• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cea-1129
HIBCH

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase
Gene Name: HIBCH
Ensembl Gene: ENSCATG00000035931.1
Ensembl Protein: ENSCATP00000024859.1
Organism: Cercocebus atys
Taxa ID: 9531
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQREVWRLM  SRFNAFKRTN  TILHHLRMSK  HTDAAEDVLL  EKKGCAGVIT  LNRPKLLNTL  60
61    TFNMIRQIYS  QLKKWEQDPE  TFLIIIKGAG  GKAFCAGGDV  RVISEAEKAK  QNMAPVFFRV  120
121   EYMLNNAIGS  CQKPYVALIH  GITMGGGVGL  SVHGQFRVAT  EKCVFAMPET  AIGLFPDVGG  180
181   GYFLPRLQGK  LGYFLALTGF  RLKGRDVYRA  GIATHFVDSE  KLAMLEEDLL  ALKSPSKENI  240
241   ASVLENYHTE  SKIDRDKSFM  LEEHMDKINS  CFSANTVEEI  IENLKQDGSS  FALEQLKVIN  300
301   KMSPTSLKIT  LRQLMEGSSK  TLQEVLTMEY  RLSQACMRGH  DFHEGVRAVL  IDKDQSPKWK  360
361   PADLKEVTDE  DLNNHFKSLG  SNDLKF  386
Nucleotide CDS Sequence (FASTA)
1     ATGGGGCAGC  GGGAGGTGTG  GAGGCTCATG  TCGAGGTTTA  ATGCATTCAA  AAGGACTAAT  60
61    ACCATACTGC  ACCATTTGAG  AATGTCCAAG  CACACAGATG  CAGCAGAAGA  TGTGCTATTG  120
121   GAAAAAAAAG  GTTGTGCGGG  AGTCATAACA  CTAAACAGAC  CAAAGTTGCT  CAATACACTG  180
181   ACTTTTAATA  TGATTCGGCA  GATTTATTCA  CAGCTAAAGA  AGTGGGAACA  AGATCCTGAA  240
241   ACTTTCCTGA  TCATTATAAA  GGGAGCTGGA  GGAAAGGCTT  TCTGTGCTGG  GGGTGATGTC  300
301   AGAGTGATCT  CGGAAGCTGA  AAAGGCAAAA  CAGAATATGG  CTCCAGTTTT  CTTCAGAGTA  360
361   GAATATATGC  TGAACAACGC  TATTGGTTCT  TGCCAGAAAC  CTTATGTTGC  ACTTATTCAT  420
421   GGAATTACAA  TGGGTGGGGG  AGTTGGTCTC  TCAGTCCATG  GGCAATTTCG  AGTGGCTACA  480
481   GAAAAGTGTG  TTTTTGCTAT  GCCAGAAACA  GCAATAGGAC  TGTTCCCTGA  TGTGGGTGGA  540
541   GGTTATTTCT  TGCCACGACT  TCAAGGAAAA  CTTGGTTACT  TCCTTGCATT  AACAGGATTC  600
601   AGACTAAAAG  GAAGAGATGT  GTACAGAGCA  GGAATTGCTA  CACACTTTGT  AGATTCTGAA  660
661   AAGTTGGCCA  TGTTAGAGGA  AGATTTGTTA  GCCTTGAAAT  CTCCTTCAAA  AGAAAATATT  720
721   GCATCTGTCT  TAGAAAATTA  CCATACAGAG  TCTAAGATTG  ATCGAGACAA  GTCTTTTATG  780
781   CTTGAGGAAC  ACATGGACAA  AATAAACAGT  TGTTTTTCAG  CCAATACCGT  GGAAGAAATT  840
841   ATTGAAAACT  TAAAGCAAGA  TGGTTCATCT  TTTGCCCTAG  AGCAATTGAA  GGTAATTAAT  900
901   AAAATGTCTC  CAACATCTTT  GAAGATCACA  CTAAGGCAAC  TCATGGAGGG  GTCTTCAAAG  960
961   ACCTTGCAAG  AAGTACTAAC  TATGGAGTAT  CGGCTAAGTC  AAGCTTGTAT  GTTTTAA  1017

▼ KEYWORD

ID
Family
Branched-chain amino acid catabolism
Complete proteome
Hydrolase
Mitochondrion
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process
Valine catabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-1900Mandrillus leucophaeus100.00.0 767
LLPS-Paa-4595Papio anubis98.930.0 735
LLPS-Man-3550Macaca nemestrina97.930.0 755
LLPS-Maf-3130Macaca fascicularis97.930.0 755
LLPS-Rhb-3883Rhinopithecus bieti97.130.0 671
LLPS-Chs-1006Chlorocebus sabaeus96.840.0 669
LLPS-Mam-1749Macaca mulatta96.060.0 729
LLPS-Pat-4296Pan troglodytes95.850.0 741
LLPS-Poa-0150Pongo abelii95.60.0 739
LLPS-Hos-0953Homo sapiens95.60.0 739
LLPS-Nol-4001Nomascus leucogenys95.340.0 738
LLPS-Gog-0230Gorilla gorilla95.340.0 737
LLPS-Pap-4569Pan paniscus94.950.0 557
LLPS-Otg-0273Otolemur garnettii93.027e-145 417
LLPS-Aon-0536Aotus nancymaae92.750.0 715
LLPS-Caj-4382Callithrix jacchus91.190.0 707
LLPS-Aim-0188Ailuropoda melanoleuca88.336e-151 434
LLPS-Urm-0656Ursus maritimus87.310.0 662
LLPS-Cas-2167Carlito syrichta87.111e-172 491
LLPS-Mup-1465Mustela putorius furo86.350.0 647
LLPS-Fec-2804Felis catus85.750.0 630
LLPS-Sus-4180Sus scrofa85.750.0 654
LLPS-Bot-1862Bos taurus85.280.0 585
LLPS-Ova-2588Ovis aries85.230.0 629
LLPS-Caf-1512Canis familiaris85.150.0 621
LLPS-Loa-2743Loxodonta africana84.880.0 629
LLPS-Orc-3621Oryctolagus cuniculus84.720.0 624
LLPS-Eqc-4263Equus caballus83.920.0 588
LLPS-Ict-3568Ictidomys tridecemlineatus83.680.0 651
LLPS-Mea-2210Mesocricetus auratus83.060.0 586
LLPS-Fud-1423Fukomys damarensis82.630.0 553
LLPS-Dio-0082Dipodomys ordii81.940.0 600
LLPS-Ran-4626Rattus norvegicus81.090.0 630
LLPS-Mum-3552Mus musculus80.310.0 628
LLPS-Myl-2978Myotis lucifugus79.790.0 580
LLPS-Sah-2128Sarcophilus harrisii78.460.0 593
LLPS-Cap-3013Cavia porcellus77.860.0 573
LLPS-Mod-4328Monodelphis domestica74.350.0 544
LLPS-Pes-1335Pelodiscus sinensis74.150.0 555
LLPS-Tag-0074Taeniopygia guttata73.070.0 517
LLPS-Meg-0328Meleagris gallopavo73.050.0 547
LLPS-Gaga-2658Gallus gallus72.530.0 545
LLPS-Fia-3838Ficedula albicollis71.542e-177 508
LLPS-Anp-3164Anas platyrhynchos70.630.0 521
LLPS-Anc-1201Anolis carolinensis70.563e-180 514
LLPS-Leo-3624Lepisosteus oculatus68.884e-175 501
LLPS-Xet-2957Xenopus tropicalis68.273e-176 503
LLPS-Lac-2939Latimeria chalumnae68.050.0 523
LLPS-Asm-3282Astyanax mexicanus65.042e-165 476
LLPS-Orn-1447Oreochromis niloticus64.883e-165 475
LLPS-Orl-2685Oryzias latipes64.885e-150 437
LLPS-Dar-3829Danio rerio64.463e-164 473
LLPS-Gaa-3417Gasterosteus aculeatus64.271e-164 474
LLPS-Scf-2903Scleropages formosus63.955e-163 470
LLPS-Icp-1799Ictalurus punctatus63.479e-163 469
LLPS-Ten-2922Tetraodon nigroviridis62.31e-163 471
LLPS-Scm-0981Scophthalmus maximus62.132e-157 455
LLPS-Pof-0448Poecilia formosa62.131e-159 461
LLPS-Ora-3331Ornithorhynchus anatinus60.54e-28 112
LLPS-Tar-2589Takifugu rubripes59.654e-156 453
LLPS-Cis-0744Ciona savignyi58.266e-128 381
LLPS-Cii-2397Ciona intestinalis57.144e-126 376
LLPS-Xim-2664Xiphophorus maculatus55.911e-132 393
LLPS-Drm-1049Drosophila melanogaster51.733e-106 325
LLPS-Zyt-1021Zymoseptoria tritici48.775e-47 167
LLPS-Cae-1991Caenorhabditis elegans47.715e-106 324
LLPS-Asni-1073Aspergillus niger42.96e-72 239
LLPS-Php-2169Physcomitrella patens42.821e-77 252
LLPS-Gas-0425Galdieria sulphuraria42.693e-75 245
LLPS-Trr-0720Trichoderma reesei42.665e-72 239
LLPS-Viv-0428Vitis vinifera42.551e-69 230
LLPS-Blg-0922Blumeria graminis42.216e-68 231
LLPS-Mua-0263Musa acuminata42.138e-80 257
LLPS-Via-1371Vigna angularis41.814e-77 256
LLPS-Phv-2462Phaseolus vulgaris41.677e-79 254
LLPS-Orp-0682Oryza punctata41.573e-80 258
LLPS-Ori-1383Oryza indica41.577e-75 246
LLPS-Trv-0743Trichoderma virens41.558e-71 236
LLPS-Orbr-1831Oryza brachyantha41.555e-81 260
LLPS-Cog-0938Colletotrichum gloeosporioides41.463e-73 242
LLPS-Fuv-1514Fusarium verticillioides41.463e-71 238
LLPS-Nec-1202Neurospora crassa41.184e-66 224
LLPS-Yal-0151Yarrowia lipolytica41.161e-63 217
LLPS-Tum-1391Tuber melanosporum41.057e-72 239
LLPS-Glm-2563Glycine max41.011e-79 256
LLPS-Met-1091Medicago truncatula41.03e-78 253
LLPS-Orb-1124Oryza barthii40.972e-79 256
LLPS-Fuo-1575Fusarium oxysporum40.928e-71 237
LLPS-Sob-2220Sorghum bicolor40.914e-75 244
LLPS-Orgl-2111Oryza glumaepatula40.915e-80 257
LLPS-Coo-1542Colletotrichum orbiculare40.854e-71 237
LLPS-Art-2956Arabidopsis thaliana40.757e-82 262
LLPS-Gor-2490Gossypium raimondii40.716e-80 257
LLPS-Zem-1409Zea mays40.696e-77 249
LLPS-Asfu-1406Aspergillus fumigatus40.671e-68 233
LLPS-Ast-1572Aspergillus terreus40.674e-69 231
LLPS-Cus-1070Cucumis sativus40.676e-74 241
LLPS-Asn-1050Aspergillus nidulans40.672e-71 238
LLPS-Brr-2685Brassica rapa40.61e-82 264
LLPS-Brn-1749Brassica napus40.61e-82 264
LLPS-Tru-0333Triticum urartu40.593e-52 185
LLPS-Dac-2346Daucus carota40.568e-76 246
LLPS-Ors-2367Oryza sativa40.556e-78 256
LLPS-Orni-1539Oryza nivara40.552e-77 256
LLPS-Gag-1303Gaeumannomyces graminis40.492e-67 228
LLPS-Fus-0994Fusarium solani40.342e-71 238
LLPS-Sei-2004Setaria italica40.342e-76 249
LLPS-Org-2126Oryza glaberrima40.273e-78 256
LLPS-Thc-0843Theobroma cacao40.272e-81 261
LLPS-Mae-0366Manihot esculenta40.172e-79 256
LLPS-Amt-1048Amborella trichopoda40.173e-76 247
LLPS-Bro-0818Brassica oleracea40.115e-80 257
LLPS-Nef-1525Neosartorya fischeri40.112e-68 230
LLPS-Orr-1956Oryza rufipogon40.04e-77 256
LLPS-Mel-1309Melampsora laricipopulina40.08e-59 205
LLPS-Sol-1247Solanum lycopersicum40.01e-77 251
LLPS-Hov-0146Hordeum vulgare39.947e-78 253
LLPS-Beb-1647Beauveria bassiana39.831e-67 228
LLPS-Asc-1135Aspergillus clavatus39.836e-69 231
LLPS-Dos-1489Dothistroma septosporum39.735e-66 224
LLPS-Arl-2879Arabidopsis lyrata39.734e-83 265
LLPS-Put-1348Puccinia triticina39.673e-62 222
LLPS-Ved-1589Verticillium dahliae39.61e-66 225
LLPS-Cogr-0909Colletotrichum graminicola39.334e-68 229
LLPS-Abg-1463Absidia glauca39.241e-74 247
LLPS-Hea-2382Helianthus annuus39.227e-76 246
LLPS-Asf-1574Aspergillus flavus39.128e-68 229
LLPS-Aso-0894Aspergillus oryzae39.127e-68 229
LLPS-Tra-2061Triticum aestivum39.111e-76 249
LLPS-Pot-1001Populus trichocarpa39.046e-75 244
LLPS-Coc-1911Corchorus capsularis38.832e-76 249
LLPS-Brd-2460Brachypodium distachyon38.834e-78 252
LLPS-Scs-0876Sclerotinia sclerotiorum38.622e-67 228
LLPS-Prp-0021Prunus persica38.469e-76 246
LLPS-Nia-0166Nicotiana attenuata38.461e-75 246
LLPS-Pug-1348Puccinia graminis38.426e-68 230
LLPS-Chc-0825Chondrus crispus38.226e-62 212
LLPS-Sem-1765Selaginella moellendorffii38.172e-64 216
LLPS-Mao-1200Magnaporthe oryzae37.652e-65 222
LLPS-Vir-2074Vigna radiata37.645e-69 228
LLPS-Kop-0210Komagataella pastoris37.536e-51 184
LLPS-Lem-1245Leptosphaeria maculans37.233e-60 213
LLPS-Miv-0680Microbotryum violaceum37.221e-56 200
LLPS-Pyt-1639Pyrenophora teres37.25e-61 211
LLPS-Sot-1237Solanum tuberosum37.192e-72 238
LLPS-Lep-0185Leersia perrieri37.182e-60 207
LLPS-Pytr-0954Pyrenophora triticirepentis37.137e-61 210
LLPS-Orm-1432Oryza meridionalis37.115e-55 191
LLPS-Scc-0311Schizosaccharomyces cryophilus36.94e-46 169
LLPS-Chr-1459Chlamydomonas reinhardtii35.665e-61 209
LLPS-Sac-1282Saccharomyces cerevisiae35.512e-44 166
LLPS-Scp-1654Schizosaccharomyces pombe35.492e-54 191
LLPS-Osl-0876Ostreococcus lucimarinus35.332e-42 157
LLPS-Cym-0629Cyanidioschyzon merolae34.442e-0654.3
LLPS-Phn-1482Phaeosphaeria nodorum34.056e-50 180
LLPS-Asg-1473Ashbya gossypii33.814e-39 150
LLPS-Spr-0544Sporisorium reilianum33.686e-37 145
LLPS-Scj-1055Schizosaccharomyces japonicus32.962e-50 180
LLPS-Crn-0044Cryptococcus neoformans31.251e-43 164
LLPS-Usm-0068Ustilago maydis30.559e-37 144