• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Beb-0359
arp2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2
Gene Name: arp2, BM221_002280
Ensembl Gene: BB8028_0004g06050
Ensembl Protein: BB8028_0004g06050.1
Organism: Beauveria bassiana
Taxa ID: 176275
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MANPPPIVLD  GGTGFLKVGY  AAQNFPEHQF  PSIVGRPILR  SEEKTDNDIV  IKDIMCGDEA  60
61    AAARTMLQIS  YPMENGIVKK  WDDMQHLWDY  TFYEKLQVDP  RGQKILLTEP  PMNPLKNREQ  120
121   MCEVMFDRYG  FGGVYVAIQA  VLALYAQGLS  SGVVVDSGDG  VTHIVPVYES  VVLNHLTKRL  180
181   DVAGRDVTRN  LIKLLLRRGY  ALNRTADFET  VRQIKEKLCY  VSYDLELDKA  LSEDTTVLVE  240
241   NYTLPDGRVI  RVGSERFEAP  ECLFQPHLVD  NESPGLGEFL  FNTIQAADVD  IRASLFKAIV  300
301   LSGGSSMYPG  LPSRLEKELK  QLWLTRALQG  NPERLSKFKV  RIEDPPRRRH  MVFLGGAVLA  360
361   NIMADKESMW  VTKAEWDEQG  PRVLEKLGPR  390
Nucleotide CDS Sequence (FASTA)
1     ATGGCCAATC  CCCCGCCCAT  CGTCCTCGAC  GGCGGTACCG  GCTTCCTCAA  GGTCGGCTAC  60
61    GCCGCGCAAA  ACTTTCCCGA  GCACCAGTTT  CCCTCCATCG  TCGGCCGGCC  GATTCTGCGT  120
121   TCAGAGGAAA  AGACGGACAA  TGACATTGTG  ATCAAGGACA  TCATGTGCGG  TGACGAGGCC  180
181   GCCGCGGCCC  GTACCATGCT  GCAAATAAGC  TACCCCATGG  AGAATGGCAT  CGTCAAGAAG  240
241   TGGGATGACA  TGCAGCACCT  GTGGGATTAT  ACTTTCTACG  AAAAGCTTCA  GGTCGACCCC  300
301   AGAGGCCAGA  AGATTCTTCT  CACAGAGCCT  CCGATGAACC  CGCTCAAGAA  CCGCGAGCAA  360
361   ATGTGCGAGG  TCATGTTTGA  CAGATATGGA  TTCGGCGGCG  TTTACGTCGC  TATTCAGGCA  420
421   GTTCTGGCCC  TCTACGCTCA  GGGTCTGAGT  TCTGGTGTCG  TTGTCGACTC  CGGCGATGGT  480
481   GTCACCCACA  TTGTCCCCGT  CTACGAATCC  GTTGTCCTTA  ACCACCTCAC  AAAACGACTC  540
541   GATGTTGCTG  GACGAGACGT  CACCCGCAAC  CTCATCAAGC  TACTGCTCCG  TCGTGGGTAC  600
601   GCCCTGAACC  GAACCGCCGA  TTTCGAGACT  GTGCGCCAGA  TCAAGGAGAA  GCTTTGCTAT  660
661   GTATCATACG  ACCTCGAGCT  AGACAAGGCT  CTCAGTGAAG  ATACGACGGT  TTTGGTGGAA  720
721   AATTATACAC  TCCCTGACGG  CCGCGTCATC  CGCGTAGGAA  GTGAGCGATT  CGAGGCCCCT  780
781   GAATGCTTGT  TCCAGCCTCA  CCTGGTCGAC  AACGAGTCGC  CTGGCCTGGG  TGAATTCCTG  840
841   TTCAATACTA  TCCAGGCTGC  CGATGTGGAT  ATCCGCGCAT  CTCTTTTCAA  GGCTATCGTT  900
901   TTATCTGGAG  GTAGCAGCAT  GTACCCAGGA  CTGCCGTCAC  GTCTGGAAAA  GGAGCTGAAG  960
961   CAGCTGTGGC  TCACGCGCGC  ACTGCAGGGC  AACCCGGAGC  GCCTGAGCAA  GTTCAAGGTG  1020
1021  CGCATAGAAG  ACCCTCCCAG  GAGAAGACAC  ATGGTCTTCC  TGGGTGGTGC  AGTCCTGGCC  1080
1081  AACATCATGG  CCGATAAGGA  GAGCATGTGG  GTAACAAAGG  CGGAGTGGGA  TGAACAAGGC  1140
1141  CCTCGCGTGT  TGGAGAAGCT  TGGCCCACGA  TAG  1173

▼ KEYWORD

ID
Family
Actin-binding
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Molecular Function
ATP binding
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fus-1028Fusarium solani96.150.0 754
LLPS-Fuv-0243Fusarium verticillioides95.380.0 748
LLPS-Fuo-0953Fusarium oxysporum95.380.0 748
LLPS-Trv-0462Trichoderma virens94.30.0 735
LLPS-Trr-0719Trichoderma reesei94.260.0 730
LLPS-Ved-0527Verticillium dahliae93.510.0 725
LLPS-Coo-0677Colletotrichum orbiculare92.330.0 721
LLPS-Cogr-0833Colletotrichum graminicola91.820.0 719
LLPS-Scs-0248Sclerotinia sclerotiorum91.450.0 709
LLPS-Map-0166Magnaporthe poae90.820.0 716
LLPS-Gag-0643Gaeumannomyces graminis90.050.0 711
LLPS-Mao-0676Magnaporthe oryzae89.920.0 712
LLPS-Nec-0806Neurospora crassa89.870.0 701
LLPS-Lem-0885Leptosphaeria maculans88.110.0 662
LLPS-Pyt-0334Pyrenophora teres88.050.0 691
LLPS-Pytr-0086Pyrenophora triticirepentis88.050.0 691
LLPS-Asni-0938Aspergillus niger87.920.0 582
LLPS-Blg-0688Blumeria graminis87.790.0 689
LLPS-Nef-1075Neosartorya fischeri87.210.0 676
LLPS-Asfu-1032Aspergillus fumigatus87.210.0 676
LLPS-Phn-0353Phaeosphaeria nodorum86.890.0 682
LLPS-Aso-0314Aspergillus oryzae86.750.0 672
LLPS-Asf-0014Aspergillus flavus86.750.0 672
LLPS-Zyt-0550Zymoseptoria tritici86.680.0 675
LLPS-Dos-0382Dothistroma septosporum86.230.0 678
LLPS-Tum-0003Tuber melanosporum85.570.0 677
LLPS-Asn-0032Aspergillus nidulans85.130.0 667
LLPS-Ast-0087Aspergillus terreus84.080.0 671
LLPS-Cog-1541Colletotrichum gloeosporioides83.890.0 637
LLPS-Asc-0361Aspergillus clavatus82.470.0 664
LLPS-Yal-0669Yarrowia lipolytica78.350.0 633
LLPS-Kop-0136Komagataella pastoris77.660.0 613
LLPS-Scc-0312Schizosaccharomyces cryophilus76.880.0 604
LLPS-Scp-1109Schizosaccharomyces pombe76.880.0 602
LLPS-Scj-0713Schizosaccharomyces japonicus76.620.0 595
LLPS-Asg-1094Ashbya gossypii75.650.0 592
LLPS-Sac-0114Saccharomyces cerevisiae75.390.0 589
LLPS-Pug-0246Puccinia graminis73.060.0 575
LLPS-Crn-0391Cryptococcus neoformans72.850.0 569
LLPS-Put-0648Puccinia triticina72.80.0 572
LLPS-Mel-0876Melampsora laricipopulina72.590.0 572
LLPS-Spr-0010Sporisorium reilianum72.450.0 573
LLPS-Usm-0338Ustilago maydis72.450.0 573
LLPS-Abg-0467Absidia glauca71.650.0 568
LLPS-Urm-1122Ursus maritimus71.341e-168 483
LLPS-Bot-2143Bos taurus70.40.0 531
LLPS-Ova-0070Ovis aries70.40.0 532
LLPS-Cas-0800Carlito syrichta70.40.0 533
LLPS-Mum-0886Mus musculus70.230.0 544
LLPS-Fud-1159Fukomys damarensis70.230.0 544
LLPS-Dio-0208Dipodomys ordii70.230.0 544
LLPS-Scf-0211Scleropages formosus70.230.0 543
LLPS-Myl-0946Myotis lucifugus70.230.0 544
LLPS-Mup-1135Mustela putorius furo70.230.0 544
LLPS-Ran-3046Rattus norvegicus70.230.0 544
LLPS-Loa-1845Loxodonta africana70.230.0 544
LLPS-Mod-0949Monodelphis domestica70.230.0 544
LLPS-Orc-2077Oryctolagus cuniculus70.230.0 544
LLPS-Poa-1599Pongo abelii70.230.0 544
LLPS-Xet-0842Xenopus tropicalis70.230.0 542
LLPS-Anp-0538Anas platyrhynchos70.130.0 532
LLPS-Fia-1120Ficedula albicollis70.130.0 531
LLPS-Tag-0326Taeniopygia guttata70.130.0 526
LLPS-Asm-2781Astyanax mexicanus69.970.0 542
LLPS-Icp-1100Ictalurus punctatus69.970.0 542
LLPS-Tar-1249Takifugu rubripes69.970.0 543
LLPS-Dar-2598Danio rerio69.970.0 542
LLPS-Gaga-0841Gallus gallus69.970.0 543
LLPS-Tut-1434Tursiops truncatus69.90.0 535
LLPS-Orl-0960Oryzias latipes69.710.0 539
LLPS-Orn-2641Oreochromis niloticus69.710.0 539
LLPS-Xim-0371Xiphophorus maculatus69.450.0 537
LLPS-Scm-1956Scophthalmus maximus69.450.0 536
LLPS-Ten-0475Tetraodon nigroviridis69.450.0 528
LLPS-Sus-2954Sus scrofa69.330.0 538
LLPS-Cea-0940Cercocebus atys69.330.0 538
LLPS-Aon-0381Aotus nancymaae69.330.0 538
LLPS-Maf-0375Macaca fascicularis69.330.0 538
LLPS-Chs-1041Chlorocebus sabaeus69.330.0 538
LLPS-Caj-3154Callithrix jacchus69.330.0 538
LLPS-Mal-0874Mandrillus leucophaeus69.330.0 538
LLPS-Paa-0923Papio anubis69.330.0 538
LLPS-Aim-0063Ailuropoda melanoleuca69.330.0 538
LLPS-Man-1249Macaca nemestrina69.330.0 538
LLPS-Hos-1469Homo sapiens69.330.0 538
LLPS-Pap-0825Pan paniscus69.330.0 538
LLPS-Pat-1378Pan troglodytes69.330.0 538
LLPS-Fec-2470Felis catus69.330.0 538
LLPS-Rhb-0923Rhinopithecus bieti69.330.0 538
LLPS-Mam-0896Macaca mulatta69.330.0 538
LLPS-Caf-0338Canis familiaris69.330.0 538
LLPS-Cap-0864Cavia porcellus69.330.0 538
LLPS-Eqc-1931Equus caballus69.330.0 538
LLPS-Nol-0179Nomascus leucogenys69.330.0 538
LLPS-Ict-2139Ictidomys tridecemlineatus69.330.0 538
LLPS-Pes-3654Pelodiscus sinensis69.190.0 538
LLPS-Lac-0674Latimeria chalumnae69.070.0 537
LLPS-Gaa-0940Gasterosteus aculeatus69.010.0 533
LLPS-Meg-1086Meleagris gallopavo69.010.0 529
LLPS-Anc-2435Anolis carolinensis68.950.0 534
LLPS-Mea-1893Mesocricetus auratus68.92e-179 512
LLPS-Leo-0977Lepisosteus oculatus68.560.0 532
LLPS-Pof-1032Poecilia formosa68.560.0 532
LLPS-Miv-0256Microbotryum violaceum67.360.0 526
LLPS-Sah-0309Sarcophilus harrisii67.22e-143 418
LLPS-Gog-0156Gorilla gorilla65.542e-169 486
LLPS-Drm-0194Drosophila melanogaster65.280.0 519
LLPS-Cae-0959Caenorhabditis elegans64.421e-174 500
LLPS-Ora-0030Ornithorhynchus anatinus62.71e-159 461
LLPS-Cis-0996Ciona savignyi61.05e-174 499
LLPS-Php-0727Physcomitrella patens59.531e-158 459
LLPS-Coc-0083Corchorus capsularis59.04e-143 433
LLPS-Via-0018Vigna angularis58.93e-125 371
LLPS-Hov-0082Hordeum vulgare58.829e-146 429
LLPS-Sem-0836Selaginella moellendorffii58.597e-157 454
LLPS-Amt-0492Amborella trichopoda58.525e-147 430
LLPS-Sot-0425Solanum tuberosum58.245e-146 427
LLPS-Tra-1245Triticum aestivum57.751e-151 441
LLPS-Tru-0391Triticum urartu57.756e-152 441
LLPS-Mua-0995Musa acuminata57.594e-154 447
LLPS-Glm-0625Glycine max57.332e-153 446
LLPS-Pot-0865Populus trichocarpa57.334e-155 450
LLPS-Thc-0560Theobroma cacao57.221e-154 449
LLPS-Sei-0609Setaria italica57.074e-153 446
LLPS-Sob-0234Sorghum bicolor57.077e-154 447
LLPS-Zem-1335Zea mays57.071e-154 449
LLPS-Brd-0186Brachypodium distachyon56.963e-155 450
LLPS-Viv-0969Vitis vinifera56.962e-155 451
LLPS-Mae-0639Manihot esculenta56.965e-155 450
LLPS-Prp-0997Prunus persica56.963e-155 450
LLPS-Nia-1298Nicotiana attenuata56.922e-153 446
LLPS-Gor-2293Gossypium raimondii56.562e-154 448
LLPS-Orb-1057Oryza barthii56.541e-153 446
LLPS-Dac-0842Daucus carota56.543e-151 440
LLPS-Orp-1273Oryza punctata56.549e-154 447
LLPS-Orbr-0911Oryza brachyantha56.542e-153 446
LLPS-Orr-0662Oryza rufipogon56.541e-153 446
LLPS-Org-1284Oryza glaberrima56.541e-153 446
LLPS-Hea-1538Helianthus annuus56.443e-153 445
LLPS-Orgl-0332Oryza glumaepatula56.436e-153 444
LLPS-Lep-1331Leersia perrieri56.422e-145 437
LLPS-Sol-0820Solanum lycopersicum56.387e-142 435
LLPS-Brn-0848Brassica napus56.332e-154 448
LLPS-Brr-0129Brassica rapa56.332e-154 448
LLPS-Art-2034Arabidopsis thaliana56.332e-155 451
LLPS-Bro-0981Brassica oleracea56.333e-154 447
LLPS-Met-0809Medicago truncatula56.281e-152 444
LLPS-Osl-0281Ostreococcus lucimarinus56.145e-144 422
LLPS-Arl-0396Arabidopsis lyrata55.813e-154 448
LLPS-Orni-0226Oryza nivara54.412e-149 436
LLPS-Cus-0102Cucumis sativus53.092e-133 394
LLPS-Ori-1064Oryza indica52.622e-134 397
LLPS-Chr-0170Chlamydomonas reinhardtii50.912e-131 390
LLPS-Otg-0577Otolemur garnettii46.059e-112 339