LLPS-Mum-4739
Glo1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase |
| Gene Name: | Glo1 |
| Ensembl Gene: | ENSMUSG00000024026.12 |
| Ensembl Protein: | ENSMUSP00000126586.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000167624.1 | ENSMUSP00000126586.1 |
| Ensembl | ENSMUST00000024823.12 | ENSMUSP00000024823.6 |
| UniProt | Q9CPU0, LGUL_MOUSE, Q543L3, Q8R3T1 | |
| GeneBank | AK002386, AK005055, AK003567, BC024663, AK049703, BC081432, AK031832 | BAB22060.1, AAH24663.1, BAB22863.1, AAH81432.1, BAC27570.1, BAB23781.1, BAC33882.1 |
| RefSeq | NM_001113560.1, NM_025374.3 | NP_001107032.1, NP_079650.3 |
| Entrez | 109801 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEPQPASSG LTDETAFSCC SDPDPSTKDF LLQQTMLRIK DPKKSLDFYT RVLGLTLLQK 60 61 LDFPAMKFSL YFLAYEDKND IPKDKSEKTA WTFSRKATLE LTHNWGTEDD ETQSYHNGNS 120 121 DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKI 180 181 ATII 184 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGAGC CACAGCCGGC GTCCAGTGGC CTCACTGATG AGACCGCTTT CAGCTGCTGC 60 61 TCCGATCCAG ACCCTAGCAC CAAGGATTTT CTACTGCAGC AAACGATGCT AAGAATTAAG 120 121 GATCCTAAGA AGTCCCTGGA TTTTTATACG AGGGTTCTTG GACTGACCCT CCTGCAGAAG 180 181 CTTGACTTCC CTGCTATGAA GTTCTCGCTC TACTTCTTAG CTTATGAGGA TAAGAACGAT 240 241 ATCCCCAAGG ACAAGTCCGA GAAGACAGCA TGGACGTTTT CCAGAAAAGC CACCCTTGAG 300 301 CTCACGCACA ACTGGGGCAC TGAAGATGAC GAGACTCAGA GTTACCACAA CGGCAACTCG 360 361 GACCCTCGTG GATTTGGTCA CATTGGGATT GCCGTTCCTG ATGTCTACAG TGCCTGTAAG 420 421 AGATTTGAAG AACTAGGTGT CAAGTTTGTG AAGAAGCCTG ATGACGGGAA AATGAAAGGA 480 481 CTGGCGTTCA TTCAAGACCC TGACGGCTAC TGGATTGAGA TTCTGAATCC TAACAAAATA 540 541 GCAACGATTA TTTAG 555 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Molecular Function | Lactoylglutathione lyase activity | |
Molecular Function | Zinc ion binding | |
Biological Process | Carbohydrate metabolic process | |
Biological Process | Glutathione metabolic process | |
Biological Process | Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione | |
Biological Process | Methylglyoxal metabolic process | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Osteoclast differentiation | |
Biological Process | Regulation of transcription by RNA polymerase II |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0738 | Rattus norvegicus | 95.11 | 1e-130 | 371 |
| LLPS-Mea-3048 | Mesocricetus auratus | 94.57 | 4e-128 | 365 |
| LLPS-Aon-3560 | Aotus nancymaae | 92.99 | 5e-107 | 310 |
| LLPS-Cas-3737 | Carlito syrichta | 92.39 | 8e-126 | 359 |
| LLPS-Caj-1080 | Callithrix jacchus | 91.85 | 7e-126 | 359 |
| LLPS-Dio-2781 | Dipodomys ordii | 91.85 | 7e-126 | 359 |
| LLPS-Caf-2015 | Canis familiaris | 91.3 | 6e-126 | 359 |
| LLPS-Eqc-4768 | Equus caballus | 91.3 | 1e-124 | 356 |
| LLPS-Ict-3114 | Ictidomys tridecemlineatus | 91.3 | 1e-123 | 353 |
| LLPS-Bot-4271 | Bos taurus | 91.3 | 3e-125 | 358 |
| LLPS-Myl-1904 | Myotis lucifugus | 91.3 | 4e-125 | 357 |
| LLPS-Mup-3776 | Mustela putorius furo | 91.3 | 3e-125 | 358 |
| LLPS-Man-0269 | Macaca nemestrina | 90.76 | 1e-124 | 356 |
| LLPS-Mam-3790 | Macaca mulatta | 90.76 | 1e-124 | 356 |
| LLPS-Nol-2630 | Nomascus leucogenys | 90.76 | 2e-123 | 353 |
| LLPS-Sus-1172 | Sus scrofa | 90.76 | 4e-124 | 355 |
| LLPS-Cea-4504 | Cercocebus atys | 90.76 | 1e-124 | 356 |
| LLPS-Maf-0196 | Macaca fascicularis | 90.76 | 1e-124 | 356 |
| LLPS-Fud-2712 | Fukomys damarensis | 90.76 | 2e-124 | 355 |
| LLPS-Mal-1770 | Mandrillus leucophaeus | 90.76 | 1e-124 | 356 |
| LLPS-Paa-4159 | Papio anubis | 90.76 | 1e-124 | 356 |
| LLPS-Ova-1773 | Ovis aries | 90.76 | 8e-125 | 357 |
| LLPS-Hos-0358 | Homo sapiens | 90.22 | 1e-123 | 353 |
| LLPS-Pap-4311 | Pan paniscus | 90.22 | 7e-124 | 354 |
| LLPS-Pat-4298 | Pan troglodytes | 90.22 | 7e-124 | 354 |
| LLPS-Poa-4516 | Pongo abelii | 90.22 | 3e-124 | 355 |
| LLPS-Chs-4347 | Chlorocebus sabaeus | 90.22 | 2e-123 | 353 |
| LLPS-Gog-2348 | Gorilla gorilla | 90.22 | 7e-124 | 354 |
| LLPS-Tut-1443 | Tursiops truncatus | 90.22 | 8e-124 | 354 |
| LLPS-Aim-3079 | Ailuropoda melanoleuca | 90.22 | 3e-123 | 352 |
| LLPS-Fec-2587 | Felis catus | 88.59 | 1e-122 | 351 |
| LLPS-Cap-4665 | Cavia porcellus | 88.04 | 3e-121 | 347 |
| LLPS-Loa-4185 | Loxodonta africana | 87.5 | 2e-119 | 343 |
| LLPS-Ora-0982 | Ornithorhynchus anatinus | 87.36 | 3e-113 | 328 |
| LLPS-Mod-2383 | Monodelphis domestica | 86.34 | 2e-115 | 333 |
| LLPS-Anc-2316 | Anolis carolinensis | 86.03 | 1e-115 | 333 |
| LLPS-Tag-3470 | Taeniopygia guttata | 85.81 | 9e-100 | 292 |
| LLPS-Pes-1006 | Pelodiscus sinensis | 85.0 | 2e-114 | 330 |
| LLPS-Anp-1745 | Anas platyrhynchos | 84.48 | 8e-111 | 321 |
| LLPS-Sah-2654 | Sarcophilus harrisii | 84.41 | 1e-113 | 328 |
| LLPS-Gaga-0008 | Gallus gallus | 84.15 | 5e-114 | 329 |
| LLPS-Urm-2102 | Ursus maritimus | 84.12 | 4e-100 | 295 |
| LLPS-Fia-1823 | Ficedula albicollis | 83.89 | 4e-112 | 324 |
| LLPS-Leo-2641 | Lepisosteus oculatus | 78.26 | 3e-94 | 278 |
| LLPS-Lac-2510 | Latimeria chalumnae | 77.72 | 2e-108 | 315 |
| LLPS-Otg-4129 | Otolemur garnettii | 77.42 | 1e-96 | 285 |
| LLPS-Scm-2017 | Scophthalmus maximus | 77.01 | 6e-100 | 295 |
| LLPS-Orn-4121 | Oreochromis niloticus | 77.01 | 4e-101 | 296 |
| LLPS-Icp-1545 | Ictalurus punctatus | 76.97 | 4e-104 | 304 |
| LLPS-Asm-2928 | Astyanax mexicanus | 76.84 | 2e-103 | 302 |
| LLPS-Scf-1933 | Scleropages formosus | 76.84 | 4e-103 | 301 |
| LLPS-Ten-1745 | Tetraodon nigroviridis | 75.86 | 2e-99 | 292 |
| LLPS-Gaa-3828 | Gasterosteus aculeatus | 75.86 | 1e-100 | 295 |
| LLPS-Tar-3284 | Takifugu rubripes | 75.86 | 7e-100 | 293 |
| LLPS-Orl-1531 | Oryzias latipes | 75.29 | 3e-98 | 289 |
| LLPS-Rhb-3539 | Rhinopithecus bieti | 75.0 | 6e-92 | 272 |
| LLPS-Pof-4166 | Poecilia formosa | 74.86 | 1e-101 | 298 |
| LLPS-Dar-1004 | Danio rerio | 74.14 | 3e-99 | 291 |
| LLPS-Xim-4081 | Xiphophorus maculatus | 73.71 | 6e-100 | 293 |
| LLPS-Chr-0540 | Chlamydomonas reinhardtii | 71.69 | 8e-87 | 261 |
| LLPS-Drm-1633 | Drosophila melanogaster | 69.77 | 2e-88 | 264 |
| LLPS-Orni-2134 | Oryza nivara | 69.33 | 3e-76 | 236 |
| LLPS-Sol-0996 | Solanum lycopersicum | 69.18 | 5e-79 | 240 |
| LLPS-Sot-2108 | Solanum tuberosum | 69.18 | 6e-79 | 242 |
| LLPS-Orm-0930 | Oryza meridionalis | 69.13 | 1e-74 | 235 |
| LLPS-Orgl-2175 | Oryza glumaepatula | 69.13 | 1e-73 | 233 |
| LLPS-Sei-1288 | Setaria italica | 69.13 | 9e-73 | 223 |
| LLPS-Brd-1999 | Brachypodium distachyon | 68.94 | 4e-82 | 250 |
| LLPS-Orp-0625 | Oryza punctata | 68.9 | 2e-83 | 254 |
| LLPS-Sem-2433 | Selaginella moellendorffii | 68.71 | 4e-82 | 248 |
| LLPS-Mae-1128 | Manihot esculenta | 68.55 | 1e-77 | 238 |
| LLPS-Hea-1598 | Helianthus annuus | 68.52 | 3e-78 | 241 |
| LLPS-Mua-1809 | Musa acuminata | 68.32 | 9e-81 | 246 |
| LLPS-Viv-0682 | Vitis vinifera | 68.29 | 1e-81 | 249 |
| LLPS-Ors-1996 | Oryza sativa | 68.29 | 2e-83 | 253 |
| LLPS-Orbr-2286 | Oryza brachyantha | 68.29 | 2e-83 | 254 |
| LLPS-Orr-1722 | Oryza rufipogon | 68.29 | 2e-83 | 253 |
| LLPS-Org-1316 | Oryza glaberrima | 68.29 | 1e-83 | 254 |
| LLPS-Orb-1541 | Oryza barthii | 68.29 | 2e-83 | 254 |
| LLPS-Ori-1531 | Oryza indica | 68.29 | 2e-83 | 253 |
| LLPS-Pot-1040 | Populus trichocarpa | 68.1 | 7e-82 | 249 |
| LLPS-Phv-0837 | Phaseolus vulgaris | 67.9 | 7e-80 | 244 |
| LLPS-Nia-1025 | Nicotiana attenuata | 67.9 | 3e-80 | 245 |
| LLPS-Zem-1916 | Zea mays | 67.68 | 1e-78 | 240 |
| LLPS-Lep-2195 | Leersia perrieri | 67.68 | 3e-82 | 250 |
| LLPS-Arl-2268 | Arabidopsis lyrata | 67.5 | 8e-78 | 239 |
| LLPS-Cus-0592 | Cucumis sativus | 67.28 | 1e-79 | 242 |
| LLPS-Hov-1189 | Hordeum vulgare | 67.23 | 1e-56 | 183 |
| LLPS-Sob-2286 | Sorghum bicolor | 67.07 | 1e-78 | 241 |
| LLPS-Tru-1859 | Triticum urartu | 67.07 | 1e-82 | 249 |
| LLPS-Tra-1288 | Triticum aestivum | 67.07 | 7e-83 | 252 |
| LLPS-Brr-1535 | Brassica rapa | 66.88 | 2e-78 | 241 |
| LLPS-Brn-3005 | Brassica napus | 66.88 | 2e-78 | 241 |
| LLPS-Prp-0580 | Prunus persica | 66.46 | 3e-80 | 245 |
| LLPS-Coc-2209 | Corchorus capsularis | 66.46 | 1e-78 | 241 |
| LLPS-Glm-0871 | Glycine max | 66.46 | 1e-79 | 243 |
| LLPS-Met-0621 | Medicago truncatula | 66.46 | 2e-79 | 243 |
| LLPS-Via-1074 | Vigna angularis | 65.93 | 1e-60 | 195 |
| LLPS-Xet-3197 | Xenopus tropicalis | 65.76 | 2e-80 | 244 |
| LLPS-Php-0448 | Physcomitrella patens | 65.66 | 7e-79 | 242 |
| LLPS-Art-2822 | Arabidopsis thaliana | 65.64 | 8e-74 | 229 |
| LLPS-Thc-0130 | Theobroma cacao | 64.85 | 5e-77 | 237 |
| LLPS-Bro-0741 | Brassica oleracea | 64.15 | 2e-16 | 76.6 |
| LLPS-Cii-1894 | Ciona intestinalis | 60.8 | 1e-79 | 242 |
| LLPS-Gor-0287 | Gossypium raimondii | 60.77 | 7e-75 | 231 |
| LLPS-Amt-0077 | Amborella trichopoda | 56.42 | 1e-63 | 203 |
| LLPS-Aso-0769 | Aspergillus oryzae | 55.33 | 1e-47 | 164 |
| LLPS-Asf-0357 | Aspergillus flavus | 55.33 | 1e-47 | 164 |
| LLPS-Ast-0911 | Aspergillus terreus | 54.61 | 3e-44 | 154 |
| LLPS-Usm-1089 | Ustilago maydis | 54.25 | 6e-50 | 165 |
| LLPS-Spr-0413 | Sporisorium reilianum | 53.59 | 5e-50 | 165 |
| LLPS-Nef-1612 | Neosartorya fischeri | 52.67 | 2e-46 | 160 |
| LLPS-Miv-1391 | Microbotryum violaceum | 52.32 | 9e-42 | 144 |
| LLPS-Asfu-0337 | Aspergillus fumigatus | 52.0 | 2e-46 | 160 |
| LLPS-Asc-1449 | Aspergillus clavatus | 51.63 | 3e-45 | 157 |
| LLPS-Asni-1490 | Aspergillus niger | 51.63 | 4e-42 | 149 |
| LLPS-Put-0843 | Puccinia triticina | 51.61 | 5e-47 | 157 |
| LLPS-Asn-1450 | Aspergillus nidulans | 51.33 | 1e-45 | 159 |
| LLPS-Abg-1171 | Absidia glauca | 50.64 | 5e-44 | 160 |
| LLPS-Pug-1137 | Puccinia graminis | 50.0 | 4e-44 | 153 |
| LLPS-Yal-1256 | Yarrowia lipolytica | 49.7 | 6e-48 | 164 |
| LLPS-Crn-1562 | Cryptococcus neoformans | 49.68 | 4e-43 | 148 |
| LLPS-Lem-0098 | Leptosphaeria maculans | 49.66 | 2e-40 | 145 |
| LLPS-Gag-0878 | Gaeumannomyces graminis | 48.7 | 5e-42 | 150 |
| LLPS-Coo-0397 | Colletotrichum orbiculare | 48.63 | 1e-39 | 142 |
| LLPS-Vir-0363 | Vigna radiata | 48.63 | 2e-38 | 136 |
| LLPS-Scj-1140 | Schizosaccharomyces japonicus | 48.34 | 8e-39 | 140 |
| LLPS-Nec-0394 | Neurospora crassa | 48.0 | 9e-39 | 141 |
| LLPS-Fuo-1213 | Fusarium oxysporum | 47.37 | 1e-42 | 152 |
| LLPS-Fuv-0944 | Fusarium verticillioides | 47.37 | 9e-43 | 152 |
| LLPS-Beb-0747 | Beauveria bassiana | 47.33 | 9e-39 | 140 |
| LLPS-Cogr-0119 | Colletotrichum graminicola | 47.26 | 8e-39 | 140 |
| LLPS-Mel-1260 | Melampsora laricipopulina | 47.24 | 3e-34 | 124 |
| LLPS-Fus-1390 | Fusarium solani | 47.06 | 3e-43 | 152 |
| LLPS-Phn-0372 | Phaeosphaeria nodorum | 47.06 | 9e-38 | 138 |
| LLPS-Trr-1230 | Trichoderma reesei | 46.98 | 2e-43 | 153 |
| LLPS-Pyt-0917 | Pyrenophora teres | 46.94 | 1e-40 | 145 |
| LLPS-Cym-0914 | Cyanidioschyzon merolae | 46.84 | 1e-40 | 142 |
| LLPS-Map-1034 | Magnaporthe poae | 46.75 | 1e-40 | 146 |
| LLPS-Cog-0734 | Colletotrichum gloeosporioides | 46.71 | 5e-39 | 141 |
| LLPS-Pytr-0537 | Pyrenophora triticirepentis | 46.41 | 4e-40 | 144 |
| LLPS-Ved-1094 | Verticillium dahliae | 45.81 | 4e-40 | 144 |
| LLPS-Sac-1224 | Saccharomyces cerevisiae | 45.75 | 3e-36 | 134 |
| LLPS-Scs-1004 | Sclerotinia sclerotiorum | 45.67 | 3e-32 | 122 |
| LLPS-Trv-1093 | Trichoderma virens | 45.56 | 4e-45 | 157 |
| LLPS-Scc-0327 | Schizosaccharomyces cryophilus | 45.45 | 6e-36 | 133 |
| LLPS-Zyt-0449 | Zymoseptoria tritici | 45.22 | 3e-40 | 145 |
| LLPS-Dos-0455 | Dothistroma septosporum | 45.16 | 5e-38 | 139 |
| LLPS-Scp-1252 | Schizosaccharomyces pombe | 44.94 | 1e-32 | 124 |
| LLPS-Kop-1117 | Komagataella pastoris | 44.59 | 3e-29 | 115 |
| LLPS-Mao-1130 | Magnaporthe oryzae | 44.52 | 3e-38 | 140 |
| LLPS-Gas-0869 | Galdieria sulphuraria | 44.52 | 3e-36 | 134 |
| LLPS-Asg-0377 | Ashbya gossypii | 43.31 | 2e-31 | 122 |
| LLPS-Tum-1505 | Tuber melanosporum | 43.2 | 3e-24 | 100 |
| LLPS-Chc-0755 | Chondrus crispus | 38.75 | 6e-27 | 110 |
| LLPS-Dac-1506 | Daucus carota | 31.01 | 6e-13 | 69.3 |
| LLPS-Osl-1135 | Ostreococcus lucimarinus | 26.24 | 5e-10 | 58.9 |