• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Loa-2743
HIBCH

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase
Gene Name: HIBCH
Ensembl Gene: ENSLAFG00000000983.4
Ensembl Protein: ENSLAFP00000000822.4
Organism: Loxodonta africana
Taxa ID: 9785
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     CSHYYVHYIY  SAFCFRFNSF  KRTHIILQHL  GMSKHTNAAD  EVLLERKGCA  GVITLNRPKF  60
61    LNALNFTMLR  QIYLQLKTWE  QDPETFLIII  KGAGEKAFCA  GGDIIVVEVS  EAGKAKQKLA  120
121   QDFFREEYIM  NSAIDSCRKP  YVALIHGITM  GGGVGLSVHG  QFRVATEKTV  FAMPETAIGL  180
181   FPDVGGGYFL  PRLQGKLGYF  LALTGFRLKG  RDVHKAGIAT  HFVDSETLGM  LEEDLLALKS  240
241   PSRENIADVL  EIYHTKSKID  QDKSFILEEH  MGKINSLFSA  NTMEQIIENL  QQDGSPFALE  300
301   QLKIINKMSP  TSLKITLRQL  IEGTSKTLQE  VLTMEYRLSQ  ACMGGHDFHE  GVRAVLIDKD  360
361   QSPKWKPADL  KEVTDEDVNN  YFKSLGSNDL  IF  392
Nucleotide CDS Sequence (FASTA)
1     ATTTCCTCCA  CTTATTCCTG  GCTGTCCTTC  CTCCGTTGCT  CCAGATTTAA  TTCATTCAAA  60
61    AGAACTCATA  TCATACTGCA  GCATTTGGGA  ATGTCCAAAC  ACACAAATGC  AGCAGATGAG  120
121   GTACTATTGG  AAAGAAAAGG  TTGTGCAGGA  GTGATCACAC  TAAACAGACC  CAAGTTCCTA  180
181   AATGCACTGA  ATTTTACTAT  GCTTCGGCAG  ATTTATCTAC  AGTTAAAGAC  GTGGGAACAA  240
241   GATCCTGAAA  CTTTCCTGAT  CATTATAAAG  GGAGCTGGAG  AAAAGGCTTT  TTGTGCTGGT  300
301   GGTGATATCA  TAGTCGTAGA  GGTCTCAGAA  GCTGGAAAGG  CAAAACAGAA  GCTAGCTCAA  360
361   GATTTCTTCA  GGGAAGAATA  CATCATGAAC  AGTGCCATTG  ATTCTTGCCG  GAAACCGTAT  420
421   GTTGCACTTA  TTCATGGAAT  TACGATGGGT  GGAGGAGTTG  GTCTCTCAGT  TCATGGACAG  480
481   TTCCGAGTGG  CTACTGAAAA  GACTGTCTTT  GCAATGCCAG  AAACAGCAAT  TGGGCTATTC  540
541   CCTGATGTGG  GCGGAGGTTA  TTTCTTGCCA  CGGCTTCAAG  GAAAACTTGG  TTACTTCCTT  600
601   GCGTTAACAG  GATTCAGACT  AAAAGGGAGA  GATGTGCACA  AAGCAGGAAT  TGCTACACAC  660
661   TTTGTAGACT  CTGAAACGTT  GGGCATGTTG  GAGGAAGATT  TGTTAGCCCT  AAAATCTCCT  720
721   TCCAGAGAAA  ATATTGCAGA  TGTCTTAGAA  ATTTACCATA  CAAAGTCCAA  GATCGATCAA  780
781   GACAAGTCTT  TCATACTGGA  GGAACACATG  GGTAAAATAA  ACAGTTTGTT  TTCAGCCAAT  840
841   ACGATGGAAC  AGATTATTGA  GAATTTACAA  CAGGATGGTT  CACCTTTTGC  TCTAGAGCAG  900
901   TTAAAGATAA  TTAATAAAAT  GTCTCCAACA  TCCCTAAAGA  TCACACTAAG  GCAACTCATA  960
961   GAGGGGACTT  CAAAGACATT  ACAGGAAGTG  TTAACTATGG  AATATCGACT  AAGTCAAGCT  1020
1021  TGTATGGGAG  GTCATGATTT  TCATGAAGGT  GTTAGAGCAG  TTTTAATAGA  TAAAGACCAG  1080
1081  AGTCCGAAGT  GGAAACCAGC  TGATCTAAAA  GAAGTTACTG  ATGAAGATGT  GAATAATTAC  1140
1141  TTTAAATCTC  TGGGAAGCAA  TGATCTGATA  TTTTGA  1176

▼ KEYWORD

ID
Family
Branched-chain amino acid catabolism
Complete proteome
Hydrolase
Mitochondrion
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process
Valine catabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Otg-0273Otolemur garnettii89.772e-136 396
LLPS-Caf-1512Canis familiaris88.40.0 663
LLPS-Urm-0656Ursus maritimus87.80.0 682
LLPS-Mup-1465Mustela putorius furo87.770.0 677
LLPS-Aim-0188Ailuropoda melanoleuca87.52e-149 430
LLPS-Ova-2588Ovis aries85.680.0 648
LLPS-Pat-4296Pan troglodytes85.680.0 667
LLPS-Fec-2804Felis catus85.60.0 652
LLPS-Mam-1749Macaca mulatta85.490.0 673
LLPS-Gog-0230Gorilla gorilla85.410.0 666
LLPS-Hos-0953Homo sapiens85.410.0 665
LLPS-Maf-3130Macaca fascicularis85.150.0 665
LLPS-Man-3550Macaca nemestrina85.150.0 665
LLPS-Nol-4001Nomascus leucogenys85.150.0 665
LLPS-Sus-4180Sus scrofa85.040.0 674
LLPS-Cea-1129Cercocebus atys84.880.0 662
LLPS-Mal-1900Mandrillus leucophaeus84.880.0 662
LLPS-Poa-0150Pongo abelii84.880.0 662
LLPS-Paa-4595Papio anubis84.570.0 656
LLPS-Chs-1006Chlorocebus sabaeus84.370.0 589
LLPS-Cas-2167Carlito syrichta84.084e-179 508
LLPS-Rhb-3883Rhinopithecus bieti84.070.0 588
LLPS-Pap-4569Pan paniscus84.033e-174 495
LLPS-Orc-3621Oryctolagus cuniculus83.860.0 638
LLPS-Caj-4382Callithrix jacchus83.420.0 648
LLPS-Aon-0536Aotus nancymaae83.160.0 647
LLPS-Myl-2978Myotis lucifugus81.960.0 630
LLPS-Ict-3568Ictidomys tridecemlineatus81.170.0 641
LLPS-Mea-2210Mesocricetus auratus80.890.0 599
LLPS-Mum-3552Mus musculus80.640.0 634
LLPS-Dio-0082Dipodomys ordii80.590.0 622
LLPS-Ran-4626Rattus norvegicus80.370.0 630
LLPS-Bot-1862Bos taurus80.150.0 613
LLPS-Eqc-4263Equus caballus79.290.0 585
LLPS-Sah-2128Sarcophilus harrisii78.780.0 627
LLPS-Fud-1423Fukomys damarensis78.670.0 563
LLPS-Mod-4328Monodelphis domestica76.130.0 578
LLPS-Cap-3013Cavia porcellus76.130.0 580
LLPS-Pes-1335Pelodiscus sinensis75.60.0 595
LLPS-Tag-0074Taeniopygia guttata73.60.0 550
LLPS-Fia-3838Ficedula albicollis72.530.0 543
LLPS-Anp-3164Anas platyrhynchos72.150.0 560
LLPS-Lac-2939Latimeria chalumnae72.070.0 566
LLPS-Meg-0328Meleagris gallopavo71.930.0 574
LLPS-Anc-1201Anolis carolinensis71.730.0 552
LLPS-Gaga-2658Gallus gallus71.730.0 568
LLPS-Xet-2957Xenopus tropicalis69.150.0 536
LLPS-Leo-3624Lepisosteus oculatus68.520.0 523
LLPS-Icp-1799Ictalurus punctatus67.515e-172 493
LLPS-Orn-1447Oreochromis niloticus65.442e-178 509
LLPS-Scf-2903Scleropages formosus65.165e-174 498
LLPS-Orl-2685Oryzias latipes64.991e-162 469
LLPS-Asm-3282Astyanax mexicanus64.911e-177 507
LLPS-Dar-3829Danio rerio64.01e-168 484
LLPS-Gaa-3417Gasterosteus aculeatus63.591e-173 497
LLPS-Scm-0981Scophthalmus maximus63.499e-172 492
LLPS-Pof-0448Poecilia formosa61.467e-169 485
LLPS-Xim-2664Xiphophorus maculatus61.193e-142 418
LLPS-Tar-2589Takifugu rubripes59.217e-166 478
LLPS-Ten-2922Tetraodon nigroviridis59.073e-168 484
LLPS-Ora-3331Ornithorhynchus anatinus58.821e-35 132
LLPS-Cii-2397Ciona intestinalis56.412e-137 405
LLPS-Cis-0744Ciona savignyi56.361e-135 400
LLPS-Drm-1049Drosophila melanogaster51.291e-115 349
LLPS-Cae-1991Caenorhabditis elegans49.322e-122 367
LLPS-Zyt-1021Zymoseptoria tritici47.936e-60 202
LLPS-Php-2169Physcomitrella patens43.562e-81 262
LLPS-Sob-2220Sorghum bicolor43.221e-83 267
LLPS-Met-1091Medicago truncatula42.982e-83 266
LLPS-Art-2956Arabidopsis thaliana42.699e-91 285
LLPS-Sei-2004Setaria italica42.663e-86 275
LLPS-Cus-1070Cucumis sativus42.581e-80 259
LLPS-Orp-0682Oryza punctata42.377e-87 275
LLPS-Arl-2879Arabidopsis lyrata42.275e-91 286
LLPS-Hov-0146Hordeum vulgare42.278e-85 271
LLPS-Asni-1073Aspergillus niger42.132e-80 261
LLPS-Orgl-2111Oryza glumaepatula42.094e-87 276
LLPS-Via-1371Vigna angularis42.068e-84 275
LLPS-Ori-1383Oryza indica42.055e-81 262
LLPS-Orni-1539Oryza nivara41.975e-84 273
LLPS-Ors-2367Oryza sativa41.972e-84 273
LLPS-Orbr-1831Oryza brachyantha41.932e-87 276
LLPS-Orb-1124Oryza barthii41.887e-86 272
LLPS-Mae-0366Manihot esculenta41.882e-84 269
LLPS-Zem-1409Zea mays41.887e-84 268
LLPS-Mua-0263Musa acuminata41.859e-86 273
LLPS-Hea-2382Helianthus annuus41.855e-88 278
LLPS-Phv-2462Phaseolus vulgaris41.834e-84 268
LLPS-Amt-1048Amborella trichopoda41.761e-84 269
LLPS-Org-2126Oryza glaberrima41.691e-84 273
LLPS-Viv-0428Vitis vinifera41.672e-74 242
LLPS-Yal-0151Yarrowia lipolytica41.643e-77 253
LLPS-Trv-0743Trichoderma virens41.628e-78 254
LLPS-Bro-0818Brassica oleracea41.622e-88 279
LLPS-Nec-1202Neurospora crassa41.592e-75 249
LLPS-Brn-1749Brassica napus41.558e-90 283
LLPS-Brr-2685Brassica rapa41.558e-90 283
LLPS-Abg-1463Absidia glauca41.487e-82 266
LLPS-Tra-2061Triticum aestivum41.449e-83 265
LLPS-Orr-1956Oryza rufipogon41.398e-84 274
LLPS-Asn-1050Aspergillus nidulans41.237e-83 269
LLPS-Trr-0720Trichoderma reesei41.132e-78 256
LLPS-Nia-0166Nicotiana attenuata41.12e-86 274
LLPS-Put-1348Puccinia triticina41.14e-71 248
LLPS-Glm-2563Glycine max41.063e-86 274
LLPS-Gas-0425Galdieria sulphuraria41.033e-80 258
LLPS-Brd-2460Brachypodium distachyon41.04e-86 273
LLPS-Dos-1489Dothistroma septosporum40.961e-79 259
LLPS-Sol-1247Solanum lycopersicum40.931e-86 275
LLPS-Dac-2346Daucus carota40.92e-82 264
LLPS-Pot-1001Populus trichocarpa40.783e-82 263
LLPS-Thc-0843Theobroma cacao40.733e-85 271
LLPS-Gor-2490Gossypium raimondii40.714e-86 273
LLPS-Asfu-1406Aspergillus fumigatus40.671e-79 262
LLPS-Cog-0938Colletotrichum gloeosporioides40.663e-81 263
LLPS-Mel-1309Melampsora laricipopulina40.641e-65 224
LLPS-Fus-0994Fusarium solani40.623e-77 253
LLPS-Asc-1135Aspergillus clavatus40.455e-80 260
LLPS-Tum-1391Tuber melanosporum40.448e-77 252
LLPS-Ast-1572Aspergillus terreus40.398e-80 259
LLPS-Beb-1647Beauveria bassiana40.281e-75 249
LLPS-Prp-0021Prunus persica40.237e-83 265
LLPS-Nef-1525Neosartorya fischeri40.113e-79 258
LLPS-Fuv-1514Fusarium verticillioides39.99e-80 260
LLPS-Fuo-1575Fusarium oxysporum39.96e-80 261
LLPS-Vir-2074Vigna radiata39.831e-76 248
LLPS-Pug-1348Puccinia graminis39.636e-72 241
LLPS-Coo-1542Colletotrichum orbiculare39.554e-78 255
LLPS-Coc-1911Corchorus capsularis39.446e-82 263
LLPS-Tru-0333Triticum urartu39.313e-60 206
LLPS-Chc-0825Chondrus crispus39.242e-68 229
LLPS-Mao-1200Magnaporthe oryzae39.194e-73 243
LLPS-Ved-1589Verticillium dahliae39.026e-75 247
LLPS-Lep-0185Leersia perrieri39.01e-67 226
LLPS-Sot-1237Solanum tuberosum38.92e-81 261
LLPS-Aso-0894Aspergillus oryzae38.641e-77 254
LLPS-Asf-1574Aspergillus flavus38.641e-77 254
LLPS-Gag-1303Gaeumannomyces graminis38.483e-76 251
LLPS-Blg-0922Blumeria graminis38.322e-75 251
LLPS-Cogr-0909Colletotrichum graminicola38.252e-77 254
LLPS-Pytr-0954Pyrenophora triticirepentis38.152e-74 246
LLPS-Orm-1432Oryza meridionalis37.965e-59 202
LLPS-Kop-0210Komagataella pastoris37.875e-57 200
LLPS-Chr-1459Chlamydomonas reinhardtii37.841e-71 237
LLPS-Lem-1245Leptosphaeria maculans37.65e-71 244
LLPS-Miv-0680Microbotryum violaceum37.41e-65 224
LLPS-Pyt-1639Pyrenophora teres37.132e-71 238
LLPS-Scp-1654Schizosaccharomyces pombe37.054e-59 204
LLPS-Scs-0876Sclerotinia sclerotiorum36.834e-75 248
LLPS-Scc-0311Schizosaccharomyces cryophilus36.112e-54 191
LLPS-Sem-1765Selaginella moellendorffii35.621e-68 228
LLPS-Phn-1482Phaeosphaeria nodorum35.57e-64 217
LLPS-Sac-1282Saccharomyces cerevisiae35.415e-53 189
LLPS-Osl-0876Ostreococcus lucimarinus34.823e-51 181
LLPS-Scj-1055Schizosaccharomyces japonicus34.552e-59 204
LLPS-Asg-1473Ashbya gossypii32.885e-48 176
LLPS-Usm-0068Ustilago maydis32.296e-45 168
LLPS-Spr-0544Sporisorium reilianum31.566e-47 174
LLPS-Crn-0044Cryptococcus neoformans31.285e-48 176
LLPS-Cym-0712Cyanidioschyzon merolae29.562e-40 155