• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-4304
METAP1D

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Methionine aminopeptidase
Gene Name: METAP1D
Ensembl Gene: ENSCAFG00000012917.3
Ensembl Protein: ENSCAFP00000019026.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSCAFT00000020501.3ENSCAFP00000019026.3
UniProtF1PFF1, F1PFF1_CANLF
GeneBankAAEX03017756

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHQNVDATNM  GRHAYLTGFF  HPTWERGLWA  SARTVAGARL  SRPERARRAA  LPLLAPGAGA  60
61    ASLPGLPQSA  PRAHARSPGA  APAPPGSRRA  ATGQFQRAGR  GGAAGAGLGG  HVTRANMAAP  120
121   SGVHLLVRRG  CHRIFSSPFN  HIYLHKQPSG  QQRRNFFFRR  QREISHSIVL  PAAVSSAHPV  180
181   PEHIKKPDYV  TTGIVPDWGD  SIEVKNEDQI  QGLRQACQLA  RHVLLLAGKS  LKVDMTTEEI  240
241   DALVHQEIIR  HDAYPSPLGY  GGFPKSVCTS  VNNVLCHGIP  DSRPLQDGDI  INIDVTVYYN  300
301   GYHGDTSETF  LVGNVDECGK  KLVEVARRCR  DEAIAACRAG  APFSVIGNTI  SHITHQNGLQ  360
361   VCPHFVGHGI  GSYFHGHPEI  WHHANDCDLL  MEEGMAFTIE  PIITEGSPEF  QVLEDAWTVV  420
421   SLDNQRSAQF  EHTVLITSEG  VQVLTKLPHE  A  451
Nucleotide CDS Sequence (FASTA)
1     ATGCACCAGA  ATGTTGATGC  TACAAATATG  GGACGCCACG  CTTACCTGAC  AGGCTTCTTC  60
61    CATCCCACCT  GGGAGCGGGG  GCTCTGGGCG  AGCGCGCGAA  CGGTGGCCGG  AGCCCGCCTC  120
121   TCGCGGCCGG  AGCGGGCTCG  GCGGGCCGCG  CTTCCCCTGC  TGGCCCCCGG  CGCCGGAGCC  180
181   GCTTCGCTGC  CGGGGCTCCC  GCAGTCAGCC  CCCCGCGCGC  ACGCGCGCTC  CCCCGGGGCG  240
241   GCCCCGGCGC  CTCCAGGTTC  CCGCAGGGCT  GCGACTGGAC  AGTTCCAGCG  GGCGGGGCGG  300
301   GGCGGGGCGG  CGGGGGCAGG  GCTCGGCGGC  CACGTGACCC  GCGCCAACAT  GGCGGCGCCC  360
361   AGCGGCGTCC  ACCTGCTCGT  CCGCAGAGGT  TGTCACAGAA  TTTTCTCTTC  ACCATTCAAT  420
421   CATATCTACT  TACACAAGCA  GCCAAGCGGT  CAACAAAGAA  GAAATTTCTT  TTTCCGGAGA  480
481   CAAAGAGAGA  TTTCCCACAG  TATAGTTTTG  CCGGCTGCAG  TTTCTTCAGC  TCACCCAGTC  540
541   CCTGAGCACA  TAAAGAAGCC  AGACTATGTG  ACGACAGGCA  TTGTACCCGA  CTGGGGAGAC  600
601   AGCATAGAAG  TTAAGAATGA  AGATCAGATT  CAAGGGCTTC  GTCAGGCTTG  TCAGCTGGCC  660
661   CGTCATGTCC  TCCTCCTGGC  TGGGAAGAGT  TTAAAGGTTG  ACATGACAAC  TGAAGAGATA  720
721   GATGCTCTTG  TCCATCAGGA  AATCATCCGT  CATGATGCTT  ATCCCTCACC  TCTAGGCTAT  780
781   GGAGGTTTTC  CAAAATCTGT  TTGTACCTCT  GTAAACAACG  TGCTATGTCA  TGGTATTCCT  840
841   GACAGTCGAC  CTCTTCAGGA  TGGAGATATT  ATCAACATTG  ATGTCACGGT  CTATTACAAT  900
901   GGCTACCATG  GAGACACCTC  TGAAACGTTT  TTGGTGGGCA  ATGTGGATGA  ATGTGGTAAA  960
961   AAGTTAGTGG  AGGTTGCCAG  GAGGTGTAGA  GATGAAGCGA  TTGCAGCTTG  CAGAGCGGGG  1020
1021  GCTCCCTTCT  CTGTAATTGG  AAACACAATC  AGCCACATAA  CTCATCAGAA  TGGTTTGCAA  1080
1081  GTCTGTCCAC  ATTTTGTGGG  ACATGGAATA  GGATCTTACT  TTCATGGACA  TCCAGAAATT  1140
1141  TGGCATCATG  CAAATGACTG  TGACCTACTC  ATGGAGGAGG  GAATGGCGTT  CACCATAGAG  1200
1201  CCAATCATAA  CCGAAGGATC  CCCTGAATTT  CAAGTCCTGG  AAGATGCCTG  GACTGTGGTC  1260
1261  TCCCTGGACA  ATCAAAGGTC  CGCCCAGTTC  GAGCACACAG  TGCTCATCAC  GTCGGAGGGC  1320
1321  GTGCAGGTCC  TGACCAAGCT  GCCCCACGAG  GCCTGA  1356

▼ KEYWORD

ID
Family
Aminopeptidase
Complete proteome
Hydrolase
Metal-binding
Protease
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Metal ion binding
Molecular Function
Metalloaminopeptidase activity
Biological Process
Protein initiator methionine removal

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-1316Dipodomys ordii97.461e-77 245
LLPS-Urm-3015Ursus maritimus96.880.0 614
LLPS-Aim-3648Ailuropoda melanoleuca96.580.0 617
LLPS-Mup-3127Mustela putorius furo96.420.0 638
LLPS-Myl-1610Myotis lucifugus95.650.0 613
LLPS-Tut-2292Tursiops truncatus95.310.0 647
LLPS-Chs-0513Chlorocebus sabaeus95.220.0 630
LLPS-Fec-2040Felis catus95.010.0 639
LLPS-Mal-2251Mandrillus leucophaeus95.00.0 602
LLPS-Poa-4306Pongo abelii94.930.0 630
LLPS-Rhb-4779Rhinopithecus bieti94.930.0 628
LLPS-Pap-2349Pan paniscus94.930.0 630
LLPS-Pat-3954Pan troglodytes94.930.0 630
LLPS-Hos-1545Homo sapiens94.930.0 630
LLPS-Nol-2922Nomascus leucogenys94.630.0 627
LLPS-Mam-1602Macaca mulatta94.630.0 625
LLPS-Man-4478Macaca nemestrina94.630.0 625
LLPS-Ova-3568Ovis aries94.630.0 631
LLPS-Gog-4670Gorilla gorilla94.630.0 627
LLPS-Maf-0633Macaca fascicularis94.630.0 625
LLPS-Sus-0419Sus scrofa94.570.0 585
LLPS-Cea-2140Cercocebus atys94.380.0 600
LLPS-Paa-2148Papio anubis94.330.0 627
LLPS-Caj-1831Callithrix jacchus94.330.0 628
LLPS-Aon-2499Aotus nancymaae93.730.0 624
LLPS-Cas-3474Carlito syrichta93.430.0 623
LLPS-Fud-3767Fukomys damarensis92.540.0 617
LLPS-Cap-1504Cavia porcellus92.240.0 614
LLPS-Otg-2188Otolemur garnettii92.240.0 620
LLPS-Orc-0335Oryctolagus cuniculus91.640.0 608
LLPS-Eqc-4675Equus caballus90.820.0 558
LLPS-Ict-0147Ictidomys tridecemlineatus90.750.0 593
LLPS-Bot-3175Bos taurus90.520.0 623
LLPS-Mum-3444Mus musculus90.150.0 595
LLPS-Ora-1953Ornithorhynchus anatinus88.20.0 568
LLPS-Ran-4151Rattus norvegicus87.760.0 585
LLPS-Loa-3307Loxodonta africana85.930.0 557
LLPS-Sah-3500Sarcophilus harrisii85.50.0 578
LLPS-Mod-3236Monodelphis domestica83.430.0 566
LLPS-Anp-3124Anas platyrhynchos82.520.0 521
LLPS-Gaga-2447Gallus gallus80.370.0 528
LLPS-Tag-1775Taeniopygia guttata79.690.0 515
LLPS-Meg-1246Meleagris gallopavo79.364e-155 448
LLPS-Fia-3369Ficedula albicollis77.980.0 519
LLPS-Xet-3203Xenopus tropicalis77.882e-179 512
LLPS-Anc-2449Anolis carolinensis77.822e-121 360
LLPS-Scf-3038Scleropages formosus75.522e-161 466
LLPS-Asm-2277Astyanax mexicanus75.263e-160 464
LLPS-Icp-3843Ictalurus punctatus74.484e-157 456
LLPS-Pof-0831Poecilia formosa73.431e-158 460
LLPS-Xim-3616Xiphophorus maculatus73.433e-158 459
LLPS-Orl-2389Oryzias latipes73.172e-156 455
LLPS-Ten-0306Tetraodon nigroviridis73.087e-155 449
LLPS-Orn-0115Oreochromis niloticus72.381e-154 449
LLPS-Tar-1922Takifugu rubripes71.681e-151 442
LLPS-Gaa-1895Gasterosteus aculeatus71.082e-155 451
LLPS-Lac-1881Latimeria chalumnae69.827e-172 493
LLPS-Leo-2956Lepisosteus oculatus66.765e-166 479
LLPS-Dar-3283Danio rerio65.582e-157 456
LLPS-Scm-0334Scophthalmus maximus63.47e-155 450
LLPS-Mea-0120Mesocricetus auratus61.171e-95 294
LLPS-Mua-0049Musa acuminata56.03e-97 306
LLPS-Nia-1730Nicotiana attenuata54.582e-94 296
LLPS-Viv-2015Vitis vinifera54.589e-95 297
LLPS-Sei-0151Setaria italica54.518e-92 287
LLPS-Sot-0149Solanum tuberosum54.419e-92 289
LLPS-Hea-2606Helianthus annuus54.219e-98 305
LLPS-Dac-1225Daucus carota54.093e-71 243
LLPS-Art-2350Arabidopsis thaliana53.933e-92 291
LLPS-Pot-0077Populus trichocarpa53.856e-92 290
LLPS-Sob-1365Sorghum bicolor53.825e-94 294
LLPS-Prp-1642Prunus persica53.681e-93 294
LLPS-Arl-1257Arabidopsis lyrata53.561e-92 291
LLPS-Amt-1369Amborella trichopoda53.488e-93 292
LLPS-Mae-2055Manihot esculenta53.484e-94 295
LLPS-Zem-2266Zea mays53.434e-91 286
LLPS-Orbr-2256Oryza brachyantha53.243e-94 295
LLPS-Bro-1586Brassica oleracea53.181e-91 289
LLPS-Brn-2980Brassica napus53.182e-91 289
LLPS-Orp-2247Oryza punctata53.093e-94 295
LLPS-Thc-0673Theobroma cacao52.754e-92 290
LLPS-Hov-1721Hordeum vulgare52.733e-91 290
LLPS-Cii-0531Ciona intestinalis52.635e-94 292
LLPS-Met-0176Medicago truncatula52.552e-91 288
LLPS-Coc-2232Corchorus capsularis52.368e-91 287
LLPS-Brd-1091Brachypodium distachyon52.353e-92 290
LLPS-Tra-1836Triticum aestivum52.331e-93 293
LLPS-Brr-1993Brassica rapa52.261e-89 284
LLPS-Drm-1381Drosophila melanogaster52.131e-93 292
LLPS-Php-2283Physcomitrella patens51.849e-89 282
LLPS-Org-2129Oryza glaberrima51.82e-91 288
LLPS-Orm-1323Oryza meridionalis51.81e-90 288
LLPS-Orb-0206Oryza barthii51.82e-91 287
LLPS-Sem-1318Selaginella moellendorffii51.763e-91 287
LLPS-Gor-2693Gossypium raimondii51.641e-90 286
LLPS-Via-2107Vigna angularis51.473e-87 278
LLPS-Sol-2256Solanum lycopersicum51.454e-89 281
LLPS-Glm-0512Glycine max51.454e-86 275
LLPS-Orr-2361Oryza rufipogon51.443e-90 285
LLPS-Ors-1643Oryza sativa51.443e-90 285
LLPS-Orni-2050Oryza nivara51.443e-90 285
LLPS-Ori-0671Oryza indica51.443e-90 285
LLPS-Orgl-0607Oryza glumaepatula51.069e-92 288
LLPS-Abg-0152Absidia glauca48.914e-83 266
LLPS-Gas-0287Galdieria sulphuraria48.422e-81 263
LLPS-Chr-0269Chlamydomonas reinhardtii47.521e-81 264
LLPS-Mel-0446Melampsora laricipopulina47.228e-78 254
LLPS-Phv-1362Phaseolus vulgaris46.981e-77 254
LLPS-Cym-0199Cyanidioschyzon merolae46.989e-76 250
LLPS-Lep-2070Leersia perrieri46.959e-85 271
LLPS-Zyt-0262Zymoseptoria tritici46.675e-76 250
LLPS-Cae-0853Caenorhabditis elegans46.672e-76 249
LLPS-Mao-1044Magnaporthe oryzae46.451e-71 238
LLPS-Pug-0119Puccinia graminis45.963e-75 248
LLPS-Cus-0278Cucumis sativus45.963e-77 253
LLPS-Usm-0427Ustilago maydis45.592e-73 242
LLPS-Spr-0292Sporisorium reilianum45.454e-72 239
LLPS-Cogr-0748Colletotrichum graminicola45.392e-71 238
LLPS-Kop-0430Komagataella pastoris45.395e-72 238
LLPS-Pes-0257Pelodiscus sinensis45.292e-76 249
LLPS-Scj-0173Schizosaccharomyces japonicus45.148e-74 243
LLPS-Map-0033Magnaporthe poae45.044e-72 239
LLPS-Chc-0445Chondrus crispus44.771e-71 237
LLPS-Tum-0972Tuber melanosporum44.731e-65 218
LLPS-Blg-0668Blumeria graminis44.732e-69 232
LLPS-Tru-0409Triticum urartu44.566e-74 242
LLPS-Osl-0448Ostreococcus lucimarinus44.564e-76 247
LLPS-Yal-0719Yarrowia lipolytica44.565e-70 233
LLPS-Dos-1172Dothistroma septosporum44.482e-74 246
LLPS-Crn-0028Cryptococcus neoformans44.488e-78 255
LLPS-Ved-0455Verticillium dahliae44.331e-69 233
LLPS-Cog-0084Colletotrichum gloeosporioides44.333e-69 232
LLPS-Coo-0004Colletotrichum orbiculare44.338e-70 233
LLPS-Gag-0143Gaeumannomyces graminis44.338e-72 238
LLPS-Nec-0021Neurospora crassa44.291e-70 235
LLPS-Ast-0847Aspergillus terreus44.253e-70 234
LLPS-Trv-1363Trichoderma virens44.03e-64 219
LLPS-Sac-0088Saccharomyces cerevisiae43.969e-73 241
LLPS-Asg-0921Ashbya gossypii43.733e-73 241
LLPS-Trr-0555Trichoderma reesei43.72e-64 219
LLPS-Miv-0608Microbotryum violaceum43.453e-75 248
LLPS-Phn-0046Phaeosphaeria nodorum43.313e-64 217
LLPS-Asn-0947Aspergillus nidulans43.164e-68 229
LLPS-Scc-0849Schizosaccharomyces cryophilus43.15e-67 225
LLPS-Scp-0382Schizosaccharomyces pombe42.911e-66 224
LLPS-Nef-0238Neosartorya fischeri42.814e-70 234
LLPS-Asf-0343Aspergillus flavus42.812e-69 233
LLPS-Aso-0501Aspergillus oryzae42.812e-69 233
LLPS-Fuv-0523Fusarium verticillioides42.82e-63 216
LLPS-Asni-0419Aspergillus niger42.79e-71 235
LLPS-Lem-0193Leptosphaeria maculans42.462e-68 231
LLPS-Scs-0874Sclerotinia sclerotiorum42.466e-69 231
LLPS-Put-0226Puccinia triticina42.441e-69 234
LLPS-Asc-1200Aspergillus clavatus42.118e-70 233
LLPS-Pyt-0572Pyrenophora teres41.45e-67 226
LLPS-Pytr-0418Pyrenophora triticirepentis41.053e-66 224
LLPS-Asfu-1037Aspergillus fumigatus40.22e-65 222