• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Poa-0150
HIBCH

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase
Gene Name: HIBCH, CR201_G0007356
Ensembl Gene: ENSPPYG00000013021.2
Ensembl Protein: ENSPPYP00000014547.2
Organism: Pongo abelii
Taxa ID: 9601
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQREVWRIM  SRFNAFKRTN  TILHHLRMSK  HTDAAEDVLL  EKKGCAGVIT  LNRPKFLNAL  60
61    TLNMIQKIYP  QLKKWEQDPE  TFLIIIKGAG  GKAFCAGGDI  RVISEAEKAK  QKIAPVFFRE  120
121   EYMLNNAVGS  CQKPYVALIH  GITMGGGVGL  SVHGQFRVAT  EKCLFAMPET  AIGLFPDVGG  180
181   GYFLPRLQGK  LGYFLALTGF  RLKGRDVYRA  GIATHFVDSE  KLAMLEEDLL  ALKSPSKENI  240
241   ASVLENYHTE  SKIDRDKSFI  LEEHMDKINS  CFSANTVEEI  IENLQQDGSS  FALEQLKVIN  300
301   KMSPTSLKIT  LRQLMEGSSK  TLQEVLTMEY  RLSQACMRGH  DFHEGVRAVL  IDKDQSPKWK  360
361   PADLKEVTEE  DLNNHFKSLG  SSDLKF  386
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGC  GGGAGGTGTG  GAGGATCATG  TCGAGGTTTA  ATGCATTCAA  AAGGACTAAT  60
61    ACCATACTGC  ACCATTTGAG  AATGTCCAAG  CACACAGATG  CAGCAGAAGA  TGTGCTATTG  120
121   GAAAAAAAAG  GTTGTGCGGG  AGTCATAACA  CTAAACAGAC  CAAAGTTCCT  CAATGCACTG  180
181   ACTCTTAATA  TGATTCAGAA  GATTTATCCA  CAGCTGAAGA  AGTGGGAACA  AGATCCTGAA  240
241   ACTTTCCTGA  TCATTATAAA  GGGAGCTGGA  GGAAAGGCTT  TCTGTGCTGG  GGGTGATATC  300
301   AGAGTGATCT  CGGAAGCTGA  AAAGGCAAAA  CAGAAGATAG  CTCCAGTTTT  CTTCAGAGAA  360
361   GAATATATGC  TGAACAATGC  TGTTGGTTCT  TGCCAGAAAC  CTTATGTTGC  ACTTATTCAT  420
421   GGAATTACAA  TGGGTGGGGG  AGTTGGTCTC  TCAGTCCATG  GGCAATTTCG  AGTGGCTACA  480
481   GAAAAATGTC  TTTTTGCTAT  GCCAGAAACT  GCAATAGGAC  TGTTCCCTGA  TGTGGGTGGA  540
541   GGTTATTTCT  TGCCACGACT  CCAAGGAAAA  CTTGGTTACT  TCCTTGCATT  AACAGGATTC  600
601   AGACTAAAAG  GAAGAGATGT  GTACAGAGCA  GGAATTGCTA  CACACTTTGT  AGATTCTGAA  660
661   AAGTTGGCCA  TGTTAGAGGA  AGATTTGTTA  GCCTTGAAAT  CTCCTTCAAA  AGAAAATATT  720
721   GCATCTGTCT  TAGAAAATTA  CCATACAGAG  TCTAAGATTG  ATCGGGACAA  GTCTTTTATA  780
781   CTTGAGGAAC  ACATGGACAA  AATAAACAGT  TGTTTTTCAG  CCAATACTGT  GGAAGAAATT  840
841   ATTGAAAACT  TACAGCAAGA  TGGTTCATCT  TTTGCCCTAG  AGCAATTGAA  GGTAATTAAT  900
901   AAAATGTCTC  CAACATCTCT  AAAGATCACT  CTAAGGCAAC  TCATGGAGGG  GTCTTCAAAG  960
961   ACCTTGCAAG  AAGTACTAAC  TATGGAGTAT  CGGCTAAGTC  AAGCTTGTAT  GAGAGGTCAT  1020
1021  GACTTTCATG  AAGGCGTTAG  AGCTGTTTTA  ATTGATAAAG  ACCAGAGTCC  AAAATGGAAA  1080
1081  CCAGCTGATC  TAAAAGAAGT  TACTGAGGAA  GATTTGAATA  ATCACTTTAA  GTCTTTGGGA  1140
1141  AGCAGTGATT  TGAAATTTTG  A  1161

▼ KEYWORD

ID
Family
Branched-chain amino acid catabolism
Complete proteome
Hydrolase
Mitochondrion
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process
Valine catabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-4296Pan troglodytes98.70.0 758
LLPS-Hos-0953Homo sapiens98.450.0 756
LLPS-Gog-0230Gorilla gorilla98.190.0 754
LLPS-Nol-4001Nomascus leucogenys98.190.0 754
LLPS-Pap-4569Pan paniscus97.980.0 572
LLPS-Maf-3130Macaca fascicularis97.670.0 751
LLPS-Man-3550Macaca nemestrina97.670.0 751
LLPS-Rhb-3883Rhinopithecus bieti97.410.0 671
LLPS-Chs-1006Chlorocebus sabaeus97.130.0 669
LLPS-Paa-4595Papio anubis96.520.0 715
LLPS-Mam-1749Macaca mulatta96.330.0 727
LLPS-Cea-1129Cercocebus atys95.60.0 739
LLPS-Mal-1900Mandrillus leucophaeus95.60.0 739
LLPS-Otg-0273Otolemur garnettii93.022e-144 416
LLPS-Aon-0536Aotus nancymaae92.490.0 715
LLPS-Caj-4382Callithrix jacchus91.970.0 711
LLPS-Urm-0656Ursus maritimus88.860.0 674
LLPS-Aim-0188Ailuropoda melanoleuca88.755e-151 434
LLPS-Fec-2804Felis catus88.080.0 645
LLPS-Mup-1465Mustela putorius furo87.930.0 658
LLPS-Cas-2167Carlito syrichta87.462e-174 495
LLPS-Sus-4180Sus scrofa87.310.0 665
LLPS-Caf-1512Canis familiaris87.00.0 634
LLPS-Bot-1862Bos taurus85.00.0 582
LLPS-Ova-2588Ovis aries84.970.0 631
LLPS-Loa-2743Loxodonta africana84.880.0 629
LLPS-Mea-2210Mesocricetus auratus84.720.0 596
LLPS-Orc-3621Oryctolagus cuniculus84.20.0 622
LLPS-Ict-3568Ictidomys tridecemlineatus84.20.0 656
LLPS-Eqc-4263Equus caballus83.650.0 585
LLPS-Fud-1423Fukomys damarensis82.630.0 556
LLPS-Ran-4626Rattus norvegicus81.350.0 632
LLPS-Dio-0082Dipodomys ordii81.130.0 597
LLPS-Myl-2978Myotis lucifugus81.10.0 588
LLPS-Mum-3552Mus musculus81.090.0 633
LLPS-Sah-2128Sarcophilus harrisii79.260.0 595
LLPS-Cap-3013Cavia porcellus77.60.0 573
LLPS-Pes-1335Pelodiscus sinensis74.670.0 561
LLPS-Mod-4328Monodelphis domestica73.580.0 541
LLPS-Tag-0074Taeniopygia guttata73.330.0 519
LLPS-Meg-0328Meleagris gallopavo72.780.0 550
LLPS-Fia-3838Ficedula albicollis72.341e-178 511
LLPS-Gaga-2658Gallus gallus71.20.0 541
LLPS-Anc-1201Anolis carolinensis70.820.0 517
LLPS-Anp-3164Anas platyrhynchos70.630.0 523
LLPS-Lac-2939Latimeria chalumnae69.350.0 532
LLPS-Xet-2957Xenopus tropicalis69.331e-179 512
LLPS-Icp-1799Ictalurus punctatus69.121e-166 479
LLPS-Leo-3624Lepisosteus oculatus68.626e-175 500
LLPS-Asm-3282Astyanax mexicanus66.943e-170 488
LLPS-Orl-2685Oryzias latipes65.682e-152 443
LLPS-Orn-1447Oreochromis niloticus65.422e-166 479
LLPS-Dar-3829Danio rerio65.251e-166 479
LLPS-Gaa-3417Gasterosteus aculeatus65.073e-167 481
LLPS-Scf-2903Scleropages formosus65.072e-165 476
LLPS-Scm-0981Scophthalmus maximus62.939e-160 461
LLPS-Pof-0448Poecilia formosa62.673e-161 465
LLPS-Ten-2922Tetraodon nigroviridis62.52e-165 476
LLPS-Ora-3331Ornithorhynchus anatinus62.181e-29 116
LLPS-Tar-2589Takifugu rubripes60.42e-159 462
LLPS-Cis-0744Ciona savignyi59.715e-131 389
LLPS-Cii-2397Ciona intestinalis59.142e-130 387
LLPS-Xim-2664Xiphophorus maculatus56.691e-135 400
LLPS-Drm-1049Drosophila melanogaster52.291e-108 331
LLPS-Zyt-1021Zymoseptoria tritici48.02e-46 166
LLPS-Cae-1991Caenorhabditis elegans47.444e-107 327
LLPS-Php-2169Physcomitrella patens43.373e-79 256
LLPS-Gas-0425Galdieria sulphuraria42.982e-76 248
LLPS-Viv-0428Vitis vinifera42.916e-71 233
LLPS-Asni-1073Aspergillus niger42.628e-73 241
LLPS-Tum-1391Tuber melanosporum42.423e-73 242
LLPS-Orbr-1831Oryza brachyantha41.834e-81 260
LLPS-Fuv-1514Fusarium verticillioides41.718e-71 237
LLPS-Blg-0922Blumeria graminis41.672e-67 229
LLPS-Ori-1383Oryza indica41.572e-75 247
LLPS-Trr-0720Trichoderma reesei41.555e-71 236
LLPS-Phv-2462Phaseolus vulgaris41.386e-78 252
LLPS-Orp-0682Oryza punctata41.295e-80 257
LLPS-Trv-0743Trichoderma virens41.262e-70 235
LLPS-Yal-0151Yarrowia lipolytica41.186e-63 215
LLPS-Fuo-1575Fusarium oxysporum41.161e-70 236
LLPS-Tru-0333Triticum urartu40.961e-52 186
LLPS-Amt-1048Amborella trichopoda40.754e-77 249
LLPS-Met-1091Medicago truncatula40.723e-77 250
LLPS-Orb-1124Oryza barthii40.692e-79 256
LLPS-Zem-1409Zea mays40.695e-77 249
LLPS-Cog-0938Colletotrichum gloeosporioides40.662e-72 240
LLPS-Orgl-2111Oryza glumaepatula40.627e-80 257
LLPS-Nec-1202Neurospora crassa40.622e-65 223
LLPS-Sob-2220Sorghum bicolor40.622e-75 245
LLPS-Coo-1542Colletotrichum orbiculare40.565e-70 234
LLPS-Glm-2563Glycine max40.458e-79 254
LLPS-Via-1371Vigna angularis40.41e-74 250
LLPS-Asn-1050Aspergillus nidulans40.396e-71 237
LLPS-Dac-2346Daucus carota40.281e-75 246
LLPS-Mua-0263Musa acuminata40.279e-78 252
LLPS-Orni-1539Oryza nivara40.273e-77 255
LLPS-Ors-2367Oryza sativa40.271e-77 255
LLPS-Orr-1956Oryza rufipogon40.226e-77 255
LLPS-Art-2956Arabidopsis thaliana40.172e-81 261
LLPS-Gor-2490Gossypium raimondii40.161e-79 256
LLPS-Cus-1070Cucumis sativus40.112e-73 240
LLPS-Ast-1572Aspergillus terreus40.114e-68 229
LLPS-Asfu-1406Aspergillus fumigatus40.112e-67 230
LLPS-Hea-2382Helianthus annuus40.062e-78 253
LLPS-Sei-2004Setaria italica40.062e-76 250
LLPS-Fus-0994Fusarium solani40.061e-71 238
LLPS-Brn-1749Brassica napus40.055e-82 262
LLPS-Brr-2685Brassica rapa40.055e-82 262
LLPS-Org-2126Oryza glaberrima40.04e-78 255
LLPS-Thc-0843Theobroma cacao39.891e-80 259
LLPS-Mae-0366Manihot esculenta39.893e-79 255
LLPS-Sol-1247Solanum lycopersicum39.732e-77 251
LLPS-Gag-1303Gaeumannomyces graminis39.736e-68 229
LLPS-Hov-0146Hordeum vulgare39.662e-77 252
LLPS-Nef-1525Neosartorya fischeri39.559e-68 228
LLPS-Bro-0818Brassica oleracea39.552e-79 255
LLPS-Beb-1647Beauveria bassiana39.547e-67 226
LLPS-Arl-2879Arabidopsis lyrata39.467e-83 265
LLPS-Dos-1489Dothistroma septosporum39.469e-66 223
LLPS-Mel-1309Melampsora laricipopulina39.433e-59 206
LLPS-Ved-1589Verticillium dahliae39.322e-66 224
LLPS-Asc-1135Aspergillus clavatus39.284e-68 229
LLPS-Pot-1001Populus trichocarpa39.041e-74 243
LLPS-Cogr-0909Colletotrichum graminicola39.042e-67 227
LLPS-Abg-1463Absidia glauca38.961e-75 250
LLPS-Tra-2061Triticum aestivum38.832e-76 248
LLPS-Mao-1200Magnaporthe oryzae38.632e-68 230
LLPS-Aso-0894Aspergillus oryzae38.61e-67 228
LLPS-Asf-1574Aspergillus flavus38.62e-67 228
LLPS-Coc-1911Corchorus capsularis38.597e-76 247
LLPS-Put-1348Puccinia triticina38.573e-63 225
LLPS-Brd-2460Brachypodium distachyon38.551e-77 251
LLPS-Nia-0166Nicotiana attenuata38.466e-76 246
LLPS-Pug-1348Puccinia graminis38.421e-68 232
LLPS-Prp-0021Prunus persica38.182e-75 245
LLPS-Sem-1765Selaginella moellendorffii38.176e-64 215
LLPS-Scs-0876Sclerotinia sclerotiorum38.113e-66 225
LLPS-Kop-0210Komagataella pastoris37.537e-52 186
LLPS-Lep-0185Leersia perrieri37.462e-60 207
LLPS-Vir-2074Vigna radiata37.368e-68 224
LLPS-Chc-0825Chondrus crispus37.364e-59 204
LLPS-Pyt-1639Pyrenophora teres37.21e-61 212
LLPS-Orm-1432Oryza meridionalis37.112e-53 187
LLPS-Pytr-0954Pyrenophora triticirepentis37.045e-62 213
LLPS-Lem-1245Leptosphaeria maculans36.963e-60 214
LLPS-Miv-0680Microbotryum violaceum36.941e-57 202
LLPS-Scc-0311Schizosaccharomyces cryophilus36.91e-47 173
LLPS-Chr-1459Chlamydomonas reinhardtii35.913e-60 206
LLPS-Scp-1654Schizosaccharomyces pombe35.772e-56 197
LLPS-Sot-1237Solanum tuberosum35.524e-72 237
LLPS-Sac-1282Saccharomyces cerevisiae34.941e-45 169
LLPS-Phn-1482Phaeosphaeria nodorum34.769e-51 182
LLPS-Osl-0876Ostreococcus lucimarinus34.733e-42 156
LLPS-Asg-1473Ashbya gossypii34.667e-41 155
LLPS-Cym-0629Cyanidioschyzon merolae34.442e-0654.3
LLPS-Scj-1055Schizosaccharomyces japonicus33.243e-52 185
LLPS-Crn-0044Cryptococcus neoformans31.253e-43 162
LLPS-Spr-0544Sporisorium reilianum30.833e-37 146
LLPS-Usm-0068Ustilago maydis30.315e-37 145