• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sot-0425
102583119

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2
Gene Name: 102583119
Ensembl Gene: PGSC0003DMG400020244
Ensembl Protein: PGSC0003DMT400052194
Organism: Solanum tuberosum
Taxa ID: 4113
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDNRNVVVCD  NGTGYVKCGF  AGENFPTSVF  PCVVGRPMLR  YEESLMEQDL  KDIIVGDECL  60
61    KLRHQLDLSY  PVNNGIVQNW  DDMGSVWDHA  FFNELKIDPT  ECKILLTDPP  LNPSKNREMM  120
121   VETMFEKYNF  AGVFIQIQAV  LTLYAQGLLT  GLVIDSGDGV  THVVPVVDGY  SFPHLTKRMN  180
181   VAGRHITSYM  VDLLLRRGYA  MNRSADFETV  RDIKEKLCYI  SYDYKREYQL  GLETTILVKN  240
241   YTLPDGRVLK  VGTERFQAPE  ALFTPDLIDV  EGDGMADMVF  RCIQEMDIDN  RMMLYQHIVL  300
301   SGGSTMYPGL  PSRLEKEILD  RYLDVVLKGN  KDGLKKLRLR  IEDPPRRKHM  VYLGGAVLAG  360
361   IMKVWWYLFP  LCSPISAPSQ  IMHIKEYLFP  GEIKRKPIS  399
Nucleotide CDS Sequence (FASTA)
1     ATGGATAATC  GAAACGTTGT  CGTTTGCGAC  AACGGCACTG  GGTATGTCAA  GTGTGGCTTT  60
61    GCGGGTGAGA  ATTTTCCCAC  ATCTGTATTT  CCTTGTGTTG  TGGGGAGGCC  AATGCTAAGA  120
121   TATGAAGAGT  CCCTTATGGA  ACAAGACTTG  AAGGATATTA  TTGTGGGAGA  TGAATGCTTG  180
181   AAGTTGCGCC  ATCAGTTGGA  TTTATCTTAT  CCCGTCAACA  ATGGAATTGT  ACAAAACTGG  240
241   GATGATATGG  GGAGTGTGTG  GGACCATGCA  TTTTTCAATG  AACTGAAGAT  AGATCCAACA  300
301   GAATGCAAAA  TTCTGCTGAC  AGATCCACCT  CTCAATCCAT  CTAAAAATCG  TGAAATGATG  360
361   GTAGAAACCA  TGTTTGAGAA  GTACAACTTT  GCTGGTGTCT  TCATCCAAAT  TCAAGCTGTT  420
421   CTAACATTGT  ATGCTCAAGG  TTTGTTGACT  GGGCTTGTCA  TCGACTCAGG  TGATGGAGTT  480
481   ACACATGTTG  TTCCCGTTGT  AGATGGATAC  TCATTTCCTC  ACCTCACGAA  AAGAATGAAT  540
541   GTAGCTGGAC  GGCATATAAC  GTCTTATATG  GTTGATCTGC  TACTTCGGAG  AGGGTATGCA  600
601   ATGAATAGAA  GTGCCGATTT  TGAGACTGTC  AGGGATATTA  AAGAAAAGCT  CTGCTATATT  660
661   AGTTATGATT  ACAAGAGAGA  ATATCAGTTG  GGGCTTGAAA  CTACAATTCT  TGTTAAGAAT  720
721   TATACTCTTC  CAGATGGGAG  GGTACTTAAA  GTTGGCACAG  AGAGGTTCCA  GGCACCTGAG  780
781   GCTCTTTTTA  CTCCAGATCT  TATTGATGTT  GAAGGTGATG  GCATGGCTGA  CATGGTATTT  840
841   CGCTGCATCC  AGGAGATGGA  TATTGACAAC  AGGATGATGC  TCTACCAGCA  TATTGTTTTG  900
901   AGTGGTGGAA  GTACCATGTA  TCCTGGCTTA  CCTAGTCGCC  TTGAGAAAGA  AATTTTGGAC  960
961   CGCTATCTTG  ATGTTGTTCT  GAAGGGGAAC  AAAGATGGTT  TGAAGAAATT  GCGCTTACGA  1020
1021  ATAGAAGATC  CACCAAGAAG  AAAGCATATG  GTGTATCTCG  GTGGTGCAGT  TCTGGCCGGG  1080
1081  ATTATGAAGG  TATGGTGGTA  TCTATTTCCT  CTCTGTAGCC  CCATCTCTGC  TCCTTCCCAG  1140
1141  ATCATGCATA  TAAAAGAGTA  TTTATTCCCA  GGAGAAATAA  AAAGAAAGCC  AATCTCTTAA  1200

▼ KEYWORD

ID
Family
Actin-binding
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Membrane
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Integral component of membrane
Molecular Function
ATP binding
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Vir-0186Vigna radiata100.02e-36 144
LLPS-Sol-0820Solanum lycopersicum99.430.0 725
LLPS-Nia-1298Nicotiana attenuata97.520.0 733
LLPS-Viv-0969Vitis vinifera95.040.0 719
LLPS-Thc-0560Theobroma cacao94.490.0 715
LLPS-Mae-0639Manihot esculenta94.490.0 716
LLPS-Pot-0865Populus trichocarpa93.940.0 712
LLPS-Prp-0997Prunus persica93.660.0 714
LLPS-Gor-2293Gossypium raimondii93.660.0 712
LLPS-Dac-0842Daucus carota93.390.0 709
LLPS-Glm-0625Glycine max93.390.0 705
LLPS-Amt-0492Amborella trichopoda93.390.0 712
LLPS-Coc-0083Corchorus capsularis92.840.0 713
LLPS-Met-0809Medicago truncatula92.560.0 701
LLPS-Mua-0995Musa acuminata92.290.0 703
LLPS-Hea-1538Helianthus annuus91.460.0 700
LLPS-Brn-0848Brassica napus91.460.0 701
LLPS-Brr-0129Brassica rapa91.460.0 701
LLPS-Art-2034Arabidopsis thaliana91.460.0 699
LLPS-Via-0018Vigna angularis91.370.0 606
LLPS-Arl-0396Arabidopsis lyrata91.180.0 699
LLPS-Bro-0981Brassica oleracea91.180.0 700
LLPS-Zem-1335Zea mays90.910.0 697
LLPS-Sob-0234Sorghum bicolor90.630.0 694
LLPS-Sei-0609Setaria italica90.360.0 694
LLPS-Tra-1245Triticum aestivum90.260.0 667
LLPS-Tru-0391Triticum urartu90.260.0 666
LLPS-Brd-0186Brachypodium distachyon89.530.0 690
LLPS-Orbr-0911Oryza brachyantha89.530.0 689
LLPS-Lep-1331Leersia perrieri89.40.0 671
LLPS-Hov-0082Hordeum vulgare89.260.0 687
LLPS-Orgl-0332Oryza glumaepatula89.260.0 688
LLPS-Orb-1057Oryza barthii89.260.0 689
LLPS-Org-1284Oryza glaberrima89.260.0 689
LLPS-Orr-0662Oryza rufipogon89.260.0 689
LLPS-Orp-1273Oryza punctata88.980.0 687
LLPS-Cus-0102Cucumis sativus87.050.0 638
LLPS-Orni-0226Oryza nivara85.710.0 679
LLPS-Ori-1064Oryza indica84.570.0 636
LLPS-Sem-0836Selaginella moellendorffii82.50.0 642
LLPS-Php-0727Physcomitrella patens80.610.0 635
LLPS-Urm-1122Ursus maritimus65.592e-149 434
LLPS-Tar-1249Takifugu rubripes64.826e-175 501
LLPS-Ten-0475Tetraodon nigroviridis64.824e-172 494
LLPS-Orn-2641Oreochromis niloticus64.821e-174 500
LLPS-Scf-0211Scleropages formosus64.542e-174 500
LLPS-Xim-0371Xiphophorus maculatus64.545e-174 499
LLPS-Asm-2781Astyanax mexicanus64.542e-174 500
LLPS-Xet-0842Xenopus tropicalis64.544e-174 499
LLPS-Myl-0946Myotis lucifugus64.276e-174 499
LLPS-Mup-1135Mustela putorius furo64.276e-174 499
LLPS-Ran-3046Rattus norvegicus64.275e-174 499
LLPS-Dio-0208Dipodomys ordii64.276e-174 499
LLPS-Icp-1100Ictalurus punctatus64.279e-174 498
LLPS-Fud-1159Fukomys damarensis64.276e-174 499
LLPS-Orl-0960Oryzias latipes64.271e-173 498
LLPS-Mum-0886Mus musculus64.276e-174 499
LLPS-Anc-2435Anolis carolinensis64.272e-174 501
LLPS-Gaga-0841Gallus gallus64.273e-174 499
LLPS-Poa-1599Pongo abelii64.276e-174 499
LLPS-Orc-2077Oryctolagus cuniculus64.276e-174 499
LLPS-Loa-1845Loxodonta africana64.276e-174 499
LLPS-Mod-0949Monodelphis domestica64.276e-174 499
LLPS-Dar-2598Danio rerio64.274e-174 499
LLPS-Sah-0309Sarcophilus harrisii63.993e-133 392
LLPS-Pes-3654Pelodiscus sinensis63.991e-172 495
LLPS-Scm-1956Scophthalmus maximus63.912e-172 497
LLPS-Gaa-0940Gasterosteus aculeatus63.815e-171 491
LLPS-Tag-0326Taeniopygia guttata63.712e-165 476
LLPS-Pof-1032Poecilia formosa63.669e-172 493
LLPS-Osl-0281Ostreococcus lucimarinus63.643e-175 502
LLPS-Bot-2143Bos taurus63.432e-165 477
LLPS-Fia-1120Ficedula albicollis63.433e-166 478
LLPS-Anp-0538Anas platyrhynchos63.433e-166 479
LLPS-Aim-0063Ailuropoda melanoleuca63.398e-172 493
LLPS-Paa-0923Papio anubis63.391e-171 493
LLPS-Mal-0874Mandrillus leucophaeus63.391e-171 493
LLPS-Caj-3154Callithrix jacchus63.391e-171 493
LLPS-Sus-2954Sus scrofa63.391e-171 493
LLPS-Leo-0977Lepisosteus oculatus63.399e-172 493
LLPS-Aon-0381Aotus nancymaae63.391e-171 493
LLPS-Cea-0940Cercocebus atys63.391e-171 493
LLPS-Chs-1041Chlorocebus sabaeus63.391e-171 493
LLPS-Maf-0375Macaca fascicularis63.391e-171 493
LLPS-Nol-0179Nomascus leucogenys63.391e-171 493
LLPS-Ict-2139Ictidomys tridecemlineatus63.391e-171 493
LLPS-Mam-0896Macaca mulatta63.391e-171 493
LLPS-Cap-0864Cavia porcellus63.391e-171 493
LLPS-Eqc-1931Equus caballus63.391e-171 493
LLPS-Caf-0338Canis familiaris63.398e-172 493
LLPS-Rhb-0923Rhinopithecus bieti63.391e-171 493
LLPS-Man-1249Macaca nemestrina63.391e-171 493
LLPS-Fec-2470Felis catus63.391e-171 493
LLPS-Hos-1469Homo sapiens63.391e-171 493
LLPS-Pap-0825Pan paniscus63.391e-171 493
LLPS-Pat-1378Pan troglodytes63.391e-171 493
LLPS-Lac-0674Latimeria chalumnae63.114e-171 491
LLPS-Tut-1434Tursiops truncatus62.854e-166 478
LLPS-Drm-0194Drosophila melanogaster62.846e-168 483
LLPS-Chr-0170Chlamydomonas reinhardtii62.58e-172 493
LLPS-Ova-0070Ovis aries62.331e-165 480
LLPS-Meg-1086Meleagris gallopavo62.334e-167 481
LLPS-Abg-0467Absidia glauca61.791e-171 493
LLPS-Cae-0959Caenorhabditis elegans61.57e-171 491
LLPS-Mea-1893Mesocricetus auratus61.163e-163 471
LLPS-Cas-0800Carlito syrichta61.041e-166 480
LLPS-Mel-0876Melampsora laricipopulina60.882e-161 466
LLPS-Spr-0010Sporisorium reilianum60.69e-160 462
LLPS-Usm-0338Ustilago maydis60.69e-160 462
LLPS-Lem-0885Leptosphaeria maculans60.352e-151 441
LLPS-Pug-0246Puccinia graminis59.672e-159 462
LLPS-Pyt-0334Pyrenophora teres59.663e-157 456
LLPS-Dos-0382Dothistroma septosporum59.662e-158 459
LLPS-Pytr-0086Pyrenophora triticirepentis59.663e-157 456
LLPS-Map-0166Magnaporthe poae59.614e-156 453
LLPS-Gag-0643Gaeumannomyces graminis59.612e-155 451
LLPS-Gog-0156Gorilla gorilla59.563e-152 443
LLPS-Crn-0391Cryptococcus neoformans59.53e-161 466
LLPS-Put-0648Puccinia triticina59.44e-159 461
LLPS-Zyt-0550Zymoseptoria tritici59.382e-156 454
LLPS-Blg-0688Blumeria graminis59.178e-154 447
LLPS-Sac-0114Saccharomyces cerevisiae59.072e-155 451
LLPS-Mao-0676Magnaporthe oryzae59.071e-156 455
LLPS-Ved-0527Verticillium dahliae58.943e-153 446
LLPS-Scs-0248Sclerotinia sclerotiorum58.824e-154 448
LLPS-Trr-0719Trichoderma reesei58.825e-154 447
LLPS-Asf-0014Aspergillus flavus58.714e-154 448
LLPS-Aso-0314Aspergillus oryzae58.714e-154 448
LLPS-Miv-0256Microbotryum violaceum58.712e-150 439
LLPS-Tum-0003Tuber melanosporum58.612e-158 459
LLPS-Fuv-0243Fusarium verticillioides58.522e-156 454
LLPS-Fuo-0953Fusarium oxysporum58.522e-156 454
LLPS-Fus-1028Fusarium solani58.523e-155 451
LLPS-Phn-0353Phaeosphaeria nodorum58.452e-153 446
LLPS-Coo-0677Colletotrichum orbiculare58.386e-154 447
LLPS-Cogr-0833Colletotrichum graminicola58.381e-154 449
LLPS-Trv-0462Trichoderma virens58.388e-154 447
LLPS-Asg-1094Ashbya gossypii58.246e-153 445
LLPS-Beb-0359Beauveria bassiana58.249e-155 449
LLPS-Asfu-1032Aspergillus fumigatus58.151e-154 449
LLPS-Nef-1075Neosartorya fischeri58.151e-154 449
LLPS-Cis-0996Ciona savignyi57.944e-161 466
LLPS-Nec-0806Neurospora crassa57.894e-153 446
LLPS-Kop-0136Komagataella pastoris57.876e-153 445
LLPS-Asn-0032Aspergillus nidulans57.582e-152 444
LLPS-Yal-0669Yarrowia lipolytica57.225e-150 437
LLPS-Asni-0938Aspergillus niger56.426e-138 405
LLPS-Scp-1109Schizosaccharomyces pombe56.188e-148 432
LLPS-Scc-0312Schizosaccharomyces cryophilus56.183e-149 436
LLPS-Scj-0713Schizosaccharomyces japonicus55.626e-146 427
LLPS-Ast-0087Aspergillus terreus55.51e-149 437
LLPS-Ora-0030Ornithorhynchus anatinus55.245e-140 412
LLPS-Asc-0361Aspergillus clavatus54.761e-148 435
LLPS-Cog-1541Colletotrichum gloeosporioides53.071e-130 387
LLPS-Cii-0697Ciona intestinalis45.281e-115 349
LLPS-Otg-1568Otolemur garnettii45.285e-116 350