• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fud-1159
H920_17503

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2
Gene Name: H920_17503
Ensembl Gene: ENSFDAG00000006882.1
Ensembl Protein: ENSFDAP00000012990.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDSQGRKVVV  CDNGTGFVKC  GYAGSNFPEH  IFPALVGRPI  IRSTTKVGNI  EIKDLMVGDE  60
61    ASELRSMLEV  NYPMENGIVR  NWDDMKHLWD  YTFGPEKLNI  DTRNCKILLT  EPPMNPTKNR  120
121   EKIVEVMFET  YQFSGVYVAI  QAVLTLYAQG  LLTGVVVDSG  DGVTHICPVY  EGFSLPHLTR  180
181   RLDIAGRDIT  RYLIKLLLLR  GYAFNHSADF  ETVRMIKEKL  CYVGYNIEQE  QKLALETTVL  240
241   VESYTLPDGR  IIKVGGERFE  APEALFQPHL  INVEGVGVAE  LLFNTIQAAD  IDTRSEFYKH  300
301   IVLSGGSTMY  PGLPSRLERE  LKQLYLERVL  KGDVEKLSKF  KIRIEDPPRR  KHMVFLGGAV  360
361   LADIMKDKDN  FWMTRQEYQE  KGVRVLEKLG  VTVR  394
Nucleotide CDS Sequence (FASTA)
1     ATGGACAGCC  AGGGCAGAAA  GGTGGTGGTG  TGCGATAACG  GCACCGGGTT  TGTGAAGTGT  60
61    GGATATGCAG  GCTCCAATTT  TCCAGAACAT  ATCTTCCCAG  CTTTGGTTGG  CAGACCTATT  120
121   ATCAGATCAA  CCACCAAAGT  GGGAAACATT  GAAATCAAGG  ATCTTATGGT  TGGTGATGAG  180
181   GCCAGTGAAT  TACGCTCGAT  GTTAGAGGTT  AACTACCCAA  TGGAAAATGG  CATAGTACGA  240
241   AATTGGGATG  ACATGAAACA  CCTGTGGGAC  TATACATTTG  GACCAGAAAA  ACTCAACATA  300
301   GATACCAGAA  ATTGCAAGAT  CTTACTTACT  GAACCTCCTA  TGAACCCAAC  CAAAAACAGA  360
361   GAGAAGATTG  TAGAGGTAAT  GTTTGAAACA  TACCAGTTTT  CTGGCGTATA  TGTAGCCATC  420
421   CAGGCAGTTC  TGACTTTATA  TGCTCAAGGT  TTATTGACTG  GTGTAGTGGT  GGACTCTGGA  480
481   GATGGCGTAA  CTCACATTTG  CCCGGTGTAT  GAAGGCTTTT  CTCTCCCTCA  TCTTACCAGG  540
541   AGACTGGATA  TTGCTGGCAG  GGACATCACC  AGATATCTCA  TCAAGCTGCT  TTTGTTGCGA  600
601   GGATACGCCT  TCAACCATTC  TGCTGATTTT  GAAACAGTTC  GAATGATTAA  AGAGAAGCTG  660
661   TGTTATGTGG  GATACAATAT  TGAACAAGAA  CAGAAACTGG  CCTTAGAAAC  CACAGTATTA  720
721   GTTGAATCTT  ATACACTCCC  AGATGGACGA  ATTATTAAAG  TTGGGGGAGA  GAGATTCGAA  780
781   GCACCAGAAG  CTTTATTTCA  GCCTCACTTG  ATCAATGTCG  AAGGAGTTGG  TGTTGCGGAA  840
841   TTGCTTTTTA  ACACAATCCA  GGCAGCTGAT  ATTGATACTA  GATCTGAATT  CTATAAGCAC  900
901   ATCGTGCTTT  CTGGAGGATC  TACTATGTAT  CCTGGCCTGC  CATCACGGTT  GGAACGAGAA  960
961   CTTAAACAGC  TTTACTTAGA  ACGAGTTTTA  AAGGGAGATG  TGGAAAAACT  TTCTAAATTT  1020
1021  AAAATCCGCA  TTGAAGACCC  ACCTCGCAGA  AAGCACATGG  TTTTCCTGGG  TGGCGCAGTA  1080
1081  CTGGCAGATA  TCATGAAAGA  CAAAGACAAC  TTTTGGATGA  CCCGACAAGA  GTACCAGGAA  1140
1141  AAAGGTGTCC  GTGTGCTGGA  GAAGCTTGGT  GTGACTGTTC  GATAA  1185

▼ KEYWORD

ID
Family
Actin-binding
ATP-binding
Complete proteome
Cytoplasm
Cytoskeleton
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin cap
Cellular Component
Arp2/3 protein complex
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Site of double-strand break
Molecular Function
Actin filament binding
Molecular Function
ATP binding
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Arp2/3 complex-mediated actin nucleation
Biological Process
Asymmetric cell division
Biological Process
Cellular response to interferon-gamma
Biological Process
Cilium assembly
Biological Process
Cytosolic transport
Biological Process
Establishment or maintenance of cell polarity
Biological Process
Meiotic chromosome movement towards spindle pole
Biological Process
Meiotic cytokinesis
Biological Process
Positive regulation of double-strand break repair via homologous recombination
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Spindle localization

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-0886Mus musculus100.00.0 778
LLPS-Dio-0208Dipodomys ordii100.00.0 778
LLPS-Bot-2143Bos taurus100.00.0 741
LLPS-Myl-0946Myotis lucifugus100.00.0 778
LLPS-Mup-1135Mustela putorius furo100.00.0 778
LLPS-Loa-1845Loxodonta africana100.00.0 778
LLPS-Urm-1122Ursus maritimus100.00.0 662
LLPS-Mod-0949Monodelphis domestica100.00.0 778
LLPS-Orc-2077Oryctolagus cuniculus100.00.0 778
LLPS-Poa-1599Pongo abelii100.00.0 778
LLPS-Ran-3046Rattus norvegicus99.750.0 776
LLPS-Anp-0538Anas platyrhynchos99.470.0 741
LLPS-Fia-1120Ficedula albicollis99.470.0 741
LLPS-Tag-0326Taeniopygia guttata99.470.0 735
LLPS-Gaga-0841Gallus gallus98.980.0 771
LLPS-Sus-2954Sus scrofa98.750.0 772
LLPS-Aon-0381Aotus nancymaae98.750.0 772
LLPS-Cea-0940Cercocebus atys98.750.0 772
LLPS-Maf-0375Macaca fascicularis98.750.0 772
LLPS-Chs-1041Chlorocebus sabaeus98.750.0 772
LLPS-Caj-3154Callithrix jacchus98.750.0 772
LLPS-Paa-0923Papio anubis98.750.0 772
LLPS-Mal-0874Mandrillus leucophaeus98.750.0 772
LLPS-Aim-0063Ailuropoda melanoleuca98.750.0 772
LLPS-Man-1249Macaca nemestrina98.750.0 772
LLPS-Hos-1469Homo sapiens98.750.0 772
LLPS-Pap-0825Pan paniscus98.750.0 772
LLPS-Pat-1378Pan troglodytes98.750.0 772
LLPS-Fec-2470Felis catus98.750.0 772
LLPS-Rhb-0923Rhinopithecus bieti98.750.0 772
LLPS-Mam-0896Macaca mulatta98.750.0 772
LLPS-Caf-0338Canis familiaris98.750.0 772
LLPS-Cap-0864Cavia porcellus98.750.0 772
LLPS-Eqc-1931Equus caballus98.750.0 772
LLPS-Nol-0179Nomascus leucogenys98.750.0 772
LLPS-Ict-2139Ictidomys tridecemlineatus98.750.0 772
LLPS-Tut-1434Tursiops truncatus98.70.0 744
LLPS-Xet-0842Xenopus tropicalis98.480.0 769
LLPS-Ova-0070Ovis aries97.940.0 746
LLPS-Anc-2435Anolis carolinensis97.670.0 753
LLPS-Asm-2781Astyanax mexicanus97.210.0 765
LLPS-Icp-1100Ictalurus punctatus97.210.0 764
LLPS-Scf-0211Scleropages formosus97.210.0 765
LLPS-Tar-1249Takifugu rubripes97.210.0 765
LLPS-Dar-2598Danio rerio97.210.0 765
LLPS-Scm-1956Scophthalmus maximus97.210.0 762
LLPS-Orn-2641Oreochromis niloticus97.210.0 763
LLPS-Pes-1675Pelodiscus sinensis97.190.0 751
LLPS-Xim-0371Xiphophorus maculatus96.950.0 762
LLPS-Lac-0674Latimeria chalumnae96.740.0 763
LLPS-Meg-1086Meleagris gallopavo96.730.0 750
LLPS-Orl-0960Oryzias latipes96.70.0 762
LLPS-Cas-0800Carlito syrichta96.690.0 745
LLPS-Ten-0475Tetraodon nigroviridis96.190.0 752
LLPS-Pof-1032Poecilia formosa95.740.0 757
LLPS-Mea-1893Mesocricetus auratus95.010.0 703
LLPS-Leo-0977Lepisosteus oculatus94.990.0 753
LLPS-Gaa-0940Gasterosteus aculeatus94.430.0 760
LLPS-Sah-0309Sarcophilus harrisii93.950.0 567
LLPS-Gog-0156Gorilla gorilla93.40.0 702
LLPS-Ora-0030Ornithorhynchus anatinus87.930.0 645
LLPS-Cii-0739Ciona intestinalis82.412e-122 360
LLPS-Drm-0194Drosophila melanogaster81.470.0 660
LLPS-Cis-0996Ciona savignyi78.660.0 650
LLPS-Cae-0959Caenorhabditis elegans76.080.0 618
LLPS-Mel-0876Melampsora laricipopulina73.710.0 572
LLPS-Pug-0246Puccinia graminis72.540.0 563
LLPS-Crn-0391Cryptococcus neoformans72.250.0 570
LLPS-Put-0648Puccinia triticina72.020.0 563
LLPS-Scs-0248Sclerotinia sclerotiorum71.540.0 545
LLPS-Abg-0467Absidia glauca71.170.0 579
LLPS-Spr-0010Sporisorium reilianum71.030.0 556
LLPS-Usm-0338Ustilago maydis71.030.0 556
LLPS-Lem-0885Leptosphaeria maculans70.270.0 520
LLPS-Blg-0688Blumeria graminis70.230.0 538
LLPS-Beb-0359Beauveria bassiana70.230.0 536
LLPS-Pyt-0334Pyrenophora teres69.970.0 539
LLPS-Pytr-0086Pyrenophora triticirepentis69.970.0 539
LLPS-Aso-0314Aspergillus oryzae69.90.0 542
LLPS-Asf-0014Aspergillus flavus69.90.0 542
LLPS-Tum-0003Tuber melanosporum69.90.0 549
LLPS-Map-0166Magnaporthe poae69.870.0 540
LLPS-Mao-0676Magnaporthe oryzae69.740.0 538
LLPS-Asni-0938Aspergillus niger69.72e-157 454
LLPS-Gag-0643Gaeumannomyces graminis69.610.0 538
LLPS-Coo-0677Colletotrichum orbiculare69.530.0 535
LLPS-Nef-1075Neosartorya fischeri69.530.0 541
LLPS-Cogr-0833Colletotrichum graminicola69.530.0 533
LLPS-Asfu-1032Aspergillus fumigatus69.530.0 541
LLPS-Nec-0806Neurospora crassa69.510.0 541
LLPS-Ved-0527Verticillium dahliae69.450.0 531
LLPS-Fuv-0243Fusarium verticillioides69.190.0 534
LLPS-Zyt-0550Zymoseptoria tritici69.190.0 539
LLPS-Fus-1028Fusarium solani69.190.0 533
LLPS-Fuo-0953Fusarium oxysporum69.190.0 534
LLPS-Trr-0719Trichoderma reesei68.850.0 529
LLPS-Trv-0462Trichoderma virens68.670.0 529
LLPS-Dos-0382Dothistroma septosporum68.670.0 533
LLPS-Asn-0032Aspergillus nidulans68.590.0 530
LLPS-Phn-0353Phaeosphaeria nodorum68.560.0 531
LLPS-Kop-0136Komagataella pastoris68.060.0 528
LLPS-Sac-0114Saccharomyces cerevisiae67.890.0 517
LLPS-Scj-0713Schizosaccharomyces japonicus67.540.0 520
LLPS-Yal-0669Yarrowia lipolytica67.360.0 527
LLPS-Scc-0312Schizosaccharomyces cryophilus67.281e-179 513
LLPS-Scp-1109Schizosaccharomyces pombe66.233e-176 504
LLPS-Ast-0087Aspergillus terreus66.170.0 526
LLPS-Asc-0361Aspergillus clavatus65.760.0 528
LLPS-Asg-1094Ashbya gossypii65.222e-176 504
LLPS-Php-0727Physcomitrella patens64.878e-179 511
LLPS-Miv-0256Microbotryum violaceum64.692e-171 492
LLPS-Mua-0995Musa acuminata64.361e-175 503
LLPS-Vir-0186Vigna radiata64.296e-34 136
LLPS-Sot-0425Solanum tuberosum64.272e-161 466
LLPS-Coc-0083Corchorus capsularis64.211e-158 473
LLPS-Amt-0492Amborella trichopoda63.991e-162 470
LLPS-Via-0018Vigna angularis63.926e-139 406
LLPS-Prp-0997Prunus persica63.92e-174 499
LLPS-Sei-0609Setaria italica63.823e-174 500
LLPS-Sob-0234Sorghum bicolor63.825e-175 501
LLPS-Zem-1335Zea mays63.821e-175 503
LLPS-Hov-0082Hordeum vulgare63.641e-160 468
LLPS-Nia-1298Nicotiana attenuata63.593e-174 499
LLPS-Cog-1541Colletotrichum gloeosporioides63.548e-164 471
LLPS-Orp-1273Oryza punctata63.456e-173 496
LLPS-Gor-2293Gossypium raimondii63.381e-172 495
LLPS-Sem-0836Selaginella moellendorffii63.282e-179 512
LLPS-Thc-0560Theobroma cacao63.121e-172 494
LLPS-Tra-1245Triticum aestivum63.12e-166 479
LLPS-Tru-0391Triticum urartu63.11e-166 479
LLPS-Orb-1057Oryza barthii63.084e-173 496
LLPS-Orr-0662Oryza rufipogon63.084e-173 496
LLPS-Org-1284Oryza glaberrima63.084e-173 496
LLPS-Brd-0186Brachypodium distachyon63.053e-173 496
LLPS-Viv-0969Vitis vinifera63.059e-174 498
LLPS-Orgl-0332Oryza glumaepatula62.981e-172 494
LLPS-Mae-0639Manihot esculenta62.866e-173 496
LLPS-Pot-0865Populus trichocarpa62.823e-172 494
LLPS-Orbr-0911Oryza brachyantha62.821e-172 495
LLPS-Art-2034Arabidopsis thaliana62.768e-175 500
LLPS-Lep-1331Leersia perrieri62.578e-162 480
LLPS-Sol-0820Solanum lycopersicum62.41e-157 476
LLPS-Dac-0842Daucus carota62.319e-171 490
LLPS-Brn-0848Brassica napus62.246e-173 496
LLPS-Arl-0396Arabidopsis lyrata62.241e-173 497
LLPS-Brr-0129Brassica rapa62.246e-173 496
LLPS-Bro-0981Brassica oleracea62.247e-173 496
LLPS-Glm-0625Glycine max62.053e-171 491
LLPS-Hea-1538Helianthus annuus62.056e-172 493
LLPS-Met-0809Medicago truncatula62.059e-172 493
LLPS-Orni-0226Oryza nivara60.743e-169 487
LLPS-Cus-0102Cucumis sativus60.261e-155 451
LLPS-Ori-1064Oryza indica58.973e-155 450
LLPS-Osl-0281Ostreococcus lucimarinus58.294e-155 451
LLPS-Chr-0170Chlamydomonas reinhardtii55.872e-155 451
LLPS-Otg-1568Otolemur garnettii47.241e-114 346
LLPS-Ors-2347Oryza sativa47.033e-115 348