• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sot-1635
102594416

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pyruvate dehydrogenase E1 component subunit alpha
Gene Name: 102594416
Ensembl Gene: PGSC0003DMG400001927
Ensembl Protein: PGSC0003DMT400004851
Organism: Solanum tuberosum
Taxa ID: 4113
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MALSTIRTVN  HLLKPFTAAT  RRLSSDSNAT  INVEISKPYT  AHNIDPPSSI  VETTPNELMT  60
61    FFSDMAEMRR  MEIAADSLYK  AKLIRGFCHL  YDGQEAVAIG  MEAAITKKDC  IITAYRDHCI  120
121   FLARGGGLVE  SFAELMGRKD  GCSKGKGGSM  HFYKKDSGFY  GGHGIVGAQV  PLGIGISFAQ  180
181   KYNKEDHVTF  AMYGDGAANQ  GQLFEALNMA  ALWDLPAILV  CENNHYGMGT  AEWRAAKSPA  240
241   YYKRGDYVPG  LKVDGMDALA  VKQACKFAKD  HVLTKGPIIL  EMDTYRYHGH  SMSDPGSTYR  300
301   TRDEISGVRG  ERDPVERIRN  LILDHNIATE  QELKDIEKGK  RKVVDEAIAK  AKEIPMPDPS  360
361   DLFTNVYVKG  FGVEVFGADR  KELRSTLP  388
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTTAT  CAACTATTCG  GACGGTTAAT  CATCTTCTAA  AGCCTTTCAC  CGCCGCCACC  60
61    CGCCGCCTAT  CGTCGGACTC  CAACGCCACC  ATCAATGTGG  AAATCAGCAA  ACCGTACACC  120
121   GCTCACAACA  TTGATCCTCC  CTCATCAATC  GTCGAAACCA  CCCCTAATGA  ACTCATGACT  180
181   TTCTTCTCAG  ACATGGCGGA  GATGCGGCGT  ATGGAGATCG  CTGCAGATTC  GCTCTACAAA  240
241   GCGAAACTAA  TCCGCGGATT  CTGTCATCTC  TATGACGGAC  AAGAAGCGGT  TGCAATAGGC  300
301   ATGGAAGCTG  CAATTACAAA  AAAGGATTGT  ATCATTACGG  CTTATAGAGA  TCACTGTATA  360
361   TTCCTTGCAC  GTGGTGGAGG  GTTAGTTGAG  TCGTTTGCGG  AGCTAATGGG  GAGAAAAGAT  420
421   GGTTGTTCCA  AAGGGAAAGG  AGGTTCGATG  CATTTCTACA  AGAAGGATAG  TGGATTTTAT  480
481   GGAGGACATG  GAATTGTAGG  TGCTCAAGTT  CCTCTAGGTA  TTGGAATTTC  TTTTGCGCAG  540
541   AAATATAACA  AAGAGGACCA  TGTTACTTTT  GCTATGTATG  GTGATGGTGC  TGCTAATCAA  600
601   GGACAGTTGT  TTGAGGCTTT  GAATATGGCT  GCTCTATGGG  ATTTGCCTGC  TATTCTAGTC  660
661   TGCGAGAATA  ATCACTATGG  AATGGGGACA  GCAGAATGGA  GGGCTGCAAA  GAGTCCAGCC  720
721   TATTACAAAA  GAGGGGATTA  TGTTCCTGGT  TTAAAGGTCG  ATGGTATGGA  TGCCCTTGCT  780
781   GTAAAACAAG  CATGCAAATT  TGCCAAGGAT  CATGTCCTCA  CGAAAGGACC  AATTATTCTT  840
841   GAAATGGACA  CCTACAGGTA  CCATGGTCAC  TCAATGTCTG  ATCCTGGAAG  CACCTACCGT  900
901   ACGCGTGACG  AGATTAGTGG  TGTTCGAGGG  GAACGTGATC  CTGTTGAAAG  AATTAGGAAT  960
961   CTCATCTTAG  ACCATAATAT  AGCCACTGAG  CAGGAGCTGA  AGGATATCGA  GAAAGGAAAG  1020
1021  AGGAAAGTGG  TTGATGAAGC  CATTGCTAAA  GCAAAGGAGA  TCCCCATGCC  TGATCCTTCT  1080
1081  GATCTGTTTA  CTAATGTATA  TGTGAAAGGG  TTTGGAGTTG  AGGTCTTTGG  AGCAGATAGG  1140
1141  AAAGAACTCA  GATCCACACT  ACCATGA  1167

▼ KEYWORD

ID
Family
Complete proteome
Oxidoreductase
Pyruvate
Reference proteome
Thiamine pyrophosphate

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Intracellular membrane-bounded organelle
Molecular Function
Pyruvate dehydrogenase (acetyl-transferring) activity
Biological Process
Acetyl-CoA biosynthetic process from pyruvate

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sol-2389Solanum lycopersicum97.70.0 793
LLPS-Nia-2260Nicotiana attenuata88.750.0 723
LLPS-Dac-1792Daucus carota83.650.0 662
LLPS-Cus-2149Cucumis sativus81.560.0 626
LLPS-Gor-2633Gossypium raimondii81.520.0 642
LLPS-Coc-0057Corchorus capsularis80.640.0 646
LLPS-Hea-1335Helianthus annuus80.510.0 667
LLPS-Lep-2180Leersia perrieri80.380.0 631
LLPS-Sei-1164Setaria italica80.121e-88 271
LLPS-Tra-2675Triticum aestivum79.950.0 635
LLPS-Brd-1072Brachypodium distachyon79.840.0 630
LLPS-Met-1234Medicago truncatula78.950.0 619
LLPS-Tru-0781Triticum urartu78.891e-101 305
LLPS-Mae-2057Manihot esculenta78.180.0 622
LLPS-Bro-0736Brassica oleracea78.150.0 643
LLPS-Art-1136Arabidopsis thaliana78.150.0 644
LLPS-Brr-0719Brassica rapa78.150.0 647
LLPS-Brn-3162Brassica napus78.150.0 647
LLPS-Zem-0520Zea mays78.020.0 621
LLPS-Pot-0824Populus trichocarpa77.860.0 620
LLPS-Orbr-2205Oryza brachyantha77.750.0 609
LLPS-Hov-0115Hordeum vulgare77.750.0 604
LLPS-Glm-2588Glycine max77.410.0 642
LLPS-Arl-2732Arabidopsis lyrata77.380.0 639
LLPS-Viv-0845Vitis vinifera77.260.0 637
LLPS-Orr-0889Oryza rufipogon77.040.0 545
LLPS-Orb-0647Oryza barthii76.550.0 579
LLPS-Mua-0794Musa acuminata76.540.0 518
LLPS-Phv-0217Phaseolus vulgaris76.310.0 577
LLPS-Orni-2110Oryza nivara76.270.0 577
LLPS-Ors-2238Oryza sativa76.020.0 596
LLPS-Ori-0363Oryza indica76.020.0 596
LLPS-Orgl-1763Oryza glumaepatula75.990.0 574
LLPS-Sob-1486Sorghum bicolor75.80.0 603
LLPS-Orm-0585Oryza meridionalis75.130.0 600
LLPS-Via-1760Vigna angularis74.80.0 597
LLPS-Php-0348Physcomitrella patens68.880.0 553
LLPS-Sem-1609Selaginella moellendorffii67.40.0 527
LLPS-Orp-0849Oryza punctata66.580.0 516
LLPS-Vir-0336Vigna radiata65.715e-179 512
LLPS-Tag-0857Taeniopygia guttata64.362e-40 144
LLPS-Chr-0340Chlamydomonas reinhardtii61.31e-159 462
LLPS-Cis-1386Ciona savignyi56.253e-122 364
LLPS-Orn-1305Oreochromis niloticus54.821e-123 370
LLPS-Asm-2302Astyanax mexicanus54.032e-124 372
LLPS-Leo-0830Lepisosteus oculatus53.743e-126 377
LLPS-Anp-1089Anas platyrhynchos53.731e-114 346
LLPS-Scm-2702Scophthalmus maximus53.592e-113 346
LLPS-Dar-1199Danio rerio53.591e-123 370
LLPS-Cii-0064Ciona intestinalis53.455e-126 376
LLPS-Sah-3031Sarcophilus harrisii53.276e-122 365
LLPS-Meg-1021Meleagris gallopavo53.032e-114 347
LLPS-Orl-0473Oryzias latipes52.994e-110 337
LLPS-Scf-2665Scleropages formosus52.847e-122 367
LLPS-Icp-1197Ictalurus punctatus52.843e-123 369
LLPS-Anc-0122Anolis carolinensis52.814e-127 379
LLPS-Tar-3150Takifugu rubripes52.669e-117 354
LLPS-Gaga-3914Gallus gallus52.64e-114 346
LLPS-Crn-0557Cryptococcus neoformans52.558e-125 374
LLPS-Ova-1453Ovis aries52.381e-115 349
LLPS-Mum-3111Mus musculus52.382e-108 331
LLPS-Ten-0221Tetraodon nigroviridis52.372e-125 375
LLPS-Xet-1836Xenopus tropicalis52.251e-124 373
LLPS-Fec-0524Felis catus52.081e-117 354
LLPS-Urm-3344Ursus maritimus52.082e-117 353
LLPS-Myl-1649Myotis lucifugus52.051e-124 372
LLPS-Blg-0670Blumeria graminis51.941e-121 365
LLPS-Pof-0701Poecilia formosa51.923e-123 369
LLPS-Pes-2339Pelodiscus sinensis51.822e-111 338
LLPS-Ere-0625Erinaceus europaeus51.783e-114 346
LLPS-Ora-2673Ornithorhynchus anatinus51.782e-114 346
LLPS-Nef-1039Neosartorya fischeri51.671e-125 375
LLPS-Gaa-2364Gasterosteus aculeatus51.677e-127 378
LLPS-Asni-1516Aspergillus niger51.677e-126 376
LLPS-Nol-2006Nomascus leucogenys51.512e-112 342
LLPS-Poa-0582Pongo abelii51.512e-111 341
LLPS-Mam-4296Macaca mulatta51.513e-112 342
LLPS-Otg-3185Otolemur garnettii51.517e-113 343
LLPS-Pap-3024Pan paniscus51.512e-111 341
LLPS-Pat-1993Pan troglodytes51.513e-112 342
LLPS-Hos-1031Homo sapiens51.513e-112 342
LLPS-Man-3836Macaca nemestrina51.515e-112 341
LLPS-Bot-1071Bos taurus51.512e-123 369
LLPS-Gog-2378Gorilla gorilla51.513e-112 342
LLPS-Caj-1340Callithrix jacchus51.513e-112 342
LLPS-Fud-3763Fukomys damarensis51.519e-124 370
LLPS-Maf-0137Macaca fascicularis51.513e-112 342
LLPS-Aon-4581Aotus nancymaae51.516e-112 341
LLPS-Cea-3575Cercocebus atys51.513e-112 342
LLPS-Dio-3942Dipodomys ordii51.475e-124 371
LLPS-Ict-4504Ictidomys tridecemlineatus51.237e-123 368
LLPS-Cap-0691Cavia porcellus51.238e-123 368
LLPS-Caf-2821Canis familiaris51.239e-123 367
LLPS-Orc-0567Oryctolagus cuniculus51.235e-123 368
LLPS-Mup-3057Mustela putorius furo51.235e-123 368
LLPS-Mea-3186Mesocricetus auratus51.237e-122 365
LLPS-Cae-2028Caenorhabditis elegans51.227e-123 369
LLPS-Fia-1189Ficedula albicollis51.126e-112 340
LLPS-Xim-0452Xiphophorus maculatus51.15e-121 365
LLPS-Drm-1058Drosophila melanogaster51.064e-112 343
LLPS-Lac-3750Latimeria chalumnae50.973e-123 369
LLPS-Eqc-2160Equus caballus50.963e-121 363
LLPS-Mod-4351Monodelphis domestica50.964e-125 374
LLPS-Sus-3185Sus scrofa50.969e-113 342
LLPS-Aso-0479Aspergillus oryzae50.751e-116 351
LLPS-Ran-3275Rattus norvegicus50.681e-119 360
LLPS-Tut-1755Tursiops truncatus50.681e-121 365
LLPS-Aim-0286Ailuropoda melanoleuca50.663e-124 371
LLPS-Ast-1273Aspergillus terreus50.44e-120 361
LLPS-Rhb-2988Rhinopithecus bieti50.142e-119 359
LLPS-Cas-0515Carlito syrichta50.139e-112 340
LLPS-Paa-2119Papio anubis49.867e-119 357
LLPS-Mal-0013Mandrillus leucophaeus49.586e-118 355
LLPS-Loa-3946Loxodonta africana49.446e-119 358
LLPS-Asf-0825Aspergillus flavus47.069e-117 353
LLPS-Put-0339Puccinia triticina44.542e-94 295
LLPS-Asfu-0296Aspergillus fumigatus43.114e-84 267
LLPS-Prp-1284Prunus persica40.232e-78 254
LLPS-Org-1261Oryza glaberrima40.01e-75 245
LLPS-Asc-0275Aspergillus clavatus39.394e-78 251
LLPS-Amt-1386Amborella trichopoda37.815e-75 246
LLPS-Gas-1278Galdieria sulphuraria37.047e-59 201
LLPS-Thc-2353Theobroma cacao36.136e-75 248
LLPS-Chc-1157Chondrus crispus35.425e-64 214
LLPS-Osl-1061Ostreococcus lucimarinus35.321e-41 155
LLPS-Cym-0832Cyanidioschyzon merolae34.72e-62 209