• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nec-1053
NCU02813

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit M
Gene Name: NCU02813
Ensembl Gene: NCU02813
Ensembl Protein: EAA35233
Organism: Neurospora crassa
Taxa ID: 367110
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAA35233EAA35233
UniProtQ7SEK1, EIF3M_NEUCR
GeneBankCM002236EAA35233.1
RefSeqXM_959376.3XP_964469.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATPQLIFVD  GTFAELAQEM  ADFVQVGEQV  QPLLEQDKRE  DALDLIVKAS  HSLNAAPEKD  60
61    FTPAYNLLIH  LVLQSEEPKK  YLPTLCANLL  KPITSSPTHG  FTLASNALTT  IFNLLDKSNP  120
121   LRFNVFMQIV  RFIRQNSQFD  LLKPRLKNVE  GWLQEWKSDS  ESQRKLYVEV  SDAANDGGDQ  180
181   EESYFYLLKA  LATFDRDNQD  EVASDEAQKL  SLRALRMAIS  SPTRFDFNDL  RSLPSVHALS  240
241   DSHPVYSQLL  DIFTEQDLED  YNDFRDEHQG  WIENEKLDHE  KLQRKMRLLT  FASLAASTPN  300
301   REIPYASIAK  ALQIPDEDVE  MWTIDVIRSK  LVEGRLSQKQ  KVFLVHRTTY  RVFGEKQWRE  360
361   LGTRVDQFKT  VVDRLVGVVR  KAQTDVEAQR  EREQQELERK  LANAGLGESE  QRGGNRGGRT  420
421   GGARQTRQRT  DDDD  434
Nucleotide CDS Sequence (FASTA)
1     ATGGCTACCC  CCCAGTTGAT  CTTCGTCGAC  GGCACCTTCG  CCGAGCTGGC  GCAGGAGATG  60
61    GCCGACTTCG  TCCAGGTCGG  CGAGCAGGTC  CAGCCTCTCC  TCGAGCAGGA  CAAGCGCGAG  120
121   GATGCCCTTG  ACCTCATCGT  CAAGGCCTCC  CACTCCCTCA  ACGCCGCCCC  CGAGAAGGAC  180
181   TTCACCCCCG  CCTACAACCT  CCTCATCCAC  CTCGTCCTCC  AGTCCGAGGA  GCCCAAGAAG  240
241   TACCTGCCCA  CCCTGTGCGC  CAACCTTCTC  AAGCCCATCA  CCTCGTCTCC  CACCCACGGC  300
301   TTCACCCTGG  CCTCCAATGC  GCTCACCACC  ATCTTCAACC  TCCTCGACAA  GTCCAACCCG  360
361   CTGCGCTTCA  ATGTCTTTAT  GCAGATCGTC  CGCTTCATCA  GGCAAAACAG  CCAGTTCGAC  420
421   CTCCTCAAGC  CCAGGTTAAA  GAACGTCGAG  GGCTGGCTCC  AGGAATGGAA  GTCCGACTCG  480
481   GAGAGCCAGC  GCAAGCTCTA  CGTCGAGGTT  TCCGATGCCG  CCAACGACGG  CGGTGATCAG  540
541   GAGGAGTCCT  ACTTCTACCT  CCTCAAGGCT  CTGGCCACTT  TCGACCGCGA  CAACCAGGAC  600
601   GAGGTCGCCT  CCGACGAGGC  CCAGAAGCTC  TCCCTCCGCG  CCCTCCGCAT  GGCCATCTCG  660
661   TCGCCCACCC  GCTTCGACTT  CAACGACCTG  CGCTCGCTCC  CCTCGGTCCA  CGCCCTGAGC  720
721   GACTCGCACC  CCGTCTACTC  GCAGCTCCTC  GACATCTTCA  CCGAGCAGGA  CCTCGAGGAC  780
781   TACAACGACT  TTAGGGACGA  GCACCAGGGA  TGGATCGAGA  ACGAGAAGCT  CGACCACGAG  840
841   AAGCTGCAGC  GCAAGATGCG  CCTGCTCACC  TTTGCGTCGC  TCGCCGCCAG  CACCCCGAAC  900
901   CGCGAGATCC  CCTACGCCAG  CATCGCCAAG  GCCCTCCAAA  TCCCCGACGA  GGACGTCGAG  960
961   ATGTGGACCA  TTGACGTGAT  CCGCTCCAAG  CTGGTCGAGG  GCCGCCTGTC  ACAGAAGCAA  1020
1021  AAGGTGTTCT  TGGTTCACCG  CACCACCTAC  CGCGTCTTTG  GCGAGAAGCA  GTGGCGCGAG  1080
1081  CTCGGCACCC  GCGTCGACCA  GTTCAAGACG  GTCGTCGATA  GGCTCGTCGG  CGTCGTGCGC  1140
1141  AAGGCCCAGA  CCGATGTCGA  GGCCCAGCGT  GAGCGTGAGC  AGCAGGAGCT  CGAGCGCAAG  1200
1201  CTGGCCAACG  CCGGTCTTGG  CGAGTCGGAG  CAGCGCGGCG  GCAACCGGGG  AGGACGTACC  1260
1261  GGCGGTGCCA  GACAGACGAG  GCAACGCACG  GATGATGATG  ACTGA  1305

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function
Translation initiation factor activity
Biological Process
Cytoplasmic translational initiation
Biological Process
Formation of cytoplasmic translation initiation complex

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mao-0818Magnaporthe oryzae59.592e-162 472
LLPS-Cogr-1488Colletotrichum graminicola58.292e-169 491
LLPS-Gag-1580Gaeumannomyces graminis57.928e-150 440
LLPS-Beb-0777Beauveria bassiana57.75e-165 479
LLPS-Ved-1443Verticillium dahliae57.511e-163 476
LLPS-Fus-1361Fusarium solani57.256e-162 471
LLPS-Coo-0138Colletotrichum orbiculare57.254e-166 483
LLPS-Fuo-1337Fusarium oxysporum56.92e-159 465
LLPS-Trr-0949Trichoderma reesei56.766e-160 466
LLPS-Blg-1327Blumeria graminis56.711e-155 453
LLPS-Trv-0450Trichoderma virens56.12e-158 462
LLPS-Fuv-1115Fusarium verticillioides55.995e-157 459
LLPS-Cog-1282Colletotrichum gloeosporioides54.153e-147 434
LLPS-Lem-0844Leptosphaeria maculans47.943e-126 381
LLPS-Phn-0993Phaeosphaeria nodorum47.731e-122 370
LLPS-Pytr-0039Pyrenophora triticirepentis47.422e-123 372
LLPS-Pyt-1099Pyrenophora teres47.423e-123 372
LLPS-Asni-0615Aspergillus niger43.517e-71 235
LLPS-Dos-1048Dothistroma septosporum42.783e-108 334
LLPS-Nef-1241Neosartorya fischeri42.227e-95 300
LLPS-Asc-0252Aspergillus clavatus41.983e-88 283
LLPS-Asfu-1660Aspergillus fumigatus41.732e-93 296
LLPS-Tum-1204Tuber melanosporum41.164e-106 328
LLPS-Ast-0394Aspergillus terreus41.093e-84 272
LLPS-Asf-0470Aspergillus flavus41.095e-86 277
LLPS-Aso-1010Aspergillus oryzae41.095e-86 277
LLPS-Asn-1371Aspergillus nidulans40.531e-75 249
LLPS-Zyt-0150Zymoseptoria tritici40.352e-92 300
LLPS-Scj-1511Schizosaccharomyces japonicus34.463e-51 184
LLPS-Dac-1404Daucus carota31.93e-1994.4
LLPS-Abg-0804Absidia glauca31.758e-51 182
LLPS-Drm-2260Drosophila melanogaster31.371e-29 123
LLPS-Arl-2256Arabidopsis lyrata30.981e-40 155
LLPS-Spr-0507Sporisorium reilianum30.294e-41 156
LLPS-Art-2879Arabidopsis thaliana30.286e-41 155
LLPS-Cus-2097Cucumis sativus30.211e-40 155
LLPS-Crn-1067Cryptococcus neoformans30.03e-1890.5
LLPS-Scc-1534Schizosaccharomyces cryophilus29.93e-49 178
LLPS-Sem-1209Selaginella moellendorffii29.663e-42 159
LLPS-Prp-2193Prunus persica29.623e-37 145
LLPS-Hov-2041Hordeum vulgare29.332e-29 121
LLPS-Scp-1355Schizosaccharomyces pombe29.274e-44 164
LLPS-Usm-0706Ustilago maydis29.151e-28 120
LLPS-Brr-1089Brassica rapa29.147e-37 144
LLPS-Sot-1181Solanum tuberosum28.93e-35 139
LLPS-Bro-1154Brassica oleracea28.623e-36 143
LLPS-Mua-0323Musa acuminata28.613e-34 137
LLPS-Viv-1470Vitis vinifera28.531e-36 143
LLPS-Pot-1176Populus trichocarpa28.534e-35 139
LLPS-Gas-1119Galdieria sulphuraria28.335e-27 115
LLPS-Brn-3417Brassica napus28.311e-35 140
LLPS-Hea-0533Helianthus annuus28.151e-30 126
LLPS-Tra-2868Triticum aestivum28.147e-28 118
LLPS-Brd-1873Brachypodium distachyon28.127e-25 109
LLPS-Php-0681Physcomitrella patens27.971e-34 138
LLPS-Nia-1369Nicotiana attenuata27.733e-33 134
LLPS-Mae-1202Manihot esculenta27.671e-31 129
LLPS-Sol-1729Solanum lycopersicum27.463e-32 130
LLPS-Fia-3566Ficedula albicollis27.333e-30 123
LLPS-Pes-2263Pelodiscus sinensis27.35e-32 129
LLPS-Mod-3495Monodelphis domestica27.223e-32 130
LLPS-Scm-0227Scophthalmus maximus27.225e-31 127
LLPS-Sah-3875Sarcophilus harrisii27.223e-32 130
LLPS-Amt-2284Amborella trichopoda27.172e-32 131
LLPS-Icp-3495Ictalurus punctatus27.126e-33 132
LLPS-Phv-1099Phaseolus vulgaris27.063e-31 128
LLPS-Asm-3199Astyanax mexicanus27.066e-33 132
LLPS-Cap-4493Cavia porcellus27.034e-32 130
LLPS-Fud-0741Fukomys damarensis27.036e-32 129
LLPS-Pof-4042Poecilia formosa27.011e-31 129
LLPS-Tag-2495Taeniopygia guttata26.982e-30 124
LLPS-Anc-2618Anolis carolinensis26.962e-30 125
LLPS-Gor-2052Gossypium raimondii26.919e-33 132
LLPS-Dar-0408Danio rerio26.858e-33 132
LLPS-Xim-2562Xiphophorus maculatus26.793e-33 133
LLPS-Coc-0769Corchorus capsularis26.761e-33 135
LLPS-Thc-1361Theobroma cacao26.762e-34 137
LLPS-Lep-1263Leersia perrieri26.752e-31 128
LLPS-Orni-1638Oryza nivara26.737e-27 115
LLPS-Mea-2694Mesocricetus auratus26.732e-32 130
LLPS-Mum-3116Mus musculus26.732e-32 130
LLPS-Ran-3154Rattus norvegicus26.732e-32 130
LLPS-Meg-2367Meleagris gallopavo26.675e-30 124
LLPS-Gaga-2766Gallus gallus26.674e-30 124
LLPS-Orm-1049Oryza meridionalis26.672e-26 114
LLPS-Lac-1664Latimeria chalumnae26.612e-31 128
LLPS-Anp-0356Anas platyrhynchos26.615e-31 127
LLPS-Ora-2429Ornithorhynchus anatinus26.619e-32 129
LLPS-Orl-0550Oryzias latipes26.541e-33 134
LLPS-Orc-4247Oryctolagus cuniculus26.439e-32 129
LLPS-Rhb-3728Rhinopithecus bieti26.439e-32 129
LLPS-Pap-3084Pan paniscus26.439e-32 129
LLPS-Urm-1068Ursus maritimus26.439e-32 129
LLPS-Pat-2427Pan troglodytes26.439e-32 129
LLPS-Hos-1475Homo sapiens26.439e-32 129
LLPS-Fec-1751Felis catus26.431e-31 129
LLPS-Man-2330Macaca nemestrina26.439e-32 129
LLPS-Loa-4250Loxodonta africana26.431e-31 129
LLPS-Cas-0386Carlito syrichta26.431e-31 129
LLPS-Ict-2988Ictidomys tridecemlineatus26.439e-32 129
LLPS-Nol-4108Nomascus leucogenys26.439e-32 129
LLPS-Caf-3801Canis familiaris26.439e-32 129
LLPS-Poa-0139Pongo abelii26.431e-31 129
LLPS-Mam-3436Macaca mulatta26.439e-32 129
LLPS-Gog-4239Gorilla gorilla26.431e-31 129
LLPS-Caj-1040Callithrix jacchus26.437e-32 129
LLPS-Maf-2845Macaca fascicularis26.439e-32 129
LLPS-Chs-3306Chlorocebus sabaeus26.439e-32 129
LLPS-Aon-1791Aotus nancymaae26.435e-32 129
LLPS-Cea-1460Cercocebus atys26.439e-32 129
LLPS-Sus-4198Sus scrofa26.435e-32 129
LLPS-Paa-4099Papio anubis26.439e-32 129
LLPS-Mal-0421Mandrillus leucophaeus26.439e-32 129
LLPS-Ova-0408Ovis aries26.431e-31 129
LLPS-Myl-2203Myotis lucifugus26.432e-31 128
LLPS-Aim-2309Ailuropoda melanoleuca26.439e-32 129
LLPS-Mup-3877Mustela putorius furo26.439e-32 129
LLPS-Tut-2193Tursiops truncatus26.433e-32 130
LLPS-Bot-0728Bos taurus26.439e-32 129
LLPS-Orr-1054Oryza rufipogon26.44e-27 115
LLPS-Orb-0146Oryza barthii26.46e-27 115
LLPS-Orgl-2130Oryza glumaepatula26.46e-27 115
LLPS-Orn-3443Oreochromis niloticus26.273e-32 130
LLPS-Leo-1557Lepisosteus oculatus26.273e-32 130
LLPS-Glm-1824Glycine max26.246e-32 130
LLPS-Met-1623Medicago truncatula26.241e-31 129
LLPS-Ors-0184Oryza sativa26.142e-27 117
LLPS-Ori-1085Oryza indica26.145e-27 115
LLPS-Xet-2861Xenopus tropicalis26.128e-31 126
LLPS-Scf-3308Scleropages formosus26.061e-26 114
LLPS-Chc-1047Chondrus crispus25.943e-23 104
LLPS-Orp-2198Oryza punctata25.845e-29 121
LLPS-Org-1057Oryza glaberrima25.848e-27 115
LLPS-Ten-3249Tetraodon nigroviridis25.742e-30 125
LLPS-Cae-1035Caenorhabditis elegans25.668e-1785.9
LLPS-Vir-1801Vigna radiata25.618e-29 120
LLPS-Zem-1511Zea mays25.534e-30 124
LLPS-Sei-2222Setaria italica25.458e-31 127
LLPS-Cii-1217Ciona intestinalis25.431e-31 128
LLPS-Via-0348Vigna angularis25.412e-29 122
LLPS-Gaa-0417Gasterosteus aculeatus25.27e-29 120
LLPS-Sob-0987Sorghum bicolor24.863e-29 122
LLPS-Eqc-3796Equus caballus24.85e-26 112
LLPS-Otg-0102Otolemur garnettii24.723e-1682.8
LLPS-Tar-2099Takifugu rubripes24.625e-1992.0
LLPS-Osl-0476Ostreococcus lucimarinus24.571e-1685.5
LLPS-Cis-0028Ciona savignyi23.341e-28 120
LLPS-Yal-1511Yarrowia lipolytica22.712e-1993.6