• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ova-1773
GLO1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lactoylglutathione lyase; Glyoxalase I
Gene Name: GLO1
Ensembl Gene: ENSOARG00000015212.1
Ensembl Protein: ENSOARP00000016319.1
Organism: Ovis aries
Taxa ID: 9940
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     SSAAMAEPQP  ASGGLTDEAA  LSCCSDPDPS  TKDFLLQQTM  LRIKDPKKSL  DFYTRILGMT  60
61    LLQKLDFPTM  KFSLYFLAYE  DKNDIPKDKD  EKVAWVFSRK  ATLELTHNWG  TEDDETQSYH  120
121   SGNSDPRGFG  HIGIAVPDVH  GACKRFEELG  VRFVKKPNDG  KMKGLAFIQD  PDGYWIEILN  180
181   PNTMITII  188
Nucleotide CDS Sequence (FASTA)
1     AGCAGTGCGG  CCATGGCAGA  ACCACAGCCC  GCGTCCGGTG  GCCTCACCGA  CGAGGCTGCC  60
61    CTCAGCTGTT  GCTCCGACCC  GGACCCCAGC  ACCAAGGATT  TTCTCTTGCA  GCAGACTATG  120
121   CTGCGAATTA  AGGATCCTAA  GAAGTCACTG  GATTTTTATA  CGAGAATTCT  TGGAATGACA  180
181   CTACTCCAGA  AACTTGATTT  CCCCACTATG  AAATTTTCAC  TCTACTTCTT  GGCTTATGAG  240
241   GATAAAAATG  ACATCCCAAA  AGATAAAGAT  GAAAAAGTAG  CGTGGGTATT  CTCCAGAAAA  300
301   GCTACACTTG  AACTGACACA  CAATTGGGGC  ACGGAAGATG  ATGAGACCCA  GAGTTACCAC  360
361   AGTGGCAATT  CAGACCCTCG  AGGATTTGGT  CACATTGGAA  TTGCTGTTCC  CGACGTTCAC  420
421   GGTGCTTGTA  AAAGATTTGA  AGAGCTGGGA  GTCAGATTTG  TGAAGAAGCC  TAATGACGGT  480
481   AAAATGAAAG  GCCTGGCATT  TATTCAAGAT  CCTGATGGTT  ACTGGATTGA  AATTTTGAAT  540
541   CCCAACACAA  TGATAACTAT  TATTTAG  567

▼ KEYWORD

ID
Family
Complete proteome
Lyase
Metal-binding
Reference proteome
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Molecular Function
Lactoylglutathione lyase activity
Molecular Function
Zinc ion binding
Biological Process
Negative regulation of apoptotic process
Biological Process
Osteoclast differentiation
Biological Process
Regulation of transcription by RNA polymerase II

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-4271Bos taurus98.372e-134 381
LLPS-Myl-1904Myotis lucifugus96.287e-135 382
LLPS-Eqc-4768Equus caballus96.24e-131 373
LLPS-Tut-1443Tursiops truncatus95.658e-131 372
LLPS-Mup-3776Mustela putorius furo95.112e-130 371
LLPS-Cas-3737Carlito syrichta95.112e-130 371
LLPS-Aim-3079Ailuropoda melanoleuca94.653e-130 370
LLPS-Sus-1172Sus scrofa94.022e-128 366
LLPS-Caf-2015Canis familiaris94.024e-129 368
LLPS-Fec-2587Felis catus92.395e-127 362
LLPS-Caj-1080Callithrix jacchus91.853e-127 363
LLPS-Ran-0738Rattus norvegicus91.35e-126 360
LLPS-Dio-2781Dipodomys ordii91.32e-127 363
LLPS-Fud-2712Fukomys damarensis91.37e-127 362
LLPS-Loa-4185Loxodonta africana91.31e-124 356
LLPS-Aon-3560Aotus nancymaae91.082e-105 306
LLPS-Mum-4739Mus musculus90.768e-125 357
LLPS-Mal-1770Mandrillus leucophaeus89.671e-124 356
LLPS-Paa-4159Papio anubis89.671e-124 356
LLPS-Gog-2348Gorilla gorilla89.672e-124 355
LLPS-Maf-0196Macaca fascicularis89.671e-124 356
LLPS-Cea-4504Cercocebus atys89.671e-124 356
LLPS-Ict-3114Ictidomys tridecemlineatus89.671e-122 351
LLPS-Mam-3790Macaca mulatta89.671e-124 356
LLPS-Pap-4311Pan paniscus89.672e-124 355
LLPS-Pat-4298Pan troglodytes89.672e-124 355
LLPS-Man-0269Macaca nemestrina89.671e-124 356
LLPS-Chs-4347Chlorocebus sabaeus89.131e-123 353
LLPS-Nol-2630Nomascus leucogenys89.131e-122 351
LLPS-Hos-0358Homo sapiens89.131e-123 353
LLPS-Urm-2102Ursus maritimus88.825e-106 310
LLPS-Cap-4665Cavia porcellus88.592e-123 353
LLPS-Poa-4516Pongo abelii88.592e-123 353
LLPS-Mea-3048Mesocricetus auratus87.56e-121 347
LLPS-Mod-2383Monodelphis domestica87.224e-115 332
LLPS-Ora-0982Ornithorhynchus anatinus85.632e-112 326
LLPS-Anp-1745Anas platyrhynchos84.484e-110 319
LLPS-Pes-1006Pelodiscus sinensis84.444e-113 327
LLPS-Anc-2316Anolis carolinensis83.82e-113 328
LLPS-Tag-3470Taeniopygia guttata83.233e-97 286
LLPS-Sah-2654Sarcophilus harrisii82.451e-112 326
LLPS-Fia-1823Ficedula albicollis82.223e-109 317
LLPS-Gaga-0008Gallus gallus81.971e-111 323
LLPS-Otg-4129Otolemur garnettii79.039e-100 293
LLPS-Tar-3284Takifugu rubripes77.011e-100 295
LLPS-Ten-1745Tetraodon nigroviridis77.011e-100 295
LLPS-Scm-2017Scophthalmus maximus77.019e-99 292
LLPS-Orn-4121Oreochromis niloticus76.448e-100 293
LLPS-Leo-2641Lepisosteus oculatus76.42e-92 274
LLPS-Asm-2928Astyanax mexicanus76.275e-102 299
LLPS-Scf-1933Scleropages formosus75.716e-101 296
LLPS-Gaa-3828Gasterosteus aculeatus75.294e-99 291
LLPS-Lac-2510Latimeria chalumnae75.01e-104 306
LLPS-Icp-1545Ictalurus punctatus74.722e-101 297
LLPS-Xim-4081Xiphophorus maculatus74.716e-100 293
LLPS-Orl-1531Oryzias latipes74.717e-97 285
LLPS-Pof-4166Poecilia formosa74.713e-100 294
LLPS-Dar-1004Danio rerio73.566e-98 288
LLPS-Rhb-3539Rhinopithecus bieti73.372e-90 268
LLPS-Chr-0540Chlamydomonas reinhardtii69.547e-86 259
LLPS-Drm-1633Drosophila melanogaster69.011e-86 259
LLPS-Brd-1999Brachypodium distachyon68.183e-77 238
LLPS-Sot-2108Solanum tuberosum67.746e-76 234
LLPS-Sol-0996Solanum lycopersicum67.748e-76 232
LLPS-Sei-1288Setaria italica67.611e-68 213
LLPS-Zem-1916Zea mays67.522e-76 235
LLPS-Sob-2286Sorghum bicolor66.883e-76 235
LLPS-Cus-0592Cucumis sativus66.672e-76 234
LLPS-Nia-1025Nicotiana attenuata66.673e-77 238
LLPS-Sem-2433Selaginella moellendorffii66.263e-78 238
LLPS-Glm-0871Glycine max65.848e-77 236
LLPS-Mae-1128Manihot esculenta65.825e-74 229
LLPS-Pot-1040Populus trichocarpa65.645e-78 240
LLPS-Phv-0837Phaseolus vulgaris65.433e-76 235
LLPS-Orni-2134Oryza nivara65.332e-70 221
LLPS-Viv-0682Vitis vinifera65.242e-77 238
LLPS-Met-0621Medicago truncatula65.191e-75 233
LLPS-Orgl-2175Oryza glumaepatula65.14e-68 218
LLPS-Orm-0930Oryza meridionalis65.14e-69 221
LLPS-Hea-1598Helianthus annuus64.814e-74 230
LLPS-Mua-1809Musa acuminata64.63e-75 232
LLPS-Xet-3197Xenopus tropicalis64.131e-78 240
LLPS-Coc-2209Corchorus capsularis63.983e-74 230
LLPS-Hov-1189Hordeum vulgare63.871e-53 176
LLPS-Php-0448Physcomitrella patens63.862e-75 234
LLPS-Prp-0580Prunus persica63.416e-76 234
LLPS-Ori-1531Oryza indica63.312e-78 241
LLPS-Orr-1722Oryza rufipogon63.312e-78 241
LLPS-Ors-1996Oryza sativa63.312e-78 241
LLPS-Bro-0741Brassica oleracea62.962e-1677.0
LLPS-Thc-0130Theobroma cacao62.426e-74 229
LLPS-Via-1074Vigna angularis62.043e-57 186
LLPS-Arl-2268Arabidopsis lyrata62.012e-76 236
LLPS-Orb-1541Oryza barthii61.852e-78 241
LLPS-Org-1316Oryza glaberrima61.852e-78 241
LLPS-Tra-1288Triticum aestivum61.543e-78 240
LLPS-Tru-1859Triticum urartu61.546e-78 238
LLPS-Brn-3005Brassica napus61.458e-78 239
LLPS-Brr-1535Brassica rapa61.458e-78 239
LLPS-Cii-1894Ciona intestinalis60.233e-78 238
LLPS-Art-2822Arabidopsis thaliana60.117e-73 226
LLPS-Orp-0625Oryza punctata59.364e-79 243
LLPS-Gor-0287Gossypium raimondii59.126e-73 227
LLPS-Orbr-2286Oryza brachyantha58.513e-79 243
LLPS-Lep-2195Leersia perrieri57.986e-79 242
LLPS-Usm-1089Ustilago maydis54.05e-49 162
LLPS-Spr-0413Sporisorium reilianum54.06e-49 162
LLPS-Amt-0077Amborella trichopoda53.631e-59 193
LLPS-Asf-0357Aspergillus flavus52.671e-45 159
LLPS-Aso-0769Aspergillus oryzae52.671e-45 159
LLPS-Ast-0911Aspergillus terreus52.481e-42 150
LLPS-Miv-1391Microbotryum violaceum51.951e-40 141
LLPS-Put-0843Puccinia triticina51.613e-47 158
LLPS-Pug-1137Puccinia graminis50.995e-44 153
LLPS-Nef-1612Neosartorya fischeri50.676e-45 157
LLPS-Abg-1171Absidia glauca50.643e-45 163
LLPS-Asc-1449Aspergillus clavatus50.338e-44 154
LLPS-Asfu-0337Aspergillus fumigatus50.07e-45 157
LLPS-Crn-1562Cryptococcus neoformans49.681e-43 150
LLPS-Asn-1450Aspergillus nidulans49.333e-44 155
LLPS-Fuv-0944Fusarium verticillioides48.633e-43 154
LLPS-Fuo-1213Fusarium oxysporum48.633e-43 154
LLPS-Asni-1490Aspergillus niger48.379e-41 146
LLPS-Sac-1224Saccharomyces cerevisiae48.32e-39 143
LLPS-Beb-0747Beauveria bassiana48.088e-43 151
LLPS-Scj-1140Schizosaccharomyces japonicus47.975e-38 138
LLPS-Fus-1390Fusarium solani47.952e-42 150
LLPS-Trr-1230Trichoderma reesei47.553e-42 150
LLPS-Coo-0397Colletotrichum orbiculare47.263e-38 139
LLPS-Mel-1260Melampsora laricipopulina47.243e-33 121
LLPS-Gag-0878Gaeumannomyces graminis46.752e-39 143
LLPS-Trv-1093Trichoderma virens46.757e-44 154
LLPS-Mao-1130Magnaporthe oryzae46.582e-37 138
LLPS-Cogr-0119Colletotrichum graminicola46.586e-38 138
LLPS-Cym-0914Cyanidioschyzon merolae46.457e-40 140
LLPS-Zyt-0449Zymoseptoria tritici46.419e-40 143
LLPS-Yal-1256Yarrowia lipolytica46.243e-47 163
LLPS-Lem-0098Leptosphaeria maculans46.25e-39 141
LLPS-Map-1034Magnaporthe poae46.052e-39 143
LLPS-Vir-0363Vigna radiata45.898e-35 127
LLPS-Cog-0734Colletotrichum gloeosporioides45.891e-36 135
LLPS-Scp-1252Schizosaccharomyces pombe45.573e-32 123
LLPS-Ved-1094Verticillium dahliae45.395e-39 141
LLPS-Nec-0394Neurospora crassa45.332e-38 141
LLPS-Dos-0455Dothistroma septosporum45.275e-37 136
LLPS-Scc-0327Schizosaccharomyces cryophilus45.033e-35 131
LLPS-Gas-0869Galdieria sulphuraria44.99e-37 135
LLPS-Pyt-0917Pyrenophora teres44.92e-38 140
LLPS-Phn-0372Phaeosphaeria nodorum44.443e-35 131
LLPS-Pytr-0537Pyrenophora triticirepentis44.444e-38 139
LLPS-Scs-1004Sclerotinia sclerotiorum43.317e-30 116
LLPS-Tum-1505Tuber melanosporum42.983e-2295.9
LLPS-Kop-1117Komagataella pastoris42.868e-30 117
LLPS-Asg-0377Ashbya gossypii42.042e-32 124
LLPS-Chc-0755Chondrus crispus38.673e-29 116
LLPS-Dac-0240Daucus carota33.783e-1472.8
LLPS-Osl-1135Ostreococcus lucimarinus26.246e-0955.8