LLPS-Asf-0737
LIA1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Deoxyhypusine hydroxylase |
| Gene Name: | LIA1, AFLA_129640 |
| Ensembl Gene: | AFLA_129640 |
| Ensembl Protein: | EED48741 |
| Organism: | Aspergillus flavus |
| Taxa ID: | 332952 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EED48741 | EED48741 |
| UniProt | B8NNR3, B8NNR3_ASPFN | |
| GeneBank | EQ963481 | EED48741.1 |
| RefSeq | XM_002382116.1 | XP_002382157.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASSAVDQPE GVDETILTLR KVLVNESEPL ARRFRALFSL KYIACLQPPT EKTLPAIQAI 60 61 AAGFTSSSAL LKHELAYCLG QTRNPDAVSY LLEVVKNTEQ DAMCRHEAAE GLGALGFDTS 120 121 LDVLKALRDD EKEEDVIRET CDIAVDRILW ENSEERKSEK LKPSDFTSID PAPPLPMASS 180 181 QPSISDLEKT LLDTKLPLFQ RYRAMFALRD LASPPDLPTA VEAVEALAKG LKDPSALFRH 240 241 EVAFVFGQLC HPASVPSLTE TLSDQKEMGM VRHEAAEALG SLGDVEGVED TLKKFLNDPE 300 301 QVVRDSIIVA LDMAEYEKNG EMEYALVPDS AAPAAVSAA 339 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTTCTT CTGCAGTTGA CCAACCTGAG GGAGTGGATG AGACCATCCT GACTCTTCGC 60 61 AAAGTTCTCG TTAATGAGTC CGAGCCGCTT GCTCGCCGAT TCCGCGCCCT GTTCTCCCTG 120 121 AAGTACATTG CTTGTTTGCA ACCACCCACC GAGAAGACAT TACCTGCGAT CCAGGCAATT 180 181 GCAGCTGGTT TTACGTCGTC CTCGGCTTTG CTGAAGCATG AGCTCGCATA CTGCTTGGGC 240 241 CAAACTCGTA ATCCAGACGC AGTCTCGTAC TTACTGGAAG TGGTGAAGAA CACTGAACAA 300 301 GATGCAATGT GTCGCCATGA AGCCGCAGAG GGTCTCGGTG CTCTGGGGTT TGATACTAGT 360 361 CTGGATGTCC TAAAAGCCTT GCGGGATGAT GAGAAAGAAG AGGATGTTAT TAGGGAGACA 420 421 TGTGACATCG CCGTTGACAG AATTCTTTGG GAGAATTCGG AAGAGAGGAA GAGCGAGAAA 480 481 CTGAAGCCTA GTGATTTTAC CTCGATTGAC CCAGCCCCAC CACTCCCAAT GGCGTCCAGC 540 541 CAGCCTTCTA TTTCCGACTT GGAAAAAACA TTGCTTGACA CAAAGCTCCC TTTGTTCCAA 600 601 AGATACCGCG CTATGTTTGC CCTGCGCGAC CTTGCTTCGC CCCCAGATCT TCCTACAGCT 660 661 GTCGAAGCTG TCGAAGCGTT GGCAAAAGGA CTCAAGGATC CGTCTGCTCT CTTCCGCCAT 720 721 GAAGTTGCCT TTGTATTCGG TCAGCTCTGC CACCCGGCAT CTGTTCCTAG TCTCACAGAA 780 781 ACCCTCAGCG ACCAGAAAGA AATGGGTATG GTGCGACACG AGGCTGCTGA GGCTCTTGGT 840 841 AGCTTGGGTG ATGTTGAAGG TGTGGAGGAC ACCCTAAAGA AGTTCTTGAA CGACCCAGAG 900 901 CAGGTGGTGA GAGACAGCAT TATTGTGGCT CTAGATATGG CGGAGTATGA GAAGAACGGG 960 961 GAGATGGAGT ATGCGTTGGT GCCGGATTCA GCAGCCCCTG CTGCTGTATC TGCTGCTTGA 1020 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Deoxyhypusine monooxygenase activity | |
Molecular Function | Metal ion binding | |
Biological Process | Microtubule cytoskeleton organization | |
Biological Process | Peptidyl-lysine modification to peptidyl-hypusine |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aso-1161 | Aspergillus oryzae | 93.49 | 0.0 | 630 |
| LLPS-Ast-0523 | Aspergillus terreus | 85.8 | 0.0 | 560 |
| LLPS-Asni-1604 | Aspergillus niger | 85.08 | 0.0 | 563 |
| LLPS-Asc-1136 | Aspergillus clavatus | 83.64 | 0.0 | 561 |
| LLPS-Nef-0946 | Neosartorya fischeri | 83.02 | 0.0 | 561 |
| LLPS-Asn-1294 | Aspergillus nidulans | 80.88 | 0.0 | 545 |
| LLPS-Asfu-1326 | Aspergillus fumigatus | 74.93 | 0.0 | 534 |
| LLPS-Phn-1113 | Phaeosphaeria nodorum | 72.76 | 2e-164 | 469 |
| LLPS-Lem-0395 | Leptosphaeria maculans | 72.44 | 3e-158 | 453 |
| LLPS-Pytr-1545 | Pyrenophora triticirepentis | 72.12 | 3e-164 | 469 |
| LLPS-Pyt-0976 | Pyrenophora teres | 71.79 | 2e-163 | 466 |
| LLPS-Dos-0912 | Dothistroma septosporum | 69.65 | 3e-153 | 441 |
| LLPS-Map-1169 | Magnaporthe poae | 69.37 | 3e-94 | 287 |
| LLPS-Coo-0911 | Colletotrichum orbiculare | 67.74 | 5e-142 | 413 |
| LLPS-Mao-0641 | Magnaporthe oryzae | 67.19 | 5e-136 | 397 |
| LLPS-Cogr-0193 | Colletotrichum graminicola | 67.18 | 1e-140 | 409 |
| LLPS-Zyt-1143 | Zymoseptoria tritici | 67.08 | 5e-150 | 433 |
| LLPS-Scs-0550 | Sclerotinia sclerotiorum | 66.46 | 2e-133 | 391 |
| LLPS-Trr-1483 | Trichoderma reesei | 66.45 | 5e-134 | 392 |
| LLPS-Fus-1090 | Fusarium solani | 65.71 | 1e-140 | 409 |
| LLPS-Ved-0856 | Verticillium dahliae | 65.51 | 6e-132 | 387 |
| LLPS-Nec-0510 | Neurospora crassa | 65.48 | 2e-133 | 390 |
| LLPS-Trv-0317 | Trichoderma virens | 65.48 | 1e-131 | 385 |
| LLPS-Fuv-0156 | Fusarium verticillioides | 65.23 | 1e-138 | 404 |
| LLPS-Fuo-0385 | Fusarium oxysporum | 64.92 | 2e-138 | 404 |
| LLPS-Gag-0826 | Gaeumannomyces graminis | 64.13 | 4e-117 | 349 |
| LLPS-Beb-1196 | Beauveria bassiana | 64.1 | 9e-132 | 386 |
| LLPS-Blg-1515 | Blumeria graminis | 61.86 | 3e-131 | 384 |
| LLPS-Cog-1246 | Colletotrichum gloeosporioides | 57.31 | 1e-115 | 345 |
| LLPS-Yal-0539 | Yarrowia lipolytica | 53.31 | 2e-95 | 292 |
| LLPS-Kop-0859 | Komagataella pastoris | 52.1 | 5e-95 | 292 |
| LLPS-Sac-0010 | Saccharomyces cerevisiae | 50.46 | 3e-86 | 270 |
| LLPS-Abg-1750 | Absidia glauca | 50.32 | 9e-81 | 271 |
| LLPS-Scp-1140 | Schizosaccharomyces pombe | 48.24 | 3e-83 | 262 |
| LLPS-Tum-0081 | Tuber melanosporum | 47.94 | 5e-77 | 245 |
| LLPS-Miv-0999 | Microbotryum violaceum | 47.59 | 7e-71 | 230 |
| LLPS-Scj-0357 | Schizosaccharomyces japonicus | 46.85 | 4e-83 | 262 |
| LLPS-Xim-2008 | Xiphophorus maculatus | 46.52 | 5e-77 | 245 |
| LLPS-Leo-0358 | Lepisosteus oculatus | 46.47 | 1e-75 | 242 |
| LLPS-Asg-1046 | Ashbya gossypii | 46.42 | 9e-78 | 248 |
| LLPS-Dio-4371 | Dipodomys ordii | 46.3 | 3e-20 | 89.4 |
| LLPS-Scc-0003 | Schizosaccharomyces cryophilus | 46.06 | 7e-79 | 250 |
| LLPS-Lac-3935 | Latimeria chalumnae | 45.83 | 1e-76 | 244 |
| LLPS-Gaga-1688 | Gallus gallus | 45.54 | 3e-72 | 233 |
| LLPS-Crn-1049 | Cryptococcus neoformans | 45.51 | 1e-69 | 228 |
| LLPS-Meg-2183 | Meleagris gallopavo | 45.22 | 7e-72 | 232 |
| LLPS-Gaa-0939 | Gasterosteus aculeatus | 45.08 | 1e-74 | 240 |
| LLPS-Scf-1863 | Scleropages formosus | 44.92 | 4e-74 | 238 |
| LLPS-Orn-3580 | Oreochromis niloticus | 44.9 | 9e-76 | 242 |
| LLPS-Spr-1140 | Sporisorium reilianum | 44.67 | 6e-73 | 236 |
| LLPS-Cii-1023 | Ciona intestinalis | 44.63 | 5e-64 | 212 |
| LLPS-Fud-3973 | Fukomys damarensis | 44.62 | 3e-23 | 98.6 |
| LLPS-Drm-0620 | Drosophila melanogaster | 44.55 | 7e-76 | 242 |
| LLPS-Tar-3610 | Takifugu rubripes | 44.41 | 1e-72 | 234 |
| LLPS-Mum-4784 | Mus musculus | 44.41 | 1e-72 | 234 |
| LLPS-Ten-2886 | Tetraodon nigroviridis | 44.41 | 2e-74 | 239 |
| LLPS-Aim-2966 | Ailuropoda melanoleuca | 44.27 | 3e-70 | 228 |
| LLPS-Ran-3876 | Rattus norvegicus | 44.23 | 3e-73 | 235 |
| LLPS-Orl-3320 | Oryzias latipes | 44.23 | 3e-75 | 241 |
| LLPS-Mup-1252 | Mustela putorius furo | 44.09 | 2e-70 | 228 |
| LLPS-Mod-1035 | Monodelphis domestica | 44.05 | 8e-51 | 179 |
| LLPS-Ora-2820 | Ornithorhynchus anatinus | 43.82 | 6e-52 | 179 |
| LLPS-Put-1257 | Puccinia triticina | 43.81 | 1e-65 | 216 |
| LLPS-Usm-1286 | Ustilago maydis | 43.79 | 6e-72 | 234 |
| LLPS-Dar-0792 | Danio rerio | 43.77 | 7e-74 | 237 |
| LLPS-Asm-1102 | Astyanax mexicanus | 43.63 | 2e-73 | 236 |
| LLPS-Icp-3389 | Ictalurus punctatus | 43.63 | 2e-75 | 241 |
| LLPS-Mea-3583 | Mesocricetus auratus | 43.59 | 2e-64 | 213 |
| LLPS-Caf-3188 | Canis familiaris | 43.59 | 2e-68 | 223 |
| LLPS-Pug-0037 | Puccinia graminis | 43.58 | 1e-66 | 219 |
| LLPS-Cap-1607 | Cavia porcellus | 43.31 | 3e-69 | 225 |
| LLPS-Bot-0260 | Bos taurus | 43.27 | 1e-67 | 221 |
| LLPS-Eqc-4804 | Equus caballus | 43.27 | 3e-62 | 207 |
| LLPS-Fec-4605 | Felis catus | 43.27 | 3e-67 | 220 |
| LLPS-Sah-1918 | Sarcophilus harrisii | 42.99 | 9e-66 | 216 |
| LLPS-Mel-1098 | Melampsora laricipopulina | 42.9 | 4e-71 | 231 |
| LLPS-Ict-1446 | Ictidomys tridecemlineatus | 42.86 | 4e-66 | 217 |
| LLPS-Pof-4197 | Poecilia formosa | 42.79 | 2e-41 | 149 |
| LLPS-Sus-4312 | Sus scrofa | 42.63 | 7e-63 | 209 |
| LLPS-Fia-2282 | Ficedula albicollis | 42.63 | 3e-69 | 225 |
| LLPS-Nol-4183 | Nomascus leucogenys | 42.59 | 2e-39 | 145 |
| LLPS-Urm-1057 | Ursus maritimus | 42.59 | 1e-16 | 82.4 |
| LLPS-Cae-1749 | Caenorhabditis elegans | 42.49 | 4e-67 | 219 |
| LLPS-Otg-1465 | Otolemur garnettii | 42.31 | 5e-67 | 219 |
| LLPS-Vir-0999 | Vigna radiata | 41.94 | 7e-34 | 134 |
| LLPS-Paa-2980 | Papio anubis | 41.53 | 2e-64 | 213 |
| LLPS-Cea-4603 | Cercocebus atys | 41.53 | 1e-64 | 214 |
| LLPS-Maf-1324 | Macaca fascicularis | 41.53 | 2e-64 | 213 |
| LLPS-Chs-4821 | Chlorocebus sabaeus | 41.53 | 4e-64 | 212 |
| LLPS-Poa-1684 | Pongo abelii | 41.53 | 4e-64 | 212 |
| LLPS-Man-4223 | Macaca nemestrina | 41.53 | 2e-64 | 213 |
| LLPS-Hos-2918 | Homo sapiens | 41.53 | 3e-64 | 212 |
| LLPS-Loa-0691 | Loxodonta africana | 41.48 | 4e-43 | 154 |
| LLPS-Coc-1321 | Corchorus capsularis | 41.41 | 1e-13 | 74.3 |
| LLPS-Aon-2867 | Aotus nancymaae | 41.35 | 3e-59 | 199 |
| LLPS-Pes-1615 | Pelodiscus sinensis | 41.35 | 2e-63 | 210 |
| LLPS-Pat-4074 | Pan troglodytes | 41.35 | 1e-63 | 211 |
| LLPS-Cus-1496 | Cucumis sativus | 41.28 | 4e-49 | 173 |
| LLPS-Cym-0972 | Cyanidioschyzon merolae | 41.09 | 6e-18 | 86.7 |
| LLPS-Pap-3339 | Pan paniscus | 41.03 | 3e-61 | 204 |
| LLPS-Brr-0673 | Brassica rapa | 41.0 | 4e-42 | 153 |
| LLPS-Viv-0362 | Vitis vinifera | 40.84 | 2e-52 | 181 |
| LLPS-Cis-1492 | Ciona savignyi | 40.79 | 3e-56 | 191 |
| LLPS-Hov-1710 | Hordeum vulgare | 40.62 | 2e-43 | 159 |
| LLPS-Tru-1140 | Triticum urartu | 40.62 | 5e-43 | 157 |
| LLPS-Thc-1922 | Theobroma cacao | 40.4 | 1e-53 | 184 |
| LLPS-Glm-0788 | Glycine max | 40.39 | 2e-53 | 184 |
| LLPS-Chc-0809 | Chondrus crispus | 40.38 | 6e-59 | 200 |
| LLPS-Met-1212 | Medicago truncatula | 40.33 | 3e-54 | 186 |
| LLPS-Php-1338 | Physcomitrella patens | 40.33 | 1e-47 | 170 |
| LLPS-Prp-2536 | Prunus persica | 40.2 | 8e-55 | 188 |
| LLPS-Mua-2263 | Musa acuminata | 40.19 | 2e-15 | 79.0 |
| LLPS-Arl-2071 | Arabidopsis lyrata | 40.07 | 1e-54 | 187 |
| LLPS-Phv-1843 | Phaseolus vulgaris | 40.07 | 6e-53 | 183 |
| LLPS-Gor-1624 | Gossypium raimondii | 40.07 | 5e-53 | 183 |
| LLPS-Art-2368 | Arabidopsis thaliana | 40.07 | 3e-55 | 189 |
| LLPS-Zem-0605 | Zea mays | 40.06 | 1e-50 | 177 |
| LLPS-Dac-2119 | Daucus carota | 40.0 | 8e-52 | 180 |
| LLPS-Brn-2832 | Brassica napus | 40.0 | 1e-48 | 172 |
| LLPS-Ori-1777 | Oryza indica | 39.87 | 6e-49 | 172 |
| LLPS-Orbr-2206 | Oryza brachyantha | 39.81 | 8e-52 | 181 |
| LLPS-Via-0380 | Vigna angularis | 39.74 | 1e-50 | 179 |
| LLPS-Sol-1289 | Solanum lycopersicum | 39.74 | 7e-53 | 183 |
| LLPS-Brd-2385 | Brachypodium distachyon | 39.67 | 7e-50 | 175 |
| LLPS-Amt-1710 | Amborella trichopoda | 39.56 | 2e-51 | 179 |
| LLPS-Orr-0156 | Oryza rufipogon | 39.53 | 4e-49 | 173 |
| LLPS-Ors-0172 | Oryza sativa | 39.53 | 5e-49 | 173 |
| LLPS-Pot-1812 | Populus trichocarpa | 39.41 | 4e-50 | 176 |
| LLPS-Sot-1193 | Solanum tuberosum | 39.4 | 2e-51 | 180 |
| LLPS-Sob-2544 | Sorghum bicolor | 39.33 | 8e-50 | 175 |
| LLPS-Sem-1163 | Selaginella moellendorffii | 39.22 | 8e-52 | 180 |
| LLPS-Mae-2114 | Manihot esculenta | 39.22 | 9e-51 | 177 |
| LLPS-Lep-0972 | Leersia perrieri | 39.14 | 4e-49 | 173 |
| LLPS-Sei-2442 | Setaria italica | 39.13 | 4e-51 | 178 |
| LLPS-Ova-0176 | Ovis aries | 39.1 | 4e-52 | 180 |
| LLPS-Xet-0999 | Xenopus tropicalis | 39.1 | 2e-21 | 96.7 |
| LLPS-Orgl-2222 | Oryza glumaepatula | 38.87 | 2e-49 | 174 |
| LLPS-Orni-0231 | Oryza nivara | 38.87 | 2e-49 | 174 |
| LLPS-Orb-1015 | Oryza barthii | 38.87 | 2e-49 | 174 |
| LLPS-Org-1931 | Oryza glaberrima | 38.87 | 2e-49 | 174 |
| LLPS-Bro-0578 | Brassica oleracea | 38.87 | 1e-41 | 154 |
| LLPS-Gog-3515 | Gorilla gorilla | 38.81 | 2e-43 | 156 |
| LLPS-Tra-0284 | Triticum aestivum | 38.54 | 1e-48 | 172 |
| LLPS-Orm-1967 | Oryza meridionalis | 38.54 | 1e-48 | 172 |
| LLPS-Orp-1278 | Oryza punctata | 38.54 | 4e-47 | 168 |
| LLPS-Nia-1663 | Nicotiana attenuata | 38.41 | 8e-52 | 181 |
| LLPS-Hea-2717 | Helianthus annuus | 38.03 | 3e-53 | 184 |
| LLPS-Caj-3953 | Callithrix jacchus | 37.94 | 5e-53 | 184 |
| LLPS-Gas-0657 | Galdieria sulphuraria | 37.83 | 2e-51 | 179 |
| LLPS-Chr-0469 | Chlamydomonas reinhardtii | 37.14 | 2e-54 | 187 |
| LLPS-Osl-1433 | Ostreococcus lucimarinus | 36.23 | 3e-14 | 75.9 |
| LLPS-Rhb-2066 | Rhinopithecus bieti | 34.62 | 1e-38 | 144 |
| LLPS-Mal-1632 | Mandrillus leucophaeus | 33.85 | 2e-38 | 143 |