LLPS-Ran-0924
Rpa1

▼ OVERVIEW


Status: Unreviewed
Protein Name: Replication protein A subunit
Gene Name: Rpa1
Ensembl Gene: ENSRNOG00000003123.8
Ensembl Protein: ENSRNOP00000004229.2
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, PML nuclear body, OthersPredicted from orthologs(View)

▼ FUNCTION


As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MQQGDTSIKP  VLQVINIRPI  TTGNSPPRYR  LLMSDGLNTL  SSFMLATQLN  ALVEGGQLAS  60
61    NCVCQVHRFI  VNTLKDGRRV  VILMDLEVVK  SAGEVGVKIG  NPVPYNEGHA  QQQAVSAPAS  120
121   AATPPASKPQ  PQNGSLGVGS  TVAKAYGASK  PFGKPAGTGL  LQPTSGTQSK  VVPIASLTPY  180
181   QSKWTICARV  TNKSQIRTWS  NSRGEGKLFS  IELVDESGEI  RATAFNEQVD  KFFPLIEVNK  240
241   VYYFSKGTLK  IANKQFSAVK  NDYEMTFNNE  TSVLPCEDGH  HLPTVQFDFT  GIGDLESKSK  300
301   DSLVDIIGIC  KSYEDATKIT  VKSNNREVAK  RNICLMDMSG  KVVTATLWGE  DADKFDGSRQ  360
361   PVMAIKGARV  SDFGGRSLSV  LSSSTVLVNP  DIPEAYKLRG  WHYVFGDGGL  KALLHRQAHD  420
421   PLMNLESQRK  QLELKCCVLT  LIPPGRQGFN  SCVLESSAES  ISGLRCGQLM  WGFDSEGQAL  480
481   DGVSISDLRS  GGTGGSNTNW  KTLYEAKSEN  LGQGDKADYF  STVATVVFLR  KENCMYQACP  540
541   TQDCNKKVID  QQNGLYRCEK  CDREFPNFKY  RMILSVNIAD  FQENQWVTCF  QESAEAILGQ  600
601   NTVYLGELKE  KVGCVFVSMN  EQAFEEVFQN  ANFRSFTFRI  RVKLETYNDE  SRIKATVIDV  660
661   KPVDYRDYSK  RLIMNIRKNI  680
Nucleotide CDS Sequence (FASTA)
1     ATGCAGCAGG  GAGATACATC  CATAAAACCC  GTTCTTCAAG  TCATTAACAT  CCGTCCCATT  60
61    ACTACAGGGA  ATAGTCCACC  GCGGTATCGA  CTGCTTATGA  GTGATGGGTT  GAACACGCTT  120
121   TCCTCCTTCA  TGCTGGCCAC  GCAGCTGAAC  GCCCTGGTCG  AGGGGGGCCA  GCTGGCCAGC  180
181   AACTGTGTCT  GCCAGGTCCA  CCGCTTCATC  GTCAACACCC  TGAAGGACGG  AAGGAGAGTA  240
241   GTTATTTTGA  TGGACTTGGA  AGTTGTGAAA  TCTGCTGGCG  AAGTTGGAGT  AAAGATTGGG  300
301   AATCCAGTGC  CCTATAATGA  AGGACATGCG  CAGCAGCAAG  CAGTCTCTGC  CCCAGCCTCT  360
361   GCAGCGACAC  CACCAGCCAG  CAAGCCCCAA  CCGCAGAATG  GGAGCTTGGG  AGTGGGTTCC  420
421   ACTGTAGCTA  AGGCATACGG  GGCCTCAAAG  CCGTTTGGAA  AGCCTGCTGG  AACTGGCCTG  480
481   CTGCAGCCTA  CAAGTGGGAC  ACAGTCCAAA  GTGGTACCCA  TCGCCAGCCT  CACCCCTTAC  540
541   CAATCCAAGT  GGACGATTTG  TGCCCGTGTC  ACCAACAAAA  GTCAGATCCG  TACCTGGAGC  600
601   AATTCCCGTG  GGGAAGGAAA  GCTCTTCTCT  ATAGAACTTG  TGGATGAAAG  TGGTGAAATC  660
661   AGAGCTACGG  CTTTCAATGA  GCAGGTGGAC  AAGTTCTTTC  CCCTTATTGA  AGTGAACAAG  720
721   GTGTATTACT  TCTCCAAGGG  CACTCTGAAA  ATCGCTAACA  AACAGTTCTC  AGCTGTTAAA  780
781   AATGACTATG  AGATGACCTT  CAATAATGAG  ACGTCTGTCC  TTCCCTGCGA  AGATGGCCAT  840
841   CACTTACCCA  CAGTTCAGTT  TGACTTCACA  GGGATCGGTG  ACCTAGAGAG  CAAGTCTAAA  900
901   GACTCACTTG  TAGACATAAT  TGGAATCTGC  AAGAGCTATG  AAGATGCGAC  TAAAATCACA  960
961   GTGAAGTCTA  ACAACAGAGA  AGTTGCTAAG  AGAAATATCT  GTTTGATGGA  CATGTCAGGG  1020
1021  AAAGTGGTGA  CTGCGACGCT  GTGGGGAGAA  GACGCTGACA  AGTTTGACGG  TTCTAGGCAG  1080
1081  CCTGTGATGG  CCATCAAAGG  AGCCCGAGTG  TCCGACTTTG  GTGGGCGGAG  CCTCTCTGTC  1140
1141  CTATCATCTA  GCACTGTCCT  TGTGAATCCT  GACATCCCAG  AGGCCTATAA  GCTCCGTGGA  1200
1201  TGGCATTATG  TCTTCGGAGA  TGGTGGCCTG  AAAGCCCTCT  TACACCGACA  AGCCCACGAT  1260
1261  CCCCTGATGA  ACCTAGAGAG  TCAGAGAAAG  CAATTAGAAC  TTAAGTGCTG  CGTGCTGACC  1320
1321  TTGATCCCAC  CAGGTAGACA  AGGTTTTAAC  AGCTGCGTGC  TGGAGAGCAG  TGCTGAGAGC  1380
1381  ATCTCCGGTT  TGCGCTGTGG  GCAGCTGATG  TGGGGGTTTG  ACTCAGAAGG  ACAAGCCTTA  1440
1441  GATGGAGTTT  CCATCTCTGA  TCTCAGGAGT  GGAGGGACCG  GAGGGAGCAA  CACCAACTGG  1500
1501  AAAACTTTGT  ATGAAGCTAA  ATCCGAGAAC  CTGGGCCAGG  GCGACAAGGC  GGACTATTTC  1560
1561  AGCACTGTGG  CAACAGTGGT  GTTTCTTCGC  AAAGAGAACT  GTATGTACCA  GGCCTGCCCG  1620
1621  ACCCAGGACT  GCAATAAGAA  AGTGATTGAC  CAGCAGAATG  GGTTGTACCG  CTGTGAGAAG  1680
1681  TGCGACCGGG  AATTTCCCAA  TTTCAAATAC  CGCATGATCT  TATCGGTAAA  TATTGCAGAT  1740
1741  TTTCAGGAGA  ATCAGTGGGT  GACGTGTTTC  CAGGAGTCCG  CGGAGGCCAT  TCTTGGACAG  1800
1801  AACACTGTGT  ACCTTGGGGA  ACTCAAAGAG  AAGGTTGGCT  GCGTGTTTGT  CAGCATGAAC  1860
1861  GAGCAGGCGT  TTGAAGAGGT  TTTCCAGAAT  GCCAACTTCC  GATCATTTAC  ATTCAGAATC  1920
1921  AGAGTCAAGC  TGGAGACCTA  CAATGATGAA  TCTCGAATTA  AGGCCACTGT  GATAGACGTG  1980
1981  AAGCCCGTGG  ACTACAGAGA  CTATAGCAAA  AGGCTGATCA  TGAACATCAG  GAAGAACATT  2040
2041  TGA  2043

▼ KEYWORD


ID
Family
Complete proteome
DNA replication
DNA-binding
Metal-binding
Nucleus
Proteomics identification
Reference proteome
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
DNA replication factor A complex
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
PML body
Cellular Component
Site of DNA damage
Molecular Function
Damaged DNA binding
Molecular Function
G-rich strand telomeric DNA binding
Molecular Function
Metal ion binding
Molecular Function
Sequence-specific DNA binding
Molecular Function
Single-stranded DNA binding
Molecular Function
Single-stranded telomeric DNA binding
Biological Process
Base-excision repair
Biological Process
DNA repair
Biological Process
DNA replication
Biological Process
DNA unwinding involved in DNA replication
Biological Process
DNA-dependent DNA replication
Biological Process
Double-strand break repair via homologous recombination
Biological Process
Meiotic cell cycle
Biological Process
Mismatch repair
Biological Process
Nucleotide-excision repair
Biological Process
Protein localization to chromosome
Biological Process
Telomere maintenance
Biological Process
Telomere maintenance via telomerase

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-2410Mesocricetus auratus94.260.0 714
LLPS-Maf-0483Macaca fascicularis91.261e-57 209
LLPS-Mum-0649Mus musculus89.92e-125 394
LLPS-Orc-3239Oryctolagus cuniculus89.864e-125 393
LLPS-Eqc-0026Equus caballus89.374e-120 379
LLPS-Urm-0968Ursus maritimus88.891e-124 390
LLPS-Fud-1093Fukomys damarensis88.895e-125 391
LLPS-Caj-0447Callithrix jacchus88.530.0 674
LLPS-Caf-1061Canis familiaris88.414e-117 371
LLPS-Bot-0263Bos taurus88.417e-125 391
LLPS-Ova-0601Ovis aries88.415e-125 391
LLPS-Sus-1256Sus scrofa88.415e-123 386
LLPS-Aim-0113Ailuropoda melanoleuca87.981e-122 385
LLPS-Cas-0226Carlito syrichta87.923e-122 384
LLPS-Aon-0319Aotus nancymaae87.530.0 670
LLPS-Fec-2495Felis catus87.310.0 665
LLPS-Dio-0054Dipodomys ordii87.280.0 683
LLPS-Mod-2017Monodelphis domestica86.961e-120 380
LLPS-Tut-1019Tursiops truncatus86.961e-120 380
LLPS-Sah-0553Sarcophilus harrisii86.962e-121 382
LLPS-Pat-1154Pan troglodytes86.780.0 674
LLPS-Hos-3885Homo sapiens86.780.0 675
LLPS-Paa-0243Papio anubis86.780.0 674
LLPS-Mam-0979Macaca mulatta86.530.0 673
LLPS-Pap-0418Pan paniscus86.530.0 671
LLPS-Mup-0934Mustela putorius furo86.530.0 660
LLPS-Cap-0034Cavia porcellus86.476e-122 384
LLPS-Nol-2708Nomascus leucogenys86.280.0 669
LLPS-Loa-0590Loxodonta africana85.993e-119 377
LLPS-Myl-3156Myotis lucifugus85.890.0 654
LLPS-Rhb-3846Rhinopithecus bieti85.790.0 673
LLPS-Chs-0622Chlorocebus sabaeus85.790.0 672
LLPS-Gog-0016Gorilla gorilla85.514e-121 380
LLPS-Man-3192Macaca nemestrina85.310.0 635
LLPS-Pes-1573Pelodiscus sinensis84.543e-116 368
LLPS-Cea-3759Cercocebus atys84.547e-123 373
LLPS-Ora-1071Ornithorhynchus anatinus82.211e-107 346
LLPS-Mal-1377Mandrillus leucophaeus81.930.0 626
LLPS-Ict-0468Ictidomys tridecemlineatus80.840.0 605
LLPS-Fia-0204Ficedula albicollis77.512e-105 340
LLPS-Tag-0806Taeniopygia guttata76.819e-105 338
LLPS-Meg-2212Meleagris gallopavo76.814e-103 334
LLPS-Gaga-0016Gallus gallus76.339e-103 333
LLPS-Xet-0535Xenopus tropicalis74.414e-100 327
LLPS-Leo-1707Lepisosteus oculatus72.463e-98 321
LLPS-Scf-1687Scleropages formosus72.331e-100 329
LLPS-Ten-1736Tetraodon nigroviridis71.367e-98 320
LLPS-Tar-1295Takifugu rubripes71.363e-100 326
LLPS-Orn-0158Oreochromis niloticus70.877e-100 325
LLPS-Xim-0841Xiphophorus maculatus69.272e-94 311
LLPS-Dar-1129Danio rerio68.932e-96 316
LLPS-Orl-0608Oryzias latipes68.932e-95 313
LLPS-Pof-0060Poecilia formosa68.296e-93 307
LLPS-Gaa-3531Gasterosteus aculeatus67.964e-95 313
LLPS-Icp-1761Ictalurus punctatus67.155e-90 299
LLPS-Anp-0087Anas platyrhynchos66.620.0 875
LLPS-Asm-1079Astyanax mexicanus66.54e-89 296
LLPS-Scm-1636Scophthalmus maximus64.853e-98 323
LLPS-Anc-1670Anolis carolinensis64.843e-169 505
LLPS-Lac-0499Latimeria chalumnae59.450.0 609
LLPS-Gag-0155Gaeumannomyces graminis49.383e-65 233
LLPS-Cii-0323Ciona intestinalis47.622e-52 196
LLPS-Map-0347Magnaporthe poae46.897e-58 212
LLPS-Sot-2069Solanum tuberosum46.284e-53 198
LLPS-Viv-1323Vitis vinifera45.953e-0861.6
LLPS-Sol-2288Solanum lycopersicum44.536e-53 198
LLPS-Bro-2412Brassica oleracea43.398e-47 183
LLPS-Brn-1681Brassica napus42.982e-46 182
LLPS-Asf-0202Aspergillus flavus42.865e-32 132
LLPS-Amt-1759Amborella trichopoda42.89e-51 193
LLPS-Art-2667Arabidopsis thaliana42.568e-52 196
LLPS-Crn-0057Cryptococcus neoformans42.424e-85 286
LLPS-Cus-1067Cucumis sativus42.251e-54 205
LLPS-Prp-0739Prunus persica42.152e-50 192
LLPS-Asg-0858Ashbya gossypii42.086e-50 190
LLPS-Miv-0787Microbotryum violaceum42.043e-84 284
LLPS-Mae-0180Manihot esculenta41.964e-49 187
LLPS-Arl-0924Arabidopsis lyrata41.743e-50 192
LLPS-Glm-1725Glycine max41.72e-49 190
LLPS-Pot-0363Populus trichocarpa41.671e-48 186
LLPS-Orbr-1792Oryza brachyantha41.674e-1583.6
LLPS-Hea-1594Helianthus annuus41.32e-53 201
LLPS-Usm-0421Ustilago maydis41.233e-87 292
LLPS-Drm-0278Drosophila melanogaster41.191e-90 301
LLPS-Asni-0427Aspergillus niger41.166e-81 275
LLPS-Trr-0291Trichoderma reesei41.031e-80 274
LLPS-Mua-1366Musa acuminata40.942e-52 197
LLPS-Phv-1011Phaseolus vulgaris40.911e-47 184
LLPS-Mao-0186Magnaporthe oryzae40.795e-79 270
LLPS-Nia-1951Nicotiana attenuata40.78e-49 188
LLPS-Nef-0725Neosartorya fischeri40.665e-77 265
LLPS-Tra-1124Triticum aestivum40.581e-51 196
LLPS-Trv-0330Trichoderma virens40.552e-78 268
LLPS-Tru-0449Triticum urartu40.353e-51 196
LLPS-Hov-2002Hordeum vulgare40.322e-47 184
LLPS-Yal-0248Yarrowia lipolytica40.328e-50 188
LLPS-Brr-0539Brassica rapa40.217e-51 193
LLPS-Via-0324Vigna angularis40.081e-48 187
LLPS-Vir-0947Vigna radiata40.087e-49 188
LLPS-Ved-1377Verticillium dahliae39.956e-77 265
LLPS-Fuo-0495Fusarium oxysporum39.844e-70 244
LLPS-Fuv-1140Fusarium verticillioides39.842e-70 245
LLPS-Scs-0400Sclerotinia sclerotiorum39.792e-65 233
LLPS-Ast-1115Aspergillus terreus39.655e-75 259
LLPS-Scj-0876Schizosaccharomyces japonicus39.654e-77 265
LLPS-Fus-0597Fusarium solani39.46e-73 253
LLPS-Asn-0287Aspergillus nidulans39.292e-70 246
LLPS-Nec-0225Neurospora crassa39.255e-77 265
LLPS-Cogr-0836Colletotrichum graminicola39.151e-79 271
LLPS-Cog-0191Colletotrichum gloeosporioides39.152e-77 266
LLPS-Sob-1229Sorghum bicolor39.122e-54 205
LLPS-Aso-0183Aspergillus oryzae39.071e-74 258
LLPS-Asfu-0132Aspergillus fumigatus38.998e-66 232
LLPS-Org-0575Oryza glaberrima38.936e-44 170
LLPS-Asc-0381Aspergillus clavatus38.898e-75 258
LLPS-Coo-0303Colletotrichum orbiculare38.395e-77 265
LLPS-Abg-0399Absidia glauca38.388e-76 261
LLPS-Scc-0168Schizosaccharomyces cryophilus38.354e-75 259
LLPS-Coc-0146Corchorus capsularis38.328e-1066.2
LLPS-Spr-0542Sporisorium reilianum38.322e-80 275
LLPS-Scp-1351Schizosaccharomyces pombe38.133e-75 259
LLPS-Lem-0311Leptosphaeria maculans37.962e-71 249
LLPS-Beb-0304Beauveria bassiana37.942e-74 257
LLPS-Chr-1159Chlamydomonas reinhardtii37.891e-42 169
LLPS-Phn-0638Phaeosphaeria nodorum37.763e-70 245
LLPS-Orr-0507Oryza rufipogon37.742e-31 134
LLPS-Ors-0337Oryza sativa37.742e-31 134
LLPS-Tum-0581Tuber melanosporum37.682e-73 255
LLPS-Sac-0155Saccharomyces cerevisiae37.582e-29 128
LLPS-Blg-0094Blumeria graminis37.414e-76 262
LLPS-Gor-1320Gossypium raimondii37.397e-31 132
LLPS-Orgl-0012Oryza glumaepatula37.381e-30 132
LLPS-Orm-1141Oryza meridionalis37.264e-31 134
LLPS-Ori-0108Oryza indica37.267e-31 132
LLPS-Orni-0152Oryza nivara37.267e-31 132
LLPS-Pyt-0998Pyrenophora teres37.253e-68 240
LLPS-Orp-0129Oryza punctata36.798e-30 129
LLPS-Orb-0134Oryza barthii36.177e-58 212
LLPS-Sei-0671Setaria italica35.714e-26 118
LLPS-Mel-0017Melampsora laricipopulina35.563e-64 228
LLPS-Brd-0627Brachypodium distachyon35.557e-28 123
LLPS-Osl-1070Ostreococcus lucimarinus35.161e-33 140
LLPS-Met-0240Medicago truncatula34.877e-60 218
LLPS-Zem-1599Zea mays34.622e-0965.1
LLPS-Put-0400Puccinia triticina34.352e-54 202
LLPS-Pug-0164Puccinia graminis34.259e-62 223
LLPS-Sem-0369Selaginella moellendorffii34.122e-29 128
LLPS-Gas-0495Galdieria sulphuraria33.795e-61 221
LLPS-Lep-0367Leersia perrieri33.183e-25 115
LLPS-Dac-1369Daucus carota33.083e-67 234
LLPS-Php-0546Physcomitrella patens33.034e-81 281
LLPS-Cae-0062Caenorhabditis elegans32.791e-23 110
LLPS-Zyt-0166Zymoseptoria tritici32.654e-103 335
LLPS-Cym-0542Cyanidioschyzon merolae31.662e-46 179
LLPS-Dos-1028Dothistroma septosporum31.488e-100 325
LLPS-Kop-0355Komagataella pastoris31.03e-94 311
LLPS-Thc-0010Theobroma cacao30.693e-82 279
LLPS-Chc-0201Chondrus crispus27.463e-63 228