• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Coo-0677
Cob_09228

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2
Gene Name: Cob_09228
Ensembl Gene: Cob_09228
Ensembl Protein: ENH82178
Organism: Colletotrichum orbiculare
Taxa ID: 1213857
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENH82178ENH82178
UniProtN4V2E4, N4V2E4_COLOR
GeneBankKB725935ENH82178.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAEAPIVLD  GGTGFLKVGY  AAQNFPEFQY  PSIVGRPILR  TEEQGDTNDV  VIKDIMCGDE  60
61    AAAARTMLQI  SYPMENGIVK  KWDDMQHLWD  YTFFEKMKVD  PRGRKILLTE  PPMNPLRNRE  120
121   QMCEVMFDRY  GFGGVYVAIQ  AVLALYAQGL  SSGVVVDSGD  GVTHIVPVYE  SVVLNHLTRR  180
181   LDVAGRDVTR  NLIALLLRRG  YALNRTADFE  TVRQIKEKLC  YVSYDLELDK  RLSEDTTVLV  240
241   ESYTLPDGRV  IRVGSERFEA  PECLFQPHLV  DCEQPGIAEF  LFNTIQAADV  DVRSSLFKAI  300
301   VLSGGSSMYP  GLPSRLEKEL  KQLWLTRVLK  GDPERLSKFK  VRIEDPPRRR  HMVFLGGAVL  360
361   ANIMADKEGM  WVTKEEWDEQ  GPRVLEKLGP  R  391
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGCTG  AGGCACCCAT  CGTCCTCGAC  GGAGGAACCG  GTTTCCTCAA  GGTCGGCTAC  60
61    GCGGCGCAAA  ACTTCCCCGA  ATTCCAGTAC  CCGTCCATCG  TCGGCCGACC  CATCCTGAGA  120
121   ACCGAGGAGC  AAGGCGATAC  CAACGATGTG  GTCATCAAGG  ACATCATGTG  CGGTGATGAG  180
181   GCCGCCGCCG  CCCGTACCAT  GCTTCAGATC  AGCTACCCCA  TGGAGAACGG  AATCGTCAAG  240
241   AAGTGGGATG  ACATGCAGCA  CCTCTGGGAC  TACACCTTTT  TCGAAAAGAT  GAAGGTGGAC  300
301   CCGCGCGGCC  GCAAGATCCT  CTTGACGGAG  CCCCCTATGA  ACCCACTGCG  CAACCGCGAG  360
361   CAGATGTGCG  AGGTCATGTT  TGACCGCTAC  GGTTTCGGCG  GCGTCTACGT  TGCGATTCAG  420
421   GCCGTGCTGG  CGCTGTACGC  CCAAGGTCTC  AGCTCCGGTG  TCGTCGTCGA  CTCGGGAGAC  480
481   GGCGTGACCC  ACATCGTTCC  TGTCTACGAG  TCGGTCGTGC  TGAACCACCT  TACGCGCAGA  540
541   CTCGACGTCG  CCGGCCGAGA  CGTCACACGC  AACCTCATCG  CGCTGCTGCT  GCGCCGCGGA  600
601   TACGCGCTCA  ACCGAACGGC  CGACTTCGAG  ACGGTGCGAC  AGATCAAGGA  GAAGCTCTGC  660
661   TACGTGTCGT  ACGACCTGGA  GCTGGACAAG  CGCCTGAGCG  AGGACACGAC  GGTGCTGGTG  720
721   GAGAGCTACA  CGCTGCCGGA  CGGCCGTGTA  ATTCGGGTGG  GAAGCGAGCG  TTTCGAGGCG  780
781   CCCGAGTGCC  TGTTCCAGCC  GCACCTCGTC  GACTGCGAAC  AGCCCGGCAT  TGCCGAGTTC  840
841   CTCTTCAACA  CGATTCAGGC  GGCCGACGTC  GACGTCCGCT  CGTCGCTGTT  TAAGGCCATC  900
901   GTGCTGTCGG  GCGGCAGCAG  CATGTACCCC  GGCCTGCCTT  CGCGCTTGGA  GAAGGAGCTC  960
961   AAGCAGCTGT  GGCTGACGAG  GGTGCTCAAG  GGCGATCCGG  AGAGATTAAG  CAAGTTCAAG  1020
1021  GTCCGGATAG  AGGACCCACC  CCGCCGTAGA  CACATGGTTT  TCCTCGGAGG  TGCGGTGCTG  1080
1081  GCCAACATCA  TGGCGGACAA  GGAGGGCATG  TGGGTTACCA  AGGAGGAGTG  GGATGAGCAG  1140
1141  GGCCCGCGTG  TGCTGGAGAA  GCTGGGCCCG  CGATAG  1176

▼ KEYWORD

ID
Family
Actin-binding
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Mitochondrion
Molecular Function
ATP binding
Molecular Function
ATPase activity
Biological Process
Arp2/3 complex-mediated actin nucleation
Biological Process
Ascospore wall assembly
Biological Process
Establishment of mitochondrion localization
Biological Process
Mitochondrion inheritance

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ved-0527Verticillium dahliae97.170.0 750
LLPS-Cogr-0833Colletotrichum graminicola96.680.0 754
LLPS-Scs-0248Sclerotinia sclerotiorum94.340.0 729
LLPS-Nec-0806Neurospora crassa93.370.0 728
LLPS-Map-0166Magnaporthe poae93.110.0 729
LLPS-Gag-0643Gaeumannomyces graminis92.350.0 723
LLPS-Beb-0359Beauveria bassiana92.330.0 721
LLPS-Fus-1028Fusarium solani92.330.0 721
LLPS-Fuo-0953Fusarium oxysporum91.30.0 713
LLPS-Fuv-0243Fusarium verticillioides91.30.0 713
LLPS-Lem-0885Leptosphaeria maculans90.570.0 672
LLPS-Mao-0676Magnaporthe oryzae90.430.0 716
LLPS-Trr-0719Trichoderma reesei90.360.0 699
LLPS-Pytr-0086Pyrenophora triticirepentis90.230.0 703
LLPS-Pyt-0334Pyrenophora teres90.230.0 703
LLPS-Trv-0462Trichoderma virens90.160.0 701
LLPS-Cog-1541Colletotrichum gloeosporioides89.510.0 681
LLPS-Blg-0688Blumeria graminis89.460.0 702
LLPS-Asni-0938Aspergillus niger89.250.0 595
LLPS-Dos-0382Dothistroma septosporum88.950.0 699
LLPS-Phn-0353Phaeosphaeria nodorum88.80.0 695
LLPS-Asfu-1032Aspergillus fumigatus88.630.0 690
LLPS-Nef-1075Neosartorya fischeri88.630.0 690
LLPS-Aso-0314Aspergillus oryzae88.170.0 687
LLPS-Asf-0014Aspergillus flavus88.170.0 687
LLPS-Zyt-0550Zymoseptoria tritici88.110.0 687
LLPS-Asn-0032Aspergillus nidulans87.40.0 684
LLPS-Tum-0003Tuber melanosporum87.370.0 683
LLPS-Ast-0087Aspergillus terreus85.710.0 687
LLPS-Asc-0361Aspergillus clavatus84.350.0 681
LLPS-Yal-0669Yarrowia lipolytica80.560.0 646
LLPS-Kop-0136Komagataella pastoris77.840.0 618
LLPS-Scj-0713Schizosaccharomyces japonicus77.320.0 600
LLPS-Scp-1109Schizosaccharomyces pombe76.740.0 605
LLPS-Asg-1094Ashbya gossypii76.530.0 601
LLPS-Sac-0114Saccharomyces cerevisiae75.770.0 597
LLPS-Scc-0312Schizosaccharomyces cryophilus75.580.0 600
LLPS-Crn-0391Cryptococcus neoformans73.260.0 579
LLPS-Pug-0246Puccinia graminis73.20.0 576
LLPS-Put-0648Puccinia triticina72.940.0 573
LLPS-Mel-0876Melampsora laricipopulina72.820.0 574
LLPS-Urm-1122Ursus maritimus72.544e-172 491
LLPS-Usm-0338Ustilago maydis71.940.0 572
LLPS-Spr-0010Sporisorium reilianum71.940.0 572
LLPS-Abg-0467Absidia glauca71.720.0 569
LLPS-Sah-0309Sarcophilus harrisii71.727e-143 417
LLPS-Cas-0800Carlito syrichta69.680.0 532
LLPS-Bot-2143Bos taurus69.680.0 529
LLPS-Ova-0070Ovis aries69.680.0 531
LLPS-Poa-1599Pongo abelii69.530.0 543
LLPS-Mod-0949Monodelphis domestica69.530.0 543
LLPS-Loa-1845Loxodonta africana69.530.0 543
LLPS-Orc-2077Oryctolagus cuniculus69.530.0 543
LLPS-Dio-0208Dipodomys ordii69.530.0 543
LLPS-Ran-3046Rattus norvegicus69.530.0 542
LLPS-Myl-0946Myotis lucifugus69.530.0 543
LLPS-Mup-1135Mustela putorius furo69.530.0 543
LLPS-Mum-0886Mus musculus69.530.0 543
LLPS-Fud-1159Fukomys damarensis69.530.0 543
LLPS-Caf-0338Canis familiaris69.510.0 537
LLPS-Aim-0063Ailuropoda melanoleuca69.510.0 537
LLPS-Tag-0326Taeniopygia guttata69.410.0 525
LLPS-Anp-0538Anas platyrhynchos69.410.0 531
LLPS-Fia-1120Ficedula albicollis69.410.0 530
LLPS-Tut-1434Tursiops truncatus69.370.0 535
LLPS-Gaga-0841Gallus gallus69.270.0 541
LLPS-Xet-0842Xenopus tropicalis69.270.0 539
LLPS-Scf-0211Scleropages formosus69.270.0 541
LLPS-Dar-2598Danio rerio69.010.0 541
LLPS-Orn-2641Oreochromis niloticus69.010.0 538
LLPS-Tar-1249Takifugu rubripes69.010.0 540
LLPS-Asm-2781Astyanax mexicanus69.010.0 540
LLPS-Icp-1100Ictalurus punctatus69.010.0 539
LLPS-Ten-0475Tetraodon nigroviridis68.750.0 527
LLPS-Scm-1956Scophthalmus maximus68.750.0 534
LLPS-Xim-0371Xiphophorus maculatus68.750.0 536
LLPS-Orl-0960Oryzias latipes68.750.0 537
LLPS-Cap-0864Cavia porcellus68.640.0 536
LLPS-Eqc-1931Equus caballus68.640.0 536
LLPS-Mam-0896Macaca mulatta68.640.0 536
LLPS-Nol-0179Nomascus leucogenys68.640.0 536
LLPS-Ict-2139Ictidomys tridecemlineatus68.640.0 536
LLPS-Hos-1469Homo sapiens68.640.0 536
LLPS-Pap-0825Pan paniscus68.640.0 536
LLPS-Pat-1378Pan troglodytes68.640.0 536
LLPS-Fec-2470Felis catus68.640.0 536
LLPS-Man-1249Macaca nemestrina68.640.0 536
LLPS-Rhb-0923Rhinopithecus bieti68.640.0 536
LLPS-Mal-0874Mandrillus leucophaeus68.640.0 536
LLPS-Paa-0923Papio anubis68.640.0 536
LLPS-Maf-0375Macaca fascicularis68.640.0 536
LLPS-Chs-1041Chlorocebus sabaeus68.640.0 536
LLPS-Sus-2954Sus scrofa68.640.0 536
LLPS-Cea-0940Cercocebus atys68.640.0 536
LLPS-Aon-0381Aotus nancymaae68.640.0 536
LLPS-Caj-3154Callithrix jacchus68.640.0 536
LLPS-Gaa-0940Gasterosteus aculeatus68.570.0 533
LLPS-Anc-2435Anolis carolinensis68.50.0 534
LLPS-Pes-3654Pelodiscus sinensis68.490.0 534
LLPS-Lac-0674Latimeria chalumnae68.380.0 536
LLPS-Meg-1086Meleagris gallopavo68.310.0 527
LLPS-Mea-1893Mesocricetus auratus68.181e-178 509
LLPS-Pof-1032Poecilia formosa67.870.0 531
LLPS-Leo-0977Lepisosteus oculatus67.610.0 530
LLPS-Drm-0194Drosophila melanogaster66.840.0 526
LLPS-Gog-0156Gorilla gorilla65.12e-169 486
LLPS-Miv-0256Microbotryum violaceum65.040.0 521
LLPS-Cae-0959Caenorhabditis elegans62.692e-171 492
LLPS-Ora-0030Ornithorhynchus anatinus61.749e-159 459
LLPS-Cis-0996Ciona savignyi60.63e-173 497
LLPS-Php-0727Physcomitrella patens58.757e-158 457
LLPS-Amt-0492Amborella trichopoda58.667e-146 427
LLPS-Sot-0425Solanum tuberosum58.384e-145 425
LLPS-Coc-0083Corchorus capsularis57.342e-141 429
LLPS-Sem-0836Selaginella moellendorffii57.224e-155 450
LLPS-Mae-0639Manihot esculenta57.186e-154 447
LLPS-Tru-0391Triticum urartu57.075e-151 439
LLPS-Tra-1245Triticum aestivum57.079e-151 439
LLPS-Viv-0969Vitis vinifera56.928e-154 447
LLPS-Thc-0560Theobroma cacao56.927e-153 444
LLPS-Via-0018Vigna angularis56.832e-123 367
LLPS-Hov-0082Hordeum vulgare56.761e-145 429
LLPS-Glm-0625Glycine max56.563e-153 445
LLPS-Prp-0997Prunus persica56.41e-152 444
LLPS-Brd-0186Brachypodium distachyon56.31e-154 449
LLPS-Gor-2293Gossypium raimondii56.251e-152 444
LLPS-Orr-0662Oryza rufipogon56.145e-153 445
LLPS-Org-1284Oryza glaberrima56.145e-153 445
LLPS-Orbr-0911Oryza brachyantha56.148e-153 444
LLPS-Orb-1057Oryza barthii56.145e-153 445
LLPS-Sol-0820Solanum lycopersicum56.129e-142 435
LLPS-Zem-1335Zea mays56.043e-154 448
LLPS-Sob-0234Sorghum bicolor56.041e-153 446
LLPS-Nia-1298Nicotiana attenuata56.043e-153 445
LLPS-Sei-0609Setaria italica56.047e-153 446
LLPS-Hea-1538Helianthus annuus56.044e-153 445
LLPS-Mua-0995Musa acuminata56.042e-152 443
LLPS-Orgl-0332Oryza glumaepatula56.022e-152 443
LLPS-Lep-1331Leersia perrieri56.01e-144 436
LLPS-Osl-0281Ostreococcus lucimarinus55.813e-143 421
LLPS-Pot-0865Populus trichocarpa55.782e-153 446
LLPS-Orp-1273Oryza punctata55.534e-153 445
LLPS-Dac-0842Daucus carota55.271e-150 439
LLPS-Bro-0981Brassica oleracea55.154e-152 442
LLPS-Brr-0129Brassica rapa55.152e-152 443
LLPS-Art-2034Arabidopsis thaliana55.152e-153 446
LLPS-Brn-0848Brassica napus55.152e-152 443
LLPS-Met-0809Medicago truncatula55.019e-152 442
LLPS-Arl-0396Arabidopsis lyrata54.642e-152 443
LLPS-Orni-0226Oryza nivara54.026e-149 435
LLPS-Cus-0102Cucumis sativus53.01e-131 389
LLPS-Ori-1064Oryza indica52.228e-134 395
LLPS-Chr-0170Chlamydomonas reinhardtii51.429e-132 391
LLPS-Otg-1568Otolemur garnettii45.173e-111 337