Cae-0841Caenorhabditis elegans70.110.0 556
LLPS-Sei-0480Setaria italica69.370.0 557
LLPS-Sot-1511Solanum tuberosum69.110.0 546
LLPS-Sem-1152Selaginella moellendorffii68.850.0 541
LLPS-Nia-2348Nicotiana attenuata68.590.0 545
LLPS-Gor-0754Gossypium raimondii68.590.0 556
LLPS-Brd-2039Brachypodium distachyon68.590.0 560
LLPS-Hov-0316Hordeum vulgare68.590.0 558
LLPS-Dac-1645Daucus carota68.590.0 541
LLPS-Sol-1543Solanum lycopersicum68.590.0 542
LLPS-Hea-0020Helianthus annuus68.420.0 552
LLPS-Tru-1611Triticum urartu68.320.0 553
LLPS-Art-0404Arabidopsis thaliana68.320.0 553
LLPS-Brr-1286Brassica rapa68.320.0 557
LLPS-Tra-0129Triticum aestivum68.320.0 556
LLPS-Brn-2492Brassica napus68.320.0 551
LLPS-Bro-1313Brassica oleracea68.060.0 550
LLPS-Org-0576Oryza glaberrima68.060.0 554
LLPS-Orr-1416Oryza rufipogon68.060.0 554
LLPS-Coc-1079Corchorus capsularis68.060.0 540
LLPS-Orbr-0781Oryza brachyantha68.060.0 553
LLPS-Sob-0293Sorghum bicolor68.060.0 552
LLPS-Ors-0164Oryza sativa68.060.0 554
LLPS-Orp-0913Oryza punctata68.060.0 554
LLPS-Cus-1888Cucumis sativus68.060.0 536
LLPS-Arl-1907Arabidopsis lyrata68.060.0 538
LLPS-Ori-1165Oryza indica68.060.0 554
LLPS-Viv-1516Vitis vinifera67.80.0 541
LLPS-Mae-0126Manihot esculenta67.540.0 540
LLPS-Met-0403Medicago truncatula67.280.0 545
LLPS-Orgl-2117Oryza glumaepatula67.280.0 543
LLPS-Lep-2275Leersia perrieri67.280.0 539
LLPS-Thc-1568Theobroma cacao67.280.0 533
LLPS-Orni-0338Oryza nivara67.280.0 543
LLPS-Rhb-0061Rhinopithecus bieti67.270.0 585
LLPS-Pot-1287Populus trichocarpa67.020.0 549
LLPS-Vir-0061Vigna radiata66.750.0 546
LLPS-Mua-1192Musa acuminata66.750.0 550
LLPS-Glm-0306Glycine max66.490.0 549
LLPS-Chr-0401Chlamydomonas reinhardtii66.320.0 529
LLPS-Phv-1458Phaseolus vulgaris66.230.0 547
LLPS-Prp-0776Prunus persica65.970.0 541
LLPS-Orb-0524Oryza barthii65.910.0 546
LLPS-Php-1829Physcomitrella patens64.920.0 536
LLPS-Orm-1742Oryza meridionalis63.323e-169 496
LLPS-Zem-0961Zea mays62.980.0 539
LLPS-Gas-0008Galdieria sulphuraria62.147e-173 500
LLPS-Put-0170Puccinia triticina61.485e-102 318
LLPS-Amt-1869Amborella trichopoda61.275e-161 471
LLPS-Scp-0507Schizosaccharomyces pombe60.992e-172 500
LLPS-Chc-1100Chondrus crispus60.683e-166 485
LLPS-Osl-0653Ostreococcus lucimarinus60.576e-158 462
LLPS-Abg-0767Absidia glauca60.523e-169 491
LLPS-Scj-0669Schizosaccharomyces japonicus60.311e-169 492
LLPS-Scc-0617Schizosaccharomyces cryophilus59.951e-167 488
LLPS-Lem-1112Leptosphaeria maculans59.791e-159 468
LLPS-Nef-0018Neosartorya fischeri59.644e-162 474
LLPS-Ast-0814Aspergillus terreus59.386e-161 471
LLPS-Pyt-0677Pyrenophora teres59.138e-158 463
LLPS-Fus-0810Fusarium solani59.025e-160 469
LLPS-Pytr-0486Pyrenophora triticirepentis58.871e-157 463
LLPS-Asni-0120Aspergillus niger58.876e-159 466
LLPS-Phn-0291Phaeosphaeria nodorum58.766e-149 440
LLPS-Nec-0478Neurospora crassa58.761e-159 468
LLPS-Mao-1254Magnaporthe oryzae58.767e-164 479
LLPS-Asn-0391Aspergillus nidulans58.674e-162 474
LLPS-Asc-0394Aspergillus clavatus58.498e-149 440
LLPS-Asf-0832Aspergillus flavus58.355e-158 464
LLPS-Dos-0711Dothistroma septosporum58.316e-160 469
LLPS-Cogr-0752Colletotrichum graminicola58.19e-155 455
LLPS-Gag-0741Gaeumannomyces graminis58.14e-161 472
LLPS-Ved-0285Verticillium dahliae57.732e-154 454
LLPS-Map-0081Magnaporthe poae57.613e-156 459
LLPS-Cog-0564Colletotrichum gloeosporioides57.583e-151 446
LLPS-Cym-0742Cyanidioschyzon merolae57.492e-159 468
LLPS-Trv-0635Trichoderma virens57.473e-156 459
LLPS-Kop-0038Komagataella pastoris57.44e-151 446
LLPS-Beb-1007Beauveria bassiana57.225e-154 453
LLPS-Pug-0627Puccinia graminis57.188e-152 448
LLPS-Zyt-0428Zymoseptoria tritici57.142e-158 465
LLPS-Trr-1246Trichoderma reesei56.843e-150 441
LLPS-Coo-1266Colletotrichum orbiculare56.811e-151 447
LLPS-Fuo-0163Fusarium oxysporum56.72e-154 454
LLPS-Fuv-0788Fusarium verticillioides56.72e-154 454
LLPS-Tum-0089Tuber melanosporum56.32e-151 446
LLPS-Asfu-0160Aspergillus fumigatus56.26e-155 457
LLPS-Asg-0220Ashbya gossypii55.775e-131 391
LLPS-Sac-1569Saccharomyces cerevisiae55.533e-135 405
LLPS-Mel-0742Melampsora laricipopulina55.385e-142 423
LLPS-Miv-1309Microbotryum violaceum55.182e-143 427
LLPS-Yal-0788Yarrowia lipolytica54.652e-150 446
LLPS-Blg-1368Blumeria graminis54.248e-144 427
LLPS-Spr-0684Sporisorium reilianum53.618e-137 410
LLPS-Usm-0536Ustilago maydis53.053e-132 395
LLPS-Crn-0326Cryptococcus neoformans52.632e-136 409
LLPS-Aso-0738Aspergillus oryzae49.362e-126 384