LLPS-Hos-1031
PDHA1

▼ OVERVIEW

Status: Reviewed
Protein Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I
Gene Name: PDHA1, PHE1A
Ensembl Gene: ENSG00000131828.13
Ensembl Protein: ENSP00000369134.5
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 3EXH (A, B, C) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENST00000379806.9ENSP00000369134.5
EnsemblENST00000540249.5ENSP00000440761.1
EnsemblENST00000417819.5ENSP00000404616.1
EnsemblENST00000423505.5ENSP00000406473.1
EnsemblENST00000355808.9ENSP00000348062.5
EnsemblENST00000422285.6ENSP00000394382.2
EnsemblENST00000545074.5ENSP00000438550.1
EnsemblENST00000379804.1ENSP00000369132.1
EnsemblENST00000379805.3ENSP00000369133.3
UniProtP08559, ODPA_HUMAN, A5YVE9, B2R5P7, B7Z3T7, B7Z3X5, Q53H41, Q5JPT8, Q9NP12, Q9UBJ8, Q9UBU0, Q9UNG4, Q9UNG5
GeneBankD90084, AK296457, AF125072, AF125078, M27257, AF125080, M29155, AL732326, AF125071, J03503, M29162, J03575, AF125081, AF125087, AF125054, M29157, CH471074, AF125065, AF125073, AF125060, AF125083, AF125058, AF125057, X52710, AK222740, AF125070, AF125074, AF125069, M29156, AF125084, M29160, AF125055, M29159, EF590117, AK296341, AF125085, M24848, AF125059, AF125075, AF125076, BC002406, AF125088, X52709, AF125063, AF125082, M29164, M29158, AK293250, AK312263, AF125056, M29163, L13318, AF125067, AF125079, AF125062, AF125086, AF125064, L48690, M29161, AF125061, AF125068, AF125066, AF125053AAD23853.1, AAA60227.1, AAA60050.1, AAD23866.1, AAD23842.1, AAD23847.1, AAD23841.1, AAD23848.1, AAD23875.1, AAB59581.1, AAD23874.1, AAD23873.1, AAD23851.1, AAA60055.1, BAH11476.1, AAD23844.1, AAD23864.1, AAD23854.1, AAD23850.1, AAH02406.1, BAH12361.1, AAD23849.1, AAD23857.1, AAD23859.1, AAD23843.1, BAH12323.1, AAD23872.1, CAA36934.1, AAD23862.1, AAD23845.1, AAD23870.1, BAD96460.1, AAD23855.1, AAA36533.1, AAD23876.1, AAD23860.1, AAD23863.1, EAW98960.1, CAA36933.1, AAD23868.1, AAD23869.1, AAD23867.1, BAG35194.1, AAD23858.1, AAA60051.1, AAD23846.1, AAD23856.1, AAD23861.1, AAD23871.1, ABQ59099.1, BAA14121.1, AAD23852.1
RefSeqNM_000284.3, NM_001173454.1, NM_001173455.1, NM_001173456.1NP_000275.1, NP_001166925.1, NP_001166926.1, NP_001166927.1
Entrez5160

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRKMLAAVSR  VLSGASQKPR  HGLATLPSLV  SISRLKQSSH  LGLPKCWDYS  HSLKTRQASR  60
61    VLVASRNFAN  DATFEIKKCD  LHRLEEGPPV  TTVLTREDGL  KYYRMMQTVR  RMELKADQLY  120
121   KQKIIRGFCH  LCDGQEACCV  GLEAGINPTD  HLITAYRAHG  FTFTRGLSVR  EILAELTGRK  180
181   GGCAKGKGGS  MHMYAKNFYG  GNGIVGAQVP  LGAGIALACK  YNGKDEVCLT  LYGDGAANQG  240
241   QIFEAYNMAA  LWKLPCIFIC  ENNRYGMGTS  VERAAASTDY  YKRGDFIPGL  RVDGMDILCV  300
301   REATRFAAAY  CRSGKGPILM  ELQTYRYHGH  SMSDPGVSYR  TREEIQEVRS  KSDPIMLLKD  360
361   RMVNSNLASV  EELKEIDVEV  RKEIEDAAQF  ATADPEPPLE  ELGYHIYSSD  PPFEVRGANQ  420
421   WIKFKSVS  428
Nucleotide CDS Sequence (FASTA)
1     ATGAGGAAGA  TGCTCGCCGC  CGTCTCCCGC  GTGCTGTCTG  GCGCTTCTCA  GAAGCCGGCA  60
61    AGCAGAGTGC  TGGTAGCATC  CCGTAATTTT  GCAAATGATG  CTACATTTGA  AATTAAGAAA  120
121   TGTGACCTTC  ACCGGCTGGA  AGAAGGCCCT  CCTGTCACAA  CAGTGCTCAC  CAGGGAGGAT  180
181   GGGCTCAAAT  ACTACAGGAT  GATGCAGACT  GTACGCCGAA  TGGAGTTGAA  AGCAGATCAG  240
241   CTGTATAAAC  AGAAAATTAT  TCGTGGTTTC  TGTCACTTGT  GTGATGGTCA  GTTTCTCCTT  300
301   CCTCTAACAC  AGGAAGCTTG  CTGTGTGGGC  CTGGAGGCCG  GCATCAACCC  CACAGACCAT  360
361   CTCATCACAG  CCTACCGGGC  TCACGGCTTT  ACTTTCACCC  GGGGCCTTTC  CGTCCGAGAA  420
421   ATTCTCGCAG  AGCTTACAGG  ACGAAAAGGA  GGTTGTGCTA  AAGGGAAAGG  AGGATCGATG  480
481   CACATGTATG  CCAAGAACTT  CTACGGGGGC  AATGGCATCG  TGGGAGCGCA  GGTGCCCCTG  540
541   GGCGCTGGGA  TTGCTCTAGC  CTGTAAGTAT  AATGGAAAAG  ATGAGGTCTG  CCTGACTTTA  600
601   TATGGCGATG  G  611

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Disease mutation
Glucose metabolism
Leigh syndrome
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Primary mitochondrial disease
Pyruvate
Reference proteome
Thiamine pyrophosphate
Transit peptide
Tricarboxylic acid cycle

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial matrix
Cellular Component
Mitochondrion
Cellular Component
Nucleolus
Cellular Component
Nucleus
Cellular Component
Pyruvate dehydrogenase complex
Molecular Function
Pyruvate dehydrogenase (acetyl-transferring) activity
Molecular Function
Pyruvate dehydrogenase (NAD+) activity
Molecular Function
Pyruvate dehydrogenase activity
Biological Process
Acetyl-CoA biosynthetic process from pyruvate
Biological Process
Glucose metabolic process
Biological Process
Mitochondrial acetyl-CoA biosynthetic process from pyruvate
Biological Process
Pyruvate metabolic process
Biological Process
Tricarboxylic acid cycle

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1993Pan troglodytes99.770.0 864
LLPS-Gog-2378Gorilla gorilla99.770.0 864
LLPS-Cea-3575Cercocebus atys99.530.0 863
LLPS-Mam-4296Macaca mulatta99.30.0 858
LLPS-Nol-2006Nomascus leucogenys99.070.0 859
LLPS-Man-3836Macaca nemestrina98.830.0 855
LLPS-Caj-1340Callithrix jacchus98.360.0 846
LLPS-Aim-0286Ailuropoda melanoleuca98.130.0 749
LLPS-Cas-0515Carlito syrichta93.710.0 795
LLPS-Otg-3185Otolemur garnettii93.470.0 798
LLPS-Ora-2673Ornithorhynchus anatinus93.010.0 710
LLPS-Mal-0043Mandrillus leucophaeus92.290.0 782
LLPS-Pap-3024Pan paniscus91.120.0 765
LLPS-Poa-0582Pongo abelii91.120.0 765
LLPS-Maf-0137Macaca fascicularis91.120.0 767
LLPS-Aon-4581Aotus nancymaae90.890.0 763
LLPS-Ict-4504Ictidomys tridecemlineatus90.420.0 763
LLPS-Fud-3763Fukomys damarensis90.420.0 763
LLPS-Orc-0567Oryctolagus cuniculus90.190.0 762
LLPS-Fec-3128Felis catus90.190.0 762
LLPS-Caf-2821Canis familiaris90.190.0 763
LLPS-Tag-0857Taeniopygia guttata90.13e-62 203
LLPS-Cap-0691Cavia porcellus89.950.0 758
LLPS-Mup-3057Mustela putorius furo89.720.0 756
LLPS-Mum-4676Mus musculus89.490.0 757
LLPS-Dio-3942Dipodomys ordii89.490.0 756
LLPS-Eqc-2160Equus caballus89.250.0 754
LLPS-Sus-3185Sus scrofa89.250.0 760
LLPS-Mea-3186Mesocricetus auratus89.250.0 756
LLPS-Ova-3461Ovis aries89.250.0 755
LLPS-Ran-0802Rattus norvegicus89.250.0 753
LLPS-Bot-1071Bos taurus89.180.0 749
LLPS-Tut-1755Tursiops truncatus88.790.0 752
LLPS-Ere-0625Erinaceus europaeus88.550.0 754
LLPS-Myl-1649Myotis lucifugus88.320.0 753
LLPS-Gaga-3914Gallus gallus86.930.0 669
LLPS-Meg-1021Meleagris gallopavo86.840.0 672
LLPS-Rhb-1793Rhinopithecus bieti86.210.0 711
LLPS-Anp-1089Anas platyrhynchos86.130.0 667
LLPS-Paa-3781Papio anubis85.980.0 712
LLPS-Pes-2339Pelodiscus sinensis85.290.0 659
LLPS-Lac-3750Latimeria chalumnae85.070.0 654
LLPS-Sah-3862Sarcophilus harrisii85.050.0 728
LLPS-Loa-1632Loxodonta africana83.530.0 693
LLPS-Mod-4351Monodelphis domestica83.410.0 723
LLPS-Leo-0830Lepisosteus oculatus83.160.0 642
LLPS-Asm-2302Astyanax mexicanus82.670.0 641
LLPS-Scf-2665Scleropages formosus82.620.0 639
LLPS-Fia-1189Ficedula albicollis81.950.0 656
LLPS-Dar-3426Danio rerio81.330.0 640
LLPS-Orl-0473Oryzias latipes80.390.0 610
LLPS-Pof-0701Poecilia formosa80.270.0 624
LLPS-Orn-1305Oreochromis niloticus79.680.0 627
LLPS-Xim-0452Xiphophorus maculatus79.520.0 623
LLPS-Xet-1836Xenopus tropicalis79.450.0 689
LLPS-Scm-2702Scophthalmus maximus78.820.0 613
LLPS-Tar-3822Takifugu rubripes78.190.0 603
LLPS-Urm-3344Ursus maritimus78.090.0 665
LLPS-Anc-0122Anolis carolinensis77.910.0 660
LLPS-Ten-0221Tetraodon nigroviridis77.630.0 610
LLPS-Gaa-2364Gasterosteus aculeatus77.00.0 613
LLPS-Icp-1197Ictalurus punctatus74.250.0 639
LLPS-Cis-1386Ciona savignyi63.699e-138 405
LLPS-Cae-2028Caenorhabditis elegans59.533e-159 463
LLPS-Cii-0064Ciona intestinalis59.313e-155 452
LLPS-Ast-1273Aspergillus terreus57.456e-121 365
LLPS-Phv-0217Phaseolus vulgaris57.096e-106 325
LLPS-Php-0348Physcomitrella patens55.796e-119 359
LLPS-Art-1136Arabidopsis thaliana55.739e-115 348
LLPS-Dac-0481Daucus carota55.739e-112 342
LLPS-Arl-2732Arabidopsis lyrata55.731e-114 348
LLPS-Sei-0325Setaria italica55.78e-76 244
LLPS-Coc-0057Corchorus capsularis55.421e-111 340
LLPS-Asf-0825Aspergillus flavus55.164e-114 347
LLPS-Aso-0479Aspergillus oryzae55.166e-115 348
LLPS-Orr-0889Oryza rufipogon54.649e-107 327
LLPS-Zem-0520Zea mays54.494e-111 339
LLPS-Brd-1072Brachypodium distachyon54.469e-113 343
LLPS-Asc-0275Aspergillus clavatus54.436e-76 247
LLPS-Asni-0796Aspergillus niger54.416e-117 355
LLPS-Sem-1609Selaginella moellendorffii54.411e-113 346
LLPS-Pot-2806Populus trichocarpa54.296e-117 354
LLPS-Mae-2057Manihot esculenta54.172e-111 340
LLPS-Gor-2633Gossypium raimondii54.016e-114 347
LLPS-Nia-2260Nicotiana attenuata53.874e-110 337
LLPS-Tra-2229Triticum aestivum53.871e-112 343
LLPS-Drm-1058Drosophila melanogaster53.851e-115 354
LLPS-Brr-0719Brassica rapa53.576e-113 344
LLPS-Hea-1630Helianthus annuus53.574e-112 342
LLPS-Brn-3162Brassica napus53.576e-113 344
LLPS-Lep-2180Leersia perrieri53.572e-111 340
LLPS-Met-1234Medicago truncatula53.565e-109 334
LLPS-Mua-0794Musa acuminata53.292e-92 288
LLPS-Glm-2588Glycine max53.253e-106 327
LLPS-Viv-0174Vitis vinifera53.223e-110 337
LLPS-Cus-2149Cucumis sativus53.141e-113 346
LLPS-Via-1760Vigna angularis52.981e-107 332
LLPS-Orbr-2205Oryza brachyantha52.964e-112 341
LLPS-Blg-0670Blumeria graminis52.822e-117 356
LLPS-Hov-0115Hordeum vulgare52.661e-107 334
LLPS-Crn-0557Cryptococcus neoformans52.64e-120 363
LLPS-Orni-2110Oryza nivara52.425e-110 336
LLPS-Orb-0647Oryza barthii52.425e-110 336
LLPS-Orgl-1763Oryza glumaepatula52.427e-110 336
LLPS-Chr-0340Chlamydomonas reinhardtii51.872e-119 360
LLPS-Ors-2238Oryza sativa51.632e-110 338
LLPS-Ori-0363Oryza indica51.632e-110 338
LLPS-Sot-1635Solanum tuberosum51.513e-112 342
LLPS-Bro-2446Brassica oleracea51.291e-110 338
LLPS-Sob-1486Sorghum bicolor51.038e-109 333
LLPS-Nef-1039Neosartorya fischeri50.71e-115 351
LLPS-Sol-2389Solanum lycopersicum50.669e-113 343
LLPS-Tru-0781Triticum urartu49.711e-54 186
LLPS-Vir-0336Vigna radiata48.966e-93 293
LLPS-Orm-0585Oryza meridionalis45.393e-111 340
LLPS-Orp-0849Oryza punctata44.548e-84 268
LLPS-Put-0339Puccinia triticina43.922e-88 281
LLPS-Asfu-0296Aspergillus fumigatus43.074e-78 253
LLPS-Org-1261Oryza glaberrima39.475e-66 221
LLPS-Amt-1386Amborella trichopoda38.921e-68 230
LLPS-Prp-1284Prunus persica38.513e-67 227
LLPS-Gas-1278Galdieria sulphuraria37.842e-58 201
LLPS-Thc-2353Theobroma cacao36.817e-64 220
LLPS-Cym-0832Cyanidioschyzon merolae36.366e-57 196
LLPS-Chc-1157Chondrus crispus35.717e-58 199
LLPS-Osl-1061Ostreococcus lucimarinus31.961e-35 140