• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-2143
ACTR2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2
Gene Name: ACTR2
Ensembl Gene: ENSBTAG00000009761.6
Ensembl Protein: ENSBTAP00000012872.6
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEGQIGCASF  TFCSPCWIFG  PGAALQRPFV  KCGYAGSNFP  EHIFPALVGR  PIIRSTTKVG  60
61    NIEIKDLMVG  DEASELRSML  EVNYPMENGI  VRNWDDMKHL  WDYTFGPEKL  NIDTRNCKIL  120
121   LTEPPMNPTK  NREKIVEVMF  ETYQFSGVYV  AIQAVLTLYA  QGLLTGVVVD  SGDGVTHICP  180
181   VYEGFSLPHL  TRRLDIAGRD  ITRYLIKLLL  LRGYAFNHSA  DFETVRMIKE  KLCYVGYNIE  240
241   QEQKLALETT  VLVESYTLPD  GRIIKVGGER  FEAPEALFQP  HLINVEGVGV  AELLFNTIQA  300
301   ADIDTRSEFY  KHIVLSGGST  MYPGLPSRLE  RELKQLYLER  VLKGDVEKLS  KFKIRIEDPP  360
361   RRKHMVFLGG  AVLADIMKDK  DNFWMTRQEY  QEKGVRVLEK  LGVTVR  406
Nucleotide CDS Sequence (FASTA)
1     ATGGACAGCC  AGGGCAGGAA  GGTGGTGGTG  TGCGACAACG  GCACCGGGTT  TGTGAAGTGT  60
61    GGATATGCAG  GCTCTAACTT  TCCAGAACAT  ATCTTCCCAG  CTTTGGTTGG  AAGACCTATT  120
121   ATCAGATCGA  CCACCAAAGT  GGGAAACATT  GAAATCAAGG  ATCTTATGGT  TGGTGATGAG  180
181   GCAAGTGAAT  TACGCTCGAT  GTTAGAAGTT  AATTACCCTA  TGGAAAATGG  CATAGTACGA  240
241   AATTGGGATG  ACATGAAACA  CCTATGGGAC  TACACATTTG  GACCAGAAAA  ACTTAACATA  300
301   GATACCAGGA  ATTGTAAAAT  TCTACTCACA  GAACCTCCTA  TGAACCCAAC  CAAAAACAGA  360
361   GAGAAGATTG  TAGAGGTAAT  GTTTGAAACT  TACCAGTTTT  CTGGTGTGTA  TGTAGCTATC  420
421   CAGGCAGTCC  TGACTTTGTA  TGCTCAAGGT  TTATTAACTG  GAGTCGTGGT  GGACTCTGGA  480
481   GATGGTGTGA  CTCACATTTG  CCCAGTGTAT  GAAGGCTTTT  CTCTCCCTCA  CCTTACCAGG  540
541   AGACTGGATA  TTGCCGGGAG  GGATATTACC  AGATATCTTA  TCAAGCTGCT  TCTGTTGCGG  600
601   GGCTATGCCT  TCAACCATTC  TGCTGATTTT  GAAACGGTTC  GCATGATTAA  AGAAAAGTTG  660
661   TGTTATGTGG  GATATAATAT  TGAGCAAGAG  CAGAAACTGG  CCTTAGAAAC  CACAGTATTG  720
721   GTTGAATCTT  ACACACTCCC  AGATGGCCGC  ATTATCAAAG  TCGGGGGAGA  GAGGTTTGAA  780
781   GCACCGGAAG  CTCTGTTTCA  GCCTCACTTG  ATCAATGTCG  AGGGAGTAGG  TGTTGCTGAA  840
841   TTGCTTTTTA  ACACAATCCA  GGCGGCTGAC  ATTGATACCA  GATCTGAGTT  CTATAAGCAC  900
901   ATTGTGCTTT  CTGGAGGGTC  TACTATGTAC  CCTGGTCTGC  CATCCCGGTT  GGAACGAGAG  960
961   CTTAAACAGC  TTTACTTAGA  ACGAGTATTG  AAGGGTGATG  TGGAAAAACT  TTCTAAATTC  1020
1021  AAGATCCGCA  TTGAAGACCC  GCCCCGCAGG  AAGCACATGG  TTTTCCTGGG  AGGTGCAGTT  1080
1081  CTAGCGGACA  TCATGAAGGA  CAAAGACAAC  TTCTGGATGA  CCCGACAGGA  ATACCAAGAA  1140
1141  AAGGGTGTTC  GTGTGCTGGA  GAAACTCGGG  GTGACGGTTC  GATAA  1185

▼ KEYWORD

ID
Family
Actin-binding
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Molecular Function
ATP binding
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Loa-1845Loxodonta africana100.00.0 742
LLPS-Mod-0949Monodelphis domestica100.00.0 742
LLPS-Urm-1122Ursus maritimus100.00.0 662
LLPS-Orc-2077Oryctolagus cuniculus100.00.0 742
LLPS-Poa-1599Pongo abelii100.00.0 742
LLPS-Cas-0800Carlito syrichta100.00.0 743
LLPS-Mum-0886Mus musculus100.00.0 742
LLPS-Fud-1159Fukomys damarensis100.00.0 742
LLPS-Dio-0208Dipodomys ordii100.00.0 742
LLPS-Myl-0946Myotis lucifugus100.00.0 742
LLPS-Ova-0070Ovis aries100.00.0 741
LLPS-Mup-1135Mustela putorius furo100.00.0 742
LLPS-Ran-3046Rattus norvegicus99.740.0 740
LLPS-Anp-0538Anas platyrhynchos99.470.0 740
LLPS-Fia-1120Ficedula albicollis99.470.0 739
LLPS-Tag-0326Taeniopygia guttata99.470.0 734
LLPS-Gaga-0841Gallus gallus99.470.0 739
LLPS-Meg-1086Meleagris gallopavo99.210.0 735
LLPS-Pes-1675Pelodiscus sinensis99.210.0 737
LLPS-Man-1249Macaca nemestrina98.690.0 736
LLPS-Fec-2470Felis catus98.690.0 736
LLPS-Pap-0825Pan paniscus98.690.0 736
LLPS-Pat-1378Pan troglodytes98.690.0 736
LLPS-Hos-1469Homo sapiens98.690.0 736
LLPS-Rhb-0923Rhinopithecus bieti98.690.0 736
LLPS-Mam-0896Macaca mulatta98.690.0 736
LLPS-Eqc-1931Equus caballus98.690.0 736
LLPS-Cap-0864Cavia porcellus98.690.0 736
LLPS-Caf-0338Canis familiaris98.690.0 736
LLPS-Ict-2139Ictidomys tridecemlineatus98.690.0 736
LLPS-Nol-0179Nomascus leucogenys98.690.0 736
LLPS-Cea-0940Cercocebus atys98.690.0 736
LLPS-Aon-0381Aotus nancymaae98.690.0 736
LLPS-Sus-2954Sus scrofa98.690.0 736
LLPS-Chs-1041Chlorocebus sabaeus98.690.0 736
LLPS-Maf-0375Macaca fascicularis98.690.0 736
LLPS-Caj-3154Callithrix jacchus98.690.0 736
LLPS-Tut-1434Tursiops truncatus98.690.0 736
LLPS-Aim-0063Ailuropoda melanoleuca98.690.0 736
LLPS-Paa-0923Papio anubis98.690.0 736
LLPS-Mal-0874Mandrillus leucophaeus98.690.0 736
LLPS-Xet-0842Xenopus tropicalis98.410.0 733
LLPS-Anc-2435Anolis carolinensis98.110.0 721
LLPS-Mea-1893Mesocricetus auratus98.080.0 699
LLPS-Dar-2598Danio rerio97.350.0 731
LLPS-Scf-0211Scleropages formosus97.350.0 731
LLPS-Scm-1956Scophthalmus maximus97.090.0 725
LLPS-Orn-2641Oreochromis niloticus97.090.0 728
LLPS-Icp-1100Ictalurus punctatus97.090.0 729
LLPS-Asm-2781Astyanax mexicanus97.090.0 729
LLPS-Tar-1249Takifugu rubripes97.090.0 729
LLPS-Lac-0674Latimeria chalumnae96.870.0 728
LLPS-Orl-0960Oryzias latipes96.830.0 728
LLPS-Xim-0371Xiphophorus maculatus96.830.0 727
LLPS-Ten-0475Tetraodon nigroviridis96.030.0 716
LLPS-Otg-1801Otolemur garnettii95.727e-113 335
LLPS-Pof-1032Poecilia formosa95.560.0 721
LLPS-Leo-0977Lepisosteus oculatus95.040.0 718
LLPS-Gaa-0940Gasterosteus aculeatus94.20.0 724
LLPS-Sah-0309Sarcophilus harrisii93.950.0 566
LLPS-Gog-0156Gorilla gorilla93.120.0 667
LLPS-Ora-0030Ornithorhynchus anatinus87.930.0 643
LLPS-Cii-0739Ciona intestinalis82.02e-109 328
LLPS-Drm-0194Drosophila melanogaster81.480.0 628
LLPS-Cis-0996Ciona savignyi78.570.0 627
LLPS-Cae-0959Caenorhabditis elegans75.60.0 586
LLPS-Mel-0876Melampsora laricipopulina73.680.0 558
LLPS-Pug-0246Puccinia graminis72.490.0 548
LLPS-Crn-0391Cryptococcus neoformans72.190.0 555
LLPS-Put-0648Puccinia triticina71.960.0 548
LLPS-Scs-0248Sclerotinia sclerotiorum71.730.0 532
LLPS-Abg-0467Absidia glauca71.20.0 563
LLPS-Beb-0359Beauveria bassiana70.40.0 524
LLPS-Blg-0688Blumeria graminis70.40.0 525
LLPS-Lem-0885Leptosphaeria maculans70.270.0 518
LLPS-Pytr-0086Pyrenophora triticirepentis70.130.0 526
LLPS-Pyt-0334Pyrenophora teres70.130.0 526
LLPS-Aso-0314Aspergillus oryzae70.050.0 530
LLPS-Tum-0003Tuber melanosporum70.050.0 536
LLPS-Asf-0014Aspergillus flavus70.050.0 530
LLPS-Map-0166Magnaporthe poae70.030.0 526
LLPS-Spr-0010Sporisorium reilianum69.90.0 540
LLPS-Usm-0338Ustilago maydis69.90.0 540
LLPS-Mao-0676Magnaporthe oryzae69.90.0 525
LLPS-Asni-0938Aspergillus niger69.881e-152 443
LLPS-Gag-0643Gaeumannomyces graminis69.760.0 525
LLPS-Nef-1075Neosartorya fischeri69.680.0 529
LLPS-Cogr-0833Colletotrichum graminicola69.680.0 520
LLPS-Asfu-1032Aspergillus fumigatus69.680.0 529
LLPS-Coo-0677Colletotrichum orbiculare69.680.0 523
LLPS-Nec-0806Neurospora crassa69.660.0 528
LLPS-Ved-0527Verticillium dahliae69.60.0 518
LLPS-Fus-1028Fusarium solani69.330.0 521
LLPS-Fuo-0953Fusarium oxysporum69.330.0 522
LLPS-Fuv-0243Fusarium verticillioides69.330.0 522
LLPS-Zyt-0550Zymoseptoria tritici69.330.0 526
LLPS-Trr-0719Trichoderma reesei68.80.0 517
LLPS-Trv-0462Trichoderma virens68.80.0 516
LLPS-Dos-0382Dothistroma septosporum68.80.0 520
LLPS-Asn-0032Aspergillus nidulans68.720.0 517
LLPS-Phn-0353Phaeosphaeria nodorum68.680.0 519
LLPS-Kop-0136Komagataella pastoris68.182e-180 515
LLPS-Sac-0114Saccharomyces cerevisiae68.08e-176 503
LLPS-Yal-0669Yarrowia lipolytica67.465e-180 514
LLPS-Scj-0713Schizosaccharomyces japonicus67.382e-176 505
LLPS-Scc-0312Schizosaccharomyces cryophilus67.119e-174 498
LLPS-Ast-0087Aspergillus terreus66.243e-179 513
LLPS-Scp-1109Schizosaccharomyces pombe66.043e-170 489
LLPS-Asc-0361Aspergillus clavatus65.834e-180 515
LLPS-Asg-1094Ashbya gossypii65.62e-170 489
LLPS-Php-0727Physcomitrella patens64.711e-168 485
LLPS-Miv-0256Microbotryum violaceum64.474e-165 476
LLPS-Vir-0186Vigna radiata64.291e-33 135
LLPS-Cog-1541Colletotrichum gloeosporioides63.561e-158 458
LLPS-Coc-0083Corchorus capsularis63.433e-149 450
LLPS-Sot-0425Solanum tuberosum63.433e-152 444
LLPS-Sob-0234Sorghum bicolor63.372e-165 477
LLPS-Zem-1335Zea mays63.374e-166 479
LLPS-Mua-0995Musa acuminata63.373e-165 477
LLPS-Sei-0609Setaria italica63.376e-165 477
LLPS-Amt-0492Amborella trichopoda63.142e-153 447
LLPS-Hov-0082Hordeum vulgare63.141e-151 444
LLPS-Prp-0997Prunus persica63.13e-165 476
LLPS-Tru-0391Triticum urartu63.17e-166 478
LLPS-Via-0018Vigna angularis63.02e-129 382
LLPS-Nia-1298Nicotiana attenuata62.839e-165 475
LLPS-Sem-0836Selaginella moellendorffii62.675e-171 491
LLPS-Orp-1273Oryza punctata62.572e-164 474
LLPS-Gor-2293Gossypium raimondii62.572e-163 472
LLPS-Orr-0662Oryza rufipogon62.572e-164 474
LLPS-Org-1284Oryza glaberrima62.572e-164 474
LLPS-Orb-1057Oryza barthii62.572e-164 474
LLPS-Lep-1331Leersia perrieri62.574e-161 479
LLPS-Brd-0186Brachypodium distachyon62.576e-164 473
LLPS-Orgl-0332Oryza glumaepatula62.475e-164 473
LLPS-Orbr-0911Oryza brachyantha62.33e-164 474
LLPS-Thc-0560Theobroma cacao62.32e-163 472
LLPS-Viv-0969Vitis vinifera62.232e-164 474
LLPS-Art-2034Arabidopsis thaliana62.23e-166 479
LLPS-Pot-0865Populus trichocarpa62.031e-162 470
LLPS-Mae-0639Manihot esculenta62.038e-164 473
LLPS-Dac-0842Daucus carota61.769e-162 468
LLPS-Brr-0129Brassica rapa61.663e-164 474
LLPS-Bro-0981Brassica oleracea61.663e-164 474
LLPS-Brn-0848Brassica napus61.663e-164 474
LLPS-Arl-0396Arabidopsis lyrata61.668e-165 475
LLPS-Tra-1245Triticum aestivum61.665e-166 479
LLPS-Hea-1538Helianthus annuus61.52e-162 469
LLPS-Met-0809Medicago truncatula61.58e-163 470
LLPS-Sol-0820Solanum lycopersicum61.43e-159 481
LLPS-Glm-0625Glycine max61.232e-161 467
LLPS-Orni-0226Oryza nivara60.153e-160 464
LLPS-Cus-0102Cucumis sativus59.362e-146 428
LLPS-Ori-1064Oryza indica58.298e-147 429
LLPS-Osl-0281Ostreococcus lucimarinus57.561e-147 432
LLPS-Chr-0170Chlamydomonas reinhardtii55.171e-145 426