• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Poa-0139
EIF3M

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit M
Gene Name: EIF3M
Ensembl Gene: ENSPPYG00000003381.2
Ensembl Protein: ENSPPYP00000003882.2
Organism: Pongo abelii
Taxa ID: 9601
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSVPAFIDIS  EEDQAAELRA  YLKSKGAEIS  EENSEGGLHI  DLAQIIEACD  VCLKEDDKDV  60
61    ESVMNSVVSL  LLILEPDKQE  ALIESLCEKL  VKFREGERPS  LRLQLLSNLF  HGMDKNTPVR  120
121   YTVYCSLIKV  AASCGAIQYI  PTELDQVRKW  ISDWNLTTEK  KHTLLRLLYE  ALVDCKKSDA  180
181   ASKVMVELLG  SYTEDNASQA  RVDAHRCIVR  ALKDPNAFLF  DHLLTLKPVK  FLEGELIHDL  240
241   LTIFVSAKLA  SYVKFYQNNK  DFIDSLGLLH  EQNMAKMRLL  TFMGMAVENK  EISFDTMQQE  300
301   LQIGADDVEA  FVIDAVRTKM  VYCKIDQTQR  KVVVSHSTHR  TFGKQQWQQL  YDTLNAWKQN  360
361   LNKVKNSLLS  LSDT  374
Nucleotide CDS Sequence (FASTA)
1     ATGAGCGTCC  CGGCCTTCAT  CGACATCAGT  GAGGAAGATC  AGGCTGCTGA  GCTTCGTGCT  60
61    TATCTGAAAT  CTAAAGGAGC  TGAGATTTCA  GAAGAGAACT  CGGAAGGTGG  ACTTCATATT  120
121   GATTTAGCTC  AAATTATTGA  AGCCTGTGAT  GTGTGTCTGA  AGGAGGATGA  TAAAGATGTT  180
181   GAAAGCGTGA  TGAACAGTGT  GGTATCCCTA  CTCTTGATCC  TGGAACCAGA  CAAGCAAGAA  240
241   GCTTTGATTG  AAAGTCTATG  TGAAAAGCTG  GTCAAATTTC  GCGAAGGTGA  ACGCCCATCT  300
301   CTGAGACTTC  AGTTGTTAAG  CAACCTTTTC  CATGGGATGG  ATAAGAATAC  TCCTGTAAGA  360
361   TACACAGTGT  ATTGCAGCCT  TATTAAAGTG  GCAGCATCTT  GTGGGGCCAT  CCAGTACATC  420
421   CCAACTGAGC  TGGATCAAGT  TAGAAAATGG  ATTTCTGACT  GGAATCTCAC  CACTGAAAAA  480
481   AAGCACACCC  TTTTAAGACT  ACTTTATGAG  GCACTTGTGG  ATTGTAAGAA  GAGTGATGCT  540
541   GCTTCAAAAG  TCATGGTGGA  ATTGCTCGGA  AGTTACACAG  AGGACAATGC  TTCCCAGGCT  600
601   CGAGTTGATG  CCCACAGGTG  TATTGTACGA  GCATTGAAAG  ATCCAAATGC  ATTTCTGTTT  660
661   GACCACCTTC  TTACTTTAAA  ACCAGTCAAG  TTTTTGGAAG  GCGAGCTTAT  TCATGATCTT  720
721   TTAACCATTT  TTGTGAGTGC  TAAATTGGCA  TCATATGTCA  AGTTTTATCA  GAATAATAAA  780
781   GACTTCATTG  ATTCACTTGG  CCTGTTACAT  GAACAGAATA  TGGCAAAAAT  GAGACTACTT  840
841   ACTTTTATGG  GAATGGCAGT  AGAAAATAAG  GAAATTTCTT  TTGACACAAT  GCAGCAAGAG  900
901   CTTCAGATTG  GAGCTGATGA  TGTTGAAGCA  TTTGTTATTG  ACGCGGTAAG  AACTAAAATG  960
961   GTCTACTGCA  AAATTGATCA  GACCCAGAGA  AAAGTAGTTG  TCAGTCATAG  CACACATCGG  1020
1021  ACATTTGGAA  AACAGCAGTG  GCAACAACTG  TATGACACAC  TTAATGCCTG  GAAACAAAAT  1080
1081  CTGAACAAAG  TGAAAAACAG  CCTTTTGAGT  CTTTCTGATA  CCTGA  1125

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Initiation factor
Phosphoprotein
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function
Translation initiation factor activity
Molecular Function
Translation initiation factor binding
Biological Process
Formation of cytoplasmic translation initiation complex

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-0728Bos taurus99.720.0 739
LLPS-Mal-0421Mandrillus leucophaeus99.720.0 739
LLPS-Paa-4099Papio anubis99.720.0 739
LLPS-Mup-3877Mustela putorius furo99.720.0 739
LLPS-Aim-2309Ailuropoda melanoleuca99.720.0 739
LLPS-Cea-1460Cercocebus atys99.720.0 739
LLPS-Maf-2845Macaca fascicularis99.720.0 739
LLPS-Chs-3306Chlorocebus sabaeus99.720.0 739
LLPS-Mam-3436Macaca mulatta99.720.0 739
LLPS-Caf-3801Canis familiaris99.720.0 739
LLPS-Ict-2988Ictidomys tridecemlineatus99.720.0 739
LLPS-Nol-4108Nomascus leucogenys99.720.0 739
LLPS-Man-2330Macaca nemestrina99.720.0 739
LLPS-Urm-1068Ursus maritimus99.720.0 739
LLPS-Pap-3084Pan paniscus99.720.0 739
LLPS-Pat-2427Pan troglodytes99.720.0 739
LLPS-Hos-1475Homo sapiens99.720.0 739
LLPS-Orc-4247Oryctolagus cuniculus99.720.0 739
LLPS-Rhb-3728Rhinopithecus bieti99.720.0 738
LLPS-Tut-2193Tursiops truncatus99.440.0 736
LLPS-Ova-0408Ovis aries99.440.0 737
LLPS-Ran-3154Rattus norvegicus99.440.0 737
LLPS-Aon-1791Aotus nancymaae99.440.0 738
LLPS-Sus-4198Sus scrofa99.440.0 738
LLPS-Mea-2694Mesocricetus auratus99.440.0 737
LLPS-Cas-0386Carlito syrichta99.440.0 738
LLPS-Loa-4250Loxodonta africana99.440.0 737
LLPS-Fec-1751Felis catus99.440.0 738
LLPS-Otg-0102Otolemur garnettii99.340.0 619
LLPS-Mum-3116Mus musculus99.160.0 736
LLPS-Gog-4239Gorilla gorilla99.130.0 711
LLPS-Myl-2203Myotis lucifugus98.60.0 733
LLPS-Sah-3875Sarcophilus harrisii98.60.0 733
LLPS-Cap-4493Cavia porcellus98.60.0 735
LLPS-Mod-3495Monodelphis domestica98.60.0 733
LLPS-Caj-1040Callithrix jacchus98.280.0 711
LLPS-Fud-0741Fukomys damarensis96.080.0 709
LLPS-Ora-2429Ornithorhynchus anatinus96.050.0 699
LLPS-Fia-3566Ficedula albicollis95.580.0 593
LLPS-Gaga-2766Gallus gallus95.520.0 717
LLPS-Pes-2263Pelodiscus sinensis95.520.0 716
LLPS-Tag-2495Taeniopygia guttata94.770.0 686
LLPS-Anc-2618Anolis carolinensis94.120.0 702
LLPS-Meg-2367Meleagris gallopavo93.840.0 696
LLPS-Lac-1664Latimeria chalumnae92.440.0 695
LLPS-Leo-1557Lepisosteus oculatus92.160.0 697
LLPS-Anp-0356Anas platyrhynchos91.620.0 683
LLPS-Orn-3443Oreochromis niloticus91.60.0 693
LLPS-Xim-2562Xiphophorus maculatus91.040.0 691
LLPS-Asm-3199Astyanax mexicanus90.760.0 684
LLPS-Pof-4042Poecilia formosa90.50.0 686
LLPS-Orl-0550Oryzias latipes90.480.0 684
LLPS-Ten-3249Tetraodon nigroviridis90.480.0 685
LLPS-Eqc-3796Equus caballus90.330.0 719
LLPS-Icp-3495Ictalurus punctatus90.20.0 686
LLPS-Xet-2861Xenopus tropicalis90.20.0 679
LLPS-Dar-0408Danio rerio89.640.0 676
LLPS-Scm-0227Scophthalmus maximus88.240.0 667
LLPS-Tar-2099Takifugu rubripes88.20.0 593
LLPS-Gaa-0417Gasterosteus aculeatus87.960.0 669
LLPS-Scf-3308Scleropages formosus87.960.0 664
LLPS-Dio-4162Dipodomys ordii72.411e-78 245
LLPS-Cis-0028Ciona savignyi47.215e-111 336
LLPS-Drm-2260Drosophila melanogaster47.061e-111 338
LLPS-Cii-1217Ciona intestinalis46.655e-110 334
LLPS-Dac-1404Daucus carota38.02e-23 105
LLPS-Cae-1035Caenorhabditis elegans31.925e-44 162
LLPS-Pot-1176Populus trichocarpa31.216e-41 154
LLPS-Met-1623Medicago truncatula30.487e-40 151
LLPS-Cus-2097Cucumis sativus30.039e-38 145
LLPS-Zem-1511Zea mays29.891e-36 142
LLPS-Hea-0533Helianthus annuus29.853e-39 150
LLPS-Glm-1824Glycine max29.526e-39 149
LLPS-Phv-1099Phaseolus vulgaris29.527e-39 149
LLPS-Mua-0323Musa acuminata29.391e-32 131
LLPS-Via-0348Vigna angularis29.218e-38 145
LLPS-Abg-0804Absidia glauca29.031e-35 139
LLPS-Sem-1209Selaginella moellendorffii28.943e-36 141
LLPS-Nia-1369Nicotiana attenuata28.926e-36 140
LLPS-Sot-1181Solanum tuberosum28.838e-35 137
LLPS-Sob-0987Sorghum bicolor28.71e-33 134
LLPS-Mae-1202Manihot esculenta28.661e-34 137
LLPS-Sol-1729Solanum lycopersicum28.532e-34 136
LLPS-Orp-2198Oryza punctata28.539e-29 120
LLPS-Prp-2193Prunus persica28.42e-34 136
LLPS-Sei-2222Setaria italica28.373e-33 133
LLPS-Vir-1801Vigna radiata28.343e-35 138
LLPS-Phn-0993Phaeosphaeria nodorum28.35e-28 117
LLPS-Ors-0184Oryza sativa28.265e-27 114
LLPS-Org-1057Oryza glaberrima28.217e-27 114
LLPS-Mao-0818Magnaporthe oryzae28.165e-27 114
LLPS-Brd-1873Brachypodium distachyon28.035e-2197.4
LLPS-Asni-0615Aspergillus niger27.941e-2198.6
LLPS-Bro-1154Brassica oleracea27.811e-33 134
LLPS-Ori-1085Oryza indica27.731e-26 113
LLPS-Usm-0706Ustilago maydis27.694e-25 109
LLPS-Fuv-0995Fusarium verticillioides27.671e-0756.6
LLPS-Brr-1089Brassica rapa27.651e-31 128
LLPS-Thc-1361Theobroma cacao27.412e-34 136
LLPS-Coc-0769Corchorus capsularis27.413e-34 135
LLPS-Nec-1053Neurospora crassa27.271e-31 128
LLPS-Brn-3417Brassica napus27.222e-32 130
LLPS-Orni-1638Oryza nivara27.229e-25 108
LLPS-Blg-1327Blumeria graminis27.182e-31 127
LLPS-Viv-1470Vitis vinifera27.086e-33 132
LLPS-Amt-2284Amborella trichopoda27.074e-34 135
LLPS-Arl-2256Arabidopsis lyrata27.034e-34 135
LLPS-Spr-0507Sporisorium reilianum27.024e-32 130
LLPS-Aso-1010Aspergillus oryzae26.974e-23 103
LLPS-Asf-0470Aspergillus flavus26.974e-23 103
LLPS-Ast-0394Aspergillus terreus26.974e-2198.2
LLPS-Fus-0622Fusarium solani26.971e-0756.6
LLPS-Orgl-2130Oryza glumaepatula26.921e-24 108
LLPS-Orb-0146Oryza barthii26.921e-24 108
LLPS-Orr-1054Oryza rufipogon26.927e-25 108
LLPS-Orm-1049Oryza meridionalis26.842e-24 107
LLPS-Lep-1263Leersia perrieri26.799e-27 114
LLPS-Lem-0844Leptosphaeria maculans26.792e-27 116
LLPS-Pyt-1099Pyrenophora teres26.791e-24 108
LLPS-Chc-1047Chondrus crispus26.713e-23 103
LLPS-Art-2879Arabidopsis thaliana26.653e-33 133
LLPS-Hov-2041Hordeum vulgare26.58e-2298.6
LLPS-Gas-1119Galdieria sulphuraria26.481e-22 101
LLPS-Asc-0252Aspergillus clavatus26.471e-2097.1
LLPS-Trr-0949Trichoderma reesei26.373e-28 118
LLPS-Gag-1580Gaeumannomyces graminis26.363e-23 103
LLPS-Fuo-1337Fusarium oxysporum26.179e-33 132
LLPS-Tum-1204Tuber melanosporum26.024e-29 120
LLPS-Gor-2052Gossypium raimondii25.842e-32 131
LLPS-Php-0681Physcomitrella patens25.696e-29 120
LLPS-Pytr-0039Pyrenophora triticirepentis25.661e-24 107
LLPS-Nef-1241Neosartorya fischeri25.68e-22 100
LLPS-Tra-2868Triticum aestivum25.562e-23 103
LLPS-Coo-0138Colletotrichum orbiculare25.37e-28 117
LLPS-Beb-0777Beauveria bassiana25.072e-27 116
LLPS-Trv-0450Trichoderma virens25.05e-26 112
LLPS-Asfu-1660Aspergillus fumigatus25.08e-2197.4
LLPS-Asn-1371Aspergillus nidulans24.933e-1374.7
LLPS-Yal-1511Yarrowia lipolytica24.691e-1272.8
LLPS-Cogr-1488Colletotrichum graminicola24.595e-28 117
LLPS-Crn-1067Cryptococcus neoformans24.355e-1373.9
LLPS-Scj-1511Schizosaccharomyces japonicus24.326e-2197.4
LLPS-Scc-1534Schizosaccharomyces cryophilus23.912e-1478.2
LLPS-Dos-1048Dothistroma septosporum23.849e-26 111
LLPS-Cog-1282Colletotrichum gloeosporioides23.647e-1991.7
LLPS-Zyt-0150Zymoseptoria tritici23.623e-1890.5
LLPS-Osl-0476Ostreococcus lucimarinus23.558e-0960.8
LLPS-Ved-1443Verticillium dahliae23.483e-28 119
LLPS-Scp-1355Schizosaccharomyces pombe22.761e-1581.6
LLPS-Kop-0709Komagataella pastoris21.822e-0653.5