LLPS-Sus-1256
RPA1
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Replication protein A subunit |
Gene Name: | RPA1 |
Ensembl Gene: | ENSSSCG00000017822.3 |
Ensembl Protein: | ENSSSCP00000023457.2 |
Organism: | Sus scrofa |
Taxa ID: | 9823 |
LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Chromatin, PML nuclear body, Others | Predicted from orthologs | (View) |
▼ FUNCTION
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSSSCT00000029329.2 | ENSSSCP00000023457.2 |
Ensembl | ENSSSCT00000019397.3 | ENSSSCP00000018882.3 |
UniProt | I3LHB2, I3LHB2_PIG | |
GeneBank | AEMK02000081 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MQQGDTSIKP ILQVINIRPI TTGNNPPRYR LLMSDGLNTL SSFMLATQLN PLVEEERLSS 60 61 NCICQINRFI VNTLKDGRRV VILMDLEVLK SAEAVGVKIG NPVPYNEGHG QQPVVPPPVS 120 121 AASPPTSNPQ QQNGSSGVGS TVSKAYGASK IFGKAGATSV VNSSGGTQAK VVPIASLTPY 180 181 QSKWTICARV TNKSQIRTWS NSRGEGKLFS IELVDESGEI RATAFNEQVD KFFPLIDVNK 240 241 VYYFSKGTLK IANKQFTAVK NDYEMTFSNE TSVMPCEDGH HLPTVQFDFT GIADLENKSK 300 301 DSLVDIIGIC KNYEDVTKIT VKSTNREVSK RNIYLMDMSG KVVNATLWGE DADKFDGSRQ 360 361 PVMAIKGARV SDFGGRSLSI LSSSTVIVNP DIPEAYKLRG WFDSEGQALD GVSISDLKSG 420 421 GIGGSNTNWK TLYEVKSENL GQGDKPDYFS AVATVVYLRK ENCMYQACPT QDCNKKVIDQ 480 481 QNGLYRCEKC DSEFPNFKYR MILSVNIADF QENQWVTCFQ ESAEAILGQS TAYLGELKEK 540 541 NEQAFEEVFQ NANFRSFTFR IRVKLETYND ESRIKGTVMD VKPVDYKEYG RRLIMSIRKN 600 601 AAM 603 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGTGGGCC ACCTGAGCGA GGGGGCCATT GCGGCCATAA TGCAACAGGG AGATACATCC 60 61 ATAAAACCCA TCCTCCAAGT CATTAACATC CGTCCCATTA CCACAGGGAA CAATCCACCC 120 121 CGTTATCGAC TGCTTATGAG TGATGGATTG AATACGCTGT CCTCTTTCAT GTTGGCGACA 180 181 CAGCTGAATC CTCTTGTTGA GGAAGAACGA TTGTCTAGCA ACTGTATTTG CCAGATTAAC 240 241 CGATTTATTG TGAACACCTT GAAAGATGGA AGGAGAGTAG TTATTTTAAT GGATTTAGAA 300 301 GTTTTGAAAT CAGCCGAAGC GGTTGGAGTA AAGATCGGCA ATCCAGTGCC TTATAACGAA 360 361 GGTTCCACTG TATCTAAGGC TTATGGTGCC TCAAAGATAT TTGGAAAAGC TGGAGCTACC 420 421 AGTGTAGTGA ACAGCTCTGG GGGAACACAG GCCAAAGTGG TCCCCATTGC CAGCCTCACC 480 481 CCTTACCAGT CCAAGTGGAC CATTTGTGCT CGTGTTACCA ACAAAAGTCA GATCCGTACC 540 541 TGGAGCAATT CCCGAGGGGA AGGGAAGCTT TTCTCTATAG AACTAGTTGA TGAAAGCGGC 600 601 GAAATCAGAG CCACTGCGTT CAACGAGCAA GTGGACAAGT TCTTTCCCCT TATTGACGTG 660 661 AACAAGGTCT ATTACTTCTC TAAAGGCACC CTGAAGATTG CCAACAAACA ATTTACGGCT 720 721 GTCAAAAACG ACTACGAGAT GACCTTCAGT AATGAGACTT CTGTCATGCC CTGTGAGGAC 780 781 GGCCATCATT TACCCACAGT TCAGTTTGAT TTCACAGGGA TCGCCGACCT GGAGAACAAG 840 841 TCGAAAGACT CCCTCGTAGA CATAATTGGG ATCTGCAAGA ACTACGAAGA TGTCACCAAA 900 901 ATCACAGTGA AGTCTACCAA CCGAGAAGTT TCCAAGAGAA ATATCTATTT GATGGACATG 960 961 TCGGGGAAGG TGGTGAATGC GACTCTGTGG GGAGAAGACG CTGATAAATT TGATGGTTCT 1020 1021 AGGCAGCCCG TGATGGCTAT CAAAGGAGCC AGAGTCTCTG ATTTTGGTGG ACGGAGCCTC 1080 1081 TCCATACTGT CTTCCAGCAC AGTCATTGTG AATCCTGACA TCCCAGAGGC CTATAAGCTT 1140 1141 CGTGGATGGT TTGACTCAGA AGGACAAGCC TTAGATGGCG TTTCCATCTC TGATCTGAAG 1200 1201 AGTGGAGGCA TAGGAGGGAG CAACACCAAC TGGAAAACTT TATATGAGGT TAAATCGGAG 1260 1261 AACCTGGGCC AAGGTGACAA GCCCGACTAT TTCAGTGCTG TGGCCACCGT GGTGTATCTT 1320 1321 CGCAAAGAGA ACTGTATGTA CCAGGCCTGC CCAACGCAGG ACTGCAACAA GAAGGTGATC 1380 1381 GATCAGCAGA ATGGGTTGTA CCGCTGCGAG AAGTGTGACA GCGAATTCCC CAACTTCAAG 1440 1441 TACCGCATGA TCCTGTCGGT AAATATTGCC GATTTTCAAG AGAATCAATG GGTCACATGT 1500 1501 TTCCAGGAGT CTGCAGAAGC CATCCTTGGG CAAAGCACTG CTTATCTTGG GGAGCTAAAG 1560 1561 GAGAAGAACG AGCAAGCCTT TGAGGAAGTT TTCCAGAACG CCAACTTCCG GTCTTTCACC 1620 1621 TTCAGGATCA GAGTCAAACT GGAGACCTAC AACGATGAGT CTCGAATTAA GGGCACTGTG 1680 1681 ATGGACGTGA AGCCCGTGGA CTACAAAGAA TATGGCAGAA GGCTGATCAT GAGCATCCGC 1740 1741 AAAAACGCAG CCATGTGA 1758 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | DNA replication factor A complex | |
Cellular Component | Nuclear chromosome, telomeric region | |
Cellular Component | PML body | |
Cellular Component | Site of DNA damage | |
Molecular Function | Damaged DNA binding | |
Molecular Function | G-rich strand telomeric DNA binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Sequence-specific DNA binding | |
Molecular Function | Single-stranded DNA binding | |
Molecular Function | Single-stranded telomeric DNA binding | |
Biological Process | Base-excision repair | |
Biological Process | DNA repair | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | DNA-dependent DNA replication | |
Biological Process | Double-strand break repair via homologous recombination | |
Biological Process | Meiotic cell cycle | |
Biological Process | Mismatch repair | |
Biological Process | Nucleotide-excision repair | |
Biological Process | Protein localization to chromosome | |
Biological Process | Telomere maintenance | |
Biological Process | Telomere maintenance via telomerase |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Ova-0601 | Ovis aries | 94.86 | 0.0 | 1143 |
LLPS-Bot-0263 | Bos taurus | 94.86 | 0.0 | 1147 |
LLPS-Tut-1019 | Tursiops truncatus | 93.36 | 0.0 | 1119 |
LLPS-Eqc-0026 | Equus caballus | 93.03 | 0.0 | 1113 |
LLPS-Urm-0968 | Ursus maritimus | 91.71 | 0.0 | 1114 |
LLPS-Aim-0113 | Ailuropoda melanoleuca | 91.56 | 0.0 | 1114 |
LLPS-Mup-0934 | Mustela putorius furo | 91.21 | 0.0 | 1105 |
LLPS-Cas-0226 | Carlito syrichta | 91.06 | 0.0 | 1105 |
LLPS-Caf-1061 | Canis familiaris | 90.55 | 0.0 | 1092 |
LLPS-Myl-3156 | Myotis lucifugus | 90.48 | 0.0 | 1095 |
LLPS-Maf-0483 | Macaca fascicularis | 90.08 | 0.0 | 923 |
LLPS-Caj-0447 | Callithrix jacchus | 89.88 | 0.0 | 1094 |
LLPS-Aon-0319 | Aotus nancymaae | 89.72 | 0.0 | 1098 |
LLPS-Pap-0418 | Pan paniscus | 89.55 | 0.0 | 1103 |
LLPS-Pat-1154 | Pan troglodytes | 89.55 | 0.0 | 1105 |
LLPS-Hos-3885 | Homo sapiens | 89.55 | 0.0 | 1107 |
LLPS-Mam-0979 | Macaca mulatta | 89.55 | 0.0 | 1112 |
LLPS-Mea-2410 | Mesocricetus auratus | 89.5 | 0.0 | 1090 |
LLPS-Fec-2495 | Felis catus | 89.4 | 0.0 | 1095 |
LLPS-Paa-0243 | Papio anubis | 89.39 | 0.0 | 1110 |
LLPS-Cea-3759 | Cercocebus atys | 88.93 | 1e-165 | 480 |
LLPS-Nol-2708 | Nomascus leucogenys | 88.72 | 0.0 | 1095 |
LLPS-Dio-0054 | Dipodomys ordii | 88.72 | 0.0 | 1080 |
LLPS-Rhb-3846 | Rhinopithecus bieti | 88.56 | 0.0 | 1112 |
LLPS-Fud-1093 | Fukomys damarensis | 88.52 | 0.0 | 1092 |
LLPS-Loa-0590 | Loxodonta africana | 88.41 | 0.0 | 1100 |
LLPS-Ran-0924 | Rattus norvegicus | 88.41 | 6e-123 | 385 |
LLPS-Man-3192 | Macaca nemestrina | 88.31 | 0.0 | 1071 |
LLPS-Cap-0034 | Cavia porcellus | 86.9 | 0.0 | 1073 |
LLPS-Gog-0016 | Gorilla gorilla | 86.73 | 0.0 | 1073 |
LLPS-Orc-3239 | Oryctolagus cuniculus | 86.57 | 0.0 | 1092 |
LLPS-Ict-0468 | Ictidomys tridecemlineatus | 84.82 | 0.0 | 993 |
LLPS-Mod-2017 | Monodelphis domestica | 84.05 | 0.0 | 1044 |
LLPS-Sah-0553 | Sarcophilus harrisii | 83.94 | 0.0 | 1031 |
LLPS-Ora-1071 | Ornithorhynchus anatinus | 83.58 | 0.0 | 1014 |
LLPS-Mal-1377 | Mandrillus leucophaeus | 83.36 | 0.0 | 1013 |
LLPS-Mum-0649 | Mus musculus | 82.38 | 0.0 | 1027 |
LLPS-Pes-1573 | Pelodiscus sinensis | 77.8 | 0.0 | 976 |
LLPS-Chs-0622 | Chlorocebus sabaeus | 77.48 | 0.0 | 916 |
LLPS-Meg-2212 | Meleagris gallopavo | 75.17 | 0.0 | 936 |
LLPS-Gaga-0016 | Gallus gallus | 75.17 | 0.0 | 933 |
LLPS-Fia-0204 | Ficedula albicollis | 74.26 | 0.0 | 917 |
LLPS-Tag-0806 | Taeniopygia guttata | 73.84 | 0.0 | 922 |
LLPS-Xet-0535 | Xenopus tropicalis | 73.73 | 0.0 | 873 |
LLPS-Leo-1707 | Lepisosteus oculatus | 68.24 | 0.0 | 818 |
LLPS-Anp-0087 | Anas platyrhynchos | 65.88 | 0.0 | 863 |
LLPS-Lac-0499 | Latimeria chalumnae | 65.67 | 0.0 | 653 |
LLPS-Scf-1687 | Scleropages formosus | 64.45 | 0.0 | 802 |
LLPS-Anc-1670 | Anolis carolinensis | 64.36 | 0.0 | 789 |
LLPS-Tar-1295 | Takifugu rubripes | 64.18 | 0.0 | 775 |
LLPS-Ten-1736 | Tetraodon nigroviridis | 63.74 | 0.0 | 792 |
LLPS-Dar-1129 | Danio rerio | 63.68 | 0.0 | 786 |
LLPS-Asm-1079 | Astyanax mexicanus | 63.41 | 0.0 | 763 |
LLPS-Orn-0158 | Oreochromis niloticus | 63.16 | 0.0 | 796 |
LLPS-Scm-1636 | Scophthalmus maximus | 63.03 | 0.0 | 609 |
LLPS-Orl-0608 | Oryzias latipes | 62.77 | 0.0 | 772 |
LLPS-Icp-1761 | Ictalurus punctatus | 62.73 | 0.0 | 770 |
LLPS-Pof-0060 | Poecilia formosa | 61.99 | 0.0 | 751 |
LLPS-Xim-0841 | Xiphophorus maculatus | 60.94 | 0.0 | 750 |
LLPS-Gaa-3531 | Gasterosteus aculeatus | 60.7 | 0.0 | 766 |
LLPS-Map-0347 | Magnaporthe poae | 42.59 | 3e-110 | 351 |
LLPS-Viv-1323 | Vitis vinifera | 41.89 | 7e-08 | 60.1 |
LLPS-Cii-0323 | Ciona intestinalis | 41.68 | 5e-163 | 486 |
LLPS-Drm-0278 | Drosophila melanogaster | 41.68 | 3e-160 | 479 |
LLPS-Asf-0202 | Aspergillus flavus | 40.9 | 9e-84 | 273 |
LLPS-Brr-0539 | Brassica rapa | 40.22 | 4e-101 | 332 |
LLPS-Mao-0186 | Magnaporthe oryzae | 40.07 | 2e-134 | 413 |
LLPS-Php-0546 | Physcomitrella patens | 39.91 | 4e-99 | 328 |
LLPS-Cogr-0836 | Colletotrichum graminicola | 39.5 | 3e-139 | 425 |
LLPS-Nia-0731 | Nicotiana attenuata | 39.46 | 5e-82 | 276 |
LLPS-Ast-1115 | Aspergillus terreus | 39.38 | 9e-126 | 390 |
LLPS-Coo-0303 | Colletotrichum orbiculare | 39.3 | 4e-135 | 415 |
LLPS-Coc-0146 | Corchorus capsularis | 39.25 | 1e-10 | 68.9 |
LLPS-Asg-0858 | Ashbya gossypii | 39.07 | 3e-94 | 311 |
LLPS-Mua-1366 | Musa acuminata | 39.03 | 5e-96 | 317 |
LLPS-Nec-0225 | Neurospora crassa | 39.02 | 1e-137 | 421 |
LLPS-Fuo-0495 | Fusarium oxysporum | 38.9 | 5e-126 | 389 |
LLPS-Art-2667 | Arabidopsis thaliana | 38.88 | 3e-97 | 322 |
LLPS-Yal-0248 | Yarrowia lipolytica | 38.84 | 9e-93 | 304 |
LLPS-Asni-0427 | Aspergillus niger | 38.8 | 8e-134 | 411 |
LLPS-Zem-1599 | Zea mays | 38.75 | 9e-93 | 311 |
LLPS-Fuv-1140 | Fusarium verticillioides | 38.72 | 4e-126 | 389 |
LLPS-Mae-2184 | Manihot esculenta | 38.7 | 2e-95 | 317 |
LLPS-Scj-0876 | Schizosaccharomyces japonicus | 38.67 | 5e-136 | 417 |
LLPS-Asn-0287 | Aspergillus nidulans | 38.61 | 2e-123 | 384 |
LLPS-Nef-0725 | Neosartorya fischeri | 38.51 | 8e-130 | 401 |
LLPS-Cog-0191 | Colletotrichum gloeosporioides | 38.41 | 6e-131 | 404 |
LLPS-Ved-1377 | Verticillium dahliae | 38.4 | 2e-130 | 403 |
LLPS-Asfu-0132 | Aspergillus fumigatus | 38.38 | 3e-118 | 369 |
LLPS-Usm-0421 | Ustilago maydis | 38.24 | 2e-137 | 421 |
LLPS-Aso-0183 | Aspergillus oryzae | 38.24 | 3e-128 | 397 |
LLPS-Sot-2069 | Solanum tuberosum | 38.24 | 3e-84 | 282 |
LLPS-Asc-0381 | Aspergillus clavatus | 38.22 | 3e-123 | 384 |
LLPS-Arl-0924 | Arabidopsis lyrata | 38.2 | 8e-96 | 318 |
LLPS-Spr-0542 | Sporisorium reilianum | 38.16 | 1e-134 | 414 |
LLPS-Pot-1065 | Populus trichocarpa | 38.12 | 3e-96 | 320 |
LLPS-Phn-0638 | Phaeosphaeria nodorum | 38.06 | 7e-117 | 367 |
LLPS-Scp-1351 | Schizosaccharomyces pombe | 38.02 | 3e-133 | 410 |
LLPS-Beb-0304 | Beauveria bassiana | 37.98 | 7e-128 | 395 |
LLPS-Phv-1011 | Phaseolus vulgaris | 37.89 | 4e-90 | 303 |
LLPS-Hov-0072 | Hordeum vulgare | 37.89 | 1e-08 | 62.4 |
LLPS-Tra-2578 | Triticum aestivum | 37.89 | 9e-10 | 66.2 |
LLPS-Zyt-0166 | Zymoseptoria tritici | 37.87 | 1e-124 | 389 |
LLPS-Gag-0155 | Gaeumannomyces graminis | 37.85 | 2e-124 | 387 |
LLPS-Sob-1229 | Sorghum bicolor | 37.82 | 1e-93 | 314 |
LLPS-Crn-0057 | Cryptococcus neoformans | 37.77 | 7e-127 | 394 |
LLPS-Dac-1369 | Daucus carota | 37.69 | 5e-76 | 256 |
LLPS-Sol-1754 | Solanum lycopersicum | 37.67 | 1e-91 | 308 |
LLPS-Cus-1067 | Cucumis sativus | 37.67 | 6e-95 | 317 |
LLPS-Trv-0330 | Trichoderma virens | 37.65 | 5e-129 | 399 |
LLPS-Scc-0168 | Schizosaccharomyces cryophilus | 37.54 | 1e-128 | 398 |
LLPS-Vir-1567 | Vigna radiata | 37.5 | 1e-92 | 305 |
LLPS-Glm-1725 | Glycine max | 37.47 | 7e-92 | 309 |
LLPS-Blg-0094 | Blumeria graminis | 37.46 | 7e-132 | 406 |
LLPS-Via-0324 | Vigna angularis | 37.44 | 1e-91 | 308 |
LLPS-Amt-1759 | Amborella trichopoda | 37.36 | 1e-92 | 309 |
LLPS-Trr-0291 | Trichoderma reesei | 37.25 | 6e-131 | 404 |
LLPS-Prp-0739 | Prunus persica | 37.21 | 2e-92 | 310 |
LLPS-Miv-0787 | Microbotryum violaceum | 37.1 | 3e-128 | 397 |
LLPS-Orbr-1792 | Oryza brachyantha | 36.99 | 1e-15 | 85.1 |
LLPS-Fus-0597 | Fusarium solani | 36.87 | 5e-125 | 389 |
LLPS-Scs-0400 | Sclerotinia sclerotiorum | 36.85 | 3e-114 | 361 |
LLPS-Gor-1320 | Gossypium raimondii | 36.82 | 4e-117 | 369 |
LLPS-Bro-2412 | Brassica oleracea | 36.74 | 6e-64 | 232 |
LLPS-Tru-0449 | Triticum urartu | 36.69 | 5e-90 | 306 |
LLPS-Brn-3420 | Brassica napus | 36.67 | 1e-114 | 362 |
LLPS-Lem-0311 | Leptosphaeria maculans | 36.36 | 4e-117 | 368 |
LLPS-Thc-0010 | Theobroma cacao | 35.62 | 1e-107 | 344 |
LLPS-Mel-0017 | Melampsora laricipopulina | 35.59 | 7e-113 | 354 |
LLPS-Dos-1028 | Dothistroma septosporum | 35.57 | 3e-119 | 374 |
LLPS-Pyt-0998 | Pyrenophora teres | 35.39 | 5e-113 | 357 |
LLPS-Tum-0581 | Tuber melanosporum | 35.28 | 2e-119 | 374 |
LLPS-Kop-0355 | Komagataella pastoris | 34.96 | 5e-108 | 345 |
LLPS-Met-0240 | Medicago truncatula | 34.73 | 5e-105 | 337 |
LLPS-Org-0575 | Oryza glaberrima | 34.62 | 8e-94 | 306 |
LLPS-Orgl-0012 | Oryza glumaepatula | 34.55 | 9e-105 | 338 |
LLPS-Sem-0369 | Selaginella moellendorffii | 34.45 | 5e-115 | 363 |
LLPS-Put-0400 | Puccinia triticina | 34.44 | 1e-99 | 323 |
LLPS-Ors-0337 | Oryza sativa | 34.36 | 4e-107 | 343 |
LLPS-Orr-0507 | Oryza rufipogon | 34.36 | 4e-107 | 343 |
LLPS-Orni-0152 | Oryza nivara | 34.21 | 2e-106 | 342 |
LLPS-Ori-0108 | Oryza indica | 34.21 | 2e-106 | 342 |
LLPS-Orp-0129 | Oryza punctata | 34.1 | 3e-104 | 336 |
LLPS-Orm-1141 | Oryza meridionalis | 34.1 | 3e-105 | 340 |
LLPS-Abg-0399 | Absidia glauca | 34.05 | 7e-116 | 365 |
LLPS-Brd-0627 | Brachypodium distachyon | 34.03 | 1e-104 | 336 |
LLPS-Hea-1965 | Helianthus annuus | 33.93 | 1e-105 | 338 |
LLPS-Pug-0164 | Puccinia graminis | 33.44 | 2e-108 | 346 |
LLPS-Orb-0134 | Oryza barthii | 33.39 | 1e-85 | 286 |
LLPS-Sei-0671 | Setaria italica | 33.39 | 1e-105 | 340 |
LLPS-Chr-1159 | Chlamydomonas reinhardtii | 32.89 | 2e-69 | 247 |
LLPS-Lep-0367 | Leersia perrieri | 32.56 | 8e-97 | 316 |
LLPS-Sac-0155 | Saccharomyces cerevisiae | 31.6 | 1e-95 | 312 |
LLPS-Cym-0542 | Cyanidioschyzon merolae | 31.49 | 2e-85 | 286 |
LLPS-Gas-0495 | Galdieria sulphuraria | 31.45 | 2e-91 | 302 |
LLPS-Cae-0062 | Caenorhabditis elegans | 30.87 | 2e-54 | 201 |
LLPS-Osl-1070 | Ostreococcus lucimarinus | 29.58 | 3e-53 | 196 |
LLPS-Chc-0201 | Chondrus crispus | 29.11 | 1e-75 | 260 |