• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Sus-1256
RPA1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Replication protein A subunit
Gene Name: RPA1
Ensembl Gene: ENSSSCG00000017822.3
Ensembl Protein: ENSSSCP00000023457.2
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, PML nuclear body, OthersPredicted from orthologs(View)

▼ FUNCTION


As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MQQGDTSIKP  ILQVINIRPI  TTGNNPPRYR  LLMSDGLNTL  SSFMLATQLN  PLVEEERLSS  60
61    NCICQINRFI  VNTLKDGRRV  VILMDLEVLK  SAEAVGVKIG  NPVPYNEGHG  QQPVVPPPVS  120
121   AASPPTSNPQ  QQNGSSGVGS  TVSKAYGASK  IFGKAGATSV  VNSSGGTQAK  VVPIASLTPY  180
181   QSKWTICARV  TNKSQIRTWS  NSRGEGKLFS  IELVDESGEI  RATAFNEQVD  KFFPLIDVNK  240
241   VYYFSKGTLK  IANKQFTAVK  NDYEMTFSNE  TSVMPCEDGH  HLPTVQFDFT  GIADLENKSK  300
301   DSLVDIIGIC  KNYEDVTKIT  VKSTNREVSK  RNIYLMDMSG  KVVNATLWGE  DADKFDGSRQ  360
361   PVMAIKGARV  SDFGGRSLSI  LSSSTVIVNP  DIPEAYKLRG  WFDSEGQALD  GVSISDLKSG  420
421   GIGGSNTNWK  TLYEVKSENL  GQGDKPDYFS  AVATVVYLRK  ENCMYQACPT  QDCNKKVIDQ  480
481   QNGLYRCEKC  DSEFPNFKYR  MILSVNIADF  QENQWVTCFQ  ESAEAILGQS  TAYLGELKEK  540
541   NEQAFEEVFQ  NANFRSFTFR  IRVKLETYND  ESRIKGTVMD  VKPVDYKEYG  RRLIMSIRKN  600
601   AAM  603
Nucleotide CDS Sequence (FASTA)
1     ATGGTGGGCC  ACCTGAGCGA  GGGGGCCATT  GCGGCCATAA  TGCAACAGGG  AGATACATCC  60
61    ATAAAACCCA  TCCTCCAAGT  CATTAACATC  CGTCCCATTA  CCACAGGGAA  CAATCCACCC  120
121   CGTTATCGAC  TGCTTATGAG  TGATGGATTG  AATACGCTGT  CCTCTTTCAT  GTTGGCGACA  180
181   CAGCTGAATC  CTCTTGTTGA  GGAAGAACGA  TTGTCTAGCA  ACTGTATTTG  CCAGATTAAC  240
241   CGATTTATTG  TGAACACCTT  GAAAGATGGA  AGGAGAGTAG  TTATTTTAAT  GGATTTAGAA  300
301   GTTTTGAAAT  CAGCCGAAGC  GGTTGGAGTA  AAGATCGGCA  ATCCAGTGCC  TTATAACGAA  360
361   GGTTCCACTG  TATCTAAGGC  TTATGGTGCC  TCAAAGATAT  TTGGAAAAGC  TGGAGCTACC  420
421   AGTGTAGTGA  ACAGCTCTGG  GGGAACACAG  GCCAAAGTGG  TCCCCATTGC  CAGCCTCACC  480
481   CCTTACCAGT  CCAAGTGGAC  CATTTGTGCT  CGTGTTACCA  ACAAAAGTCA  GATCCGTACC  540
541   TGGAGCAATT  CCCGAGGGGA  AGGGAAGCTT  TTCTCTATAG  AACTAGTTGA  TGAAAGCGGC  600
601   GAAATCAGAG  CCACTGCGTT  CAACGAGCAA  GTGGACAAGT  TCTTTCCCCT  TATTGACGTG  660
661   AACAAGGTCT  ATTACTTCTC  TAAAGGCACC  CTGAAGATTG  CCAACAAACA  ATTTACGGCT  720
721   GTCAAAAACG  ACTACGAGAT  GACCTTCAGT  AATGAGACTT  CTGTCATGCC  CTGTGAGGAC  780
781   GGCCATCATT  TACCCACAGT  TCAGTTTGAT  TTCACAGGGA  TCGCCGACCT  GGAGAACAAG  840
841   TCGAAAGACT  CCCTCGTAGA  CATAATTGGG  ATCTGCAAGA  ACTACGAAGA  TGTCACCAAA  900
901   ATCACAGTGA  AGTCTACCAA  CCGAGAAGTT  TCCAAGAGAA  ATATCTATTT  GATGGACATG  960
961   TCGGGGAAGG  TGGTGAATGC  GACTCTGTGG  GGAGAAGACG  CTGATAAATT  TGATGGTTCT  1020
1021  AGGCAGCCCG  TGATGGCTAT  CAAAGGAGCC  AGAGTCTCTG  ATTTTGGTGG  ACGGAGCCTC  1080
1081  TCCATACTGT  CTTCCAGCAC  AGTCATTGTG  AATCCTGACA  TCCCAGAGGC  CTATAAGCTT  1140
1141  CGTGGATGGT  TTGACTCAGA  AGGACAAGCC  TTAGATGGCG  TTTCCATCTC  TGATCTGAAG  1200
1201  AGTGGAGGCA  TAGGAGGGAG  CAACACCAAC  TGGAAAACTT  TATATGAGGT  TAAATCGGAG  1260
1261  AACCTGGGCC  AAGGTGACAA  GCCCGACTAT  TTCAGTGCTG  TGGCCACCGT  GGTGTATCTT  1320
1321  CGCAAAGAGA  ACTGTATGTA  CCAGGCCTGC  CCAACGCAGG  ACTGCAACAA  GAAGGTGATC  1380
1381  GATCAGCAGA  ATGGGTTGTA  CCGCTGCGAG  AAGTGTGACA  GCGAATTCCC  CAACTTCAAG  1440
1441  TACCGCATGA  TCCTGTCGGT  AAATATTGCC  GATTTTCAAG  AGAATCAATG  GGTCACATGT  1500
1501  TTCCAGGAGT  CTGCAGAAGC  CATCCTTGGG  CAAAGCACTG  CTTATCTTGG  GGAGCTAAAG  1560
1561  GAGAAGAACG  AGCAAGCCTT  TGAGGAAGTT  TTCCAGAACG  CCAACTTCCG  GTCTTTCACC  1620
1621  TTCAGGATCA  GAGTCAAACT  GGAGACCTAC  AACGATGAGT  CTCGAATTAA  GGGCACTGTG  1680
1681  ATGGACGTGA  AGCCCGTGGA  CTACAAAGAA  TATGGCAGAA  GGCTGATCAT  GAGCATCCGC  1740
1741  AAAAACGCAG  CCATGTGA  1758

▼ KEYWORD


ID
Family
Complete proteome
DNA replication
DNA-binding
Metal-binding
Nucleus
Proteomics identification
Reference proteome
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
DNA replication factor A complex
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
PML body
Cellular Component
Site of DNA damage
Molecular Function
Damaged DNA binding
Molecular Function
G-rich strand telomeric DNA binding
Molecular Function
Metal ion binding
Molecular Function
Sequence-specific DNA binding
Molecular Function
Single-stranded DNA binding
Molecular Function
Single-stranded telomeric DNA binding
Biological Process
Base-excision repair
Biological Process
DNA repair
Biological Process
DNA unwinding involved in DNA replication
Biological Process
DNA-dependent DNA replication
Biological Process
Double-strand break repair via homologous recombination
Biological Process
Meiotic cell cycle
Biological Process
Mismatch repair
Biological Process
Nucleotide-excision repair
Biological Process
Protein localization to chromosome
Biological Process
Telomere maintenance
Biological Process
Telomere maintenance via telomerase

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-0601Ovis aries94.860.01143
LLPS-Bot-0263Bos taurus94.860.01147
LLPS-Tut-1019Tursiops truncatus93.360.01119
LLPS-Eqc-0026Equus caballus93.030.01113
LLPS-Urm-0968Ursus maritimus91.710.01114
LLPS-Aim-0113Ailuropoda melanoleuca91.560.01114
LLPS-Mup-0934Mustela putorius furo91.210.01105
LLPS-Cas-0226Carlito syrichta91.060.01105
LLPS-Caf-1061Canis familiaris90.550.01092
LLPS-Myl-3156Myotis lucifugus90.480.01095
LLPS-Maf-0483Macaca fascicularis90.080.0 923
LLPS-Caj-0447Callithrix jacchus89.880.01094
LLPS-Aon-0319Aotus nancymaae89.720.01098
LLPS-Pap-0418Pan paniscus89.550.01103
LLPS-Pat-1154Pan troglodytes89.550.01105
LLPS-Hos-3885Homo sapiens89.550.01107
LLPS-Mam-0979Macaca mulatta89.550.01112
LLPS-Mea-2410Mesocricetus auratus89.50.01090
LLPS-Fec-2495Felis catus89.40.01095
LLPS-Paa-0243Papio anubis89.390.01110
LLPS-Cea-3759Cercocebus atys88.931e-165 480
LLPS-Nol-2708Nomascus leucogenys88.720.01095
LLPS-Dio-0054Dipodomys ordii88.720.01080
LLPS-Rhb-3846Rhinopithecus bieti88.560.01112
LLPS-Fud-1093Fukomys damarensis88.520.01092
LLPS-Loa-0590Loxodonta africana88.410.01100
LLPS-Ran-0924Rattus norvegicus88.416e-123 385
LLPS-Man-3192Macaca nemestrina88.310.01071
LLPS-Cap-0034Cavia porcellus86.90.01073
LLPS-Gog-0016Gorilla gorilla86.730.01073
LLPS-Orc-3239Oryctolagus cuniculus86.570.01092
LLPS-Ict-0468Ictidomys tridecemlineatus84.820.0 993
LLPS-Mod-2017Monodelphis domestica84.050.01044
LLPS-Sah-0553Sarcophilus harrisii83.940.01031
LLPS-Ora-1071Ornithorhynchus anatinus83.580.01014
LLPS-Mal-1377Mandrillus leucophaeus83.360.01013
LLPS-Mum-0649Mus musculus82.380.01027
LLPS-Pes-1573Pelodiscus sinensis77.80.0 976
LLPS-Chs-0622Chlorocebus sabaeus77.480.0 916
LLPS-Meg-2212Meleagris gallopavo75.170.0 936
LLPS-Gaga-0016Gallus gallus75.170.0 933
LLPS-Fia-0204Ficedula albicollis74.260.0 917
LLPS-Tag-0806Taeniopygia guttata73.840.0 922
LLPS-Xet-0535Xenopus tropicalis73.730.0 873
LLPS-Leo-1707Lepisosteus oculatus68.240.0 818
LLPS-Anp-0087Anas platyrhynchos65.880.0 863
LLPS-Lac-0499Latimeria chalumnae65.670.0 653
LLPS-Scf-1687Scleropages formosus64.450.0 802
LLPS-Anc-1670Anolis carolinensis64.360.0 789
LLPS-Tar-1295Takifugu rubripes64.180.0 775
LLPS-Ten-1736Tetraodon nigroviridis63.740.0 792
LLPS-Dar-1129Danio rerio63.680.0 786
LLPS-Asm-1079Astyanax mexicanus63.410.0 763
LLPS-Orn-0158Oreochromis niloticus63.160.0 796
LLPS-Scm-1636Scophthalmus maximus63.030.0 609
LLPS-Orl-0608Oryzias latipes62.770.0 772
LLPS-Icp-1761Ictalurus punctatus62.730.0 770
LLPS-Pof-0060Poecilia formosa61.990.0 751
LLPS-Xim-0841Xiphophorus maculatus60.940.0 750
LLPS-Gaa-3531Gasterosteus aculeatus60.70.0 766
LLPS-Map-0347Magnaporthe poae42.593e-110 351
LLPS-Viv-1323Vitis vinifera41.897e-0860.1
LLPS-Cii-0323Ciona intestinalis41.685e-163 486
LLPS-Drm-0278Drosophila melanogaster41.683e-160 479
LLPS-Asf-0202Aspergillus flavus40.99e-84 273
LLPS-Brr-0539Brassica rapa40.224e-101 332
LLPS-Mao-0186Magnaporthe oryzae40.072e-134 413
LLPS-Php-0546Physcomitrella patens39.914e-99 328
LLPS-Cogr-0836Colletotrichum graminicola39.53e-139 425
LLPS-Nia-0731Nicotiana attenuata39.465e-82 276
LLPS-Ast-1115Aspergillus terreus39.389e-126 390
LLPS-Coo-0303Colletotrichum orbiculare39.34e-135 415
LLPS-Coc-0146Corchorus capsularis39.251e-1068.9
LLPS-Asg-0858Ashbya gossypii39.073e-94 311
LLPS-Mua-1366Musa acuminata39.035e-96 317
LLPS-Nec-0225Neurospora crassa39.021e-137 421
LLPS-Fuo-0495Fusarium oxysporum38.95e-126 389
LLPS-Art-2667Arabidopsis thaliana38.883e-97 322
LLPS-Yal-0248Yarrowia lipolytica38.849e-93 304
LLPS-Asni-0427Aspergillus niger38.88e-134 411
LLPS-Zem-1599Zea mays38.759e-93 311
LLPS-Fuv-1140Fusarium verticillioides38.724e-126 389
LLPS-Mae-2184Manihot esculenta38.72e-95 317
LLPS-Scj-0876Schizosaccharomyces japonicus38.675e-136 417
LLPS-Asn-0287Aspergillus nidulans38.612e-123 384
LLPS-Nef-0725Neosartorya fischeri38.518e-130 401
LLPS-Cog-0191Colletotrichum gloeosporioides38.416e-131 404
LLPS-Ved-1377Verticillium dahliae38.42e-130 403
LLPS-Asfu-0132Aspergillus fumigatus38.383e-118 369
LLPS-Usm-0421Ustilago maydis38.242e-137 421
LLPS-Aso-0183Aspergillus oryzae38.243e-128 397
LLPS-Sot-2069Solanum tuberosum38.243e-84 282
LLPS-Asc-0381Aspergillus clavatus38.223e-123 384
LLPS-Arl-0924Arabidopsis lyrata38.28e-96 318
LLPS-Spr-0542Sporisorium reilianum38.161e-134 414
LLPS-Pot-1065Populus trichocarpa38.123e-96 320
LLPS-Phn-0638Phaeosphaeria nodorum38.067e-117 367
LLPS-Scp-1351Schizosaccharomyces pombe38.023e-133 410
LLPS-Beb-0304Beauveria bassiana37.987e-128 395
LLPS-Phv-1011Phaseolus vulgaris37.894e-90 303
LLPS-Hov-0072Hordeum vulgare37.891e-0862.4
LLPS-Tra-2578Triticum aestivum37.899e-1066.2
LLPS-Zyt-0166Zymoseptoria tritici37.871e-124 389
LLPS-Gag-0155Gaeumannomyces graminis37.852e-124 387
LLPS-Sob-1229Sorghum bicolor37.821e-93 314
LLPS-Crn-0057Cryptococcus neoformans37.777e-127 394
LLPS-Dac-1369Daucus carota37.695e-76 256
LLPS-Sol-1754Solanum lycopersicum37.671e-91 308
LLPS-Cus-1067Cucumis sativus37.676e-95 317
LLPS-Trv-0330Trichoderma virens37.655e-129 399
LLPS-Scc-0168Schizosaccharomyces cryophilus37.541e-128 398
LLPS-Vir-1567Vigna radiata37.51e-92 305
LLPS-Glm-1725Glycine max37.477e-92 309
LLPS-Blg-0094Blumeria graminis37.467e-132 406
LLPS-Via-0324Vigna angularis37.441e-91 308
LLPS-Amt-1759Amborella trichopoda37.361e-92 309
LLPS-Trr-0291Trichoderma reesei37.256e-131 404
LLPS-Prp-0739Prunus persica37.212e-92 310
LLPS-Miv-0787Microbotryum violaceum37.13e-128 397
LLPS-Orbr-1792Oryza brachyantha36.991e-1585.1
LLPS-Fus-0597Fusarium solani36.875e-125 389
LLPS-Scs-0400Sclerotinia sclerotiorum36.853e-114 361
LLPS-Gor-1320Gossypium raimondii36.824e-117 369
LLPS-Bro-2412Brassica oleracea36.746e-64 232
LLPS-Tru-0449Triticum urartu36.695e-90 306
LLPS-Brn-3420Brassica napus36.671e-114 362
LLPS-Lem-0311Leptosphaeria maculans36.364e-117 368
LLPS-Thc-0010Theobroma cacao35.621e-107 344
LLPS-Mel-0017Melampsora laricipopulina35.597e-113 354
LLPS-Dos-1028Dothistroma septosporum35.573e-119 374
LLPS-Pyt-0998Pyrenophora teres35.395e-113 357
LLPS-Tum-0581Tuber melanosporum35.282e-119 374
LLPS-Kop-0355Komagataella pastoris34.965e-108 345
LLPS-Met-0240Medicago truncatula34.735e-105 337
LLPS-Org-0575Oryza glaberrima34.628e-94 306
LLPS-Orgl-0012Oryza glumaepatula34.559e-105 338
LLPS-Sem-0369Selaginella moellendorffii34.455e-115 363
LLPS-Put-0400Puccinia triticina34.441e-99 323
LLPS-Ors-0337Oryza sativa34.364e-107 343
LLPS-Orr-0507Oryza rufipogon34.364e-107 343
LLPS-Orni-0152Oryza nivara34.212e-106 342
LLPS-Ori-0108Oryza indica34.212e-106 342
LLPS-Orp-0129Oryza punctata34.13e-104 336
LLPS-Orm-1141Oryza meridionalis34.13e-105 340
LLPS-Abg-0399Absidia glauca34.057e-116 365
LLPS-Brd-0627Brachypodium distachyon34.031e-104 336
LLPS-Hea-1965Helianthus annuus33.931e-105 338
LLPS-Pug-0164Puccinia graminis33.442e-108 346
LLPS-Orb-0134Oryza barthii33.391e-85 286
LLPS-Sei-0671Setaria italica33.391e-105 340
LLPS-Chr-1159Chlamydomonas reinhardtii32.892e-69 247
LLPS-Lep-0367Leersia perrieri32.568e-97 316
LLPS-Sac-0155Saccharomyces cerevisiae31.61e-95 312
LLPS-Cym-0542Cyanidioschyzon merolae31.492e-85 286
LLPS-Gas-0495Galdieria sulphuraria31.452e-91 302
LLPS-Cae-0062Caenorhabditis elegans30.872e-54 201
LLPS-Osl-1070Ostreococcus lucimarinus29.583e-53 196
LLPS-Chc-0201Chondrus crispus29.111e-75 260