LLPS-Lac-0499
RPA1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Replication protein A subunit |
| Gene Name: | RPA1 |
| Ensembl Gene: | ENSLACG00000007210.1 |
| Ensembl Protein: | ENSLACP00000008142.1 |
| Organism: | Latimeria chalumnae |
| Taxa ID: | 7897 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, PML nuclear body, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLACT00000008208.1 | ENSLACP00000008142.1 |
| UniProt | H3AES1, H3AES1_LATCH | |
| GeneBank | AFYH01222769, AFYH01222768 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 FNTGQGQQLL PAPTASKPQQ HAFGSSVAVS SLNGNPAKQF GKTGGMGGAS PTPVGSQPKA 60 61 VPISSLNPYQ TRWTIRARVT NKSQIRTWSN SRGEGKLFSI ELVDESGEIR ATAFNEQVDK 120 121 FFHLIEVNKV YYFSKFNMKI ANKQYTAVKN DYEMTFNGES MLIPCDDVDT LPMVQFEFVP 180 181 IDTLEALKKD TLVDIIGICR SYEDATKVTV RSNNREVSKR NLHLMDMSRK VVTVTLWGED 240 241 ADLFDGSGQP VVAVKGARLS DFGGRSLSVL ASSTFVKNPD IPEAFKLRGW FDSEGRALEA 300 301 VSISDMKSDL LLRDGATNWK TLLEIEAEAM DLAGKTEYYS CVGTVIFLRK ETCLYRACIS 360 361 EGCNKKVVDQ QNGFYRCEKC DREFPNFKYR LVLSVNIADF GSHRWVTCFQ DVAETLLGQN 420 421 AAYIGELKDT NEEAFEEVFQ QACFCSYMFR IRVQMETYND ESRIKATVMN FKPVNHKEYS 480 481 KKLIMNIRNY AAQLN 495 |
| Nucleotide CDS Sequence (FASTA) |
1 TTTAATACAG GTCAGGGACA GCAGCTGCTA CCAGCTCCTA CAGCCAGCAA GCCCCAGCAG 60 61 CATGCATTTG GCTCCAGCGT TGCTGTTTCA TCTCTGAATG GCAATCCTGC TAAGCAGTTT 120 121 GGTAAGACTG GTGGAATGGG AGGTGCTTCC CCAACTCCTG TTGGATCCCA GCCCAAGGCA 180 181 GTACCGATAA GCAGCCTGAA CCCCTACCAG ACAAGGTGGA CCATACGAGC CCGTGTTACC 240 241 AACAAGAGTC AAATTCGAAC TTGGAGCAAT TCCCGCGGAG AAGGAAAGCT CTTTTCTATA 300 301 GAGCTGGTGG ATGAGAGTGG AGAGATCCGA GCTACTGCTT TCAACGAACA GGTGGACAAG 360 361 TTCTTTCACC TCATTGAAGT CAACAAGGTC TACTATTTCT CTAAGTTTAA TATGAAAATC 420 421 GCCAACAAGC AGTACACAGC TGTGAAGAAT GATTATGAGA TGACGTTCAA TGGGGAGAGC 480 481 ATGCTGATCC CATGTGATGA TGTGGACACC CTGCCTATGG TGCAGTTTGA GTTTGTACCC 540 541 ATAGATACCT TAGAAGCCCT GAAAAAGGAC ACGCTGGTTG ACATTATTGG AATTTGCAGG 600 601 AGCTATGAAG ATGCTACGAA GGTAACAGTG AGATCCAACA ACCGTGAAGT ATCCAAGAGG 660 661 AACCTGCATC TGATGGACAT GAGTAGGAAG GTGGTCACTG TTACACTGTG GGGCGAGGAT 720 721 GCAGATTTGT TTGATGGCTC AGGACAACCG GTGGTGGCAG TTAAAGGCGC AAGACTCTCT 780 781 GATTTTGGTG GACGAAGTCT TTCTGTTTTG GCATCAAGTA CCTTTGTTAA AAACCCAGAT 840 841 ATTCCAGAGG CCTTCAAACT CCGCGGATGG TTTGACTCAG AAGGTCGTGC CCTTGAAGCA 900 901 GTTTCCATCT CTGACATGAA GTCGGATTTG CTGTTGAGAG ATGGTGCTAC AAACTGGAAA 960 961 ACCCTGTTGG AAATCGAAGC GGAGGCCATG GACCTTGCTG GGAAGACAGA ATATTACAGC 1020 1021 TGTGTTGGCA CAGTGATTTT TCTGCGGAAG GAAACCTGCT TGTATCGGGC CTGCATCTCC 1080 1081 GAGGGCTGCA ACAAGAAAGT GGTGGATCAG CAGAATGGTT TCTACCGCTG TGAGAAGTGT 1140 1141 GATCGCGAGT TCCCTAATTT CAAATATCGC TTAGTCTTGT CGGTAAATAT TGCAGATTTT 1200 1201 GGTTCACACA GGTGGGTGAC TTGTTTCCAA GATGTGGCTG AAACACTCCT TGGGCAAAAT 1260 1261 GCTGCTTACA TTGGAGAGCT TAAGGACACG AATGAGGAAG CCTTTGAGGA GGTGTTTCAA 1320 1321 CAGGCCTGCT TCTGCTCCTA CATGTTTAGG ATCCGTGTCC AAATGGAGAC GTACAACGAT 1380 1381 GAATCTCGTA TCAAAGCCAC AGTTATGAAT TTCAAGCCTG TGAACCACAA AGAATACAGT 1440 1441 AAGAAGTTGA TCATGAACAT AAGAAACTAC GCGGCTCAGC TAAACTGA 1488 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Metal ion binding | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | Heart development |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-0016 | Gorilla gorilla | 70.55 | 0.0 | 680 |
| LLPS-Maf-0483 | Macaca fascicularis | 69.74 | 0.0 | 544 |
| LLPS-Mam-0979 | Macaca mulatta | 69.25 | 0.0 | 690 |
| LLPS-Paa-0243 | Papio anubis | 69.25 | 0.0 | 689 |
| LLPS-Man-3192 | Macaca nemestrina | 69.04 | 0.0 | 681 |
| LLPS-Nol-2708 | Nomascus leucogenys | 68.91 | 0.0 | 684 |
| LLPS-Pat-1154 | Pan troglodytes | 68.84 | 0.0 | 683 |
| LLPS-Pap-0418 | Pan paniscus | 68.84 | 0.0 | 682 |
| LLPS-Hos-3885 | Homo sapiens | 68.84 | 0.0 | 684 |
| LLPS-Caj-0447 | Callithrix jacchus | 68.07 | 0.0 | 678 |
| LLPS-Fud-1093 | Fukomys damarensis | 68.0 | 0.0 | 682 |
| LLPS-Mod-2017 | Monodelphis domestica | 67.99 | 0.0 | 699 |
| LLPS-Sah-0553 | Sarcophilus harrisii | 67.9 | 0.0 | 684 |
| LLPS-Pes-1573 | Pelodiscus sinensis | 67.86 | 0.0 | 697 |
| LLPS-Xet-0535 | Xenopus tropicalis | 67.84 | 0.0 | 666 |
| LLPS-Orc-3239 | Oryctolagus cuniculus | 67.8 | 0.0 | 671 |
| LLPS-Mum-0649 | Mus musculus | 67.5 | 0.0 | 655 |
| LLPS-Aon-0319 | Aotus nancymaae | 67.4 | 0.0 | 695 |
| LLPS-Mal-1377 | Mandrillus leucophaeus | 67.36 | 0.0 | 653 |
| LLPS-Ora-1071 | Ornithorhynchus anatinus | 67.33 | 0.0 | 686 |
| LLPS-Cas-0226 | Carlito syrichta | 67.07 | 0.0 | 673 |
| LLPS-Cap-0034 | Cavia porcellus | 67.0 | 0.0 | 696 |
| LLPS-Rhb-3846 | Rhinopithecus bieti | 66.87 | 0.0 | 690 |
| LLPS-Mea-2410 | Mesocricetus auratus | 66.73 | 0.0 | 683 |
| LLPS-Tag-0806 | Taeniopygia guttata | 66.67 | 0.0 | 655 |
| LLPS-Loa-0590 | Loxodonta africana | 66.53 | 0.0 | 664 |
| LLPS-Caf-1061 | Canis familiaris | 66.33 | 0.0 | 683 |
| LLPS-Aim-0113 | Ailuropoda melanoleuca | 66.2 | 0.0 | 665 |
| LLPS-Cea-3759 | Cercocebus atys | 66.03 | 2e-125 | 374 |
| LLPS-Eqc-0026 | Equus caballus | 65.8 | 0.0 | 664 |
| LLPS-Fia-0204 | Ficedula albicollis | 65.74 | 0.0 | 645 |
| LLPS-Sus-1256 | Sus scrofa | 65.67 | 0.0 | 671 |
| LLPS-Mup-0934 | Mustela putorius furo | 65.61 | 0.0 | 657 |
| LLPS-Ova-0601 | Ovis aries | 65.48 | 0.0 | 680 |
| LLPS-Myl-3156 | Myotis lucifugus | 65.47 | 0.0 | 687 |
| LLPS-Dio-0054 | Dipodomys ordii | 65.4 | 0.0 | 684 |
| LLPS-Fec-2495 | Felis catus | 65.34 | 0.0 | 667 |
| LLPS-Urm-0968 | Ursus maritimus | 65.33 | 0.0 | 657 |
| LLPS-Ict-0468 | Ictidomys tridecemlineatus | 65.19 | 0.0 | 636 |
| LLPS-Tut-1019 | Tursiops truncatus | 65.08 | 0.0 | 652 |
| LLPS-Bot-0263 | Bos taurus | 64.88 | 0.0 | 679 |
| LLPS-Gaga-0016 | Gallus gallus | 64.74 | 0.0 | 650 |
| LLPS-Meg-2212 | Meleagris gallopavo | 64.34 | 0.0 | 646 |
| LLPS-Tar-1295 | Takifugu rubripes | 64.07 | 0.0 | 636 |
| LLPS-Ten-1736 | Tetraodon nigroviridis | 63.08 | 0.0 | 657 |
| LLPS-Scf-1687 | Scleropages formosus | 63.03 | 0.0 | 653 |
| LLPS-Leo-1707 | Lepisosteus oculatus | 62.63 | 0.0 | 654 |
| LLPS-Asm-1079 | Astyanax mexicanus | 62.47 | 0.0 | 636 |
| LLPS-Orn-0158 | Oreochromis niloticus | 62.42 | 0.0 | 642 |
| LLPS-Anc-1670 | Anolis carolinensis | 61.51 | 0.0 | 584 |
| LLPS-Dar-1129 | Danio rerio | 61.24 | 0.0 | 635 |
| LLPS-Pof-0060 | Poecilia formosa | 61.2 | 0.0 | 643 |
| LLPS-Orl-0608 | Oryzias latipes | 61.1 | 0.0 | 637 |
| LLPS-Xim-0841 | Xiphophorus maculatus | 60.61 | 0.0 | 631 |
| LLPS-Icp-1761 | Ictalurus punctatus | 60.29 | 0.0 | 629 |
| LLPS-Gaa-3531 | Gasterosteus aculeatus | 59.55 | 0.0 | 624 |
| LLPS-Chs-0622 | Chlorocebus sabaeus | 59.38 | 0.0 | 544 |
| LLPS-Ran-0924 | Rattus norvegicus | 59.09 | 0.0 | 614 |
| LLPS-Scm-1636 | Scophthalmus maximus | 56.94 | 0.0 | 590 |
| LLPS-Anp-0087 | Anas platyrhynchos | 56.39 | 0.0 | 592 |
| LLPS-Drm-0278 | Drosophila melanogaster | 46.31 | 6e-136 | 413 |
| LLPS-Cii-0323 | Ciona intestinalis | 43.57 | 2e-136 | 414 |
| LLPS-Mao-0186 | Magnaporthe oryzae | 41.11 | 6e-112 | 351 |
| LLPS-Gag-0155 | Gaeumannomyces graminis | 40.23 | 3e-109 | 344 |
| LLPS-Spr-0542 | Sporisorium reilianum | 39.27 | 3e-115 | 360 |
| LLPS-Ved-1377 | Verticillium dahliae | 39.26 | 4e-112 | 352 |
| LLPS-Scp-1351 | Schizosaccharomyces pombe | 39.01 | 3e-114 | 357 |
| LLPS-Nia-0731 | Nicotiana attenuata | 38.79 | 4e-90 | 294 |
| LLPS-Pot-1065 | Populus trichocarpa | 38.6 | 1e-100 | 328 |
| LLPS-Fuo-0495 | Fusarium oxysporum | 38.6 | 5e-110 | 344 |
| LLPS-Fuv-1140 | Fusarium verticillioides | 38.6 | 6e-110 | 344 |
| LLPS-Coo-0303 | Colletotrichum orbiculare | 38.6 | 8e-113 | 353 |
| LLPS-Scs-0400 | Sclerotinia sclerotiorum | 38.52 | 2e-100 | 321 |
| LLPS-Brr-2944 | Brassica rapa | 38.51 | 6e-96 | 314 |
| LLPS-Map-0347 | Magnaporthe poae | 38.46 | 5e-104 | 331 |
| LLPS-Sot-2069 | Solanum tuberosum | 38.34 | 2e-89 | 292 |
| LLPS-Mae-2184 | Manihot esculenta | 38.29 | 3e-99 | 324 |
| LLPS-Pyt-0998 | Pyrenophora teres | 38.15 | 2e-98 | 315 |
| LLPS-Fus-0597 | Fusarium solani | 38.05 | 9e-106 | 335 |
| LLPS-Usm-0421 | Ustilago maydis | 38.04 | 5e-116 | 362 |
| LLPS-Nef-0725 | Neosartorya fischeri | 38.02 | 3e-104 | 331 |
| LLPS-Crn-0057 | Cryptococcus neoformans | 37.94 | 1e-108 | 342 |
| LLPS-Brd-0627 | Brachypodium distachyon | 37.9 | 1e-87 | 288 |
| LLPS-Miv-0787 | Microbotryum violaceum | 37.61 | 8e-106 | 335 |
| LLPS-Scc-0168 | Schizosaccharomyces cryophilus | 37.59 | 1e-108 | 343 |
| LLPS-Asg-0858 | Ashbya gossypii | 37.59 | 1e-95 | 311 |
| LLPS-Scj-0876 | Schizosaccharomyces japonicus | 37.59 | 3e-110 | 346 |
| LLPS-Mua-1366 | Musa acuminata | 37.56 | 2e-97 | 317 |
| LLPS-Sol-2288 | Solanum lycopersicum | 37.53 | 2e-90 | 296 |
| LLPS-Asn-0287 | Aspergillus nidulans | 37.47 | 5e-98 | 314 |
| LLPS-Viv-1323 | Vitis vinifera | 37.44 | 4e-91 | 303 |
| LLPS-Orp-0129 | Oryza punctata | 37.27 | 4e-87 | 287 |
| LLPS-Ori-0108 | Oryza indica | 37.25 | 1e-87 | 288 |
| LLPS-Coc-0146 | Corchorus capsularis | 37.16 | 2e-92 | 306 |
| LLPS-Asfu-0132 | Aspergillus fumigatus | 37.16 | 1e-104 | 330 |
| LLPS-Asc-0381 | Aspergillus clavatus | 37.14 | 2e-99 | 318 |
| LLPS-Beb-0304 | Beauveria bassiana | 37.11 | 3e-106 | 336 |
| LLPS-Arl-0924 | Arabidopsis lyrata | 37.1 | 3e-95 | 313 |
| LLPS-Art-2667 | Arabidopsis thaliana | 37.08 | 3e-94 | 310 |
| LLPS-Ors-0337 | Oryza sativa | 37.05 | 9e-88 | 289 |
| LLPS-Orr-0507 | Oryza rufipogon | 37.05 | 9e-88 | 289 |
| LLPS-Orm-1141 | Oryza meridionalis | 37.05 | 3e-86 | 286 |
| LLPS-Orni-0152 | Oryza nivara | 37.05 | 4e-87 | 287 |
| LLPS-Orgl-0012 | Oryza glumaepatula | 37.05 | 8e-87 | 287 |
| LLPS-Gor-1320 | Gossypium raimondii | 37.03 | 8e-93 | 301 |
| LLPS-Kop-0355 | Komagataella pastoris | 37.02 | 2e-100 | 321 |
| LLPS-Cog-0191 | Colletotrichum gloeosporioides | 36.98 | 5e-109 | 343 |
| LLPS-Phn-0638 | Phaeosphaeria nodorum | 36.93 | 9e-102 | 323 |
| LLPS-Prp-0739 | Prunus persica | 36.92 | 2e-93 | 309 |
| LLPS-Tum-0581 | Tuber melanosporum | 36.91 | 2e-108 | 342 |
| LLPS-Org-0575 | Oryza glaberrima | 36.83 | 9e-88 | 286 |
| LLPS-Cus-1067 | Cucumis sativus | 36.75 | 5e-93 | 308 |
| LLPS-Trr-0291 | Trichoderma reesei | 36.74 | 7e-107 | 337 |
| LLPS-Php-0546 | Physcomitrella patens | 36.73 | 1e-97 | 320 |
| LLPS-Aso-0183 | Aspergillus oryzae | 36.66 | 4e-102 | 325 |
| LLPS-Vir-0947 | Vigna radiata | 36.61 | 3e-94 | 311 |
| LLPS-Asni-0427 | Aspergillus niger | 36.57 | 3e-106 | 336 |
| LLPS-Glm-1725 | Glycine max | 36.54 | 5e-94 | 311 |
| LLPS-Brn-1062 | Brassica napus | 36.46 | 5e-94 | 307 |
| LLPS-Trv-0330 | Trichoderma virens | 36.43 | 2e-105 | 334 |
| LLPS-Amt-0003 | Amborella trichopoda | 36.42 | 9e-95 | 307 |
| LLPS-Blg-0094 | Blumeria graminis | 36.36 | 8e-107 | 338 |
| LLPS-Nec-0225 | Neurospora crassa | 36.36 | 1e-112 | 353 |
| LLPS-Thc-0010 | Theobroma cacao | 36.26 | 3e-88 | 290 |
| LLPS-Hea-1594 | Helianthus annuus | 36.24 | 7e-91 | 302 |
| LLPS-Cogr-0836 | Colletotrichum graminicola | 36.16 | 7e-115 | 358 |
| LLPS-Sei-0671 | Setaria italica | 36.12 | 4e-89 | 292 |
| LLPS-Via-0324 | Vigna angularis | 35.94 | 1e-92 | 306 |
| LLPS-Sem-0369 | Selaginella moellendorffii | 35.87 | 1e-93 | 304 |
| LLPS-Orbr-0768 | Oryza brachyantha | 35.68 | 8e-82 | 273 |
| LLPS-Lep-0367 | Leersia perrieri | 35.68 | 1e-82 | 276 |
| LLPS-Tra-0329 | Triticum aestivum | 35.67 | 2e-82 | 275 |
| LLPS-Lem-0311 | Leptosphaeria maculans | 35.6 | 1e-96 | 311 |
| LLPS-Ast-1115 | Aspergillus terreus | 35.55 | 4e-100 | 320 |
| LLPS-Sac-0155 | Saccharomyces cerevisiae | 35.32 | 4e-94 | 305 |
| LLPS-Hov-0072 | Hordeum vulgare | 35.27 | 1e-88 | 300 |
| LLPS-Abg-0399 | Absidia glauca | 35.21 | 6e-94 | 304 |
| LLPS-Zem-1599 | Zea mays | 35.14 | 5e-87 | 292 |
| LLPS-Bro-2412 | Brassica oleracea | 34.99 | 1e-69 | 245 |
| LLPS-Met-0240 | Medicago truncatula | 34.88 | 3e-88 | 290 |
| LLPS-Phv-1011 | Phaseolus vulgaris | 34.85 | 1e-91 | 304 |
| LLPS-Sob-0913 | Sorghum bicolor | 34.75 | 2e-80 | 270 |
| LLPS-Put-0400 | Puccinia triticina | 34.65 | 1e-84 | 280 |
| LLPS-Dac-1369 | Daucus carota | 34.53 | 9e-82 | 268 |
| LLPS-Orb-0134 | Oryza barthii | 34.5 | 5e-81 | 270 |
| LLPS-Dos-1028 | Dothistroma septosporum | 34.09 | 8e-91 | 296 |
| LLPS-Tru-0449 | Triticum urartu | 33.97 | 1e-88 | 298 |
| LLPS-Zyt-0166 | Zymoseptoria tritici | 33.46 | 2e-92 | 301 |
| LLPS-Asf-0202 | Aspergillus flavus | 32.8 | 2e-72 | 241 |
| LLPS-Mel-0017 | Melampsora laricipopulina | 32.65 | 6e-97 | 309 |
| LLPS-Gas-0495 | Galdieria sulphuraria | 32.58 | 1e-73 | 251 |
| LLPS-Pug-0164 | Puccinia graminis | 32.49 | 2e-93 | 303 |
| LLPS-Yal-0248 | Yarrowia lipolytica | 32.41 | 1e-85 | 281 |
| LLPS-Cym-0542 | Cyanidioschyzon merolae | 31.54 | 1e-76 | 259 |
| LLPS-Chr-1159 | Chlamydomonas reinhardtii | 31.35 | 5e-70 | 246 |
| LLPS-Osl-0759 | Ostreococcus lucimarinus | 30.79 | 6e-58 | 208 |
| LLPS-Chc-0201 | Chondrus crispus | 29.01 | 1e-61 | 218 |
| LLPS-Cae-0062 | Caenorhabditis elegans | 28.81 | 2e-54 | 199 |