LLPS-Yal-0539
LIA1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Deoxyhypusine hydroxylase |
| Gene Name: | LIA1, YALI0A08129g |
| Ensembl Gene: | YALI0_A08129g |
| Ensembl Protein: | CAG83790 |
| Organism: | Yarrowia lipolytica |
| Taxa ID: | 284591 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CAG83790 | CAG83790 |
| UniProt | Q6CHJ7, DOHH_YARLI | |
| GeneBank | CR382127 | CAG83790.1 |
| RefSeq | XM_499864.1 | XP_499864.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MATETLPELK KVLLNEDGQT ALALRFRALF SLKDMGEKGD NGAIDVIAEG FKDDSELLKH 60 61 ELAYVLGQTK NFHAVKPLQG VLADTNQQAM VRHEAAEALG ALGDKGSVAM LQEYFENDPL 120 121 EVIRETCELA LERIKWENSE AAKTETLQKS AYTSIDPAPP LPTDQAEGSD KATVEKLQKT 180 181 LMDKSQSLFH RYRAMFRLRD IGTEDAVLAL ATGFDDSSAL FRHEIAYVFG QMSDPASVPA 240 241 LIKVLGKTEE EGMVRHEAAE ALGSIATDDV LPILKKFAED KDQVVRESAI VALDMYEYEN 300 301 SNEVEYAH 308 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTACCG AAACTCTCCC CGAGCTGAAA AAAGTGCTGC TGAACGAAGA CGGACAGACC 60 61 GCGCTGGCCC TGCGGTTCCG AGCGCTGTTT TCGCTCAAGG ACATGGGTGA AAAGGGCGAC 120 121 AACGGCGCCA TCGATGTGAT TGCCGAGGGC TTCAAGGACG ACTCCGAGCT GCTCAAGCAC 180 181 GAGCTGGCCT ACGTTCTGGG CCAGACCAAA AACTTCCACG CAGTCAAGCC TCTGCAGGGA 240 241 GTGCTGGCCG ACACCAACCA GCAGGCCATG GTGCGACACG AGGCTGCCGA GGCTCTGGGA 300 301 GCTCTGGGAG ACAAGGGCTC CGTGGCCATG CTGCAGGAGT ACTTTGAGAA CGACCCTCTG 360 361 GAGGTGATTC GAGAGACGTG CGAGCTTGCA CTGGAGCGAA TCAAGTGGGA GAACTCGGAG 420 421 GCTGCCAAGA CGGAGACTCT GCAAAAGTCT GCCTACACCT CCATTGACCC TGCTCCTCCT 480 481 CTGCCCACCG ACCAGGCCGA GGGCTCCGAT AAGGCCACCG TGGAGAAGCT GCAGAAGACC 540 541 CTGATGGACA AGTCGCAGAG CCTGTTCCAC CGGTACAGAG CCATGTTCCG TCTGCGAGAC 600 601 ATTGGAACCG AAGACGCTGT TCTGGCACTT GCTACCGGCT TCGATGACTC CTCTGCTCTT 660 661 TTCCGACATG AGATTGCCTA CGTGTTTGGC CAGATGAGCG ATCCTGCCTC CGTTCCTGCT 720 721 CTCATCAAGG TACTTGGCAA GACCGAGGAG GAGGGAATGG TCCGACACGA GGCCGCTGAG 780 781 GCTCTGGGCT CCATTGCCAC CGACGACGTG CTGCCCATTC TCAAGAAGTT TGCCGAGGAC 840 841 AAGGACCAGG TGGTCCGAGA GTCTGCCATT GTCGCTCTGG ACATGTACGA GTACGAAAAC 900 901 TCCAACGAGG TCGAGTACGC TCACTAG 927 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Deoxyhypusine monooxygenase activity | |
Molecular Function | Metal ion binding | |
Biological Process | Peptidyl-lysine modification to peptidyl-hypusine |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Kop-0859 | Komagataella pastoris | 63.67 | 4e-122 | 360 |
| LLPS-Sac-0010 | Saccharomyces cerevisiae | 59.03 | 1e-111 | 333 |
| LLPS-Scj-0357 | Schizosaccharomyces japonicus | 57.28 | 3e-109 | 328 |
| LLPS-Scs-0550 | Sclerotinia sclerotiorum | 57.09 | 9e-91 | 280 |
| LLPS-Scp-1140 | Schizosaccharomyces pombe | 57.01 | 2e-112 | 335 |
| LLPS-Miv-0999 | Microbotryum violaceum | 56.99 | 9e-96 | 293 |
| LLPS-Asg-1046 | Ashbya gossypii | 56.96 | 8e-110 | 329 |
| LLPS-Ved-0856 | Verticillium dahliae | 56.87 | 2e-90 | 280 |
| LLPS-Asni-1604 | Aspergillus niger | 56.73 | 9e-92 | 283 |
| LLPS-Scc-0003 | Schizosaccharomyces cryophilus | 56.69 | 6e-114 | 339 |
| LLPS-Abg-1750 | Absidia glauca | 56.51 | 3e-87 | 288 |
| LLPS-Trv-0317 | Trichoderma virens | 56.49 | 5e-91 | 281 |
| LLPS-Urm-1057 | Ursus maritimus | 56.45 | 2e-12 | 70.5 |
| LLPS-Asc-1136 | Aspergillus clavatus | 55.84 | 5e-90 | 279 |
| LLPS-Nef-0946 | Neosartorya fischeri | 55.84 | 7e-91 | 281 |
| LLPS-Coo-0911 | Colletotrichum orbiculare | 55.7 | 4e-96 | 295 |
| LLPS-Mao-0641 | Magnaporthe oryzae | 55.68 | 2e-82 | 259 |
| LLPS-Nec-0510 | Neurospora crassa | 54.96 | 1e-85 | 267 |
| LLPS-Ast-0523 | Aspergillus terreus | 54.96 | 1e-85 | 268 |
| LLPS-Cogr-0193 | Colletotrichum graminicola | 54.4 | 6e-89 | 276 |
| LLPS-Fuo-0385 | Fusarium oxysporum | 54.06 | 2e-90 | 280 |
| LLPS-Pyt-0976 | Pyrenophora teres | 54.01 | 4e-92 | 284 |
| LLPS-Fuv-0156 | Fusarium verticillioides | 53.75 | 7e-90 | 278 |
| LLPS-Lem-0395 | Leptosphaeria maculans | 53.65 | 9e-86 | 267 |
| LLPS-Tum-0081 | Tuber melanosporum | 53.65 | 1e-86 | 269 |
| LLPS-Asn-1294 | Aspergillus nidulans | 53.65 | 2e-87 | 272 |
| LLPS-Pytr-1545 | Pyrenophora triticirepentis | 53.65 | 3e-91 | 281 |
| LLPS-Phn-1113 | Phaeosphaeria nodorum | 53.65 | 6e-92 | 283 |
| LLPS-Map-1169 | Magnaporthe poae | 53.51 | 2e-66 | 214 |
| LLPS-Fus-1090 | Fusarium solani | 53.29 | 1e-90 | 280 |
| LLPS-Gaga-1688 | Gallus gallus | 53.16 | 1e-84 | 263 |
| LLPS-Meg-2183 | Meleagris gallopavo | 53.16 | 2e-84 | 263 |
| LLPS-Beb-1196 | Beauveria bassiana | 53.12 | 4e-87 | 271 |
| LLPS-Trr-1483 | Trichoderma reesei | 53.12 | 1e-90 | 280 |
| LLPS-Lac-3935 | Latimeria chalumnae | 52.96 | 8e-83 | 259 |
| LLPS-Cog-1246 | Colletotrichum gloeosporioides | 52.63 | 8e-78 | 247 |
| LLPS-Dio-4371 | Dipodomys ordii | 52.44 | 2e-18 | 83.6 |
| LLPS-Fia-2282 | Ficedula albicollis | 52.04 | 3e-81 | 255 |
| LLPS-Orn-3580 | Oreochromis niloticus | 51.82 | 5e-87 | 270 |
| LLPS-Zyt-1143 | Zymoseptoria tritici | 51.46 | 2e-83 | 261 |
| LLPS-Asf-0737 | Aspergillus flavus | 51.1 | 9e-89 | 275 |
| LLPS-Asfu-1326 | Aspergillus fumigatus | 50.66 | 6e-84 | 264 |
| LLPS-Leo-0358 | Lepisosteus oculatus | 50.56 | 1e-81 | 256 |
| LLPS-Asm-1102 | Astyanax mexicanus | 50.55 | 4e-83 | 260 |
| LLPS-Scf-1863 | Scleropages formosus | 50.0 | 5e-82 | 257 |
| LLPS-Orl-3320 | Oryzias latipes | 50.0 | 1e-83 | 261 |
| LLPS-Gag-0826 | Gaeumannomyces graminis | 50.0 | 4e-78 | 248 |
| LLPS-Drm-0620 | Drosophila melanogaster | 49.81 | 1e-84 | 263 |
| LLPS-Tar-3610 | Takifugu rubripes | 49.46 | 2e-84 | 263 |
| LLPS-Sus-4312 | Sus scrofa | 49.44 | 2e-72 | 232 |
| LLPS-Icp-3389 | Ictalurus punctatus | 49.15 | 3e-81 | 255 |
| LLPS-Ran-3876 | Rattus norvegicus | 49.07 | 3e-79 | 250 |
| LLPS-Pes-1615 | Pelodiscus sinensis | 49.07 | 1e-68 | 222 |
| LLPS-Put-1257 | Puccinia triticina | 49.06 | 2e-73 | 236 |
| LLPS-Dos-0912 | Dothistroma septosporum | 49.06 | 1e-89 | 277 |
| LLPS-Dar-0792 | Danio rerio | 48.89 | 2e-81 | 255 |
| LLPS-Mel-1098 | Melampsora laricipopulina | 48.87 | 1e-78 | 249 |
| LLPS-Ora-2820 | Ornithorhynchus anatinus | 48.85 | 2e-56 | 189 |
| LLPS-Ten-2886 | Tetraodon nigroviridis | 48.75 | 5e-80 | 252 |
| LLPS-Cii-1023 | Ciona intestinalis | 48.71 | 6e-77 | 244 |
| LLPS-Poa-1684 | Pongo abelii | 48.7 | 1e-79 | 251 |
| LLPS-Blg-1515 | Blumeria graminis | 48.43 | 1e-80 | 254 |
| LLPS-Pug-0037 | Puccinia graminis | 48.43 | 6e-72 | 232 |
| LLPS-Gaa-0939 | Gasterosteus aculeatus | 48.4 | 3e-83 | 260 |
| LLPS-Mup-1252 | Mustela putorius furo | 48.33 | 6e-77 | 244 |
| LLPS-Mum-4784 | Mus musculus | 48.33 | 4e-79 | 249 |
| LLPS-Caf-3188 | Canis familiaris | 48.33 | 3e-76 | 242 |
| LLPS-Fec-4605 | Felis catus | 48.33 | 2e-76 | 243 |
| LLPS-Sah-1918 | Sarcophilus harrisii | 48.15 | 5e-78 | 247 |
| LLPS-Bot-0260 | Bos taurus | 47.96 | 2e-75 | 240 |
| LLPS-Paa-2980 | Papio anubis | 47.96 | 3e-77 | 244 |
| LLPS-Maf-1324 | Macaca fascicularis | 47.96 | 4e-77 | 244 |
| LLPS-Chs-4821 | Chlorocebus sabaeus | 47.96 | 4e-77 | 244 |
| LLPS-Eqc-4804 | Equus caballus | 47.96 | 3e-68 | 222 |
| LLPS-Man-4223 | Macaca nemestrina | 47.96 | 4e-77 | 244 |
| LLPS-Hos-2918 | Homo sapiens | 47.96 | 9e-77 | 243 |
| LLPS-Otg-1465 | Otolemur garnettii | 47.96 | 5e-77 | 244 |
| LLPS-Chc-0809 | Chondrus crispus | 47.86 | 7e-71 | 230 |
| LLPS-Aim-2966 | Ailuropoda melanoleuca | 47.78 | 4e-73 | 234 |
| LLPS-Xim-2008 | Xiphophorus maculatus | 47.76 | 2e-85 | 266 |
| LLPS-Aon-2867 | Aotus nancymaae | 47.58 | 4e-69 | 224 |
| LLPS-Cea-4603 | Cercocebus atys | 47.58 | 2e-76 | 243 |
| LLPS-Mea-3583 | Mesocricetus auratus | 47.58 | 7e-69 | 223 |
| LLPS-Pat-4074 | Pan troglodytes | 47.58 | 3e-76 | 242 |
| LLPS-Aso-1161 | Aspergillus oryzae | 47.56 | 2e-80 | 254 |
| LLPS-Xet-0999 | Xenopus tropicalis | 47.41 | 6e-64 | 210 |
| LLPS-Crn-1049 | Cryptococcus neoformans | 47.4 | 3e-72 | 234 |
| LLPS-Cae-1749 | Caenorhabditis elegans | 47.23 | 2e-74 | 237 |
| LLPS-Cap-1607 | Cavia porcellus | 47.23 | 2e-72 | 232 |
| LLPS-Pap-3339 | Pan paniscus | 47.21 | 1e-72 | 232 |
| LLPS-Coc-1321 | Corchorus capsularis | 46.97 | 6e-09 | 60.1 |
| LLPS-Ict-1446 | Ictidomys tridecemlineatus | 46.77 | 6e-73 | 233 |
| LLPS-Mae-2114 | Manihot esculenta | 46.53 | 1e-20 | 94.4 |
| LLPS-Loa-0691 | Loxodonta africana | 46.24 | 1e-47 | 165 |
| LLPS-Mod-1035 | Monodelphis domestica | 46.05 | 5e-53 | 184 |
| LLPS-Caj-3953 | Callithrix jacchus | 45.79 | 2e-24 | 105 |
| LLPS-Nol-4183 | Nomascus leucogenys | 45.75 | 2e-54 | 184 |
| LLPS-Usm-1286 | Ustilago maydis | 45.32 | 5e-72 | 233 |
| LLPS-Ova-0176 | Ovis aries | 44.8 | 3e-26 | 109 |
| LLPS-Spr-1140 | Sporisorium reilianum | 44.44 | 4e-71 | 231 |
| LLPS-Amt-1710 | Amborella trichopoda | 44.35 | 8e-20 | 91.3 |
| LLPS-Sol-1289 | Solanum lycopersicum | 44.12 | 5e-18 | 86.7 |
| LLPS-Fud-3973 | Fukomys damarensis | 44.0 | 1e-26 | 107 |
| LLPS-Orm-1967 | Oryza meridionalis | 43.94 | 8e-20 | 91.3 |
| LLPS-Cis-1492 | Ciona savignyi | 43.84 | 8e-67 | 218 |
| LLPS-Zem-0605 | Zea mays | 43.65 | 3e-57 | 194 |
| LLPS-Gor-1624 | Gossypium raimondii | 43.56 | 6e-18 | 86.3 |
| LLPS-Glm-0788 | Glycine max | 43.48 | 2e-60 | 201 |
| LLPS-Hov-1710 | Hordeum vulgare | 43.45 | 4e-60 | 202 |
| LLPS-Orb-1015 | Oryza barthii | 43.18 | 6e-20 | 91.7 |
| LLPS-Ori-1777 | Oryza indica | 43.18 | 6e-20 | 91.7 |
| LLPS-Orni-0231 | Oryza nivara | 43.18 | 6e-20 | 91.7 |
| LLPS-Org-1931 | Oryza glaberrima | 43.18 | 6e-20 | 91.7 |
| LLPS-Orbr-2206 | Oryza brachyantha | 43.18 | 2e-19 | 90.5 |
| LLPS-Tra-0284 | Triticum aestivum | 43.07 | 1e-60 | 202 |
| LLPS-Chr-0469 | Chlamydomonas reinhardtii | 43.0 | 1e-65 | 215 |
| LLPS-Pof-4197 | Poecilia formosa | 42.86 | 2e-43 | 154 |
| LLPS-Brn-2832 | Brassica napus | 42.75 | 1e-16 | 82.0 |
| LLPS-Mal-1632 | Mandrillus leucophaeus | 42.62 | 4e-25 | 106 |
| LLPS-Rhb-2066 | Rhinopithecus bieti | 42.62 | 2e-25 | 107 |
| LLPS-Mua-2263 | Musa acuminata | 42.59 | 1e-47 | 167 |
| LLPS-Art-2368 | Arabidopsis thaliana | 42.49 | 8e-64 | 210 |
| LLPS-Viv-0362 | Vitis vinifera | 42.46 | 2e-58 | 196 |
| LLPS-Orgl-2222 | Oryza glumaepatula | 42.42 | 9e-20 | 91.3 |
| LLPS-Phv-1843 | Phaseolus vulgaris | 42.42 | 1e-60 | 202 |
| LLPS-Gog-3515 | Gorilla gorilla | 42.4 | 1e-25 | 107 |
| LLPS-Brr-0673 | Brassica rapa | 42.31 | 4e-58 | 194 |
| LLPS-Met-1212 | Medicago truncatula | 42.2 | 2e-19 | 90.5 |
| LLPS-Lep-0972 | Leersia perrieri | 42.19 | 2e-59 | 199 |
| LLPS-Via-0380 | Vigna angularis | 41.98 | 3e-58 | 197 |
| LLPS-Bro-0578 | Brassica oleracea | 41.98 | 2e-11 | 67.8 |
| LLPS-Tru-1140 | Triticum urartu | 41.91 | 7e-60 | 200 |
| LLPS-Hea-2717 | Helianthus annuus | 41.67 | 3e-59 | 198 |
| LLPS-Orr-0156 | Oryza rufipogon | 41.67 | 2e-19 | 90.5 |
| LLPS-Ors-0172 | Oryza sativa | 41.67 | 2e-19 | 90.5 |
| LLPS-Orp-1278 | Oryza punctata | 41.48 | 2e-57 | 194 |
| LLPS-Sob-2544 | Sorghum bicolor | 41.45 | 3e-58 | 196 |
| LLPS-Arl-2071 | Arabidopsis lyrata | 41.39 | 1e-61 | 205 |
| LLPS-Php-1338 | Physcomitrella patens | 41.29 | 1e-52 | 182 |
| LLPS-Sei-2442 | Setaria italica | 41.12 | 7e-57 | 192 |
| LLPS-Brd-2385 | Brachypodium distachyon | 41.12 | 4e-60 | 201 |
| LLPS-Osl-1433 | Ostreococcus lucimarinus | 41.09 | 5e-16 | 80.5 |
| LLPS-Thc-1922 | Theobroma cacao | 40.98 | 3e-17 | 84.0 |
| LLPS-Dac-2119 | Daucus carota | 40.88 | 8e-23 | 100 |
| LLPS-Cus-1496 | Cucumis sativus | 40.8 | 1e-51 | 179 |
| LLPS-Sem-1163 | Selaginella moellendorffii | 40.53 | 2e-54 | 186 |
| LLPS-Cym-0972 | Cyanidioschyzon merolae | 40.51 | 4e-57 | 192 |
| LLPS-Prp-2536 | Prunus persica | 39.87 | 5e-56 | 190 |
| LLPS-Sot-1193 | Solanum tuberosum | 39.83 | 4e-15 | 78.2 |
| LLPS-Nia-1663 | Nicotiana attenuata | 39.83 | 1e-15 | 79.7 |
| LLPS-Pot-1812 | Populus trichocarpa | 39.64 | 3e-58 | 196 |
| LLPS-Gas-0657 | Galdieria sulphuraria | 39.35 | 1e-57 | 194 |
| LLPS-Vir-0999 | Vigna radiata | 39.08 | 9e-44 | 160 |