LLPS-Asf-0202
AFLA_130480
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Replication protein A subunit |
| Gene Name: | AFLA_130480 |
| Ensembl Gene: | AFLA_130480 |
| Ensembl Protein: | EED48825 |
| Organism: | Aspergillus flavus |
| Taxa ID: | 332952 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nucleolus, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EED48825 | EED48825 |
| UniProt | B8NPH6, B8NPH6_ASPFN | |
| GeneBank | EQ963481 | EED48825.1 |
| RefSeq | XM_002382200.1 | XP_002382241.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLYDVFQEGS VYYISSPCGV KLAKKQFTNL NNDYELTFER DTVVEKAEDQ ADVPQIRFSF 60 61 TTIGDLQSVE KDTTIDVIGV LKEVAEVSQI MSKTTNKPYN KRELTLVDST GFSVRLTVWG 120 121 STALNFNVTP ESVIAFKGVK VSDFGGRSLS LLSSGSMTVD PDIEEAHKLK GWYDAQGRDG 180 181 VFASHASMPG VAASTTKLEQ FKTVAQVKEE QLGMSDEVAY FSLKATVIYI KQDTMCYPAC 240 241 LSEGCNKKVT ELDPGQWRCE RCDKTHPRPE YRYIMLISVS DHTGQLYLSC FDEVGRYMMG 300 301 TSADQLMEIR QNDDKAAGDI FQDANCRTWN FRCRAKIDNF GDQQRIRCQI VTAKPVNYSE 360 361 EALRLANMID SYSVS 375 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTCTATG ACGTCTTCCA GGAGGGCAGT GTTTATTACA TCTCTAGCCC ATGCGGCGTG 60 61 AAGCTTGCCA AGAAACAGTT TACCAATTTG AACAATGACT ATGAACTCAC ATTTGAACGG 120 121 GATACGGTTG TTGAAAAGGC AGAGGATCAA GCCGACGTTC CACAAATCAG ATTCAGCTTT 180 181 ACGACCATCG GTGACCTGCA GTCTGTCGAG AAGGATACCA CCATTGATGT AATTGGAGTA 240 241 CTGAAAGAGG TTGCTGAGGT TTCTCAGATT ATGTCCAAGA CCACCAACAA GCCTTATAAC 300 301 AAACGTGAGC TTACATTAGT GGACAGCACG GGGTTTTCCG TTCGCCTAAC TGTCTGGGGA 360 361 TCAACTGCGC TGAATTTCAA CGTGACACCC GAGTCTGTAA TAGCGTTCAA GGGTGTGAAA 420 421 GTGTCTGACT TTGGAGGTAG AAGTTTAAGC TTGCTGAGTT CAGGTTCAAT GACGGTTGAT 480 481 CCTGATATTG AGGAAGCCCA CAAATTGAAG GGTTGGTACG ACGCTCAAGG CCGGGATGGA 540 541 GTCTTTGCTT CACATGCTTC AATGCCTGGT GTAGCCGCAT CTACTACAAA ACTTGAACAA 600 601 TTCAAGACTG TCGCACAGGT CAAAGAGGAG CAATTGGGTA TGTCAGATGA GGTGGCCTAT 660 661 TTCTCACTGA AGGCGACTGT TATCTACATC AAGCAAGATA CCATGTGCTA TCCTGCCTGT 720 721 CTTTCTGAAG GTTGCAATAA AAAAGTAACA GAGCTTGATC CTGGCCAATG GCGGTGTGAA 780 781 CGTTGCGATA AAACTCATCC ACGACCAGAG TATCGCTATA TAATGCTCAT TAGCGTTAGC 840 841 GATCATACTG GACAACTTTA TCTCAGCTGT TTCGATGAAG TGGGCAGGTA CATGATGGGC 900 901 ACTTCCGCAG ATCAGCTCAT GGAGATACGC CAGAACGATG ACAAAGCAGC CGGAGATATT 960 961 TTCCAGGATG CAAATTGCCG AACTTGGAAT TTCAGATGTC GGGCCAAGAT TGACAATTTT 1020 1021 GGTGATCAAC AACGCATTCG TTGTCAGATA GTAACGGCGA AACCGGTTAA TTATTCTGAA 1080 1081 GAGGCACTGC GCCTTGCGAA CATGATCGAT TCATATAGTG TTTCGTGA 1128 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Metal ion binding | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aso-0183 | Aspergillus oryzae | 100.0 | 0.0 | 759 |
| LLPS-Asfu-0132 | Aspergillus fumigatus | 81.6 | 0.0 | 642 |
| LLPS-Nef-0725 | Neosartorya fischeri | 81.33 | 0.0 | 642 |
| LLPS-Ast-1115 | Aspergillus terreus | 80.51 | 0.0 | 592 |
| LLPS-Asni-0427 | Aspergillus niger | 80.37 | 0.0 | 619 |
| LLPS-Asc-0381 | Aspergillus clavatus | 79.2 | 0.0 | 608 |
| LLPS-Asn-0287 | Aspergillus nidulans | 78.07 | 0.0 | 609 |
| LLPS-Scs-0400 | Sclerotinia sclerotiorum | 63.64 | 2e-174 | 507 |
| LLPS-Ved-1377 | Verticillium dahliae | 63.2 | 2e-168 | 492 |
| LLPS-Coo-0303 | Colletotrichum orbiculare | 63.0 | 6e-173 | 503 |
| LLPS-Cogr-0836 | Colletotrichum graminicola | 63.0 | 6e-172 | 500 |
| LLPS-Cog-0191 | Colletotrichum gloeosporioides | 63.0 | 2e-171 | 499 |
| LLPS-Dos-1028 | Dothistroma septosporum | 62.27 | 6e-159 | 468 |
| LLPS-Nec-0225 | Neurospora crassa | 62.1 | 1e-167 | 489 |
| LLPS-Zyt-0166 | Zymoseptoria tritici | 61.64 | 1e-159 | 470 |
| LLPS-Mao-0186 | Magnaporthe oryzae | 60.32 | 1e-157 | 464 |
| LLPS-Trv-0330 | Trichoderma virens | 59.89 | 2e-162 | 476 |
| LLPS-Fuo-0495 | Fusarium oxysporum | 59.63 | 9e-164 | 477 |
| LLPS-Trr-0291 | Trichoderma reesei | 59.52 | 2e-162 | 476 |
| LLPS-Fuv-1140 | Fusarium verticillioides | 59.36 | 3e-163 | 476 |
| LLPS-Gag-0155 | Gaeumannomyces graminis | 58.98 | 4e-156 | 461 |
| LLPS-Fus-0597 | Fusarium solani | 58.87 | 4e-159 | 468 |
| LLPS-Map-0347 | Magnaporthe poae | 58.71 | 6e-157 | 462 |
| LLPS-Beb-0304 | Beauveria bassiana | 58.29 | 2e-161 | 473 |
| LLPS-Blg-0094 | Blumeria graminis | 57.64 | 1e-156 | 461 |
| LLPS-Phn-0638 | Phaeosphaeria nodorum | 56.8 | 1e-143 | 427 |
| LLPS-Lem-0311 | Leptosphaeria maculans | 55.03 | 6e-140 | 419 |
| LLPS-Pyt-0998 | Pyrenophora teres | 55.03 | 5e-140 | 418 |
| LLPS-Tum-0581 | Tuber melanosporum | 51.34 | 8e-125 | 380 |
| LLPS-Scj-0876 | Schizosaccharomyces japonicus | 50.0 | 2e-125 | 381 |
| LLPS-Scp-1351 | Schizosaccharomyces pombe | 49.46 | 1e-124 | 379 |
| LLPS-Scc-0168 | Schizosaccharomyces cryophilus | 49.46 | 7e-121 | 370 |
| LLPS-Miv-0787 | Microbotryum violaceum | 45.33 | 2e-109 | 340 |
| LLPS-Spr-0542 | Sporisorium reilianum | 44.47 | 2e-103 | 325 |
| LLPS-Crn-0057 | Cryptococcus neoformans | 44.24 | 5e-103 | 323 |
| LLPS-Usm-0421 | Ustilago maydis | 44.09 | 8e-102 | 321 |
| LLPS-Pug-0164 | Puccinia graminis | 43.73 | 1e-99 | 315 |
| LLPS-Ran-0924 | Rattus norvegicus | 42.86 | 3e-32 | 132 |
| LLPS-Maf-0483 | Macaca fascicularis | 42.39 | 1e-60 | 209 |
| LLPS-Anp-0087 | Anas platyrhynchos | 42.2 | 8e-31 | 128 |
| LLPS-Put-0400 | Puccinia triticina | 42.13 | 4e-94 | 300 |
| LLPS-Mel-0017 | Melampsora laricipopulina | 41.94 | 7e-101 | 315 |
| LLPS-Urm-0968 | Ursus maritimus | 41.74 | 2e-85 | 277 |
| LLPS-Bot-0263 | Bos taurus | 41.18 | 5e-86 | 279 |
| LLPS-Kop-0355 | Komagataella pastoris | 40.99 | 7e-97 | 308 |
| LLPS-Ova-0601 | Ovis aries | 40.9 | 2e-85 | 277 |
| LLPS-Sus-1256 | Sus scrofa | 40.9 | 4e-85 | 276 |
| LLPS-Sah-0553 | Sarcophilus harrisii | 40.62 | 4e-84 | 274 |
| LLPS-Aim-0113 | Ailuropoda melanoleuca | 40.6 | 4e-83 | 272 |
| LLPS-Cea-3759 | Cercocebus atys | 40.5 | 6e-53 | 182 |
| LLPS-Sac-0155 | Saccharomyces cerevisiae | 40.16 | 1e-91 | 294 |
| LLPS-Loa-0590 | Loxodonta africana | 40.16 | 2e-83 | 273 |
| LLPS-Cas-0226 | Carlito syrichta | 40.06 | 3e-82 | 269 |
| LLPS-Tut-1019 | Tursiops truncatus | 39.89 | 5e-83 | 271 |
| LLPS-Fec-2495 | Felis catus | 39.78 | 2e-80 | 265 |
| LLPS-Mod-2017 | Monodelphis domestica | 39.78 | 3e-82 | 270 |
| LLPS-Myl-3156 | Myotis lucifugus | 39.62 | 2e-83 | 272 |
| LLPS-Dar-1129 | Danio rerio | 39.62 | 6e-86 | 278 |
| LLPS-Leo-1707 | Lepisosteus oculatus | 39.35 | 3e-81 | 266 |
| LLPS-Paa-0243 | Papio anubis | 39.34 | 8e-83 | 271 |
| LLPS-Mea-2410 | Mesocricetus auratus | 39.34 | 9e-84 | 273 |
| LLPS-Eqc-0026 | Equus caballus | 39.34 | 6e-82 | 268 |
| LLPS-Caf-1061 | Canis familiaris | 39.34 | 2e-82 | 270 |
| LLPS-Mam-0979 | Macaca mulatta | 39.34 | 5e-83 | 271 |
| LLPS-Man-3192 | Macaca nemestrina | 39.34 | 4e-83 | 271 |
| LLPS-Rhb-3846 | Rhinopithecus bieti | 39.34 | 6e-83 | 271 |
| LLPS-Dio-0054 | Dipodomys ordii | 39.19 | 2e-83 | 272 |
| LLPS-Gog-0016 | Gorilla gorilla | 39.19 | 2e-83 | 271 |
| LLPS-Caj-0447 | Callithrix jacchus | 39.19 | 3e-83 | 272 |
| LLPS-Nol-2708 | Nomascus leucogenys | 39.19 | 4e-83 | 272 |
| LLPS-Pat-1154 | Pan troglodytes | 39.19 | 4e-83 | 271 |
| LLPS-Hos-3885 | Homo sapiens | 39.19 | 4e-83 | 271 |
| LLPS-Mup-0934 | Mustela putorius furo | 39.07 | 8e-83 | 271 |
| LLPS-Orc-3239 | Oryctolagus cuniculus | 39.07 | 8e-82 | 269 |
| LLPS-Gaa-3531 | Gasterosteus aculeatus | 38.92 | 9e-84 | 273 |
| LLPS-Aon-0319 | Aotus nancymaae | 38.92 | 6e-83 | 271 |
| LLPS-Pap-0418 | Pan paniscus | 38.92 | 1e-82 | 270 |
| LLPS-Fud-1093 | Fukomys damarensis | 38.8 | 5e-82 | 269 |
| LLPS-Mal-1377 | Mandrillus leucophaeus | 38.25 | 5e-75 | 250 |
| LLPS-Xim-0841 | Xiphophorus maculatus | 38.11 | 2e-82 | 270 |
| LLPS-Tar-1295 | Takifugu rubripes | 37.98 | 2e-83 | 272 |
| LLPS-Scf-1687 | Scleropages formosus | 37.98 | 2e-80 | 265 |
| LLPS-Gaga-0016 | Gallus gallus | 37.91 | 2e-79 | 262 |
| LLPS-Mum-0649 | Mus musculus | 37.7 | 4e-78 | 259 |
| LLPS-Asm-1079 | Astyanax mexicanus | 37.7 | 7e-81 | 265 |
| LLPS-Cap-0034 | Cavia porcellus | 37.7 | 2e-79 | 261 |
| LLPS-Ora-1071 | Ornithorhynchus anatinus | 37.64 | 2e-78 | 259 |
| LLPS-Meg-2212 | Meleagris gallopavo | 37.64 | 3e-79 | 261 |
| LLPS-Icp-1761 | Ictalurus punctatus | 37.5 | 4e-80 | 263 |
| LLPS-Ict-0468 | Ictidomys tridecemlineatus | 37.43 | 1e-71 | 241 |
| LLPS-Anc-1670 | Anolis carolinensis | 37.43 | 9e-74 | 246 |
| LLPS-Ten-1736 | Tetraodon nigroviridis | 37.36 | 5e-81 | 266 |
| LLPS-Orl-0608 | Oryzias latipes | 37.33 | 2e-79 | 262 |
| LLPS-Pes-1573 | Pelodiscus sinensis | 37.33 | 3e-79 | 261 |
| LLPS-Yal-0248 | Yarrowia lipolytica | 37.3 | 3e-78 | 258 |
| LLPS-Abg-0399 | Absidia glauca | 37.2 | 1e-81 | 267 |
| LLPS-Xet-0535 | Xenopus tropicalis | 37.16 | 6e-80 | 263 |
| LLPS-Fia-0204 | Ficedula albicollis | 37.13 | 7e-76 | 253 |
| LLPS-Tag-0806 | Taeniopygia guttata | 37.09 | 1e-77 | 257 |
| LLPS-Orn-0158 | Oreochromis niloticus | 37.09 | 1e-79 | 262 |
| LLPS-Pof-0060 | Poecilia formosa | 37.03 | 1e-78 | 259 |
| LLPS-Drm-0278 | Drosophila melanogaster | 37.02 | 3e-75 | 250 |
| LLPS-Asg-0858 | Ashbya gossypii | 36.81 | 5e-81 | 268 |
| LLPS-Scm-1636 | Scophthalmus maximus | 36.49 | 2e-74 | 249 |
| LLPS-Brn-1681 | Brassica napus | 36.34 | 2e-46 | 176 |
| LLPS-Bro-2412 | Brassica oleracea | 36.02 | 2e-44 | 169 |
| LLPS-Cym-0542 | Cyanidioschyzon merolae | 35.66 | 6e-61 | 213 |
| LLPS-Pot-0363 | Populus trichocarpa | 35.58 | 1e-60 | 213 |
| LLPS-Coc-0265 | Corchorus capsularis | 35.32 | 7e-59 | 207 |
| LLPS-Nia-1951 | Nicotiana attenuata | 35.32 | 3e-61 | 216 |
| LLPS-Sol-0330 | Solanum lycopersicum | 35.31 | 2e-61 | 214 |
| LLPS-Mae-0180 | Manihot esculenta | 35.14 | 3e-60 | 211 |
| LLPS-Gor-1320 | Gossypium raimondii | 34.88 | 4e-62 | 216 |
| LLPS-Vir-1567 | Vigna radiata | 34.7 | 1e-60 | 212 |
| LLPS-Sot-2069 | Solanum tuberosum | 34.66 | 2e-51 | 187 |
| LLPS-Phv-1120 | Phaseolus vulgaris | 34.45 | 5e-60 | 210 |
| LLPS-Via-0127 | Vigna angularis | 34.19 | 2e-58 | 206 |
| LLPS-Mua-1271 | Musa acuminata | 34.19 | 5e-63 | 217 |
| LLPS-Thc-0010 | Theobroma cacao | 34.11 | 2e-59 | 209 |
| LLPS-Viv-1323 | Vitis vinifera | 34.1 | 2e-64 | 226 |
| LLPS-Ori-0741 | Oryza indica | 33.96 | 4e-52 | 189 |
| LLPS-Orb-0134 | Oryza barthii | 33.96 | 4e-52 | 188 |
| LLPS-Orr-1095 | Oryza rufipogon | 33.96 | 4e-52 | 188 |
| LLPS-Org-0327 | Oryza glaberrima | 33.96 | 4e-52 | 188 |
| LLPS-Ors-0670 | Oryza sativa | 33.96 | 4e-52 | 188 |
| LLPS-Orp-0778 | Oryza punctata | 33.96 | 6e-52 | 188 |
| LLPS-Glm-1725 | Glycine max | 33.94 | 9e-58 | 206 |
| LLPS-Sem-0369 | Selaginella moellendorffii | 33.85 | 7e-61 | 213 |
| LLPS-Prp-0002 | Prunus persica | 33.85 | 8e-63 | 218 |
| LLPS-Amt-0003 | Amborella trichopoda | 33.85 | 1e-59 | 209 |
| LLPS-Gas-0495 | Galdieria sulphuraria | 33.77 | 2e-57 | 204 |
| LLPS-Art-0079 | Arabidopsis thaliana | 33.77 | 1e-60 | 212 |
| LLPS-Orni-1864 | Oryza nivara | 33.69 | 7e-52 | 188 |
| LLPS-Orm-0795 | Oryza meridionalis | 33.69 | 2e-51 | 186 |
| LLPS-Tra-2578 | Triticum aestivum | 33.5 | 5e-59 | 211 |
| LLPS-Cus-0490 | Cucumis sativus | 33.5 | 3e-61 | 214 |
| LLPS-Tru-0449 | Triticum urartu | 33.5 | 1e-56 | 204 |
| LLPS-Chs-0622 | Chlorocebus sabaeus | 33.33 | 3e-54 | 193 |
| LLPS-Hea-1965 | Helianthus annuus | 33.33 | 1e-59 | 209 |
| LLPS-Hov-0072 | Hordeum vulgare | 33.25 | 4e-60 | 215 |
| LLPS-Arl-2024 | Arabidopsis lyrata | 33.25 | 9e-59 | 207 |
| LLPS-Sob-0913 | Sorghum bicolor | 33.24 | 2e-60 | 212 |
| LLPS-Sei-0671 | Setaria italica | 33.07 | 1e-61 | 215 |
| LLPS-Dac-1369 | Daucus carota | 33.07 | 1e-49 | 179 |
| LLPS-Brr-0539 | Brassica rapa | 32.99 | 2e-60 | 213 |
| LLPS-Lac-0499 | Latimeria chalumnae | 32.8 | 1e-72 | 241 |
| LLPS-Php-0546 | Physcomitrella patens | 32.64 | 7e-56 | 201 |
| LLPS-Brd-0529 | Brachypodium distachyon | 32.62 | 8e-50 | 182 |
| LLPS-Zem-0194 | Zea mays | 32.51 | 4e-55 | 197 |
| LLPS-Met-0240 | Medicago truncatula | 32.47 | 3e-57 | 203 |
| LLPS-Orbr-0768 | Oryza brachyantha | 32.34 | 1e-57 | 204 |
| LLPS-Lep-0367 | Leersia perrieri | 32.17 | 4e-54 | 194 |
| LLPS-Cii-0323 | Ciona intestinalis | 31.27 | 2e-61 | 214 |
| LLPS-Osl-1070 | Ostreococcus lucimarinus | 30.77 | 9e-36 | 141 |
| LLPS-Orgl-0012 | Oryza glumaepatula | 30.68 | 2e-54 | 195 |
| LLPS-Cae-0062 | Caenorhabditis elegans | 29.79 | 7e-38 | 148 |
| LLPS-Chc-0201 | Chondrus crispus | 29.74 | 2e-43 | 164 |
| LLPS-Chr-1159 | Chlamydomonas reinhardtii | 27.76 | 3e-42 | 163 |