• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asfu-1140
cap1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: F-actin-capping protein subunit alpha
Gene Name: cap1, AFUA_6G10060
Ensembl Gene: AFUA_6G10060
Ensembl Protein: EAL88857
Organism: Aspergillus fumigatus
Taxa ID: 330879
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAL88857EAL88857
UniProtQ4WMF7, CAPZA_ASPFU
GeneBankAAHF01000006EAL88857.1
RefSeqXM_745802.1XP_750895.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSTVELASS  FIEGAPPGEA  LTSDGSDIIP  SLAPAFERYN  EKQLTTVKLP  GASQEVIVSE  60
61    FNKIEGNRYF  DVESQTSFGV  DHVTQQASGA  QSYVLESQNA  DLIHVEVHSR  SNQCSKSLLK  120
121   SLAKHAAEHY  PNCSYGVYPT  EDDTAVAILL  VANRYSPNNF  WNGRFRSIYR  VPVSESTTVS  180
181   GKILVDVHYY  EDGNVALNTN  KPINIAIPSI  SAESIISRIA  AAERDYQEEL  NRAFVQMAEG  240
241   AFKNLRRQLP  ITRQKVEWEK  VGGYRLGQDI  SGGKGR  276
Nucleotide CDS Sequence (FASTA)
1     ATGAGTTCCA  CAGTTGAGCT  CGCATCCTCG  TTCATCGAAG  GTGCCCCGCC  AGGCGAGGCT  60
61    CTTACCTCGG  ACGGATCGGA  TATTATCCCC  TCTCTCGCGC  CTGCGTTTGA  AAGATACAAT  120
121   GAGAAGCAAT  TGACTACCGT  GAAGCTACCC  GGAGCGAGTC  AGGAGGTCAT  CGTCAGTGAA  180
181   TTCAACAAGA  TAGAAGGGAA  CCGATACTTT  GATGTTGAGA  GTCAAACGTC  GTTCGGGGTG  240
241   GATCATGTAA  CACAGCAAGC  GTCTGGTGCG  CAGTCCTATG  TCCTGGAATC  ACAAAATGCG  300
301   GATTTGATTC  ATGTGGAGGT  TCACTCGAGG  TCTAACCAGT  GCAGCAAATC  TCTCCTCAAA  360
361   TCGCTCGCTA  AACACGCTGC  GGAACACTAC  CCCAACTGCT  CCTACGGGGT  CTACCCTACT  420
421   GAGGACGATA  CCGCTGTCGC  TATTCTACTT  GTTGCAAACC  GCTACTCGCC  AAATAACTTC  480
481   TGGAACGGTC  GCTTCCGCTC  CATCTACCGA  GTCCCCGTGT  CCGAGTCGAC  CACCGTGAGC  540
541   GGCAAGATCC  TTGTGGATGT  GCATTACTAT  GAGGATGGCA  ATGTGGCTCT  CAACACGAAC  600
601   AAGCCCATTA  ATATTGCCAT  TCCCTCGATC  TCTGCTGAGA  GCATCATCTC  CCGCATTGCG  660
661   GCTGCAGAGC  GAGACTATCA  GGAGGAGCTC  AATCGTGCAT  TCGTGCAGAT  GGCCGAGGGC  720
721   GCGTTCAAGA  ACCTGCGGAG  ACAATTGCCC  ATTACCCGGC  AGAAGGTGGA  ATGGGAGAAG  780
781   GTTGGAGGGT  ACCGGCTGGG  ACAGGATATT  TCTGGTGGAA  AGGGACGGTA  A  831

▼ KEYWORD

ID
Family
Actin capping
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin cortical patch
Cellular Component
F-actin capping protein complex
Molecular Function
Actin filament binding
Biological Process
Actin cytoskeleton organization
Biological Process
Barbed-end actin filament capping

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nef-0479Neosartorya fischeri92.393e-166 469
LLPS-Asc-0098Aspergillus clavatus86.962e-159 452
LLPS-Ast-0585Aspergillus terreus82.492e-135 390
LLPS-Asf-1581Aspergillus flavus78.253e-147 421
LLPS-Asn-0768Aspergillus nidulans77.541e-140 408
LLPS-Cogr-0686Colletotrichum graminicola55.486e-101 303
LLPS-Lem-1304Leptosphaeria maculans54.774e-91 278
LLPS-Trv-1603Trichoderma virens54.422e-97 294
LLPS-Ved-1032Verticillium dahliae54.265e-96 290
LLPS-Gag-1172Gaeumannomyces graminis54.128e-95 287
LLPS-Trr-1265Trichoderma reesei54.063e-98 296
LLPS-Fuo-1023Fusarium oxysporum53.871e-93 284
LLPS-Beb-1301Beauveria bassiana53.714e-98 296
LLPS-Fuv-1551Fusarium verticillioides53.527e-93 282
LLPS-Map-0667Magnaporthe poae52.869e-94 285
LLPS-Pytr-1180Pyrenophora triticirepentis52.821e-87 269
LLPS-Pyt-0873Pyrenophora teres51.761e-85 264
LLPS-Zyt-0457Zymoseptoria tritici51.577e-84 259
LLPS-Dos-1509Dothistroma septosporum51.233e-89 273
LLPS-Scs-0110Sclerotinia sclerotiorum50.882e-80 250
LLPS-Blg-1504Blumeria graminis50.02e-84 261
LLPS-Phn-1409Phaeosphaeria nodorum49.642e-82 270
LLPS-Crn-1470Cryptococcus neoformans44.273e-23 102
LLPS-Put-1021Puccinia triticina43.481e-1681.6
LLPS-Spr-0539Sporisorium reilianum42.525e-2195.1
LLPS-Usm-1406Ustilago maydis41.737e-2092.0
LLPS-Miv-0865Microbotryum violaceum39.068e-2091.7
LLPS-Mao-1143Magnaporthe oryzae37.214e-38 141
LLPS-Yal-1069Yarrowia lipolytica34.745e-38 140
LLPS-Abg-1951Absidia glauca34.527e-42 151
LLPS-Dar-3028Danio rerio32.971e-36 138
LLPS-Icp-1325Ictalurus punctatus32.278e-32 124
LLPS-Ora-2232Ornithorhynchus anatinus32.261e-32 126
LLPS-Ors-0988Oryza sativa32.125e-1575.5
LLPS-Fec-3024Felis catus31.919e-34 132
LLPS-Mel-1025Melampsora laricipopulina31.776e-36 135
LLPS-Sac-0429Saccharomyces cerevisiae31.675e-31 122
LLPS-Cap-3458Cavia porcellus31.652e-33 128
LLPS-Sus-0690Sus scrofa31.586e-35 133
LLPS-Aim-0099Ailuropoda melanoleuca31.583e-34 131
LLPS-Meg-2541Meleagris gallopavo31.581e-35 134
LLPS-Urm-3272Ursus maritimus31.585e-35 132
LLPS-Otg-1763Otolemur garnettii31.587e-35 132
LLPS-Caf-0055Canis familiaris31.586e-35 133
LLPS-Gaga-2783Gallus gallus31.589e-36 135
LLPS-Bot-1899Bos taurus31.566e-35 134
LLPS-Xet-2225Xenopus tropicalis31.562e-34 131
LLPS-Dio-1766Dipodomys ordii31.491e-34 132
LLPS-Xim-0796Xiphophorus maculatus31.478e-37 138
LLPS-Tut-0922Tursiops truncatus31.456e-33 126
LLPS-Pof-3335Poecilia formosa31.454e-37 139
LLPS-Lac-0386Latimeria chalumnae31.456e-36 135
LLPS-Cas-1795Carlito syrichta31.452e-32 125
LLPS-Scp-1522Schizosaccharomyces pombe31.442e-31 122
LLPS-Mum-3706Mus musculus31.236e-35 133
LLPS-Fud-2366Fukomys damarensis31.233e-35 133
LLPS-Ran-4465Rattus norvegicus31.236e-35 133
LLPS-Fia-2312Ficedula albicollis31.233e-35 134
LLPS-Eqc-2669Equus caballus31.233e-34 130
LLPS-Tag-3045Taeniopygia guttata31.232e-35 134
LLPS-Scf-0386Scleropages formosus31.143e-38 141
LLPS-Orn-2165Oreochromis niloticus31.122e-37 139
LLPS-Ten-0097Tetraodon nigroviridis31.122e-38 142
LLPS-Anp-0259Anas platyrhynchos30.92e-35 134
LLPS-Orl-0586Oryzias latipes30.883e-37 139
LLPS-Sah-0136Sarcophilus harrisii30.886e-35 133
LLPS-Asm-1875Astyanax mexicanus30.883e-32 125
LLPS-Myl-2919Myotis lucifugus30.887e-35 132
LLPS-Mod-2334Monodelphis domestica30.886e-35 132
LLPS-Orc-1907Oryctolagus cuniculus30.883e-34 131
LLPS-Anc-1947Anolis carolinensis30.882e-35 134
LLPS-Gaa-0666Gasterosteus aculeatus30.852e-35 134
LLPS-Scm-0160Scophthalmus maximus30.853e-38 142
LLPS-Mam-1704Macaca mulatta30.859e-34 130
LLPS-Scj-1077Schizosaccharomyces japonicus30.774e-27 111
LLPS-Ict-2393Ictidomys tridecemlineatus30.774e-34 130
LLPS-Cae-1407Caenorhabditis elegans30.666e-36 135
LLPS-Asg-0334Ashbya gossypii30.632e-27 112
LLPS-Kop-0891Komagataella pastoris30.633e-30 120
LLPS-Leo-2179Lepisosteus oculatus30.538e-37 137
LLPS-Cea-4320Cercocebus atys30.532e-33 129
LLPS-Tar-1782Takifugu rubripes30.532e-38 142
LLPS-Ere-0700Erinaceus europaeus30.532e-30 120
LLPS-Cis-2038Ciona savignyi30.51e-32 127
LLPS-Loa-2293Loxodonta africana30.382e-35 134
LLPS-Sei-0884Setaria italica30.343e-28 116
LLPS-Maf-3014Macaca fascicularis30.185e-34 130
LLPS-Chs-1298Chlorocebus sabaeus30.185e-34 130
LLPS-Gog-2035Gorilla gorilla30.185e-34 130
LLPS-Caj-0255Callithrix jacchus30.186e-34 130
LLPS-Mal-2848Mandrillus leucophaeus30.184e-34 130
LLPS-Paa-0583Papio anubis30.185e-34 130
LLPS-Hos-0715Homo sapiens30.185e-34 130
LLPS-Pat-2150Pan troglodytes30.185e-34 130
LLPS-Pap-3969Pan paniscus30.183e-34 130
LLPS-Man-2933Macaca nemestrina30.185e-34 130
LLPS-Rhb-2622Rhinopithecus bieti30.185e-34 130
LLPS-Poa-2398Pongo abelii30.185e-34 130
LLPS-Nol-4091Nomascus leucogenys30.181e-33 129
LLPS-Cii-0086Ciona intestinalis29.892e-35 134
LLPS-Mea-0838Mesocricetus auratus29.823e-33 128
LLPS-Mup-1705Mustela putorius furo29.824e-33 128
LLPS-Aon-2469Aotus nancymaae29.792e-32 126
LLPS-Pes-3499Pelodiscus sinensis29.761e-31 124
LLPS-Zem-2285Zea mays29.668e-27 111
LLPS-Drm-0389Drosophila melanogaster29.476e-33 127
LLPS-Orbr-0678Oryza brachyantha29.318e-26 108
LLPS-Sob-0366Sorghum bicolor29.218e-26 108
LLPS-Brd-0470Brachypodium distachyon28.877e-25 105
LLPS-Lep-0218Leersia perrieri28.571e-2299.4
LLPS-Tra-0086Triticum aestivum28.525e-25 106
LLPS-Mua-2416Musa acuminata28.474e-2297.8
LLPS-Amt-1614Amborella trichopoda28.291e-26 110
LLPS-Ori-1664Oryza indica28.283e-24 103
LLPS-Org-0207Oryza glaberrima28.283e-24 103
LLPS-Glm-1589Glycine max28.143e-25 106
LLPS-Orb-0390Oryza barthii28.115e-23 100
LLPS-Orni-1671Oryza nivara28.115e-23 100
LLPS-Orgl-0561Oryza glumaepatula28.115e-23 100
LLPS-Orr-0644Oryza rufipogon28.115e-23 100
LLPS-Gor-1136Gossypium raimondii27.82e-23 101
LLPS-Brr-0624Brassica rapa27.787e-2297.1
LLPS-Met-0111Medicago truncatula27.71e-24 105
LLPS-Brn-1392Brassica napus27.554e-24 103
LLPS-Nia-0014Nicotiana attenuata27.465e-24 106
LLPS-Pot-1038Populus trichocarpa27.213e-24 103
LLPS-Hea-2777Helianthus annuus27.122e-24 104
LLPS-Phv-2085Phaseolus vulgaris27.126e-23 100
LLPS-Coc-1524Corchorus capsularis27.15e-1577.0
LLPS-Arl-1504Arabidopsis lyrata27.035e-23 100
LLPS-Viv-1389Vitis vinifera26.872e-23 101
LLPS-Art-2114Arabidopsis thaliana26.855e-2297.8
LLPS-Bro-0821Brassica oleracea26.534e-2297.8
LLPS-Via-1021Vigna angularis26.442e-2298.2
LLPS-Sem-1540Selaginella moellendorffii26.31e-1887.4
LLPS-Prp-0619Prunus persica26.191e-2299.0
LLPS-Thc-0460Theobroma cacao25.851e-23 102
LLPS-Cus-1812Cucumis sativus25.855e-24 103
LLPS-Mae-2085Manihot esculenta25.852e-2195.5
LLPS-Orp-1694Oryza punctata25.151e-1579.3
LLPS-Dac-0260Daucus carota25.084e-25 106
LLPS-Sol-2406Solanum lycopersicum24.831e-23 102
LLPS-Sot-1176Solanum tuberosum24.756e-24 102
LLPS-Php-1657Physcomitrella patens24.742e-1784.3
LLPS-Vir-1391Vigna radiata24.463e-1576.6