• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-2311
PSEN1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Presenilin
Gene Name: PSEN1
Ensembl Gene: ENSOCUG00000014545.3
Ensembl Protein: ENSOCUP00000012504.3
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLAPPLRLGP  PGWPSANDAR  AGNDDTGEPS  EAGPGPGCTG  GRGSTAETKQ  RLLRQEPRLR  60
61    ADGGGGGGKS  VAPPEALFSV  KKHFCTVAPM  TELPAPVSYF  QNAQMSEDNH  LSNTNENRER  120
121   QEHSDRRRVG  NPEPLSNGRP  QGNSRQVVEQ  DEEDDEELTL  KYGAKHVIML  FVPVTLCMVV  180
181   VVATIKSVSF  YTRKDGQLIY  TPFTEDTETV  GQRALHSILN  AAIMISVIVI  MTILLVVLYK  240
241   YRCYKVIHAW  LIVSSLLLLF  FFSFIYLGEV  FKTYNVAVDY  ITVALLIWNF  GVVGMISIHW  300
301   KGPLRLQQAY  LIMISALMAL  VFIKYLPEWT  AWLILAVISV  YDLVAVLCPK  GPLRMLVETA  360
361   QERNETLFPA  LIYSSTMVWL  VNMAEGDPEA  QRRVSKNSKY  SAQNAERESP  QDTVPESDDG  420
421   GFSEEWEAQR  DSHLGPHQST  PESRAAAQEL  SSSVLASEDP  EERGVKLGLG  DFIFYSVLVG  480
481   KASATASGDW  NTTIACFVAI  LIGLCLTLLL  LAIFKKALPA  LPISITFGLV  FYFATDYLVQ  540
541   PFMDQLAFHQ  FYI  553
Nucleotide CDS Sequence (FASTA)
1     ATGCTGGCTC  CACCCCTCCG  ATTGGGCCCG  CCCGGATGGC  CGTCCGCCAA  CGACGCCAGA  60
61    GCCGGAAATG  ACGACACCGG  CGAGCCCTCC  GAGGCGGGGC  CTGGGCCGGG  CTGCACTGGG  120
121   GGCCGAGGTT  CCACAGCGGA  AACAAAACAG  CGGCTGCTCC  GGCAGGAGCC  TCGGTTGCGA  180
181   GCGGACGGCG  GCGGCGGCGG  CGGGAAAAGC  GTAGCACCCC  CAGAGGCTTT  GTTTTCTGTG  240
241   AAAAAGCATT  TCTGTACTGT  TGCTCCAATG  ACGGAGTTAC  CTGCGCCGGT  ATCCTACTTC  300
301   CAGAATGCAC  AGATGTCTGA  GGACAACCAC  CTGAGCAACA  CTAATGAAAA  CCGAGAGCGG  360
361   CAGGAGCACA  GCGACAGGAG  GAGAGTTGGC  AACCCCGAGC  CTTTATCCAA  TGGACGACCC  420
421   CAGGGTAACT  CACGGCAGGT  GGTGGAGCAA  GATGAGGAAG  ACGATGAGGA  GCTGACACTG  480
481   AAATATGGCG  CCAAACATGT  CATCATGCTA  TTTGTCCCTG  TGACCCTCTG  CATGGTGGTG  540
541   GTTGTGGCTA  CTATCAAGTC  GGTCAGCTTT  TACACCCGGA  AGGACGGGCA  GCTAATCTAT  600
601   ACCCCGTTTA  CAGAAGACAC  CGAGACAGTG  GGCCAGAGAG  CGCTGCACTC  GATTCTGAAT  660
661   GCTGCCATCA  TGATCAGTGT  CATTGTCATC  ATGACTATCC  TCCTGGTGGT  TCTCTATAAA  720
721   TACAGGTGCT  ATAAGGTTAT  CCATGCCTGG  CTTATTGTTT  CATCTCTATT  ATTGCTGTTC  780
781   TTTTTTTCAT  TCATTTATTT  GGGGGAAGTG  TTTAAAACAT  ACAATGTTGC  TGTGGACTAC  840
841   ATTACTGTTG  CACTCTTGAT  CTGGAATTTT  GGTGTGGTGG  GAATGATTTC  CATTCACTGG  900
901   AAGGGCCCTC  TTCGGCTCCA  GCAGGCGTAT  CTCATTATGA  TCAGTGCTCT  CATGGCTCTG  960
961   GTGTTTATCA  AGTACCTCCC  CGAATGGACT  GCGTGGCTCA  TCTTGGCTGT  GATTTCAGTA  1020
1021  TATGATTTAG  TGGCTGTTTT  GTGTCCAAAA  GGTCCACTTC  GTATGCTGGT  TGAAACAGCT  1080
1081  CAGGAGAGAA  ATGAAACTCT  TTTTCCAGCT  CTCATTTACT  CGTCAACGAT  GGTGTGGTTG  1140
1141  GTGAATATGG  CAGAAGGAGA  CCCAGAAGCC  CAAAGGAGGG  TATCCAAAAA  CTCCAAGTAC  1200
1201  AGTGCACAAA  ATGCAGAGAG  GGAGTCACCG  CAAGACACGG  TTCCGGAGAG  TGACGACGGG  1260
1261  GGCTTCAGTG  AGGAGTGGGA  GGCCCAGAGG  GACAGTCACC  TCGGGCCGCA  TCAGTCCACA  1320
1321  CCTGAGTCAC  GTGCTGCAGC  CCAGGAACTC  TCCAGCAGCG  TCCTGGCCAG  TGAGGACCCA  1380
1381  GAGGAGAGGG  GAGTAAAACT  TGGACTGGGA  GATTTCATTT  TCTACAGTGT  TCTGGTTGGG  1440
1441  AAAGCCTCAG  CGACAGCCAG  TGGCGACTGG  AACACAACCA  TAGCCTGTTT  TGTAGCCATA  1500
1501  TTAATTGGTT  TGTGCCTTAC  GCTATTACTC  CTCGCCATTT  TCAAGAAGGC  ATTGCCAGCT  1560
1561  CTTCCCATCT  CTATCACCTT  TGGGCTCGTT  TTCTACTTTG  CCACAGATTA  CCTTGTGCAG  1620
1621  CCCTTCATGG  ACCAGCTAGC  GTTCCATCAG  TTTTATATCT  AG  1662

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Notch signaling pathway
Protease
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Aggresome
Cellular Component
Cell cortex
Cellular Component
Cell junction
Cellular Component
Centrosome
Cellular Component
Ciliary rootlet
Cellular Component
Cytoplasmic vesicle
Cellular Component
Dendritic shaft
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Gamma-secretase complex
Cellular Component
Golgi membrane
Cellular Component
Growth cone
Cellular Component
Integral component of plasma membrane
Cellular Component
Kinetochore
Cellular Component
Membrane raft
Cellular Component
Mitochondrion
Cellular Component
Neuronal cell body
Cellular Component
Nuclear outer membrane
Cellular Component
Presynapse
Cellular Component
Rough endoplasmic reticulum
Cellular Component
Smooth endoplasmic reticulum
Molecular Function
Aspartic endopeptidase activity, intramembrane cleaving
Molecular Function
Beta-catenin binding
Molecular Function
Cadherin binding
Molecular Function
Calcium channel activity
Molecular Function
PDZ domain binding
Biological Process
Activation of MAPKK activity
Biological Process
Amyloid-beta formation
Biological Process
Astrocyte activation involved in immune response
Biological Process
Autophagosome assembly
Biological Process
Blood vessel development
Biological Process
Brain morphogenesis
Biological Process
Cajal-Retzius cell differentiation
Biological Process
Cell fate specification
Biological Process
Cell-cell adhesion
Biological Process
Cellular response to amyloid-beta
Biological Process
Cellular response to DNA damage stimulus
Biological Process
Cerebral cortex cell migration
Biological Process
Choline transport
Biological Process
Dorsal/ventral neural tube patterning
Biological Process
Embryonic limb morphogenesis
Biological Process
Epithelial cell proliferation
Biological Process
Heart looping
Biological Process
Hematopoietic progenitor cell differentiation
Biological Process
Intracellular signal transduction
Biological Process
Membrane protein ectodomain proteolysis
Biological Process
Memory
Biological Process
Mitochondrial transport
Biological Process
Modulation of age-related behavioral decline
Biological Process
Myeloid dendritic cell differentiation
Biological Process
Negative regulation of apoptotic signaling pathway
Biological Process
Negative regulation of axonogenesis
Biological Process
Negative regulation of core promoter binding
Biological Process
Negative regulation of epidermal growth factor-activated receptor activity
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Negative regulation of ubiquitin-dependent protein catabolic process
Biological Process
Negative regulation of ubiquitin-protein transferase activity
Biological Process
Neuron apoptotic process
Biological Process
Neuron development
Biological Process
Neuron migration
Biological Process
Neuron projection maintenance
Biological Process
Notch receptor processing
Biological Process
Notch signaling pathway
Biological Process
Positive regulation of amyloid fibril formation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of coagulation
Biological Process
Positive regulation of dendritic spine development
Biological Process
Positive regulation of L-glutamate import across plasma membrane
Biological Process
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process
Positive regulation of protein binding
Biological Process
Positive regulation of protein import into nucleus
Biological Process
Positive regulation of receptor recycling
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Post-embryonic development
Biological Process
Protein glycosylation
Biological Process
Protein processing
Biological Process
Protein transport
Biological Process
Regulation of canonical Wnt signaling pathway
Biological Process
Regulation of resting membrane potential
Biological Process
Regulation of synaptic plasticity
Biological Process
Regulation of synaptic transmission, glutamatergic
Biological Process
Response to oxidative stress
Biological Process
Skeletal system morphogenesis
Biological Process
Skin morphogenesis
Biological Process
Smooth endoplasmic reticulum calcium ion homeostasis
Biological Process
Somitogenesis
Biological Process
Synapse organization
Biological Process
Synaptic vesicle targeting
Biological Process
T cell activation involved in immune response
Biological Process
T cell receptor signaling pathway
Biological Process
Thymus development

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aon-1680Aotus nancymaae95.910.0 778
LLPS-Caj-4180Callithrix jacchus95.690.0 770
LLPS-Poa-3349Pongo abelii95.470.0 773
LLPS-Chs-2329Chlorocebus sabaeus95.090.0 771
LLPS-Mal-4659Mandrillus leucophaeus94.870.0 770
LLPS-Cea-2734Cercocebus atys94.870.0 770
LLPS-Maf-1756Macaca fascicularis94.870.0 770
LLPS-Nol-3807Nomascus leucogenys94.870.0 770
LLPS-Mam-4610Macaca mulatta94.870.0 770
LLPS-Man-3948Macaca nemestrina94.870.0 770
LLPS-Hos-0229Homo sapiens94.870.0 770
LLPS-Pat-4016Pan troglodytes94.870.0 770
LLPS-Pap-2693Pan paniscus94.870.0 770
LLPS-Fud-3331Fukomys damarensis93.80.0 767
LLPS-Cas-1188Carlito syrichta93.80.0 761
LLPS-Gog-1553Gorilla gorilla93.630.0 635
LLPS-Ict-1589Ictidomys tridecemlineatus93.590.0 759
LLPS-Cap-3353Cavia porcellus93.380.0 754
LLPS-Fec-3228Felis catus92.960.0 738
LLPS-Mup-1992Mustela putorius furo92.90.0 746
LLPS-Dio-4331Dipodomys ordii92.740.0 762
LLPS-Caf-0916Canis familiaris92.080.0 740
LLPS-Mea-2209Mesocricetus auratus91.670.0 747
LLPS-Myl-1194Myotis lucifugus91.470.0 735
LLPS-Ran-3649Rattus norvegicus91.240.0 745
LLPS-Ere-0423Erinaceus europaeus91.236e-174 501
LLPS-Mum-3451Mus musculus91.030.0 733
LLPS-Aim-1010Ailuropoda melanoleuca90.960.0 564
LLPS-Sus-4218Sus scrofa90.410.0 724
LLPS-Eqc-1974Equus caballus90.360.0 745
LLPS-Paa-0012Papio anubis89.960.0 708
LLPS-Ova-3225Ovis aries89.770.0 718
LLPS-Bot-3381Bos taurus88.520.0 718
LLPS-Loa-0888Loxodonta africana88.010.0 639
LLPS-Xim-0809Xiphophorus maculatus87.784e-26 114
LLPS-Ora-2366Ornithorhynchus anatinus87.426e-163 474
LLPS-Rhb-3189Rhinopithecus bieti87.390.0 677
LLPS-Sah-3412Sarcophilus harrisii87.050.0 694
LLPS-Mod-2110Monodelphis domestica86.860.0 692
LLPS-Tag-3175Taeniopygia guttata86.765e-167 485
LLPS-Meg-0821Meleagris gallopavo83.370.0 653
LLPS-Fia-3431Ficedula albicollis83.160.0 644
LLPS-Anp-2593Anas platyrhynchos82.770.0 642
LLPS-Pes-3073Pelodiscus sinensis82.520.0 650
LLPS-Gaga-1189Gallus gallus81.720.0 634
LLPS-Anc-3329Anolis carolinensis81.660.0 660
LLPS-Dar-2676Danio rerio78.79e-179 519
LLPS-Orn-2186Oreochromis niloticus77.696e-180 524
LLPS-Tar-2870Takifugu rubripes77.333e-173 506
LLPS-Xet-1426Xenopus tropicalis77.020.0 589
LLPS-Pof-2375Poecilia formosa76.196e-177 515
LLPS-Scm-1073Scophthalmus maximus75.692e-165 486
LLPS-Scf-1951Scleropages formosus72.471e-174 508
LLPS-Asm-2522Astyanax mexicanus72.474e-179 520
LLPS-Icp-4236Ictalurus punctatus72.258e-177 514
LLPS-Ten-1255Tetraodon nigroviridis71.658e-161 474
LLPS-Gaa-3841Gasterosteus aculeatus71.182e-150 447
LLPS-Lac-1374Latimeria chalumnae65.111e-173 507
LLPS-Arl-0226Arabidopsis lyrata58.828e-1168.6
LLPS-Brd-1691Brachypodium distachyon54.04e-1066.6
LLPS-Drm-1443Drosophila melanogaster52.358e-112 350
LLPS-Chc-0955Chondrus crispus50.856e-1065.9
LLPS-Osl-1471Ostreococcus lucimarinus37.886e-40 153
LLPS-Sei-1031Setaria italica37.419e-24 108
LLPS-Vir-2043Vigna radiata37.032e-34 138
LLPS-Sem-1837Selaginella moellendorffii36.999e-36 142
LLPS-Hov-0889Hordeum vulgare36.112e-31 128
LLPS-Prp-1993Prunus persica35.935e-36 144
LLPS-Viv-1899Vitis vinifera35.912e-34 139
LLPS-Via-2394Vigna angularis35.484e-35 140
LLPS-Phv-2258Phaseolus vulgaris34.571e-36 145
LLPS-Sot-0293Solanum tuberosum34.535e-43 164
LLPS-Orb-2200Oryza barthii34.253e-31 129
LLPS-Nia-1020Nicotiana attenuata34.238e-39 152
LLPS-Dac-1535Daucus carota34.222e-38 151
LLPS-Zem-0185Zea mays34.182e-33 137
LLPS-Bro-2033Brassica oleracea34.096e-33 134
LLPS-Tru-1880Triticum urartu33.96e-31 128
LLPS-Orbr-1011Oryza brachyantha33.831e-33 138
LLPS-Met-2504Medicago truncatula33.743e-37 147
LLPS-Tra-1419Triticum aestivum33.721e-33 136
LLPS-Brn-0480Brassica napus33.653e-36 144
LLPS-Mae-0556Manihot esculenta33.643e-35 141
LLPS-Orp-2362Oryza punctata33.422e-33 135
LLPS-Gor-2618Gossypium raimondii33.422e-35 142
LLPS-Amt-1824Amborella trichopoda33.419e-38 149
LLPS-Orgl-1676Oryza glumaepatula33.331e-33 136
LLPS-Orni-1970Oryza nivara33.332e-33 136
LLPS-Orr-1673Oryza rufipogon33.332e-33 135
LLPS-Ors-0876Oryza sativa33.331e-33 136
LLPS-Thc-1713Theobroma cacao32.912e-34 139
LLPS-Coc-1807Corchorus capsularis32.885e-34 138
LLPS-Hea-0901Helianthus annuus32.814e-35 141
LLPS-Brr-2369Brassica rapa32.774e-35 140
LLPS-Pot-1757Populus trichocarpa32.731e-41 160
LLPS-Sol-2327Solanum lycopersicum32.684e-33 134
LLPS-Sob-0943Sorghum bicolor32.299e-35 140
LLPS-Abg-1272Absidia glauca32.271e-32 135
LLPS-Lep-0962Leersia perrieri31.983e-31 129
LLPS-Orm-1243Oryza meridionalis31.852e-35 142
LLPS-Cus-0346Cucumis sativus31.414e-28 120
LLPS-Ori-1544Oryza indica31.324e-34 138
LLPS-Org-0827Oryza glaberrima31.323e-34 139
LLPS-Art-2993Arabidopsis thaliana31.212e-34 139
LLPS-Glm-2366Glycine max30.85e-34 138
LLPS-Cae-0700Caenorhabditis elegans30.732e-35 140