LLPS-Asn-1371
AN4259
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 3 subunit M |
| Gene Name: | AN4259 |
| Ensembl Gene: | ANIA_04259 |
| Ensembl Protein: | CBF74373 |
| Organism: | Aspergillus nidulans |
| Taxa ID: | 227321 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CBF74373 | CBF74373 |
| UniProt | Q5B5C1, EIF3M_EMENI, C8V418 | |
| GeneBank | AACD01000069, BN001302 | EAA58927.1, CBF74373.1 |
| RefSeq | XM_656771.1 | XP_661863.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MPAPSTTLLI EGSFSELAEE FAAYLDALNK PDDTTVQTEV APLLQPLREQ EQNDTQLDQS 60 61 KRDEVLKKLV SAATVLNTAP EKEITPAYNL LIHLVQQASD PDMFLSRICS YLAKPIPSSP 120 121 QFGASLSIAI LSTIFNTLAP TDSSRFHVLL AIVTVIRQSG SSAAFDALKP QLTAQLPNWR 180 181 STWELDDEEA RRLHLAIADA AQAAGDLDWA QTHVVDALQT IPPAEASSPA ARDLAVRALT 240 241 SALTHPAVFD FTPLTAADAV QALRSSDAPL FELLEIFTAD TLDAYEDFIS ATPVENILPD 300 301 NALAPHAEAL QTKIRLLTLA SLAAAATTTT GPSARSLSYE TIASALRVPQ EEVEKWVIDT 360 361 IRAGLVEGKL SQLRSEFLVH RATYRVFGEK QWAEVQGRLM VWRRSLENVL GVIRSERERF 420 421 VREAAAAAAA AAAEGEKGDK NNKGPSERRR APQEIAAAE 459 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCCCGCTC CTTCAACCAC CCTCCTGATC GAGGGTTCCT TCTCCGAACT CGCCGAGGAA 60 61 TTTGCTGCGT ACCTCGATGC CCTCAACAAG CCCGACGATA CCACCGTTCA GACCGAGGTC 120 121 GCCCCGCTGC TGCAACCCCT CCGCGAGCAG GAACAGAATG ATACCCAGCT TGATCAGAGC 180 181 AAGCGGGATG AGGTGCTGAA GAAGCTGGTC TCGGCCGCCA CTGTGCTCAA CACGGCGCCG 240 241 GAGAAGGAGA TTACACCCGC TTACAACCTC CTGATCCACC TCGTCCAGCA GGCCTCCGAC 300 301 CCTGACATGT TCCTCTCTCG CATCTGCTCA TACCTCGCCA AGCCCATCCC CTCCTCTCCT 360 361 CAGTTCGGTG CCTCTCTTTC CATCGCCATC CTGTCCACCA TCTTCAACAC ACTCGCCCCT 420 421 ACCGACTCCA GCCGATTCCA CGTTCTCTTG GCCATTGTCA CCGTGATCCG CCAGTCTGGC 480 481 TCCTCTGCGG CTTTTGATGC TCTGAAGCCC CAGTTGACTG CACAGCTGCC CAACTGGCGC 540 541 TCCACCTGGG AACTTGACGA TGAGGAGGCC CGCCGTCTGC ATCTGGCCAT CGCTGACGCC 600 601 GCCCAGGCGG CCGGCGACCT CGATTGGGCT CAGACTCACG TTGTCGATGC TCTCCAGACC 660 661 ATTCCTCCGG CCGAAGCCTC ATCCCCTGCA GCACGCGACC TTGCCGTGCG TGCTCTGACC 720 721 TCAGCGCTCA CCCACCCGGC CGTCTTCGAC TTCACCCCGT TAACCGCCGC CGATGCCGTT 780 781 CAGGCCTTGC GATCTAGCGA CGCACCCCTC TTCGAGCTGC TTGAGATTTT CACCGCTGAT 840 841 ACCCTTGATG CCTACGAGGA TTTCATCTCC GCCACCCCTG TCGAAAACAT CCTCCCTGAC 900 901 AACGCCTTGG CCCCCCATGC CGAAGCTCTG CAGACCAAGA TCCGTCTACT CACTCTGGCA 960 961 TCTCTTGCCG CGGCCGCCAC AACCACAACA GGTCCGTCCG CGCGCTCTCT GTCATACGAG 1020 1021 ACTATTGCGT CCGCCCTTCG CGTGCCGCAG GAGGAAGTTG AAAAGTGGGT CATTGACACC 1080 1081 ATCCGTGCTG GTCTGGTTGA GGGCAAGCTT TCTCAATTGC GTTCTGAGTT TTTGGTCCAT 1140 1141 CGTGCCACCT ACCGTGTGTT CGGTGAGAAG CAGTGGGCCG AAGTCCAGGG TCGTCTTATG 1200 1201 GTGTGGCGAC GAAGCCTGGA GAACGTCCTT GGTGTCATTC GCAGCGAGCG TGAGCGATTT 1260 1261 GTACGGGAAG CTGCTGCTGC TGCGGCTGCG GCTGCTGCAG AGGGTGAGAA GGGAGATAAG 1320 1321 AATAACAAGG GACCGTCTGA GCGTCGACGT GCTCCTCAGG AGATAGCTGC CGCGGAGTAG 1380 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex, eIF3m | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Cellular response to farnesol | |
Biological Process | Cytoplasmic translational initiation | |
Biological Process | Formation of cytoplasmic translation initiation complex |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ast-0394 | Aspergillus terreus | 77.25 | 0.0 | 601 |
| LLPS-Asni-0615 | Aspergillus niger | 76.72 | 5e-155 | 452 |
| LLPS-Asf-0470 | Aspergillus flavus | 75.94 | 0.0 | 613 |
| LLPS-Aso-1010 | Aspergillus oryzae | 75.94 | 0.0 | 613 |
| LLPS-Nef-1241 | Neosartorya fischeri | 75.28 | 0.0 | 617 |
| LLPS-Asfu-1660 | Aspergillus fumigatus | 75.28 | 0.0 | 613 |
| LLPS-Asc-0252 | Aspergillus clavatus | 72.81 | 0.0 | 567 |
| LLPS-Pytr-0039 | Pyrenophora triticirepentis | 51.17 | 1e-122 | 371 |
| LLPS-Pyt-1099 | Pyrenophora teres | 50.94 | 2e-122 | 371 |
| LLPS-Phn-0993 | Phaeosphaeria nodorum | 50.93 | 5e-119 | 362 |
| LLPS-Zyt-0150 | Zymoseptoria tritici | 50.59 | 2e-107 | 340 |
| LLPS-Lem-0844 | Leptosphaeria maculans | 48.03 | 7e-118 | 361 |
| LLPS-Dos-1048 | Dothistroma septosporum | 46.58 | 3e-111 | 342 |
| LLPS-Fuo-1337 | Fusarium oxysporum | 41.79 | 2e-74 | 247 |
| LLPS-Blg-1327 | Blumeria graminis | 41.39 | 5e-75 | 247 |
| LLPS-Fuv-1115 | Fusarium verticillioides | 41.3 | 3e-73 | 244 |
| LLPS-Nec-1053 | Neurospora crassa | 40.53 | 2e-72 | 241 |
| LLPS-Beb-0777 | Beauveria bassiana | 40.28 | 5e-72 | 240 |
| LLPS-Trr-0949 | Trichoderma reesei | 40.19 | 7e-72 | 240 |
| LLPS-Cogr-1488 | Colletotrichum graminicola | 39.95 | 9e-72 | 240 |
| LLPS-Tum-1204 | Tuber melanosporum | 39.72 | 4e-68 | 229 |
| LLPS-Fus-1361 | Fusarium solani | 39.29 | 1e-67 | 229 |
| LLPS-Mao-0818 | Magnaporthe oryzae | 38.41 | 2e-73 | 244 |
| LLPS-Trv-0450 | Trichoderma virens | 38.24 | 2e-68 | 231 |
| LLPS-Gag-1580 | Gaeumannomyces graminis | 37.86 | 1e-64 | 221 |
| LLPS-Ved-1443 | Verticillium dahliae | 37.79 | 2e-66 | 226 |
| LLPS-Coo-0138 | Colletotrichum orbiculare | 35.94 | 1e-63 | 219 |
| LLPS-Cog-1282 | Colletotrichum gloeosporioides | 35.84 | 6e-63 | 216 |
| LLPS-Abg-0804 | Absidia glauca | 32.65 | 8e-33 | 132 |
| LLPS-Tra-2868 | Triticum aestivum | 32.21 | 2e-13 | 76.3 |
| LLPS-Hov-2041 | Hordeum vulgare | 32.21 | 4e-13 | 74.3 |
| LLPS-Hea-0533 | Helianthus annuus | 32.0 | 2e-12 | 72.8 |
| LLPS-Dac-1404 | Daucus carota | 31.76 | 5e-13 | 75.1 |
| LLPS-Lep-1263 | Leersia perrieri | 31.76 | 6e-13 | 74.3 |
| LLPS-Brd-1873 | Brachypodium distachyon | 31.54 | 7e-11 | 68.2 |
| LLPS-Orni-1638 | Oryza nivara | 31.08 | 1e-12 | 73.6 |
| LLPS-Ori-1085 | Oryza indica | 31.08 | 1e-12 | 73.6 |
| LLPS-Orb-0146 | Oryza barthii | 31.08 | 1e-12 | 73.6 |
| LLPS-Orgl-2130 | Oryza glumaepatula | 31.08 | 1e-12 | 73.6 |
| LLPS-Ors-0184 | Oryza sativa | 31.08 | 1e-12 | 73.2 |
| LLPS-Orp-2198 | Oryza punctata | 31.08 | 1e-12 | 73.9 |
| LLPS-Org-1057 | Oryza glaberrima | 31.08 | 1e-12 | 73.6 |
| LLPS-Orm-1049 | Oryza meridionalis | 31.08 | 1e-12 | 73.6 |
| LLPS-Orr-1054 | Oryza rufipogon | 31.08 | 2e-12 | 73.2 |
| LLPS-Gas-1119 | Galdieria sulphuraria | 30.53 | 1e-16 | 85.5 |
| LLPS-Scj-1511 | Schizosaccharomyces japonicus | 30.47 | 3e-35 | 140 |
| LLPS-Usm-0706 | Ustilago maydis | 30.39 | 4e-29 | 122 |
| LLPS-Crn-1067 | Cryptococcus neoformans | 30.27 | 5e-09 | 62.4 |
| LLPS-Spr-0507 | Sporisorium reilianum | 29.44 | 4e-31 | 128 |
| LLPS-Scp-1355 | Schizosaccharomyces pombe | 28.71 | 2e-28 | 120 |
| LLPS-Sem-1209 | Selaginella moellendorffii | 28.61 | 3e-23 | 104 |
| LLPS-Scc-1534 | Schizosaccharomyces cryophilus | 27.71 | 2e-30 | 125 |
| LLPS-Eqc-3796 | Equus caballus | 27.57 | 1e-09 | 64.3 |
| LLPS-Bro-1154 | Brassica oleracea | 27.3 | 2e-19 | 94.0 |
| LLPS-Cus-2097 | Cucumis sativus | 27.27 | 6e-20 | 95.5 |
| LLPS-Cae-1035 | Caenorhabditis elegans | 27.06 | 1e-10 | 67.0 |
| LLPS-Cii-1217 | Ciona intestinalis | 26.94 | 1e-15 | 82.4 |
| LLPS-Brr-1089 | Brassica rapa | 26.91 | 1e-20 | 97.8 |
| LLPS-Fia-3566 | Ficedula albicollis | 26.67 | 6e-13 | 73.6 |
| LLPS-Brn-3417 | Brassica napus | 26.63 | 1e-17 | 88.6 |
| LLPS-Arl-2256 | Arabidopsis lyrata | 26.35 | 3e-19 | 93.6 |
| LLPS-Pes-2263 | Pelodiscus sinensis | 26.32 | 3e-13 | 75.1 |
| LLPS-Cas-0386 | Carlito syrichta | 26.32 | 4e-13 | 74.7 |
| LLPS-Amt-2284 | Amborella trichopoda | 26.23 | 1e-16 | 85.5 |
| LLPS-Php-0681 | Physcomitrella patens | 26.17 | 1e-14 | 79.7 |
| LLPS-Art-2879 | Arabidopsis thaliana | 26.06 | 3e-18 | 90.5 |
| LLPS-Tag-2495 | Taeniopygia guttata | 26.03 | 5e-13 | 74.3 |
| LLPS-Prp-2193 | Prunus persica | 25.98 | 2e-16 | 84.7 |
| LLPS-Mae-1202 | Manihot esculenta | 25.81 | 6e-14 | 77.4 |
| LLPS-Vir-1801 | Vigna radiata | 25.64 | 3e-15 | 81.6 |
| LLPS-Scf-3308 | Scleropages formosus | 25.61 | 3e-11 | 68.9 |
| LLPS-Meg-2367 | Meleagris gallopavo | 25.61 | 2e-12 | 72.8 |
| LLPS-Gaga-2766 | Gallus gallus | 25.61 | 2e-12 | 72.8 |
| LLPS-Sot-1181 | Solanum tuberosum | 25.57 | 4e-19 | 93.2 |
| LLPS-Yal-1511 | Yarrowia lipolytica | 25.42 | 6e-19 | 92.4 |
| LLPS-Fud-0741 | Fukomys damarensis | 25.29 | 4e-13 | 74.7 |
| LLPS-Cap-4493 | Cavia porcellus | 25.29 | 2e-13 | 75.9 |
| LLPS-Mua-0323 | Musa acuminata | 25.28 | 4e-14 | 77.8 |
| LLPS-Nia-1369 | Nicotiana attenuata | 25.28 | 3e-14 | 78.6 |
| LLPS-Met-1623 | Medicago truncatula | 25.21 | 3e-16 | 84.3 |
| LLPS-Pot-1176 | Populus trichocarpa | 25.14 | 2e-13 | 75.9 |
| LLPS-Gog-4239 | Gorilla gorilla | 25.0 | 2e-13 | 75.9 |
| LLPS-Chs-3306 | Chlorocebus sabaeus | 25.0 | 2e-13 | 75.9 |
| LLPS-Ora-2429 | Ornithorhynchus anatinus | 25.0 | 5e-14 | 77.4 |
| LLPS-Maf-2845 | Macaca fascicularis | 25.0 | 2e-13 | 75.9 |
| LLPS-Mum-3116 | Mus musculus | 25.0 | 1e-13 | 76.3 |
| LLPS-Mea-2694 | Mesocricetus auratus | 25.0 | 1e-13 | 76.3 |
| LLPS-Sus-4198 | Sus scrofa | 25.0 | 6e-14 | 77.4 |
| LLPS-Cea-1460 | Cercocebus atys | 25.0 | 2e-13 | 75.9 |
| LLPS-Sah-3875 | Sarcophilus harrisii | 25.0 | 4e-14 | 77.8 |
| LLPS-Aon-1791 | Aotus nancymaae | 25.0 | 6e-14 | 77.4 |
| LLPS-Ran-3154 | Rattus norvegicus | 25.0 | 1e-13 | 76.3 |
| LLPS-Mup-3877 | Mustela putorius furo | 25.0 | 2e-13 | 75.9 |
| LLPS-Aim-2309 | Ailuropoda melanoleuca | 25.0 | 2e-13 | 75.9 |
| LLPS-Ova-0408 | Ovis aries | 25.0 | 2e-13 | 75.9 |
| LLPS-Mal-0421 | Mandrillus leucophaeus | 25.0 | 2e-13 | 75.9 |
| LLPS-Paa-4099 | Papio anubis | 25.0 | 2e-13 | 75.9 |
| LLPS-Drm-2260 | Drosophila melanogaster | 25.0 | 3e-10 | 65.9 |
| LLPS-Bot-0728 | Bos taurus | 25.0 | 2e-13 | 75.9 |
| LLPS-Rhb-3728 | Rhinopithecus bieti | 25.0 | 1e-13 | 76.3 |
| LLPS-Orc-4247 | Oryctolagus cuniculus | 25.0 | 2e-13 | 75.9 |
| LLPS-Fec-1751 | Felis catus | 25.0 | 1e-13 | 75.9 |
| LLPS-Mod-3495 | Monodelphis domestica | 25.0 | 4e-14 | 77.8 |
| LLPS-Hos-1475 | Homo sapiens | 25.0 | 2e-13 | 75.9 |
| LLPS-Pat-2427 | Pan troglodytes | 25.0 | 2e-13 | 75.9 |
| LLPS-Urm-1068 | Ursus maritimus | 25.0 | 2e-13 | 75.9 |
| LLPS-Viv-1470 | Vitis vinifera | 25.0 | 4e-19 | 93.2 |
| LLPS-Pap-3084 | Pan paniscus | 25.0 | 2e-13 | 75.9 |
| LLPS-Loa-4250 | Loxodonta africana | 25.0 | 2e-13 | 75.5 |
| LLPS-Man-2330 | Macaca nemestrina | 25.0 | 2e-13 | 75.9 |
| LLPS-Nol-4108 | Nomascus leucogenys | 25.0 | 2e-13 | 75.9 |
| LLPS-Ict-2988 | Ictidomys tridecemlineatus | 25.0 | 2e-13 | 75.9 |
| LLPS-Poa-0139 | Pongo abelii | 25.0 | 1e-13 | 76.3 |
| LLPS-Caf-3801 | Canis familiaris | 25.0 | 2e-13 | 75.9 |
| LLPS-Mam-3436 | Macaca mulatta | 25.0 | 2e-13 | 75.9 |
| LLPS-Sol-1729 | Solanum lycopersicum | 24.93 | 2e-16 | 84.7 |
| LLPS-Anp-0356 | Anas platyrhynchos | 24.71 | 2e-13 | 75.9 |
| LLPS-Sob-0987 | Sorghum bicolor | 24.65 | 8e-13 | 73.9 |
| LLPS-Zem-1511 | Zea mays | 24.65 | 1e-13 | 76.6 |
| LLPS-Via-0348 | Vigna angularis | 24.58 | 3e-15 | 81.3 |
| LLPS-Tut-2193 | Tursiops truncatus | 24.57 | 4e-14 | 77.8 |
| LLPS-Gaa-0417 | Gasterosteus aculeatus | 24.57 | 6e-13 | 74.3 |
| LLPS-Lac-1664 | Latimeria chalumnae | 24.57 | 1e-14 | 79.3 |
| LLPS-Chc-1047 | Chondrus crispus | 24.5 | 2e-16 | 85.5 |
| LLPS-Anc-2618 | Anolis carolinensis | 24.5 | 1e-13 | 75.9 |
| LLPS-Orl-0550 | Oryzias latipes | 24.43 | 5e-13 | 74.3 |
| LLPS-Glm-1824 | Glycine max | 24.3 | 1e-17 | 88.6 |
| LLPS-Sei-2222 | Setaria italica | 24.2 | 3e-13 | 75.1 |
| LLPS-Cis-0028 | Ciona savignyi | 24.16 | 9e-17 | 85.9 |
| LLPS-Icp-3495 | Ictalurus punctatus | 24.14 | 2e-13 | 75.9 |
| LLPS-Pof-4042 | Poecilia formosa | 24.07 | 6e-11 | 68.2 |
| LLPS-Leo-1557 | Lepisosteus oculatus | 23.99 | 1e-12 | 73.2 |
| LLPS-Myl-2203 | Myotis lucifugus | 23.99 | 8e-13 | 73.6 |
| LLPS-Thc-1361 | Theobroma cacao | 23.86 | 6e-16 | 83.6 |
| LLPS-Orn-3443 | Oreochromis niloticus | 23.85 | 3e-12 | 72.0 |
| LLPS-Phv-1099 | Phaseolus vulgaris | 23.8 | 7e-16 | 83.6 |
| LLPS-Caj-1040 | Callithrix jacchus | 23.73 | 9e-14 | 77.0 |
| LLPS-Asm-3199 | Astyanax mexicanus | 23.7 | 8e-12 | 70.9 |
| LLPS-Xim-2562 | Xiphophorus maculatus | 23.56 | 2e-12 | 72.4 |
| LLPS-Dar-0408 | Danio rerio | 23.56 | 4e-13 | 74.7 |
| LLPS-Scm-0227 | Scophthalmus maximus | 23.41 | 2e-11 | 69.3 |
| LLPS-Xet-2861 | Xenopus tropicalis | 23.41 | 1e-13 | 76.3 |
| LLPS-Coc-0769 | Corchorus capsularis | 22.91 | 9e-15 | 80.1 |
| LLPS-Gor-2052 | Gossypium raimondii | 22.79 | 1e-11 | 70.5 |
| LLPS-Ten-3249 | Tetraodon nigroviridis | 22.54 | 1e-10 | 67.4 |