• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fia-2282
DOHH

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Deoxyhypusine hydroxylase
Gene Name: DOHH
Ensembl Gene: ENSFALG00000011564.1
Ensembl Protein: ENSFALP00000012070.1
Organism: Ficedula albicollis
Taxa ID: 59894
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSFALT00000012119.1ENSFALP00000012070.1
UniProtU3KAL6, U3KAL6_FICAL
GeneBankAGTO01021841

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVTEQEVEAI  GRTLVDTEQP  LPTRFRALFT  LRNLGGRAAV  EWISRAFGDG  SALLKHELAF  60
61    CLGQMQDEAA  IPVLVRVLED  TAQEPMVRHE  AGEALGAIGN  PDVLDILKRY  SEDPVVEVAE  120
121   TCQLAVRRLE  WLQNNKEKGG  TSPYLSVDPA  PPAEETDVAK  LREILLDESQ  ELFDRYRAMF  180
181   ALRNVGGQAA  VLALAEGLRC  GSALFRHEIG  YVLGQLQDEA  CVPQLTAALR  SRAESPMVRH  240
241   ECAEALGSIA  RPSCLRALRA  FAGDEERVVR  ESCQVALDMY  EYENSGQFQY  ADRLCKLQA  299
Nucleotide CDS Sequence (FASTA)
1     ATGGTGACGG  AGCAGGAGGT  GGAGGCCATC  GGCCGCACGC  TGGTGGACAC  GGAGCAGCCG  60
61    CTGCCCACCC  GGTTCCGCGC  CCTCTTCACC  CTGCGGAACT  TGGGCGGCCG  CGCGGCCGTG  120
121   GAGTGGATCA  GCCGCGCCTT  TGGAGACGGC  TCGGCGCTGC  TGAAGCACGA  GCTGGCCTTT  180
181   TGCCTGGGCC  AGATGCAGGA  TGAGGCGGCC  ATCCCGGTGC  TCGTCCGCGT  GCTGGAGGAC  240
241   ACGGCCCAGG  AGCCCATGGT  CAGGCACGAG  GCAGGTGAAG  CCCTGGGCGC  TATTGGGAAC  300
301   CCTGACGTGC  TGGATATCCT  GAAACGCTAC  TCCGAGGATC  CTGTGGTCGA  GGTGGCAGAG  360
361   ACTTGTCAGC  TGGCTGTGAG  GAGGCTGGAG  TGGCTGCAGA  ACAACAAGGA  GAAGGGAGGC  420
421   ACCAGCCCGT  ACCTCTCTGT  AGATCCTGCT  CCCCCCGCTG  AGGAGACGGA  TGTGGCCAAG  480
481   CTGCGGGAGA  TCCTCCTGGA  TGAGTCCCAG  GAGCTGTTTG  ACCGCTACCG  GGCCATGTTT  540
541   GCCCTGCGGA  ACGTGGGGGG  CCAGGCTGCC  GTGCTGGCAC  TGGCAGAAGG  GCTGCGCTGC  600
601   GGCAGCGCGC  TGTTCCGCCA  CGAGATCGGG  TACGTGCTGG  GGCAGCTGCA  GGACGAGGCG  660
661   TGCGTGCCTC  AGCTGACGGC  CGCGCTGCGC  AGCCGCGCCG  AGAGCCCCAT  GGTGCGGCAC  720
721   GAGTGCGCCG  AGGCGCTGGG  CTCCATCGCC  CGGCCCTCCT  GCCTGCGCGC  CCTGCGCGCC  780
781   TTCGCCGGCG  ACGAGGAGCG  CGTGGTGCGC  GAGAGCTGCC  AGGTGGCCCT  GGACATGTAC  840
841   GAGTACGAGA  ACAGCGGCCA  GTTCCAGTAC  GCCGACAGGC  TCTGCAAGCT  GCAGGCC  897

▼ KEYWORD

ID
Family
Complete proteome
Hypusine biosynthesis
Iron
Metal-binding
Monooxygenase
Oxidoreductase
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Cofactor binding
Molecular Function
Deoxyhypusine monooxygenase activity
Molecular Function
Iron ion binding
Biological Process
Peptidyl-lysine modification to peptidyl-hypusine

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-1688Gallus gallus82.273e-177 499
LLPS-Meg-2183Meleagris gallopavo81.275e-174 491
LLPS-Pes-1615Pelodiscus sinensis79.261e-158 452
LLPS-Caf-3188Canis familiaris78.415e-165 468
LLPS-Loa-0691Loxodonta africana77.996e-109 322
LLPS-Sah-1918Sarcophilus harrisii77.853e-167 474
LLPS-Dio-4371Dipodomys ordii77.781e-56 185
LLPS-Ora-2820Ornithorhynchus anatinus77.733e-130 378
LLPS-Mup-1252Mustela putorius furo77.672e-164 467
LLPS-Sus-4312Sus scrofa77.672e-153 439
LLPS-Urm-1057Ursus maritimus77.085e-42 152
LLPS-Aon-2867Aotus nancymaae76.922e-152 436
LLPS-Fec-4605Felis catus76.599e-161 457
LLPS-Ict-1446Ictidomys tridecemlineatus76.213e-150 430
LLPS-Otg-1465Otolemur garnettii76.172e-161 459
LLPS-Mod-1035Monodelphis domestica75.952e-123 365
LLPS-Poa-1684Pongo abelii75.843e-158 451
LLPS-Pat-4074Pan troglodytes75.842e-158 451
LLPS-Maf-1324Macaca fascicularis75.842e-158 451
LLPS-Fud-3973Fukomys damarensis75.842e-71 224
LLPS-Aim-2966Ailuropoda melanoleuca75.752e-157 449
LLPS-Cap-1607Cavia porcellus75.673e-156 446
LLPS-Bot-0260Bos taurus75.678e-158 450
LLPS-Chs-4821Chlorocebus sabaeus75.591e-157 450
LLPS-Man-4223Macaca nemestrina75.51e-157 449
LLPS-Paa-2980Papio anubis75.59e-158 449
LLPS-Eqc-4804Equus caballus75.251e-148 427
LLPS-Lac-3935Latimeria chalumnae75.255e-167 473
LLPS-Ran-3876Rattus norvegicus75.255e-156 445
LLPS-Mea-3583Mesocricetus auratus75.256e-147 422
LLPS-Hos-2918Homo sapiens75.179e-157 447
LLPS-Leo-0358Lepisosteus oculatus74.924e-158 451
LLPS-Cea-4603Cercocebus atys74.921e-156 447
LLPS-Mum-4784Mus musculus74.251e-153 439
LLPS-Pap-3339Pan paniscus74.168e-151 431
LLPS-Caj-3953Callithrix jacchus70.523e-142 411
LLPS-Gog-3515Gorilla gorilla69.515e-114 337
LLPS-Scf-1863Scleropages formosus69.211e-147 424
LLPS-Icp-3389Ictalurus punctatus68.751e-144 416
LLPS-Ova-0176Ovis aries68.331e-132 385
LLPS-Dar-0792Danio rerio68.323e-145 418
LLPS-Asm-1102Astyanax mexicanus67.991e-143 414
LLPS-Orn-3580Oreochromis niloticus67.879e-141 407
LLPS-Orl-3320Oryzias latipes67.338e-139 402
LLPS-Ten-2886Tetraodon nigroviridis66.783e-133 387
LLPS-Gaa-0939Gasterosteus aculeatus65.158e-135 392
LLPS-Tar-3610Takifugu rubripes65.026e-133 387
LLPS-Pof-4197Poecilia formosa64.531e-83 258
LLPS-Xim-2008Xiphophorus maculatus64.264e-134 390
LLPS-Nol-4183Nomascus leucogenys61.132e-104 312
LLPS-Drm-0620Drosophila melanogaster60.671e-128 375
LLPS-Mal-1632Mandrillus leucophaeus59.738e-107 319
LLPS-Xet-0999Xenopus tropicalis58.762e-113 337
LLPS-Rhb-2066Rhinopithecus bieti58.721e-104 313
LLPS-Cae-1749Caenorhabditis elegans57.592e-115 342
LLPS-Cii-1023Ciona intestinalis53.791e-97 297
LLPS-Abg-1750Absidia glauca53.61e-79 266
LLPS-Tru-1140Triticum urartu53.393e-75 239
LLPS-Brr-0673Brassica rapa52.991e-71 229
LLPS-Sob-2544Sorghum bicolor52.842e-86 268
LLPS-Tra-0284Triticum aestivum52.844e-85 265
LLPS-Sei-2442Setaria italica52.844e-86 267
LLPS-Orgl-2222Oryza glumaepatula52.523e-84 263
LLPS-Orb-1015Oryza barthii52.522e-84 263
LLPS-Orni-0231Oryza nivara52.522e-84 263
LLPS-Brn-2832Brassica napus52.451e-81 256
LLPS-Viv-0362Vitis vinifera52.287e-84 262
LLPS-Amt-1710Amborella trichopoda52.281e-84 264
LLPS-Hov-1710Hordeum vulgare52.264e-75 240
LLPS-Orr-0156Oryza rufipogon52.165e-83 259
LLPS-Org-1931Oryza glaberrima52.132e-84 263
LLPS-Brd-2385Brachypodium distachyon52.139e-84 262
LLPS-Ori-1777Oryza indica52.131e-84 264
LLPS-Mel-1098Melampsora laricipopulina52.041e-86 270
LLPS-Coc-1321Corchorus capsularis52.032e-69 224
LLPS-Phv-1843Phaseolus vulgaris51.933e-84 263
LLPS-Orm-1967Oryza meridionalis51.81e-83 261
LLPS-Ors-0172Oryza sativa51.773e-83 260
LLPS-Arl-2071Arabidopsis lyrata51.583e-87 270
LLPS-Nia-1663Nicotiana attenuata51.417e-86 268
LLPS-Glm-0788Glycine max51.234e-83 259
LLPS-Yal-0539Yarrowia lipolytica51.26e-87 270
LLPS-Prp-2536Prunus persica51.062e-83 260
LLPS-Orp-1278Oryza punctata51.065e-82 257
LLPS-Art-2368Arabidopsis thaliana50.881e-86 269
LLPS-Gor-1624Gossypium raimondii50.884e-83 260
LLPS-Thc-1922Theobroma cacao50.885e-83 259
LLPS-Lep-0972Leersia perrieri50.711e-82 259
LLPS-Sol-1289Solanum lycopersicum50.71e-83 262
LLPS-Zem-0605Zea mays50.339e-83 259
LLPS-Mua-2263Musa acuminata50.192e-68 221
LLPS-Bro-0578Brassica oleracea50.181e-74 239
LLPS-Met-1212Medicago truncatula50.182e-83 260
LLPS-Cus-1496Cucumis sativus50.184e-76 242
LLPS-Mae-2114Manihot esculenta50.171e-83 261
LLPS-Chr-0469Chlamydomonas reinhardtii50.02e-92 284
LLPS-Dac-2119Daucus carota50.08e-84 261
LLPS-Map-1169Magnaporthe poae50.05e-54 182
LLPS-Miv-0999Microbotryum violaceum49.662e-88 274
LLPS-Via-0380Vigna angularis49.669e-81 256
LLPS-Pot-1812Populus trichocarpa49.652e-80 253
LLPS-Sot-1193Solanum tuberosum49.651e-81 256
LLPS-Kop-0859Komagataella pastoris49.482e-88 273
LLPS-Orbr-2206Oryza brachyantha49.335e-81 255
LLPS-Hea-2717Helianthus annuus49.323e-85 265
LLPS-Ved-0856Verticillium dahliae49.21e-78 249
LLPS-Sac-0010Saccharomyces cerevisiae48.961e-85 267
LLPS-Beb-1196Beauveria bassiana48.692e-80 253
LLPS-Scp-1140Schizosaccharomyces pombe48.372e-85 266
LLPS-Lem-0395Leptosphaeria maculans48.269e-75 239
LLPS-Coo-0911Colletotrichum orbiculare48.015e-76 243
LLPS-Cogr-0193Colletotrichum graminicola47.99e-73 234
LLPS-Fus-1090Fusarium solani47.883e-77 245
LLPS-Cis-1492Ciona savignyi47.755e-93 285
LLPS-Pytr-1545Pyrenophora triticirepentis47.638e-78 246
LLPS-Pyt-0976Pyrenophora teres47.631e-77 246
LLPS-Trv-0317Trichoderma virens47.563e-72 232
LLPS-Pug-0037Puccinia graminis47.526e-81 255
LLPS-Nec-0510Neurospora crassa47.423e-77 245
LLPS-Gag-0826Gaeumannomyces graminis47.421e-72 233
LLPS-Asg-1046Ashbya gossypii47.394e-73 234
LLPS-Scc-0003Schizosaccharomyces cryophilus47.188e-82 256
LLPS-Sem-1163Selaginella moellendorffii47.029e-74 236
LLPS-Mao-0641Magnaporthe oryzae46.962e-75 241
LLPS-Scj-0357Schizosaccharomyces japonicus46.914e-83 260
LLPS-Tum-0081Tuber melanosporum46.896e-75 239
LLPS-Fuo-0385Fusarium oxysporum46.652e-76 243
LLPS-Fuv-0156Fusarium verticillioides46.652e-76 243
LLPS-Nef-0946Neosartorya fischeri46.569e-75 239
LLPS-Put-1257Puccinia triticina46.444e-78 248
LLPS-Phn-1113Phaeosphaeria nodorum46.373e-75 240
LLPS-Crn-1049Cryptococcus neoformans46.342e-77 247
LLPS-Scs-0550Sclerotinia sclerotiorum46.234e-70 227
LLPS-Php-1338Physcomitrella patens46.213e-71 230
LLPS-Asc-1136Aspergillus clavatus45.812e-73 236
LLPS-Trr-1483Trichoderma reesei45.785e-73 234
LLPS-Zyt-1143Zymoseptoria tritici45.484e-70 227
LLPS-Blg-1515Blumeria graminis44.638e-78 246
LLPS-Asni-1604Aspergillus niger44.582e-71 231
LLPS-Dos-0912Dothistroma septosporum44.272e-70 228
LLPS-Ast-0523Aspergillus terreus44.091e-66 218
LLPS-Asn-1294Aspergillus nidulans44.097e-73 234
LLPS-Cog-1246Colletotrichum gloeosporioides44.051e-61 204
LLPS-Chc-0809Chondrus crispus43.931e-77 247
LLPS-Osl-1433Ostreococcus lucimarinus43.059e-53 181
LLPS-Asf-0737Aspergillus flavus42.819e-70 226
LLPS-Vir-0999Vigna radiata42.353e-53 185
LLPS-Cym-0972Cyanidioschyzon merolae42.312e-55 188
LLPS-Spr-1140Sporisorium reilianum41.573e-67 220
LLPS-Asfu-1326Aspergillus fumigatus41.524e-70 228
LLPS-Gas-0657Galdieria sulphuraria41.051e-61 204
LLPS-Usm-1286Ustilago maydis41.042e-67 221
LLPS-Aso-1161Aspergillus oryzae40.242e-63 210