LLPS-Pat-2150
CAPZA2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | F-actin-capping protein subunit alpha-2; CapZ alpha-2 |
| Gene Name: | CAPZA2 |
| Ensembl Gene: | ENSPTRG00000019615.5 |
| Ensembl Protein: | ENSPTRP00000079269.1 |
| Organism: | Pan troglodytes |
| Taxa ID: | 9598 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPTRT00000079240.1 | ENSPTRP00000079269.1 |
| Ensembl | ENSPTRT00000100963.1 | ENSPTRP00000071756.1 |
| Ensembl | ENSPTRT00000077468.1 | ENSPTRP00000081073.1 |
| Ensembl | ENSPTRT00000036331.4 | ENSPTRP00000047674.2 |
| UniProt | Q2QLF0, CAZA2_PANTR | |
| GeneBank | DP000016 | AAR16248.1 |
| RefSeq | NM_001135817.1 | NP_001129289.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD 60 61 QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW 120 121 RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT 180 181 ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ 240 241 TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA 286 |
| Nucleotide CDS Sequence (FASTA) |
1 GTGCGTATAG CAGCAAAATT CATCATTCAT GCCCCTCCTG GAGAATTTAA TGAAGTTTTT 60 61 AATGATGTTC GGTTACTGCT TAATAATGAC AATCTTCTCA GGGAAGGAGC AGCCCATGCA 120 121 TTTGCACAGT ATAACTTGGA CCAGTTTACT CCAGTAAAAA TTGAAGGTTA TGAAGATCAG 180 181 GTATTGATAA CAGAACATGG CGACTTGGGA AATGGAAAGT TTTTGGATCC AAAGAACAGA 240 241 ATCTGTTTTA AATTTGATCA CTTAAGGAAG GAGGCAACTG ATCCAAGACC CTGTGAAGTA 300 301 GAAAATGCAG TTGAATCATG GAGAACTTCA GTAGAAACTG CTCTGAGAGC TTACGTAAAA 360 361 GAACATTACC CGAATGGAGT CTGCACTGTG TATGGCAAAA AAATAGATGG ACAGCAAACC 420 421 ATTATTGCAT GCATAGAAAG CCATCAGTTC CAAGCAAAAA ACTTTTGCTG CTGTTTTTAT 480 481 TTTTAA 486 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Actin cortical patch | |
Cellular Component | Brush border | |
Cellular Component | F-actin capping protein complex | |
Cellular Component | Membrane | |
Molecular Function | Actin filament binding | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Barbed-end actin filament capping |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-2035 | Gorilla gorilla | 100.0 | 0.0 | 565 |
| LLPS-Chs-1298 | Chlorocebus sabaeus | 100.0 | 0.0 | 565 |
| LLPS-Maf-3014 | Macaca fascicularis | 100.0 | 0.0 | 565 |
| LLPS-Mal-2848 | Mandrillus leucophaeus | 100.0 | 0.0 | 539 |
| LLPS-Paa-0583 | Papio anubis | 100.0 | 0.0 | 565 |
| LLPS-Rhb-2622 | Rhinopithecus bieti | 100.0 | 0.0 | 565 |
| LLPS-Hos-0715 | Homo sapiens | 100.0 | 0.0 | 565 |
| LLPS-Pap-3969 | Pan paniscus | 100.0 | 0.0 | 541 |
| LLPS-Man-2933 | Macaca nemestrina | 100.0 | 0.0 | 565 |
| LLPS-Poa-2398 | Pongo abelii | 100.0 | 0.0 | 565 |
| LLPS-Mam-1704 | Macaca mulatta | 100.0 | 0.0 | 539 |
| LLPS-Caj-0255 | Callithrix jacchus | 99.65 | 0.0 | 564 |
| LLPS-Sus-0690 | Sus scrofa | 99.3 | 0.0 | 560 |
| LLPS-Fec-3024 | Felis catus | 99.3 | 0.0 | 558 |
| LLPS-Caf-0055 | Canis familiaris | 99.3 | 0.0 | 560 |
| LLPS-Urm-3272 | Ursus maritimus | 99.27 | 0.0 | 533 |
| LLPS-Otg-1763 | Otolemur garnettii | 98.95 | 0.0 | 558 |
| LLPS-Eqc-2669 | Equus caballus | 98.95 | 0.0 | 558 |
| LLPS-Cas-1795 | Carlito syrichta | 98.74 | 7e-178 | 498 |
| LLPS-Tut-0922 | Tursiops truncatus | 98.33 | 8e-177 | 495 |
| LLPS-Mum-3706 | Mus musculus | 98.25 | 0.0 | 558 |
| LLPS-Ran-4465 | Rattus norvegicus | 98.25 | 0.0 | 558 |
| LLPS-Ova-1539 | Ovis aries | 98.25 | 0.0 | 555 |
| LLPS-Cap-3458 | Cavia porcellus | 98.21 | 0.0 | 540 |
| LLPS-Bot-1899 | Bos taurus | 98.18 | 0.0 | 529 |
| LLPS-Fud-2366 | Fukomys damarensis | 98.17 | 0.0 | 526 |
| LLPS-Ict-2393 | Ictidomys tridecemlineatus | 97.56 | 0.0 | 549 |
| LLPS-Orc-1907 | Oryctolagus cuniculus | 97.55 | 0.0 | 553 |
| LLPS-Aim-0099 | Ailuropoda melanoleuca | 97.13 | 0.0 | 530 |
| LLPS-Mod-2334 | Monodelphis domestica | 96.85 | 0.0 | 546 |
| LLPS-Dio-1766 | Dipodomys ordii | 96.7 | 0.0 | 523 |
| LLPS-Sah-0136 | Sarcophilus harrisii | 96.5 | 0.0 | 545 |
| LLPS-Ere-0700 | Erinaceus europaeus | 96.5 | 0.0 | 540 |
| LLPS-Myl-2919 | Myotis lucifugus | 95.44 | 0.0 | 536 |
| LLPS-Aon-2469 | Aotus nancymaae | 95.1 | 0.0 | 534 |
| LLPS-Gaga-2783 | Gallus gallus | 95.1 | 0.0 | 541 |
| LLPS-Tag-3045 | Taeniopygia guttata | 95.1 | 0.0 | 540 |
| LLPS-Meg-2541 | Meleagris gallopavo | 94.87 | 0.0 | 515 |
| LLPS-Ora-2232 | Ornithorhynchus anatinus | 94.56 | 5e-169 | 477 |
| LLPS-Loa-2293 | Loxodonta africana | 94.12 | 0.0 | 530 |
| LLPS-Anp-0259 | Anas platyrhynchos | 93.62 | 0.0 | 523 |
| LLPS-Cea-4697 | Cercocebus atys | 93.36 | 0.0 | 549 |
| LLPS-Fia-2312 | Ficedula albicollis | 92.31 | 0.0 | 520 |
| LLPS-Anc-1947 | Anolis carolinensis | 91.96 | 0.0 | 531 |
| LLPS-Xet-3734 | Xenopus tropicalis | 90.91 | 0.0 | 524 |
| LLPS-Leo-2179 | Lepisosteus oculatus | 87.06 | 1e-180 | 506 |
| LLPS-Mup-1705 | Mustela putorius furo | 87.06 | 2e-178 | 501 |
| LLPS-Mea-0838 | Mesocricetus auratus | 86.71 | 1e-178 | 501 |
| LLPS-Nol-4091 | Nomascus leucogenys | 86.71 | 8e-178 | 499 |
| LLPS-Pes-3499 | Pelodiscus sinensis | 85.92 | 4e-168 | 474 |
| LLPS-Xim-0796 | Xiphophorus maculatus | 85.31 | 5e-177 | 497 |
| LLPS-Pof-3335 | Poecilia formosa | 85.31 | 5e-178 | 500 |
| LLPS-Lac-0386 | Latimeria chalumnae | 84.78 | 2e-166 | 471 |
| LLPS-Orl-0586 | Oryzias latipes | 84.27 | 3e-176 | 495 |
| LLPS-Gaa-0666 | Gasterosteus aculeatus | 84.27 | 2e-176 | 496 |
| LLPS-Scf-0386 | Scleropages formosus | 83.51 | 6e-170 | 479 |
| LLPS-Tar-1782 | Takifugu rubripes | 82.87 | 1e-173 | 489 |
| LLPS-Asm-1875 | Astyanax mexicanus | 81.82 | 1e-167 | 473 |
| LLPS-Scm-0160 | Scophthalmus maximus | 81.82 | 1e-165 | 468 |
| LLPS-Orn-2165 | Oreochromis niloticus | 81.12 | 2e-168 | 475 |
| LLPS-Ten-0097 | Tetraodon nigroviridis | 80.85 | 6e-166 | 469 |
| LLPS-Icp-1325 | Ictalurus punctatus | 79.02 | 1e-159 | 453 |
| LLPS-Dar-3028 | Danio rerio | 77.62 | 2e-157 | 449 |
| LLPS-Drm-0389 | Drosophila melanogaster | 61.65 | 1e-119 | 352 |
| LLPS-Cii-0086 | Ciona intestinalis | 55.36 | 2e-107 | 320 |
| LLPS-Cae-1407 | Caenorhabditis elegans | 53.17 | 2e-87 | 269 |
| LLPS-Cis-2038 | Ciona savignyi | 52.8 | 7e-100 | 301 |
| LLPS-Abg-1951 | Absidia glauca | 40.14 | 2e-64 | 210 |
| LLPS-Spr-0539 | Sporisorium reilianum | 39.52 | 2e-27 | 114 |
| LLPS-Mel-1025 | Melampsora laricipopulina | 38.18 | 6e-48 | 167 |
| LLPS-Put-1021 | Puccinia triticina | 37.7 | 2e-20 | 92.8 |
| LLPS-Crn-1470 | Cryptococcus neoformans | 36.72 | 2e-22 | 100 |
| LLPS-Zyt-0457 | Zymoseptoria tritici | 36.17 | 2e-48 | 168 |
| LLPS-Beb-1301 | Beauveria bassiana | 36.16 | 1e-53 | 182 |
| LLPS-Ved-1032 | Verticillium dahliae | 36.16 | 8e-54 | 182 |
| LLPS-Cogr-0686 | Colletotrichum graminicola | 36.16 | 4e-56 | 188 |
| LLPS-Usm-1406 | Ustilago maydis | 36.0 | 1e-23 | 102 |
| LLPS-Map-0667 | Magnaporthe poae | 35.53 | 2e-53 | 181 |
| LLPS-Pytr-1180 | Pyrenophora triticirepentis | 35.34 | 1e-50 | 174 |
| LLPS-Gag-1172 | Gaeumannomyces graminis | 35.29 | 7e-53 | 180 |
| LLPS-Pyt-0873 | Pyrenophora teres | 34.96 | 2e-49 | 171 |
| LLPS-Lem-1304 | Leptosphaeria maculans | 34.96 | 4e-49 | 170 |
| LLPS-Trr-1265 | Trichoderma reesei | 34.96 | 6e-53 | 180 |
| LLPS-Cus-1812 | Cucumis sativus | 34.92 | 3e-45 | 160 |
| LLPS-Sei-0884 | Setaria italica | 34.83 | 5e-44 | 159 |
| LLPS-Orbr-0678 | Oryza brachyantha | 34.83 | 1e-47 | 167 |
| LLPS-Asf-1581 | Aspergillus flavus | 34.8 | 9e-50 | 172 |
| LLPS-Ors-0988 | Oryza sativa | 34.78 | 4e-35 | 132 |
| LLPS-Fuv-1551 | Fusarium verticillioides | 34.66 | 3e-51 | 176 |
| LLPS-Ori-1664 | Oryza indica | 34.6 | 4e-44 | 157 |
| LLPS-Via-1021 | Vigna angularis | 34.6 | 7e-47 | 165 |
| LLPS-Org-0207 | Oryza glaberrima | 34.6 | 4e-44 | 157 |
| LLPS-Zem-2285 | Zea mays | 34.48 | 8e-45 | 160 |
| LLPS-Prp-0619 | Prunus persica | 34.46 | 2e-47 | 167 |
| LLPS-Brd-0470 | Brachypodium distachyon | 34.36 | 2e-41 | 151 |
| LLPS-Fuo-1023 | Fusarium oxysporum | 34.3 | 6e-51 | 175 |
| LLPS-Sob-0366 | Sorghum bicolor | 34.14 | 3e-44 | 158 |
| LLPS-Dac-0260 | Daucus carota | 34.12 | 5e-49 | 171 |
| LLPS-Trv-1603 | Trichoderma virens | 34.07 | 4e-53 | 180 |
| LLPS-Met-0111 | Medicago truncatula | 33.68 | 2e-43 | 156 |
| LLPS-Phv-2085 | Phaseolus vulgaris | 33.68 | 8e-46 | 162 |
| LLPS-Blg-1504 | Blumeria graminis | 33.58 | 6e-51 | 175 |
| LLPS-Gor-1136 | Gossypium raimondii | 33.56 | 1e-45 | 162 |
| LLPS-Asc-0098 | Aspergillus clavatus | 33.33 | 9e-45 | 158 |
| LLPS-Glm-1589 | Glycine max | 33.33 | 4e-43 | 155 |
| LLPS-Miv-0865 | Microbotryum violaceum | 33.33 | 4e-19 | 90.1 |
| LLPS-Viv-1389 | Vitis vinifera | 33.33 | 2e-45 | 161 |
| LLPS-Coc-1524 | Corchorus capsularis | 33.22 | 4e-41 | 150 |
| LLPS-Hea-2777 | Helianthus annuus | 32.89 | 6e-45 | 160 |
| LLPS-Thc-0460 | Theobroma cacao | 32.88 | 3e-42 | 155 |
| LLPS-Phn-1409 | Phaeosphaeria nodorum | 32.86 | 1e-42 | 160 |
| LLPS-Ast-0585 | Aspergillus terreus | 32.62 | 2e-43 | 155 |
| LLPS-Nef-0479 | Neosartorya fischeri | 32.6 | 1e-43 | 155 |
| LLPS-Orni-1671 | Oryza nivara | 32.53 | 4e-42 | 152 |
| LLPS-Orb-0390 | Oryza barthii | 32.53 | 4e-42 | 152 |
| LLPS-Orgl-0561 | Oryza glumaepatula | 32.53 | 4e-42 | 152 |
| LLPS-Orr-0644 | Oryza rufipogon | 32.53 | 4e-42 | 152 |
| LLPS-Pot-1038 | Populus trichocarpa | 32.43 | 1e-46 | 164 |
| LLPS-Mua-2416 | Musa acuminata | 32.42 | 3e-41 | 150 |
| LLPS-Php-1657 | Physcomitrella patens | 32.41 | 1e-43 | 157 |
| LLPS-Amt-1614 | Amborella trichopoda | 32.41 | 5e-45 | 160 |
| LLPS-Sem-1262 | Selaginella moellendorffii | 32.29 | 2e-43 | 155 |
| LLPS-Asn-0768 | Aspergillus nidulans | 32.23 | 7e-44 | 159 |
| LLPS-Tra-0086 | Triticum aestivum | 32.07 | 1e-36 | 138 |
| LLPS-Sac-0429 | Saccharomyces cerevisiae | 31.6 | 1e-30 | 121 |
| LLPS-Brr-0624 | Brassica rapa | 31.56 | 4e-42 | 153 |
| LLPS-Mae-2085 | Manihot esculenta | 31.51 | 8e-42 | 152 |
| LLPS-Dos-1509 | Dothistroma septosporum | 31.44 | 1e-43 | 156 |
| LLPS-Mao-1143 | Magnaporthe oryzae | 31.33 | 8e-34 | 129 |
| LLPS-Brn-1392 | Brassica napus | 31.23 | 3e-42 | 153 |
| LLPS-Sol-2406 | Solanum lycopersicum | 31.16 | 1e-43 | 157 |
| LLPS-Sot-1176 | Solanum tuberosum | 31.16 | 4e-44 | 158 |
| LLPS-Bro-0821 | Brassica oleracea | 31.16 | 1e-40 | 149 |
| LLPS-Asfu-1140 | Aspergillus fumigatus | 30.88 | 5e-40 | 146 |
| LLPS-Nia-0014 | Nicotiana attenuata | 30.8 | 7e-41 | 154 |
| LLPS-Art-2114 | Arabidopsis thaliana | 30.56 | 8e-38 | 143 |
| LLPS-Vir-1391 | Vigna radiata | 30.49 | 1e-28 | 114 |
| LLPS-Arl-1504 | Arabidopsis lyrata | 30.48 | 5e-42 | 152 |
| LLPS-Lep-0218 | Leersia perrieri | 30.31 | 1e-35 | 135 |
| LLPS-Kop-0891 | Komagataella pastoris | 30.15 | 5e-26 | 108 |
| LLPS-Scs-0110 | Sclerotinia sclerotiorum | 29.89 | 7e-34 | 129 |
| LLPS-Yal-1069 | Yarrowia lipolytica | 29.48 | 1e-30 | 121 |
| LLPS-Orp-1694 | Oryza punctata | 29.48 | 5e-32 | 126 |
| LLPS-Scp-1522 | Schizosaccharomyces pombe | 29.07 | 1e-21 | 95.9 |
| LLPS-Asg-0334 | Ashbya gossypii | 28.83 | 6e-31 | 122 |
| LLPS-Scj-1077 | Schizosaccharomyces japonicus | 28.79 | 1e-23 | 101 |