• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tag-2495
EIF3M

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit M
Gene Name: EIF3M
Ensembl Gene: ENSTGUG00000004912.1
Ensembl Protein: ENSTGUP00000005078.1
Organism: Taeniopygia guttata
Taxa ID: 59729
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSTGUT00000005128.1ENSTGUP00000005078.1
UniProtH0Z3D5, H0Z3D5_TAEGU
GeneBankABQF01124541

▼ SEQUENCE

Protein Sequence (FASTA)
1     KAAELRAYLK  SKGAEISEEN  AEGGLHVDLA  QIIEVCDVCL  KEDDKDVESV  MNSVVSLLLI  60
61    LEPDKQEALI  ENLCEKLVKF  REGERPSLRL  QLLSNLFHGM  DKNTPVRYTV  YCSLLKVASS  120
121   CGAIQYIPTE  LDQVRKWISD  WNLATEKKHT  LLRLLYDVLV  DCKKSDTAAK  VMVELLGSYT  180
181   EDNASQARVD  AHRCIVRALK  DPNTFLFDHL  LALKPVKFLE  GELIHDLLTI  FVSAKLASYV  240
241   KFYQNNKDFI  DSLGLLHEHN  MAKMRLLTFM  GMAVENKEIS  FDTMQQELQI  GADDVEAFVI  300
301   DAVKTKMVYC  KIDQTQRKVI  VSHSTHRTFG  KQQWQQLYDT  LNTWKQNLNQ  VKNSLLSLSD  360
361   T  361
Nucleotide CDS Sequence (FASTA)
1     AAGGCTGCAG  AACTGCGAGC  TTACCTGAAA  TCCAAAGGAG  CAGAAATCTC  TGAAGAAAAC  60
61    GCTGAAGGCG  GACTTCATGT  GGACTTGGCA  CAGATTATTG  AAGTGTGTGA  TGTGTGCCTG  120
121   AAAGAGGATG  ACAAAGATGT  GGAGAGTGTG  ATGAACAGCG  TTGTCTCTCT  GCTTCTTATC  180
181   CTGGAACCTG  ACAAACAAGA  AGCACTGATT  GAAAATCTAT  GTGAGAAGTT  AGTAAAGTTT  240
241   CGAGAAGGAG  AGCGCCCATC  TCTTAGACTG  CAGCTCCTGA  GCAATCTCTT  CCATGGCATG  300
301   GACAAGAACA  CTCCTGTGAG  GTACACAGTG  TACTGCAGCC  TTCTCAAAGT  GGCCTCGTCC  360
361   TGTGGTGCCA  TCCAGTACAT  TCCAACTGAA  CTAGATCAGG  TCCGAAAATG  GATTTCTGAC  420
421   TGGAATCTGG  CTACAGAGAA  AAAGCACACT  CTCCTGAGAC  TGCTATATGA  TGTCCTAGTA  480
481   GACTGCAAGA  AAAGTGACAC  TGCAGCAAAA  GTAATGGTGG  AGCTATTGGG  AAGTTACACA  540
541   GAGGACAATG  CTTCCCAGGC  TAGAGTTGAT  GCTCACAGAT  GTATTGTACG  AGCATTGAAG  600
601   GATCCAAATA  CCTTTCTTTT  TGATCATCTT  CTTGCCTTAA  AACCAGTTAA  ATTTTTGGAA  660
661   GGAGAACTTA  TTCATGATCT  TTTGACAATT  TTTGTAAGTG  CTAAACTAGC  GTCCTATGTC  720
721   AAGTTTTATC  AGAACAACAA  AGACTTCATT  GACTCCCTGG  GCTTGTTGCA  TGAACACAAT  780
781   ATGGCCAAGA  TGAGGCTCCT  TACTTTCATG  GGAATGGCTG  TAGAGAATAA  AGAAATCTCA  840
841   TTTGACACAA  TGCAGCAGGA  ACTCCAGATA  GGGGCTGATG  ATGTGGAAGC  ATTTGTCATT  900
901   GATGCTGTAA  AAACAAAGAT  GGTGTACTGC  AAAATAGATC  AGACACAAAG  GAAAGTCATT  960
961   GTCAGTCACA  GCACACATCG  GACTTTTGGA  AAGCAGCAGT  GGCAGCAATT  GTATGACACT  1020
1021  CTAAACACCT  GGAAACAAAA  TTTGAATCAA  GTGAAAAACA  GTCTCCTCAG  TCTCTCAGAC  1080
1081  ACATAA  1086

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function
Translation initiation factor activity
Molecular Function
Translation initiation factor binding
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fia-3566Ficedula albicollis99.680.0 644
LLPS-Meg-2367Meleagris gallopavo98.060.0 731
LLPS-Gaga-2766Gallus gallus97.780.0 732
LLPS-Anp-0356Anas platyrhynchos97.490.0 717
LLPS-Pes-2263Pelodiscus sinensis96.40.0 723
LLPS-Sah-3875Sarcophilus harrisii95.290.0 718
LLPS-Mod-3495Monodelphis domestica95.290.0 718
LLPS-Fec-1751Felis catus95.290.0 718
LLPS-Otg-0102Otolemur garnettii95.160.0 572
LLPS-Caj-1040Callithrix jacchus95.010.0 715
LLPS-Gog-4239Gorilla gorilla95.010.0 717
LLPS-Sus-4198Sus scrofa95.010.0 716
LLPS-Cea-1460Cercocebus atys95.010.0 717
LLPS-Aon-1791Aotus nancymaae95.010.0 716
LLPS-Maf-2845Macaca fascicularis95.010.0 717
LLPS-Chs-3306Chlorocebus sabaeus95.010.0 717
LLPS-Mal-0421Mandrillus leucophaeus95.010.0 717
LLPS-Paa-4099Papio anubis95.010.0 717
LLPS-Myl-2203Myotis lucifugus95.010.0 717
LLPS-Mup-3877Mustela putorius furo95.010.0 717
LLPS-Aim-2309Ailuropoda melanoleuca95.010.0 717
LLPS-Bot-0728Bos taurus95.010.0 717
LLPS-Orc-4247Oryctolagus cuniculus95.010.0 717
LLPS-Man-2330Macaca nemestrina95.010.0 717
LLPS-Hos-1475Homo sapiens95.010.0 717
LLPS-Urm-1068Ursus maritimus95.010.0 717
LLPS-Pap-3084Pan paniscus95.010.0 717
LLPS-Pat-2427Pan troglodytes95.010.0 717
LLPS-Nol-4108Nomascus leucogenys95.010.0 717
LLPS-Anc-2618Anolis carolinensis95.010.0 712
LLPS-Ict-2988Ictidomys tridecemlineatus95.010.0 717
LLPS-Mam-3436Macaca mulatta95.010.0 717
LLPS-Caf-3801Canis familiaris95.010.0 717
LLPS-Ora-2429Ornithorhynchus anatinus95.00.0 715
LLPS-Mea-2694Mesocricetus auratus94.740.0 715
LLPS-Ova-0408Ovis aries94.740.0 716
LLPS-Ran-3154Rattus norvegicus94.740.0 715
LLPS-Tut-2193Tursiops truncatus94.740.0 714
LLPS-Loa-4250Loxodonta africana94.740.0 715
LLPS-Cas-0386Carlito syrichta94.740.0 716
LLPS-Poa-0139Pongo abelii94.740.0 716
LLPS-Mum-3116Mus musculus94.460.0 714
LLPS-Fud-0741Fukomys damarensis94.180.0 714
LLPS-Cap-4493Cavia porcellus94.180.0 714
LLPS-Rhb-3728Rhinopithecus bieti94.080.0 702
LLPS-Lac-1664Latimeria chalumnae90.810.0 687
LLPS-Leo-1557Lepisosteus oculatus89.970.0 684
LLPS-Asm-3199Astyanax mexicanus87.810.0 667
LLPS-Orn-3443Oreochromis niloticus87.530.0 669
LLPS-Xet-2861Xenopus tropicalis87.530.0 670
LLPS-Tar-2099Takifugu rubripes86.730.0 560
LLPS-Orl-0550Oryzias latipes86.70.0 661
LLPS-Xim-2562Xiphophorus maculatus86.70.0 665
LLPS-Pof-4042Poecilia formosa86.460.0 660
LLPS-Icp-3495Ictalurus punctatus86.430.0 664
LLPS-Dar-0408Danio rerio86.150.0 657
LLPS-Eqc-3796Equus caballus86.150.0 698
LLPS-Ten-3249Tetraodon nigroviridis85.870.0 657
LLPS-Scm-0227Scophthalmus maximus84.490.0 643
LLPS-Gaa-0417Gasterosteus aculeatus84.210.0 644
LLPS-Scf-3308Scleropages formosus84.210.0 644
LLPS-Dio-4162Dipodomys ordii71.733e-87 266
LLPS-Drm-2260Drosophila melanogaster46.942e-111 338
LLPS-Cis-0028Ciona savignyi46.372e-107 327
LLPS-Cii-1217Ciona intestinalis45.11e-104 319
LLPS-Dac-1404Daucus carota40.461e-25 111
LLPS-Cae-1035Caenorhabditis elegans32.146e-43 159
LLPS-Cus-2097Cucumis sativus31.082e-41 155
LLPS-Pot-1176Populus trichocarpa31.084e-44 163
LLPS-Zem-1511Zea mays30.612e-38 147
LLPS-Hea-0533Helianthus annuus30.355e-42 157
LLPS-Sob-0987Sorghum bicolor29.972e-37 144
LLPS-Prp-2193Prunus persica29.77e-38 145
LLPS-Sot-1181Solanum tuberosum29.65e-38 146
LLPS-Glm-1824Glycine max29.454e-42 157
LLPS-Brr-2586Brassica rapa29.242e-0755.8
LLPS-Mae-1202Manihot esculenta29.233e-38 146
LLPS-Met-1623Medicago truncatula29.165e-44 162
LLPS-Nia-1369Nicotiana attenuata29.158e-39 148
LLPS-Via-0348Vigna angularis29.145e-41 154
LLPS-Phv-1099Phaseolus vulgaris29.141e-41 156
LLPS-Phn-0993Phaeosphaeria nodorum29.042e-30 125
LLPS-Mua-0323Musa acuminata29.028e-35 137
LLPS-Sol-1729Solanum lycopersicum28.927e-38 145
LLPS-Sem-1209Selaginella moellendorffii28.882e-39 150
LLPS-Abg-0804Absidia glauca28.717e-36 139
LLPS-Brn-3263Brassica napus28.653e-0755.5
LLPS-Bro-0642Brassica oleracea28.653e-0755.5
LLPS-Viv-1470Vitis vinifera28.621e-36 142
LLPS-Arl-2256Arabidopsis lyrata28.481e-37 145
LLPS-Orp-2198Oryza punctata28.488e-31 125
LLPS-Sei-2222Setaria italica28.339e-36 140
LLPS-Asni-0615Aspergillus niger28.327e-24 104
LLPS-Amt-2284Amborella trichopoda28.262e-36 141
LLPS-Ors-0184Oryza sativa28.233e-29 121
LLPS-Org-1057Oryza glaberrima28.236e-29 120
LLPS-Art-2879Arabidopsis thaliana28.181e-36 142
LLPS-Blg-1327Blumeria graminis28.16e-35 137
LLPS-Vir-1801Vigna radiata28.03e-38 146
LLPS-Coc-0769Corchorus capsularis27.781e-37 145
LLPS-Thc-1361Theobroma cacao27.763e-36 141
LLPS-Ori-1085Oryza indica27.719e-29 119
LLPS-Brd-1873Brachypodium distachyon27.76e-23 102
LLPS-Pyt-1099Pyrenophora teres27.577e-28 117
LLPS-Lem-0844Leptosphaeria maculans27.575e-30 124
LLPS-Mao-0818Magnaporthe oryzae27.273e-27 115
LLPS-Nef-1241Neosartorya fischeri27.242e-23 104
LLPS-Orni-1638Oryza nivara27.229e-27 114
LLPS-Lep-1263Leersia perrieri27.054e-29 120
LLPS-Nec-1053Neurospora crassa26.982e-30 124
LLPS-Orb-0146Oryza barthii26.937e-27 114
LLPS-Orgl-2130Oryza glumaepatula26.937e-27 114
LLPS-Orr-1054Oryza rufipogon26.935e-27 114
LLPS-Asfu-1660Aspergillus fumigatus26.889e-23 102
LLPS-Cogr-1488Colletotrichum graminicola26.874e-28 118
LLPS-Orm-1049Oryza meridionalis26.861e-26 113
LLPS-Ast-0394Aspergillus terreus26.768e-22 100
LLPS-Trv-0450Trichoderma virens26.741e-25 110
LLPS-Php-0681Physcomitrella patens26.652e-33 133
LLPS-Hov-2041Hordeum vulgare26.62e-24 106
LLPS-Gor-2052Gossypium raimondii26.578e-35 137
LLPS-Asc-0252Aspergillus clavatus26.529e-23 102
LLPS-Asf-0470Aspergillus flavus26.474e-24 106
LLPS-Tum-1204Tuber melanosporum26.478e-33 131
LLPS-Aso-1010Aspergillus oryzae26.474e-24 106
LLPS-Pytr-0039Pyrenophora triticirepentis26.479e-28 117
LLPS-Spr-0507Sporisorium reilianum26.434e-31 126
LLPS-Usm-0706Ustilago maydis26.384e-23 103
LLPS-Asn-1371Aspergillus nidulans26.324e-1477.4
LLPS-Trr-0949Trichoderma reesei26.242e-27 116
LLPS-Beb-0777Beauveria bassiana26.239e-29 119
LLPS-Fus-1361Fusarium solani26.159e-30 122
LLPS-Gas-1119Galdieria sulphuraria25.989e-2298.6
LLPS-Chc-1047Chondrus crispus25.933e-24 106
LLPS-Ved-1443Verticillium dahliae25.834e-29 120
LLPS-Gag-1580Gaeumannomyces graminis25.741e-23 104
LLPS-Coo-0138Colletotrichum orbiculare25.671e-28 119
LLPS-Tra-2868Triticum aestivum25.622e-25 110
LLPS-Fuo-1337Fusarium oxysporum25.485e-31 126
LLPS-Zyt-0150Zymoseptoria tritici25.469e-2094.7
LLPS-Fuv-1115Fusarium verticillioides25.216e-29 120
LLPS-Cog-1282Colletotrichum gloeosporioides25.089e-2094.0
LLPS-Scj-1511Schizosaccharomyces japonicus24.928e-2094.0
LLPS-Crn-1067Cryptococcus neoformans24.297e-1579.3
LLPS-Dos-1048Dothistroma septosporum23.942e-27 115
LLPS-Scp-1355Schizosaccharomyces pombe23.475e-1476.6
LLPS-Yal-1511Yarrowia lipolytica23.181e-1272.8
LLPS-Osl-0476Ostreococcus lucimarinus22.55e-1167.8
LLPS-Scc-1534Schizosaccharomyces cryophilus22.294e-1477.0
LLPS-Kop-0709Komagataella pastoris21.66e-0652.0