• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mam-4610
PSEN1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Presenilin
Gene Name: PSEN1
Ensembl Gene: ENSMMUG00000010173.3
Ensembl Protein: ENSMMUP00000032752.2
Organism: Macaca mulatta
Taxa ID: 9544
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTELPAPLSY  FQNAQMSEDN  HLSNTVRSQN  DNRERQEHND  RRSLGHPEPL  SNGRPQGNSR  60
61    QVVEQDEEED  EELTLKYGAK  HVIMLFVPVT  LCMVVVVATI  KSVSFYTRKD  GQLIYTPFTE  120
121   DTETVGQRAL  HSILNAAIMI  SVIVVMTILL  VVLYKYRCYK  VIHAWLIISS  LLLLFFFSFI  180
181   YLGEVFKTYN  VAVDYITVAL  LIWNFGVVGM  ISIHWKGPLR  LQQAYLIMIS  ALMALVFIKY  240
241   LPEWTAWLIL  AVISVYDLVA  VLCPKGPLRM  LVETAQERNE  TLFPALIYSS  TMVWLVNMAE  300
301   GDPEAQRRVS  KNSKYNAEST  ERESQDTVAE  NDDGGFSEEW  EAQRDSHLGP  HRSTPESRAA  360
361   VQELSSSILA  GEDPEERGVK  LGLGDFIFYS  VLVGKASATA  SGDWNTTIAC  FVAILIGLCL  420
421   TLLLLAIFKK  ALPALPISIT  FGLVFYFATD  YLVQPFMDQL  AFHQFYI  467
Nucleotide CDS Sequence (FASTA)
1     ATGACAGAGT  TACCTGCACC  GTTGTCCTAC  TTCCAGAATG  CACAGATGTC  CGAGGACAAC  60
61    CACTTGAGCA  ATACTGTACG  TAGCCAGAAT  GACAATAGAG  AACGGCAGGA  GCACAACGAC  120
121   AGGCGGAGCC  TTGGCCACCC  TGAGCCATTA  TCTAATGGAC  GACCCCAGGG  TAACTCTCGG  180
181   CAGGTGGTGG  AGCAAGATGA  AGAAGAAGAT  GAGGAGCTGA  CATTGAAATA  TGGCGCCAAA  240
241   CATGTGATCA  TGCTCTTTGT  CCCTGTGACT  CTCTGCATGG  TGGTGGTCGT  GGCTACCATC  300
301   AAGTCAGTCA  GCTTTTATAC  CCGGAAGGAT  GGGCAGCTAA  TCTATACCCC  ATTCACAGAA  360
361   GATACCGAGA  CTGTGGGCCA  GAGAGCCCTG  CACTCAATTC  TGAATGCGGC  CATCATGATC  420
421   AGTGTCATTG  TTGTCATGAC  TATCCTCCTG  GTGGTTCTGT  ATAAATACAG  GTGCTATAAG  480
481   GTCATCCATG  CCTGGCTTAT  TATATCATCT  CTATTGTTGC  TGTTCTTTTT  TTCATTCATT  540
541   TACTTGGGGG  AAGTGTTTAA  AACCTATAAC  GTTGCTGTGG  ACTACATTAC  TGTTGCACTC  600
601   CTGATCTGGA  ATTTTGGTGT  GGTGGGAATG  ATTTCCATTC  ACTGGAAAGG  TCCACTTCGA  660
661   CTCCAGCAGG  CATATCTCAT  TATGATTAGT  GCCCTCATGG  CCCTGGTGTT  TATCAAGTAC  720
721   CTCCCTGAAT  GGACTGCGTG  GCTCATCTTG  GCTGTGATTT  CAGTATATGA  TTTAGTGGCT  780
781   GTTTTGTGTC  CGAAAGGTCC  ACTTCGTATG  CTGGTTGAGA  CAGCTCAGGA  GAGAAATGAA  840
841   ACACTTTTTC  CAGCTCTCAT  TTACTCCTCA  ACAATGGTGT  GGTTGGTGAA  TATGGCAGAA  900
901   GGAGACCCGG  AAGCTCAAAG  GAGAGTATCC  AAAAATTCCA  AGTATAATGC  AGAAAGGGGA  960
961   GTAAAACTTG  GATTGGGAGA  TTTCATTTTC  TACAGTGTTC  TGGTTGGTAA  AGCCTCAGCA  1020
1021  ACAGCCAGTG  GAGACTGGAA  CACAACCATA  GCCTGTTTTG  TAGCCATATT  AATTGGTTTG  1080
1081  TGCCTTACAT  TATTACTCCT  CGCCATTTTC  AAGAAAGCAT  TGCCAGCTCT  TCCAATCTCC  1140
1141  ATCACCTTTG  GGCTTGTTTT  CTACTTTGCC  ACAGATTATC  TTGTACAGCC  TTTTATGGAC  1200
1201  CAATTAGCAT  TCCATCAATT  TTATATCTAG  1230

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Membrane
Notch signaling pathway
Protease
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Aggresome
Cellular Component
Cell cortex
Cellular Component
Cell junction
Cellular Component
Centrosome
Cellular Component
Ciliary rootlet
Cellular Component
Cytoplasmic vesicle
Cellular Component
Dendritic shaft
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Gamma-secretase complex
Cellular Component
Glutamatergic synapse
Cellular Component
Golgi membrane
Cellular Component
Growth cone
Cellular Component
Integral component of plasma membrane
Cellular Component
Kinetochore
Cellular Component
Membrane raft
Cellular Component
Mitochondrion
Cellular Component
Neuronal cell body
Cellular Component
Nuclear outer membrane
Cellular Component
Nucleus
Cellular Component
Postsynapse
Cellular Component
Presynapse
Cellular Component
Rough endoplasmic reticulum
Cellular Component
Smooth endoplasmic reticulum
Molecular Function
Aspartic endopeptidase activity, intramembrane cleaving
Molecular Function
Beta-catenin binding
Molecular Function
Cadherin binding
Molecular Function
Calcium channel activity
Molecular Function
Endopeptidase activity
Molecular Function
PDZ domain binding
Biological Process
Activation of MAPKK activity
Biological Process
Amyloid-beta formation
Biological Process
Astrocyte activation involved in immune response
Biological Process
Autophagosome assembly
Biological Process
Blood vessel development
Biological Process
Brain morphogenesis
Biological Process
Cajal-Retzius cell differentiation
Biological Process
Cell fate specification
Biological Process
Cell-cell adhesion
Biological Process
Cellular response to amyloid-beta
Biological Process
Cellular response to DNA damage stimulus
Biological Process
Cerebral cortex cell migration
Biological Process
Choline transport
Biological Process
Dorsal/ventral neural tube patterning
Biological Process
Embryonic limb morphogenesis
Biological Process
Epithelial cell proliferation
Biological Process
Heart looping
Biological Process
Hematopoietic progenitor cell differentiation
Biological Process
Intracellular signal transduction
Biological Process
Membrane protein ectodomain proteolysis
Biological Process
Memory
Biological Process
Mitochondrial transport
Biological Process
Modulation of age-related behavioral decline
Biological Process
Myeloid dendritic cell differentiation
Biological Process
Negative regulation of apoptotic signaling pathway
Biological Process
Negative regulation of axonogenesis
Biological Process
Negative regulation of core promoter binding
Biological Process
Negative regulation of epidermal growth factor-activated receptor activity
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Negative regulation of ubiquitin-dependent protein catabolic process
Biological Process
Negative regulation of ubiquitin-protein transferase activity
Biological Process
Neuron apoptotic process
Biological Process
Neuron development
Biological Process
Neuron migration
Biological Process
Neuron projection maintenance
Biological Process
Notch receptor processing
Biological Process
Notch signaling pathway
Biological Process
Positive regulation of amyloid fibril formation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of coagulation
Biological Process
Positive regulation of dendritic spine development
Biological Process
Positive regulation of L-glutamate import across plasma membrane
Biological Process
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process
Positive regulation of protein binding
Biological Process
Positive regulation of protein import into nucleus
Biological Process
Positive regulation of receptor recycling
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Post-embryonic development
Biological Process
Protein glycosylation
Biological Process
Protein processing
Biological Process
Protein transport
Biological Process
Regulation of canonical Wnt signaling pathway
Biological Process
Regulation of resting membrane potential
Biological Process
Regulation of synaptic plasticity
Biological Process
Regulation of synaptic transmission, glutamatergic
Biological Process
Response to oxidative stress
Biological Process
Skeletal system morphogenesis
Biological Process
Skin morphogenesis
Biological Process
Smooth endoplasmic reticulum calcium ion homeostasis
Biological Process
Somitogenesis
Biological Process
Synapse organization
Biological Process
Synaptic vesicle targeting
Biological Process
T cell activation involved in immune response
Biological Process
T cell receptor signaling pathway
Biological Process
Thymus development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-3807Nomascus leucogenys100.00.0 816
LLPS-Man-3948Macaca nemestrina100.00.0 816
LLPS-Hos-0229Homo sapiens100.00.0 816
LLPS-Pat-4016Pan troglodytes100.00.0 816
LLPS-Pap-2693Pan paniscus100.00.0 816
LLPS-Mal-4659Mandrillus leucophaeus100.00.0 816
LLPS-Gog-1553Gorilla gorilla100.00.0 682
LLPS-Cea-2734Cercocebus atys100.00.0 816
LLPS-Maf-1756Macaca fascicularis100.00.0 816
LLPS-Chs-2329Chlorocebus sabaeus99.790.0 814
LLPS-Poa-3349Pongo abelii98.930.0 801
LLPS-Aon-1680Aotus nancymaae98.50.0 798
LLPS-Caj-4180Callithrix jacchus98.070.0 789
LLPS-Cas-1188Carlito syrichta97.430.0 794
LLPS-Ict-1589Ictidomys tridecemlineatus96.360.0 783
LLPS-Cap-3353Cavia porcellus95.50.0 776
LLPS-Fud-3331Fukomys damarensis95.290.0 779
LLPS-Dio-4331Dipodomys ordii95.070.0 780
LLPS-Orc-2311Oryctolagus cuniculus94.870.0 768
LLPS-Fec-3228Felis catus94.870.0 757
LLPS-Paa-0012Papio anubis94.430.0 743
LLPS-Caf-0916Canis familiaris94.00.0 757
LLPS-Mea-2209Mesocricetus auratus93.790.0 763
LLPS-Mup-1992Mustela putorius furo93.160.0 746
LLPS-Myl-1194Myotis lucifugus93.160.0 752
LLPS-Sus-4218Sus scrofa92.950.0 742
LLPS-Mum-3451Mus musculus92.720.0 756
LLPS-Ran-3649Rattus norvegicus92.320.0 745
LLPS-Rhb-3189Rhinopithecus bieti92.290.0 721
LLPS-Aim-1010Ailuropoda melanoleuca92.050.0 567
LLPS-Ere-0423Erinaceus europaeus91.211e-174 500
LLPS-Ova-3225Ovis aries91.030.0 735
LLPS-Eqc-1974Equus caballus90.430.0 744
LLPS-Loa-0888Loxodonta africana90.090.0 656
LLPS-Bot-3381Bos taurus89.750.0 731
LLPS-Sah-3412Sarcophilus harrisii88.30.0 708
LLPS-Xim-0809Xiphophorus maculatus87.781e-26 114
LLPS-Mod-2110Monodelphis domestica87.690.0 704
LLPS-Ora-2366Ornithorhynchus anatinus87.382e-164 475
LLPS-Tag-3175Taeniopygia guttata87.325e-170 489
LLPS-Fia-3431Ficedula albicollis83.690.0 647
LLPS-Meg-0821Meleagris gallopavo83.470.0 651
LLPS-Anp-2593Anas platyrhynchos82.660.0 640
LLPS-Pes-3073Pelodiscus sinensis82.420.0 647
LLPS-Gaga-1189Gallus gallus81.970.0 637
LLPS-Anc-3329Anolis carolinensis80.930.0 650
LLPS-Dar-2676Danio rerio79.152e-179 518
LLPS-Xet-1426Xenopus tropicalis78.560.0 597
LLPS-Orn-2186Oreochromis niloticus76.732e-178 516
LLPS-Tar-2870Takifugu rubripes76.563e-175 508
LLPS-Scm-1073Scophthalmus maximus75.623e-166 485
LLPS-Pof-2375Poecilia formosa74.811e-174 506
LLPS-Scf-1951Scleropages formosus72.891e-176 510
LLPS-Icp-4236Ictalurus punctatus72.335e-177 512
LLPS-Asm-2522Astyanax mexicanus72.287e-179 516
LLPS-Gaa-3841Gasterosteus aculeatus71.861e-151 447
LLPS-Ten-2205Tetraodon nigroviridis70.97e-141 418
LLPS-Lac-1374Latimeria chalumnae66.62e-177 513
LLPS-Chc-0955Chondrus crispus60.984e-0963.2
LLPS-Drm-1443Drosophila melanogaster53.243e-110 343
LLPS-Vir-2043Vigna radiata38.442e-37 146
LLPS-Sem-1837Selaginella moellendorffii37.714e-35 139
LLPS-Sei-1031Setaria italica37.062e-24 108
LLPS-Osl-1471Ostreococcus lucimarinus36.979e-40 152
LLPS-Orb-2200Oryza barthii36.094e-32 130
LLPS-Viv-1899Vitis vinifera35.663e-37 147
LLPS-Hov-0889Hordeum vulgare35.496e-31 126
LLPS-Via-2394Vigna angularis35.456e-39 150
LLPS-Orr-1673Oryza rufipogon35.131e-34 139
LLPS-Orgl-1676Oryza glumaepatula35.139e-35 139
LLPS-Dac-1535Daucus carota34.946e-39 151
LLPS-Phv-2258Phaseolus vulgaris34.98e-38 147
LLPS-Ors-0876Oryza sativa34.873e-34 137
LLPS-Orni-1970Oryza nivara34.874e-34 137
LLPS-Abg-1272Absidia glauca34.826e-33 135
LLPS-Sot-0293Solanum tuberosum34.678e-43 162
LLPS-Brn-0480Brassica napus34.521e-37 147
LLPS-Bro-2033Brassica oleracea34.356e-36 142
LLPS-Mae-0556Manihot esculenta34.117e-37 145
LLPS-Nia-1020Nicotiana attenuata34.068e-40 154
LLPS-Gor-2618Gossypium raimondii33.999e-38 148
LLPS-Met-2504Medicago truncatula33.986e-38 148
LLPS-Thc-1713Theobroma cacao33.923e-37 146
LLPS-Hea-0901Helianthus annuus33.732e-36 144
LLPS-Orp-2362Oryza punctata33.425e-33 134
LLPS-Pot-1757Populus trichocarpa33.413e-41 158
LLPS-Coc-1807Corchorus capsularis33.331e-36 144
LLPS-Sob-0943Sorghum bicolor33.332e-35 141
LLPS-Amt-1824Amborella trichopoda33.263e-38 149
LLPS-Orbr-1011Oryza brachyantha33.255e-32 132
LLPS-Prp-1993Prunus persica33.184e-36 143
LLPS-Tra-1419Triticum aestivum33.033e-33 134
LLPS-Org-0827Oryza glaberrima32.892e-35 141
LLPS-Brr-2369Brassica rapa32.863e-36 143
LLPS-Zem-0185Zea mays32.812e-34 139
LLPS-Art-2993Arabidopsis thaliana32.732e-36 144
LLPS-Ori-1544Oryza indica32.661e-34 139
LLPS-Sol-2327Solanum lycopersicum32.64e-33 134
LLPS-Tru-1880Triticum urartu32.494e-28 119
LLPS-Glm-2366Glycine max32.053e-36 144
LLPS-Orm-1243Oryza meridionalis31.984e-36 143
LLPS-Lep-0962Leersia perrieri31.988e-32 130
LLPS-Cus-0346Cucumis sativus31.256e-29 121
LLPS-Brd-1691Brachypodium distachyon31.081e-29 124
LLPS-Cae-0700Caenorhabditis elegans31.074e-37 144
LLPS-Arl-0226Arabidopsis lyrata30.826e-35 140