• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sus-0419
METAP1D

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Methionine aminopeptidase
Gene Name: METAP1D
Ensembl Gene: ENSSSCG00000015951.3
Ensembl Protein: ENSSSCP00000041312.1
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAPSGVHLL  VRRGCHRIFS  SPLNHIYLHK  QSSSQQRRNF  FFRRQREISH  SIVLPAAVSS  60
61    AHPVPKHIKK  PDYVTTGIVP  DWGDSIEVKT  EDQIQGLHQA  CQLARHVLLL  AGKSLKVGMT  120
121   TEEIDALVHQ  EIISHDAYPS  PLGYGGFPKS  VCTSVNNVLC  HGIPDSRPLQ  DGDIINIDVT  180
181   VYYNGYHGDT  SETFLVGSVD  EGGKKLVEVA  RRCRDEAIAA  CRAGAPFSVI  GNTISQISHQ  240
241   NGLQVCPHFV  GHGIGSYFHG  HPEIWHHAND  SDLLMEEGMA  FTIEPIITEG  SPEFKVLEDA  300
301   WTVVSLDNQR  CSRSARLHLN  GLGREGSSVD  AGGLLLPARG  ALADRCVCVS  GLPSSSTQFS  360
361   LRPGACGY  368
Nucleotide CDS Sequence (FASTA)
1     ATGACAACAG  AAGAGATAGA  TGCTCTTGTT  CATCAGGAGA  TCATCAGTCA  TGATGCCTAT  60
61    CCTTCACCTC  TAGGCTATGG  AGGTTTTCCA  AAATCTGTTT  GTACCTCTGT  AAACAATGTG  120
121   CTTTGTCATG  GTATTCCTGA  CAGTCGACCT  CTTCAGGATG  GAGATATTAT  CAACATTGAT  180
181   GTCACGGTTT  ACTACAATGG  CTACCATGGA  GACACCTCTG  AAACATTTTT  GGTGGGCAGT  240
241   GTGGATGAAG  GCGGTAAAAA  GTTAGTGGAG  GTTGCCAGGA  GGTGTAGAGA  TGAAGCAATT  300
301   GCTGCTTGCA  GAGCAGGGGC  TCCCTTCTCT  GTAATTGGAA  ACACAATCAG  CCAGATAAGT  360
361   CACCAGAATG  GTTTGCAAGT  CTGTCCACAT  TTTGTGGGAC  ATGGAATAGG  CTCTTACTTT  420
421   CATGGACATC  CAGAAATCTG  GCATCATGCG  AATGACAGCG  ATCTGCTCAT  GGAGGAGGGT  480
481   ATGGCGTTCA  CCATAGAGCC  AATTATAACC  GAGGGATCCC  CTGAATTTAA  AGTGCTGGAG  540
541   GATGCATGGA  CCGTGGTCTC  CTTGGACAAT  CAAAGGTCTG  CCCAGTTCGA  GCACACAGTT  600
601   CTCATTACGT  CCAGGGGCGT  GCGGATACTG  ACCAAACTGC  CCCACGAGGC  CTGA  654

▼ KEYWORD

ID
Family
Aminopeptidase
Complete proteome
Hydrolase
Metal-binding
Protease
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Metal ion binding
Molecular Function
Metalloaminopeptidase activity
Biological Process
Protein initiator methionine removal

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-1316Dipodomys ordii96.616e-76 238
LLPS-Tut-2292Tursiops truncatus95.850.0 586
LLPS-Urm-3015Ursus maritimus95.650.0 553
LLPS-Myl-1610Myotis lucifugus95.330.0 555
LLPS-Aim-3648Ailuropoda melanoleuca95.330.0 555
LLPS-Mup-3127Mustela putorius furo95.210.0 580
LLPS-Hos-1545Homo sapiens95.210.0 578
LLPS-Chs-0513Chlorocebus sabaeus94.890.0 578
LLPS-Pap-2349Pan paniscus94.890.0 577
LLPS-Pat-3954Pan troglodytes94.890.0 577
LLPS-Mal-2251Mandrillus leucophaeus94.630.0 551
LLPS-Ova-3568Ovis aries94.570.0 580
LLPS-Gog-4670Gorilla gorilla94.570.0 575
LLPS-Caf-4304Canis familiaris94.570.0 580
LLPS-Rhb-4779Rhinopithecus bieti94.570.0 576
LLPS-Fec-2040Felis catus94.570.0 573
LLPS-Maf-0633Macaca fascicularis94.250.0 573
LLPS-Mam-1602Macaca mulatta94.250.0 573
LLPS-Poa-4306Pongo abelii94.250.0 572
LLPS-Man-4478Macaca nemestrina94.250.0 573
LLPS-Cea-2140Cercocebus atys93.960.0 548
LLPS-Paa-2148Papio anubis93.930.0 575
LLPS-Caj-1831Callithrix jacchus93.930.0 572
LLPS-Nol-2922Nomascus leucogenys93.930.0 570
LLPS-Aon-2499Aotus nancymaae93.610.0 569
LLPS-Fud-3767Fukomys damarensis92.330.0 568
LLPS-Cas-3474Carlito syrichta92.010.0 564
LLPS-Otg-2188Otolemur garnettii92.010.0 570
LLPS-Cap-1504Cavia porcellus91.690.0 562
LLPS-Ict-0147Ictidomys tridecemlineatus91.370.0 548
LLPS-Bot-3175Bos taurus91.10.0 575
LLPS-Orc-0335Oryctolagus cuniculus90.730.0 556
LLPS-Mum-3444Mus musculus90.10.0 550
LLPS-Ora-1953Ornithorhynchus anatinus89.00.0 529
LLPS-Ran-4151Rattus norvegicus86.580.0 536
LLPS-Loa-3307Loxodonta africana85.531e-178 507
LLPS-Sah-3500Sarcophilus harrisii85.170.0 535
LLPS-Eqc-4675Equus caballus83.60.0 563
LLPS-Mod-3236Monodelphis domestica83.280.0 525
LLPS-Anp-3124Anas platyrhynchos82.02e-174 495
LLPS-Gaga-2447Gallus gallus81.272e-171 490
LLPS-Tag-1775Taeniopygia guttata80.271e-169 483
LLPS-Meg-1246Meleagris gallopavo79.369e-154 442
LLPS-Xet-3203Xenopus tropicalis78.326e-168 480
LLPS-Fia-3369Ficedula albicollis78.031e-168 481
LLPS-Anc-2449Anolis carolinensis77.411e-120 356
LLPS-Scf-3038Scleropages formosus74.724e-149 432
LLPS-Asm-2277Astyanax mexicanus74.343e-147 427
LLPS-Icp-3843Ictalurus punctatus73.581e-144 421
LLPS-Ten-0306Tetraodon nigroviridis73.581e-145 422
LLPS-Tar-1922Takifugu rubripes72.082e-141 412
LLPS-Orl-2389Oryzias latipes72.081e-142 416
LLPS-Orn-0115Oreochromis niloticus72.082e-143 417
LLPS-Pof-0831Poecilia formosa72.082e-145 423
LLPS-Xim-3616Xiphophorus maculatus71.72e-144 421
LLPS-Gaa-1895Gasterosteus aculeatus70.572e-143 418
LLPS-Lac-1881Latimeria chalumnae69.813e-160 460
LLPS-Leo-2956Lepisosteus oculatus65.612e-152 441
LLPS-Dar-3283Danio rerio64.876e-144 419
LLPS-Scm-0334Scophthalmus maximus62.152e-143 417
LLPS-Mea-0120Mesocricetus auratus56.973e-80 252
LLPS-Nia-1730Nicotiana attenuata54.09e-84 266
LLPS-Viv-2015Vitis vinifera54.03e-85 270
LLPS-Sei-0151Setaria italica53.977e-81 256
LLPS-Art-2350Arabidopsis thaliana53.695e-84 266
LLPS-Sot-0149Solanum tuberosum53.62e-81 259
LLPS-Prp-1642Prunus persica53.62e-84 268
LLPS-Mua-0049Musa acuminata53.523e-85 272
LLPS-Orbr-2256Oryza brachyantha53.332e-85 269
LLPS-Arl-1257Arabidopsis lyrata53.283e-84 267
LLPS-Brn-2980Brassica napus53.284e-84 267
LLPS-Bro-1586Brassica oleracea53.284e-84 267
LLPS-Hea-2606Helianthus annuus53.25e-87 274
LLPS-Dac-1225Daucus carota53.183e-70 238
LLPS-Sob-1365Sorghum bicolor53.175e-84 266
LLPS-Orp-2247Oryza punctata52.995e-84 266
LLPS-Amt-1369Amborella trichopoda52.82e-82 262
LLPS-Pot-0077Populus trichocarpa52.85e-81 259
LLPS-Zem-2266Zea mays52.789e-81 256
LLPS-Met-0176Medicago truncatula52.47e-82 261
LLPS-Coc-2232Corchorus capsularis52.42e-80 257
LLPS-Mae-2055Manihot esculenta52.42e-82 263
LLPS-Hov-1721Hordeum vulgare52.381e-81 262
LLPS-Brr-1993Brassica rapa52.055e-82 261
LLPS-Thc-0673Theobroma cacao52.05e-82 261
LLPS-Brd-1091Brachypodium distachyon51.971e-82 262
LLPS-Tra-1836Triticum aestivum51.955e-84 266
LLPS-Glm-0512Glycine max51.785e-78 251
LLPS-Gor-2693Gossypium raimondii51.64e-80 256
LLPS-Cii-0531Ciona intestinalis51.54e-86 269
LLPS-Orb-0206Oryza barthii51.372e-81 259
LLPS-Org-2129Oryza glaberrima51.372e-81 259
LLPS-Orm-1323Oryza meridionalis51.371e-80 259
LLPS-Php-2283Physcomitrella patens51.21e-80 258
LLPS-Orni-2050Oryza nivara50.983e-80 256
LLPS-Ori-0671Oryza indica50.983e-80 256
LLPS-Orr-2361Oryza rufipogon50.983e-80 256
LLPS-Ors-1643Oryza sativa50.983e-80 256
LLPS-Via-2107Vigna angularis50.87e-78 251
LLPS-Sol-2256Solanum lycopersicum50.591e-79 254
LLPS-Sem-1318Selaginella moellendorffii50.585e-80 255
LLPS-Orgl-0607Oryza glumaepatula50.571e-81 259
LLPS-Drm-1381Drosophila melanogaster49.813e-82 260
LLPS-Gas-0287Galdieria sulphuraria47.353e-73 239
LLPS-Put-0226Puccinia triticina46.481e-61 211
LLPS-Lep-2070Leersia perrieri46.345e-75 243
LLPS-Cae-0853Caenorhabditis elegans45.91e-69 229
LLPS-Abg-0152Absidia glauca45.423e-76 245
LLPS-Chr-0269Chlamydomonas reinhardtii45.283e-73 239
LLPS-Mel-0446Melampsora laricipopulina45.041e-68 228
LLPS-Cym-0199Cyanidioschyzon merolae44.914e-68 227
LLPS-Zyt-0262Zymoseptoria tritici44.242e-67 225
LLPS-Kop-0430Komagataella pastoris44.231e-63 214
LLPS-Spr-0292Sporisorium reilianum44.031e-66 222
LLPS-Usm-0427Ustilago maydis43.922e-66 221
LLPS-Phv-1362Phaseolus vulgaris43.775e-69 228
LLPS-Pes-0257Pelodiscus sinensis43.631e-69 229
LLPS-Mao-1044Magnaporthe oryzae43.617e-63 212
LLPS-Chc-0445Chondrus crispus43.488e-63 212
LLPS-Cus-0278Cucumis sativus43.49e-70 231
LLPS-Dos-1172Dothistroma septosporum43.42e-67 224
LLPS-Pug-0119Puccinia graminis43.245e-66 221
LLPS-Cogr-0748Colletotrichum graminicola43.233e-63 214
LLPS-Scj-0173Schizosaccharomyces japonicus42.913e-62 210
LLPS-Map-0033Magnaporthe poae42.867e-64 215
LLPS-Nec-0021Neurospora crassa42.89e-63 211
LLPS-Blg-0668Blumeria graminis42.694e-61 207
LLPS-Gag-0143Gaeumannomyces graminis42.482e-63 214
LLPS-Crn-0028Cryptococcus neoformans42.373e-68 227
LLPS-Scp-0382Schizosaccharomyces pombe42.321e-59 203
LLPS-Miv-0608Microbotryum violaceum42.322e-67 224
LLPS-Yal-0719Yarrowia lipolytica42.265e-61 207
LLPS-Coo-0004Colletotrichum orbiculare42.111e-61 209
LLPS-Ved-0455Verticillium dahliae42.112e-61 209
LLPS-Cog-0084Colletotrichum gloeosporioides42.113e-61 208
LLPS-Tum-0972Tuber melanosporum41.943e-57 193
LLPS-Asg-0921Ashbya gossypii41.73e-64 215
LLPS-Ast-0847Aspergillus terreus41.72e-61 209
LLPS-Scc-0849Schizosaccharomyces cryophilus41.575e-59 202
LLPS-Scs-0874Sclerotinia sclerotiorum41.542e-62 211
LLPS-Tru-0409Triticum urartu41.513e-65 217
LLPS-Sac-0088Saccharomyces cerevisiae41.53e-63 213
LLPS-Osl-0448Ostreococcus lucimarinus41.263e-67 221
LLPS-Lem-0193Leptosphaeria maculans40.938e-60 205
LLPS-Asni-0419Aspergillus niger40.931e-63 214
LLPS-Asn-0947Aspergillus nidulans40.932e-59 204
LLPS-Asf-0343Aspergillus flavus40.541e-60 207
LLPS-Aso-0501Aspergillus oryzae40.541e-60 207
LLPS-Nef-0238Neosartorya fischeri40.541e-61 209
LLPS-Trr-0555Trichoderma reesei40.381e-56 196
LLPS-Pyt-0572Pyrenophora teres40.155e-59 202
LLPS-Pytr-0418Pyrenophora triticirepentis40.152e-59 203
LLPS-Asc-1200Aspergillus clavatus39.771e-60 207
LLPS-Asfu-1037Aspergillus fumigatus37.866e-57 197