LLPS-Urm-0656
HIBCH
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase |
| Gene Name: | HIBCH |
| Ensembl Gene: | ENSUMAG00000019133.1 |
| Ensembl Protein: | ENSUMAP00000026277.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000031108.1 | ENSUMAP00000026277.1 |
| UniProt | A0A384BSC3, A0A384BSC3_URSMA | |
| RefSeq | , XM_008687264.1 | , XP_008685486.1, XP_008685486.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGLQQVWRLM SRFNSFKRTN IILQHLRMSK HTDAVEVLLE RKGCAGVITL NRPKFLNALN 60 61 LSMIRHIYPQ LKNWEQDPET FLIIIKGAGG KAFCAGGDIR AISEAGGANQ KIAQDFFREE 120 121 YMLNNAIGSC RKPYVALIHG ITMGGGVGLS VHGQFRVATE KSLFAMPETA IGLFPDVGGG 180 181 YFLPRLQGEL GYFLALTGFR LKGRDVYVAG IATHFVDSEK LGMLEEDLLA LKAPSKENIA 240 241 DVLDAYHAKS KIDQDKSFIL EEHMDKINSW FSANTVEQIV ENLQQDGSSF ALEQLKVINK 300 301 MSPTSLKITL RQLKEGSSKT LQEVLTMEYR LSQACMGGHD FYEGVRAVLI DKDQSPKWKP 360 361 ADLKEVTDED LNNYFKSLGS NDLKF 385 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGCTGC AGCAGGTGTG GAGGCTCATG TCGAGGTTTA ATTCATTCAA AAGGACTAAT 60 61 ATCATACTGC AACATTTGAG AATGTCTAAG CACACGGATG CAGTGGAAGT ACTGTTGGAA 120 121 AGAAAAGGTT GTGCGGGAGT GATAACACTA AACAGACCAA AGTTCCTAAA TGCTCTGAAT 180 181 CTTAGTATGA TTCGGCACAT TTATCCACAG CTAAAGAATT GGGAACAAGA TCCTGAAACT 240 241 TTCCTGATCA TTATAAAAGG AGCTGGAGGA AAGGCTTTCT GTGCTGGGGG TGATATCAGA 300 301 GCAATCTCTG AAGCTGGAGG GGCAAACCAG AAGATAGCTC AAGATTTCTT TAGAGAAGAA 360 361 TATATGCTGA ACAATGCCAT TGGTTCTTGC CGGAAACCGT ATGTTGCACT TATTCATGGA 420 421 ATTACGATGG GTGGGGGAGT TGGTCTCTCA GTTCATGGGC AATTCCGAGT GGCCACAGAA 480 481 AAGTCTCTTT TTGCGATGCC AGAAACAGCA ATAGGACTGT TCCCTGATGT GGGTGGAGGT 540 541 TATTTCTTGC CACGACTTCA AGGAGAACTT GGTTACTTCC TTGCATTGAC GGGATTCAGG 600 601 CTGAAAGGAA GAGATGTGTA TGTAGCAGGA ATTGCTACAC ATTTTGTAGA TTCTGAAAAG 660 661 TTGGGCATGT TAGAAGAAGA TTTGTTAGCC CTAAAAGCTC CTTCAAAGGA AAATATTGCA 720 721 GATGTCTTAG ATGCTTACCA TGCAAAGTCC AAGATTGATC AAGACAAGTC TTTTATACTT 780 781 GAGGAACACA TGGACAAAAT AAACAGTTGG TTCTCAGCCA ATACTGTGGA ACAGATAGTT 840 841 GAAAATTTAC AGCAAGATGG TTCATCTTTT GCCCTAGAAC AGTTGAAGGT AATTAATAAA 900 901 ATGTCTCCAA CATCCCTAAA GATCACACTA AGGCAACTCA AAGAGGGGTC TTCAAAGACC 960 961 TTACAAGAAG TATTAACTAT GGAATATCGG CTGAGTCAAG CTTGTATGGG AGGCCATGAC 1020 1021 TTTTATGAAG GTGTCAGGGC AGTTTTAATA GATAAAGACC AGAGTCCAAA GTGGAAACCA 1080 1081 GCTGATCTAA AAGAAGTTAC TGATGAAGAT TTGAATAATT ACTTTAAATC TCTGGGAAGT 1140 1141 AATGATTTGA AATTTTAA 1158 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | 3-hydroxyisobutyryl-CoA hydrolase activity | |
Biological Process | Valine catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-0188 | Ailuropoda melanoleuca | 95.0 | 1e-162 | 463 |
| LLPS-Mup-1465 | Mustela putorius furo | 94.47 | 0.0 | 716 |
| LLPS-Caf-1512 | Canis familiaris | 90.98 | 0.0 | 666 |
| LLPS-Fec-2804 | Felis catus | 90.93 | 0.0 | 669 |
| LLPS-Otg-0273 | Otolemur garnettii | 90.23 | 7e-138 | 399 |
| LLPS-Ova-2588 | Ovis aries | 89.64 | 0.0 | 660 |
| LLPS-Pat-4296 | Pan troglodytes | 89.12 | 0.0 | 675 |
| LLPS-Man-3550 | Macaca nemestrina | 88.86 | 0.0 | 672 |
| LLPS-Hos-0953 | Homo sapiens | 88.86 | 0.0 | 673 |
| LLPS-Poa-0150 | Pongo abelii | 88.86 | 0.0 | 673 |
| LLPS-Maf-3130 | Macaca fascicularis | 88.86 | 0.0 | 672 |
| LLPS-Nol-4001 | Nomascus leucogenys | 88.6 | 0.0 | 672 |
| LLPS-Gog-0230 | Gorilla gorilla | 88.6 | 0.0 | 672 |
| LLPS-Sus-4180 | Sus scrofa | 88.6 | 0.0 | 676 |
| LLPS-Paa-4595 | Papio anubis | 88.24 | 0.0 | 642 |
| LLPS-Loa-2743 | Loxodonta africana | 87.8 | 0.0 | 648 |
| LLPS-Mam-1749 | Macaca mulatta | 87.66 | 0.0 | 654 |
| LLPS-Pap-4569 | Pan paniscus | 87.54 | 7e-177 | 501 |
| LLPS-Rhb-3883 | Rhinopithecus bieti | 87.36 | 0.0 | 591 |
| LLPS-Cea-1129 | Cercocebus atys | 87.31 | 0.0 | 661 |
| LLPS-Mal-1900 | Mandrillus leucophaeus | 87.31 | 0.0 | 661 |
| LLPS-Chs-1006 | Chlorocebus sabaeus | 87.07 | 0.0 | 589 |
| LLPS-Caj-4382 | Callithrix jacchus | 87.01 | 0.0 | 665 |
| LLPS-Aon-0536 | Aotus nancymaae | 86.79 | 0.0 | 657 |
| LLPS-Cas-2167 | Carlito syrichta | 85.71 | 5e-170 | 484 |
| LLPS-Orc-3621 | Oryctolagus cuniculus | 84.97 | 0.0 | 625 |
| LLPS-Bot-1862 | Bos taurus | 84.78 | 0.0 | 602 |
| LLPS-Eqc-4263 | Equus caballus | 84.7 | 0.0 | 592 |
| LLPS-Myl-2978 | Myotis lucifugus | 84.25 | 0.0 | 607 |
| LLPS-Mea-2210 | Mesocricetus auratus | 84.12 | 0.0 | 589 |
| LLPS-Ict-3568 | Ictidomys tridecemlineatus | 82.9 | 0.0 | 630 |
| LLPS-Ran-4626 | Rattus norvegicus | 82.6 | 0.0 | 635 |
| LLPS-Mum-3552 | Mus musculus | 81.82 | 0.0 | 632 |
| LLPS-Sah-2128 | Sarcophilus harrisii | 81.65 | 0.0 | 607 |
| LLPS-Fud-1423 | Fukomys damarensis | 80.95 | 0.0 | 539 |
| LLPS-Dio-0082 | Dipodomys ordii | 80.86 | 0.0 | 588 |
| LLPS-Cap-3013 | Cavia porcellus | 78.12 | 0.0 | 567 |
| LLPS-Pes-1335 | Pelodiscus sinensis | 77.02 | 0.0 | 582 |
| LLPS-Mod-4328 | Monodelphis domestica | 76.68 | 0.0 | 564 |
| LLPS-Tag-0074 | Taeniopygia guttata | 75.2 | 0.0 | 534 |
| LLPS-Fia-3838 | Ficedula albicollis | 73.4 | 0.0 | 525 |
| LLPS-Anp-3164 | Anas platyrhynchos | 73.35 | 0.0 | 533 |
| LLPS-Anc-1201 | Anolis carolinensis | 72.94 | 0.0 | 533 |
| LLPS-Meg-0328 | Meleagris gallopavo | 72.73 | 0.0 | 553 |
| LLPS-Xet-2957 | Xenopus tropicalis | 72.53 | 0.0 | 533 |
| LLPS-Gaga-2658 | Gallus gallus | 72.0 | 0.0 | 546 |
| LLPS-Lac-2939 | Latimeria chalumnae | 71.61 | 0.0 | 546 |
| LLPS-Leo-3624 | Lepisosteus oculatus | 70.48 | 3e-177 | 506 |
| LLPS-Scf-2903 | Scleropages formosus | 67.38 | 7e-171 | 489 |
| LLPS-Orn-1447 | Oreochromis niloticus | 67.2 | 2e-171 | 491 |
| LLPS-Orl-2685 | Oryzias latipes | 66.67 | 2e-155 | 451 |
| LLPS-Icp-1799 | Ictalurus punctatus | 66.23 | 1e-169 | 487 |
| LLPS-Dar-3829 | Danio rerio | 66.04 | 2e-165 | 476 |
| LLPS-Gaa-3417 | Gasterosteus aculeatus | 65.78 | 3e-168 | 483 |
| LLPS-Asm-3282 | Astyanax mexicanus | 65.35 | 1e-171 | 492 |
| LLPS-Ora-3331 | Ornithorhynchus anatinus | 65.25 | 6e-31 | 119 |
| LLPS-Xim-2664 | Xiphophorus maculatus | 64.72 | 8e-139 | 409 |
| LLPS-Scm-0981 | Scophthalmus maximus | 64.44 | 5e-164 | 472 |
| LLPS-Pof-0448 | Poecilia formosa | 63.64 | 8e-164 | 472 |
| LLPS-Ten-2922 | Tetraodon nigroviridis | 63.03 | 8e-165 | 474 |
| LLPS-Tar-2589 | Takifugu rubripes | 60.55 | 4e-158 | 458 |
| LLPS-Cii-2397 | Ciona intestinalis | 59.94 | 9e-129 | 382 |
| LLPS-Cis-0744 | Ciona savignyi | 59.06 | 3e-128 | 382 |
| LLPS-Drm-1049 | Drosophila melanogaster | 52.41 | 4e-111 | 337 |
| LLPS-Cae-1991 | Caenorhabditis elegans | 50.56 | 4e-110 | 335 |
| LLPS-Zyt-1021 | Zymoseptoria tritici | 47.98 | 2e-50 | 176 |
| LLPS-Php-2169 | Physcomitrella patens | 44.54 | 1e-76 | 249 |
| LLPS-Asn-1050 | Aspergillus nidulans | 43.27 | 6e-75 | 248 |
| LLPS-Gas-0425 | Galdieria sulphuraria | 43.27 | 3e-76 | 248 |
| LLPS-Viv-0428 | Vitis vinifera | 43.07 | 1e-69 | 229 |
| LLPS-Asfu-1406 | Aspergillus fumigatus | 42.44 | 2e-72 | 243 |
| LLPS-Asni-1073 | Aspergillus niger | 42.25 | 1e-72 | 241 |
| LLPS-Ast-1572 | Aspergillus terreus | 42.15 | 4e-72 | 239 |
| LLPS-Nef-1525 | Neosartorya fischeri | 41.86 | 2e-72 | 240 |
| LLPS-Asc-1135 | Aspergillus clavatus | 41.86 | 6e-73 | 241 |
| LLPS-Mao-1200 | Magnaporthe oryzae | 41.83 | 1e-65 | 223 |
| LLPS-Met-1091 | Medicago truncatula | 41.76 | 7e-77 | 249 |
| LLPS-Orbr-1831 | Oryza brachyantha | 41.71 | 2e-79 | 256 |
| LLPS-Trr-0720 | Trichoderma reesei | 41.67 | 6e-69 | 231 |
| LLPS-Nec-1202 | Neurospora crassa | 41.59 | 1e-64 | 221 |
| LLPS-Trv-0743 | Trichoderma virens | 41.45 | 4e-69 | 232 |
| LLPS-Aso-0894 | Aspergillus oryzae | 41.45 | 5e-70 | 234 |
| LLPS-Abg-1463 | Absidia glauca | 41.43 | 2e-76 | 251 |
| LLPS-Hov-0146 | Hordeum vulgare | 41.41 | 1e-79 | 257 |
| LLPS-Coo-1542 | Colletotrichum orbiculare | 41.37 | 2e-68 | 230 |
| LLPS-Asf-1574 | Aspergillus flavus | 41.28 | 3e-70 | 235 |
| LLPS-Zem-1409 | Zea mays | 41.14 | 8e-79 | 254 |
| LLPS-Blg-0922 | Blumeria graminis | 41.08 | 2e-66 | 227 |
| LLPS-Yal-0151 | Yarrowia lipolytica | 41.0 | 1e-67 | 228 |
| LLPS-Sei-2004 | Setaria italica | 40.85 | 1e-77 | 253 |
| LLPS-Glm-2563 | Glycine max | 40.78 | 2e-79 | 256 |
| LLPS-Phv-2462 | Phaseolus vulgaris | 40.74 | 1e-78 | 254 |
| LLPS-Tum-1391 | Tuber melanosporum | 40.71 | 8e-71 | 236 |
| LLPS-Ved-1589 | Verticillium dahliae | 40.54 | 2e-64 | 219 |
| LLPS-Sob-2220 | Sorghum bicolor | 40.51 | 3e-75 | 245 |
| LLPS-Sol-1247 | Solanum lycopersicum | 40.34 | 3e-76 | 248 |
| LLPS-Amt-1048 | Amborella trichopoda | 40.29 | 1e-77 | 251 |
| LLPS-Orp-0682 | Oryza punctata | 40.28 | 9e-81 | 259 |
| LLPS-Cog-0938 | Colletotrichum gloeosporioides | 40.22 | 1e-70 | 236 |
| LLPS-Gor-2490 | Gossypium raimondii | 40.17 | 6e-79 | 254 |
| LLPS-Via-1371 | Vigna angularis | 40.17 | 7e-75 | 251 |
| LLPS-Brr-2685 | Brassica rapa | 40.16 | 2e-83 | 266 |
| LLPS-Brn-1749 | Brassica napus | 40.16 | 2e-83 | 266 |
| LLPS-Fuv-1514 | Fusarium verticillioides | 40.16 | 8e-70 | 234 |
| LLPS-Tru-0333 | Triticum urartu | 40.15 | 1e-52 | 186 |
| LLPS-Hea-2382 | Helianthus annuus | 40.06 | 8e-79 | 254 |
| LLPS-Pot-1001 | Populus trichocarpa | 40.0 | 3e-75 | 245 |
| LLPS-Ors-2367 | Oryza sativa | 40.0 | 2e-77 | 254 |
| LLPS-Orni-1539 | Oryza nivara | 40.0 | 5e-77 | 254 |
| LLPS-Ori-1383 | Oryza indica | 40.0 | 1e-74 | 245 |
| LLPS-Fus-0994 | Fusarium solani | 39.94 | 1e-68 | 230 |
| LLPS-Bro-0818 | Brassica oleracea | 39.94 | 2e-81 | 261 |
| LLPS-Fuo-1575 | Fusarium oxysporum | 39.89 | 4e-70 | 235 |
| LLPS-Put-1348 | Puccinia triticina | 39.84 | 5e-65 | 230 |
| LLPS-Mua-0263 | Musa acuminata | 39.84 | 1e-76 | 249 |
| LLPS-Beb-1647 | Beauveria bassiana | 39.83 | 3e-64 | 219 |
| LLPS-Thc-0843 | Theobroma cacao | 39.83 | 5e-80 | 257 |
| LLPS-Orb-1124 | Oryza barthii | 39.83 | 9e-79 | 254 |
| LLPS-Orgl-2111 | Oryza glumaepatula | 39.83 | 1e-79 | 256 |
| LLPS-Org-2126 | Oryza glaberrima | 39.71 | 2e-77 | 253 |
| LLPS-Cus-1070 | Cucumis sativus | 39.66 | 8e-73 | 238 |
| LLPS-Dos-1489 | Dothistroma septosporum | 39.62 | 1e-70 | 236 |
| LLPS-Nia-0166 | Nicotiana attenuata | 39.55 | 4e-76 | 247 |
| LLPS-Mae-0366 | Manihot esculenta | 39.54 | 4e-77 | 249 |
| LLPS-Mel-1309 | Melampsora laricipopulina | 39.54 | 1e-59 | 207 |
| LLPS-Orr-1956 | Oryza rufipogon | 39.44 | 9e-77 | 255 |
| LLPS-Brd-2460 | Brachypodium distachyon | 39.43 | 7e-78 | 251 |
| LLPS-Arl-2879 | Arabidopsis lyrata | 39.35 | 1e-81 | 261 |
| LLPS-Cogr-0909 | Colletotrichum graminicola | 39.32 | 8e-66 | 223 |
| LLPS-Art-2956 | Arabidopsis thaliana | 39.19 | 1e-80 | 259 |
| LLPS-Gag-1303 | Gaeumannomyces graminis | 39.19 | 7e-67 | 226 |
| LLPS-Tra-2061 | Triticum aestivum | 39.01 | 2e-75 | 245 |
| LLPS-Prp-0021 | Prunus persica | 38.97 | 5e-75 | 244 |
| LLPS-Chc-0825 | Chondrus crispus | 38.97 | 4e-64 | 218 |
| LLPS-Miv-0680 | Microbotryum violaceum | 38.5 | 4e-61 | 212 |
| LLPS-Dac-2346 | Daucus carota | 38.42 | 7e-73 | 238 |
| LLPS-Pug-1348 | Puccinia graminis | 38.21 | 5e-63 | 217 |
| LLPS-Pytr-0954 | Pyrenophora triticirepentis | 38.21 | 5e-66 | 223 |
| LLPS-Vir-2074 | Vigna radiata | 37.78 | 1e-67 | 224 |
| LLPS-Scs-0876 | Sclerotinia sclerotiorum | 37.77 | 7e-66 | 224 |
| LLPS-Sem-1765 | Selaginella moellendorffii | 37.69 | 4e-63 | 213 |
| LLPS-Lem-1245 | Leptosphaeria maculans | 37.67 | 1e-62 | 220 |
| LLPS-Scp-1654 | Schizosaccharomyces pombe | 37.64 | 7e-54 | 190 |
| LLPS-Pyt-1639 | Pyrenophora teres | 37.63 | 2e-64 | 219 |
| LLPS-Coc-1911 | Corchorus capsularis | 37.57 | 3e-74 | 243 |
| LLPS-Sot-1237 | Solanum tuberosum | 37.57 | 3e-72 | 237 |
| LLPS-Kop-0210 | Komagataella pastoris | 37.14 | 1e-51 | 186 |
| LLPS-Lep-0185 | Leersia perrieri | 36.8 | 2e-59 | 204 |
| LLPS-Orm-1432 | Oryza meridionalis | 36.26 | 5e-50 | 178 |
| LLPS-Osl-0876 | Ostreococcus lucimarinus | 35.42 | 1e-42 | 157 |
| LLPS-Sac-1282 | Saccharomyces cerevisiae | 35.03 | 2e-47 | 174 |
| LLPS-Scc-0311 | Schizosaccharomyces cryophilus | 34.78 | 2e-49 | 178 |
| LLPS-Chr-1459 | Chlamydomonas reinhardtii | 34.78 | 4e-60 | 206 |
| LLPS-Asg-1473 | Ashbya gossypii | 34.47 | 2e-42 | 160 |
| LLPS-Scj-1055 | Schizosaccharomyces japonicus | 33.79 | 2e-52 | 185 |
| LLPS-Cym-0629 | Cyanidioschyzon merolae | 33.33 | 3e-06 | 53.9 |
| LLPS-Phn-1482 | Phaeosphaeria nodorum | 33.24 | 3e-53 | 189 |
| LLPS-Spr-0544 | Sporisorium reilianum | 32.92 | 8e-41 | 156 |
| LLPS-Usm-0068 | Ustilago maydis | 31.58 | 4e-39 | 151 |
| LLPS-Crn-0044 | Cryptococcus neoformans | 30.43 | 4e-43 | 162 |