LLPS-Nef-1612
NFIA_053640
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Lactoylglutathione lyase; Glyoxalase I |
| Gene Name: | NFIA_053640 |
| Ensembl Gene: | NFIA_053640 |
| Ensembl Protein: | EAW16018 |
| Organism: | Neosartorya fischeri |
| Taxa ID: | 331117 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAW16018 | EAW16018 |
| UniProt | A1DMJ7, A1DMJ7_NEOFI | |
| GeneBank | DS027698 | EAW16018.1 |
| RefSeq | XM_001257914.1 | XP_001257915.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MATETSKYKL NHTMIRVKDP KRSVEFYKFL GLNQIQQLDF PENKFSLYFL AYNGPQSLQG 60 61 DRHWTDRNAV LELTHNYGTE NDPNYTVANG NTEPHRGFGH IAISVDNVEA ACKRLEDAGY 120 121 QFQKKLTEGR MKHIAFAKDP DGYWVEIIRR HDQDVGTATD PGTYRLNHTM LRVKSAETSL 180 181 KFYQEVMGMT LVRTIENKDA AFNLYFLGYP ASNPTAQEGA KNPVAEWEGL LELTWNYGTE 240 241 KQEGKVYHDG NSEPQGFGHI CVSVDDLNAA CDRFESLNVN WKKRLTDGRM KNVAFILDPD 300 301 GYWIEVIQNE ALKRTSNW 318 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGACAG AAACCTCCAA GTATAAGCTT AATCACACTA TGATCCGGGT CAAGGACCCA 60 61 AAGAGATCAG TGGAGTTCTA CAAGTTCCTT GGGCTCAATC AGATCCAGCA GCTCGACTTT 120 121 CCTGAGAACA AGTTCTCCCT CTACTTCCTC GCCTACAATG GCCCCCAGTC GCTGCAGGGC 180 181 GACCGTCACT GGACGGACCG CAATGCGGTG CTGGAACTCA CGCACAACTA TGGCACGGAG 240 241 AATGACCCCA ATTACACTGT TGCCAATGGG AATACGGAGC CCCATCGCGG TTTCGGACAC 300 301 ATTGCCATCT CGGTCGACAA CGTCGAAGCG GCCTGCAAGA GACTCGAAGA CGCTGGGTAT 360 361 CAATTCCAGA AAAAGCTCAC CGAGGGTCGC ATGAAGCACA TTGCGTTCGC AAAGGATCCC 420 421 GATGGATACT GGGTTGAGAT CATCCGCCGC CACGATCAGG ATGTGGGGAC TGCGACAGAT 480 481 CCAGGCACCT ACCGACTGAA CCACACCATG TTACGGGTCA AGTCCGCTGA GACCAGTCTC 540 541 AAGTTCTACC AGGAGGTTAT GGGCATGACC CTTGTGCGCA CTATCGAGAA CAAGGATGCT 600 601 GCCTTCAATC TCTACTTCCT GGGTTACCCT GCGTCCAACC CCACTGCGCA GGAGGGCGCG 660 661 AAGAATCCTG TGGCTGAATG GGAGGGGCTG CTCGAGCTTA CCTGGAACTA CGGTACGGAG 720 721 AAGCAAGAAG GCAAGGTTTA CCATGATGGT AATTCGGAGC CTCAAGGGTT CGGTCATATT 780 781 TGTGTCTCTG TTGACGATCT CAATGCTGCC TGCGATCGGT TCGAGTCGCT CAACGTGAAC 840 841 TGGAAGAAGC GTCTGACAGA CGGGCGGATG AAGAATGTGG CTTTCATTCT TGACCCGGAT 900 901 GGCTATTGGA TCGAGGTGAT CCAAAACGAG GCGTTGAAGC GTACCAGCAA TTGGTAA 957 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Molecular Function | Lactoylglutathione lyase activity | |
Molecular Function | Zinc ion binding | |
Biological Process | Glutathione metabolic process | |
Biological Process | Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asfu-0337 | Aspergillus fumigatus | 98.74 | 0.0 | 664 |
| LLPS-Asn-1450 | Aspergillus nidulans | 88.99 | 0.0 | 616 |
| LLPS-Aso-0769 | Aspergillus oryzae | 88.68 | 0.0 | 611 |
| LLPS-Asf-0357 | Aspergillus flavus | 88.68 | 0.0 | 611 |
| LLPS-Asc-1449 | Aspergillus clavatus | 88.4 | 0.0 | 597 |
| LLPS-Ast-0911 | Aspergillus terreus | 87.87 | 0.0 | 563 |
| LLPS-Asni-1490 | Aspergillus niger | 84.38 | 0.0 | 585 |
| LLPS-Zyt-0449 | Zymoseptoria tritici | 68.25 | 1e-162 | 464 |
| LLPS-Dos-0455 | Dothistroma septosporum | 67.92 | 1e-160 | 459 |
| LLPS-Pytr-0537 | Pyrenophora triticirepentis | 66.67 | 6e-162 | 462 |
| LLPS-Pyt-0917 | Pyrenophora teres | 66.36 | 2e-160 | 458 |
| LLPS-Beb-0747 | Beauveria bassiana | 66.24 | 2e-154 | 443 |
| LLPS-Lem-0098 | Leptosphaeria maculans | 65.11 | 1e-159 | 456 |
| LLPS-Trv-1093 | Trichoderma virens | 65.06 | 2e-153 | 440 |
| LLPS-Phn-0372 | Phaeosphaeria nodorum | 64.91 | 6e-157 | 449 |
| LLPS-Nec-0394 | Neurospora crassa | 64.58 | 2e-150 | 434 |
| LLPS-Trr-1230 | Trichoderma reesei | 64.42 | 2e-146 | 422 |
| LLPS-Fus-1390 | Fusarium solani | 63.55 | 1e-154 | 443 |
| LLPS-Fuv-0944 | Fusarium verticillioides | 63.24 | 9e-155 | 445 |
| LLPS-Fuo-1213 | Fusarium oxysporum | 63.24 | 1e-154 | 445 |
| LLPS-Scs-1004 | Sclerotinia sclerotiorum | 63.22 | 1e-116 | 345 |
| LLPS-Mao-1130 | Magnaporthe oryzae | 62.38 | 2e-149 | 432 |
| LLPS-Cogr-0119 | Colletotrichum graminicola | 61.78 | 6e-141 | 408 |
| LLPS-Cog-0734 | Colletotrichum gloeosporioides | 60.5 | 7e-139 | 403 |
| LLPS-Tum-1505 | Tuber melanosporum | 60.29 | 5e-115 | 341 |
| LLPS-Gag-0878 | Gaeumannomyces graminis | 60.0 | 6e-134 | 392 |
| LLPS-Bro-0741 | Brassica oleracea | 60.0 | 9e-07 | 51.6 |
| LLPS-Ved-1094 | Verticillium dahliae | 59.87 | 1e-138 | 402 |
| LLPS-Coo-0397 | Colletotrichum orbiculare | 59.69 | 2e-139 | 405 |
| LLPS-Map-1034 | Magnaporthe poae | 58.93 | 7e-141 | 409 |
| LLPS-Nia-1025 | Nicotiana attenuata | 55.63 | 4e-47 | 165 |
| LLPS-Sot-2108 | Solanum tuberosum | 54.97 | 2e-46 | 163 |
| LLPS-Sol-0996 | Solanum lycopersicum | 54.97 | 1e-46 | 162 |
| LLPS-Usm-1089 | Ustilago maydis | 54.79 | 1e-49 | 168 |
| LLPS-Yal-1256 | Yarrowia lipolytica | 54.34 | 4e-114 | 340 |
| LLPS-Orgl-2175 | Oryza glumaepatula | 54.23 | 6e-40 | 149 |
| LLPS-Spr-0413 | Sporisorium reilianum | 53.74 | 3e-47 | 162 |
| LLPS-Mua-1809 | Musa acuminata | 53.64 | 4e-43 | 154 |
| LLPS-Prp-0580 | Prunus persica | 53.64 | 5e-44 | 157 |
| LLPS-Pot-1040 | Populus trichocarpa | 53.33 | 1e-45 | 161 |
| LLPS-Orni-2134 | Oryza nivara | 53.15 | 9e-40 | 146 |
| LLPS-Aon-3560 | Aotus nancymaae | 53.06 | 4e-45 | 157 |
| LLPS-Orbr-2286 | Oryza brachyantha | 52.98 | 1e-43 | 156 |
| LLPS-Abg-1171 | Absidia glauca | 52.83 | 2e-48 | 177 |
| LLPS-Orm-0930 | Oryza meridionalis | 52.82 | 2e-38 | 145 |
| LLPS-Zem-1916 | Zea mays | 52.76 | 1e-44 | 158 |
| LLPS-Mum-4739 | Mus musculus | 52.67 | 4e-46 | 160 |
| LLPS-Poa-4516 | Pongo abelii | 52.67 | 2e-45 | 158 |
| LLPS-Anc-2316 | Anolis carolinensis | 52.67 | 2e-46 | 161 |
| LLPS-Mod-2383 | Monodelphis domestica | 52.67 | 1e-46 | 162 |
| LLPS-Lac-2510 | Latimeria chalumnae | 52.67 | 1e-45 | 159 |
| LLPS-Pes-1006 | Pelodiscus sinensis | 52.67 | 9e-47 | 162 |
| LLPS-Otg-4129 | Otolemur garnettii | 52.54 | 1e-32 | 125 |
| LLPS-Lep-2195 | Leersia perrieri | 52.32 | 5e-42 | 151 |
| LLPS-Brn-3005 | Brassica napus | 52.32 | 5e-43 | 154 |
| LLPS-Orb-1541 | Oryza barthii | 52.32 | 5e-42 | 151 |
| LLPS-Ori-1531 | Oryza indica | 52.32 | 5e-42 | 151 |
| LLPS-Orr-1722 | Oryza rufipogon | 52.32 | 5e-42 | 151 |
| LLPS-Org-1316 | Oryza glaberrima | 52.32 | 5e-42 | 151 |
| LLPS-Orp-0625 | Oryza punctata | 52.32 | 1e-41 | 151 |
| LLPS-Brr-1535 | Brassica rapa | 52.32 | 5e-43 | 154 |
| LLPS-Ors-1996 | Oryza sativa | 52.32 | 5e-42 | 151 |
| LLPS-Sei-1288 | Setaria italica | 52.29 | 3e-42 | 149 |
| LLPS-Paa-4159 | Papio anubis | 52.0 | 1e-45 | 159 |
| LLPS-Mal-1770 | Mandrillus leucophaeus | 52.0 | 1e-45 | 159 |
| LLPS-Ran-0738 | Rattus norvegicus | 52.0 | 2e-45 | 159 |
| LLPS-Cea-4504 | Cercocebus atys | 52.0 | 1e-45 | 159 |
| LLPS-Maf-0196 | Macaca fascicularis | 52.0 | 1e-45 | 159 |
| LLPS-Chs-4347 | Chlorocebus sabaeus | 52.0 | 1e-45 | 159 |
| LLPS-Fud-2712 | Fukomys damarensis | 52.0 | 2e-45 | 159 |
| LLPS-Caj-1080 | Callithrix jacchus | 52.0 | 2e-45 | 159 |
| LLPS-Mam-3790 | Macaca mulatta | 52.0 | 1e-45 | 159 |
| LLPS-Cap-4665 | Cavia porcellus | 52.0 | 1e-45 | 159 |
| LLPS-Nol-2630 | Nomascus leucogenys | 52.0 | 8e-45 | 157 |
| LLPS-Ict-3114 | Ictidomys tridecemlineatus | 52.0 | 6e-45 | 157 |
| LLPS-Man-0269 | Macaca nemestrina | 52.0 | 1e-45 | 159 |
| LLPS-Cus-0592 | Cucumis sativus | 51.66 | 2e-43 | 153 |
| LLPS-Brd-1999 | Brachypodium distachyon | 51.66 | 1e-42 | 153 |
| LLPS-Php-0448 | Physcomitrella patens | 51.66 | 6e-43 | 154 |
| LLPS-Mae-1128 | Manihot esculenta | 51.66 | 4e-43 | 154 |
| LLPS-Crn-1562 | Cryptococcus neoformans | 51.59 | 2e-43 | 153 |
| LLPS-Scj-1140 | Schizosaccharomyces japonicus | 51.46 | 5e-105 | 316 |
| LLPS-Dio-2781 | Dipodomys ordii | 51.33 | 1e-45 | 159 |
| LLPS-Mea-3048 | Mesocricetus auratus | 51.33 | 4e-45 | 158 |
| LLPS-Ora-0982 | Ornithorhynchus anatinus | 51.33 | 1e-45 | 159 |
| LLPS-Gog-2348 | Gorilla gorilla | 51.33 | 2e-44 | 156 |
| LLPS-Gaga-0008 | Gallus gallus | 51.33 | 9e-45 | 157 |
| LLPS-Cas-3737 | Carlito syrichta | 51.33 | 7e-45 | 157 |
| LLPS-Anp-1745 | Anas platyrhynchos | 51.33 | 7e-45 | 157 |
| LLPS-Loa-4185 | Loxodonta africana | 51.33 | 2e-44 | 156 |
| LLPS-Hos-0358 | Homo sapiens | 51.33 | 4e-44 | 155 |
| LLPS-Pat-4298 | Pan troglodytes | 51.33 | 2e-44 | 156 |
| LLPS-Pap-4311 | Pan paniscus | 51.33 | 2e-44 | 156 |
| LLPS-Sob-2286 | Sorghum bicolor | 51.23 | 1e-43 | 155 |
| LLPS-Mel-1260 | Melampsora laricipopulina | 51.2 | 6e-35 | 129 |
| LLPS-Tag-3470 | Taeniopygia guttata | 51.02 | 3e-43 | 152 |
| LLPS-Tra-1288 | Triticum aestivum | 50.99 | 1e-42 | 153 |
| LLPS-Coc-2209 | Corchorus capsularis | 50.99 | 9e-42 | 150 |
| LLPS-Tru-1859 | Triticum urartu | 50.99 | 6e-43 | 152 |
| LLPS-Gor-0287 | Gossypium raimondii | 50.99 | 2e-42 | 152 |
| LLPS-Sah-2654 | Sarcophilus harrisii | 50.98 | 1e-43 | 154 |
| LLPS-Scc-0327 | Schizosaccharomyces cryophilus | 50.94 | 9e-44 | 158 |
| LLPS-Bot-4271 | Bos taurus | 50.67 | 1e-44 | 157 |
| LLPS-Tut-1443 | Tursiops truncatus | 50.67 | 3e-44 | 155 |
| LLPS-Aim-3079 | Ailuropoda melanoleuca | 50.67 | 3e-44 | 155 |
| LLPS-Ova-1773 | Ovis aries | 50.67 | 1e-44 | 157 |
| LLPS-Myl-1904 | Myotis lucifugus | 50.67 | 3e-44 | 156 |
| LLPS-Caf-2015 | Canis familiaris | 50.67 | 8e-45 | 157 |
| LLPS-Fia-1823 | Ficedula albicollis | 50.67 | 6e-44 | 154 |
| LLPS-Chr-0540 | Chlamydomonas reinhardtii | 50.66 | 6e-43 | 153 |
| LLPS-Arl-2268 | Arabidopsis lyrata | 50.0 | 4e-43 | 154 |
| LLPS-Mup-3776 | Mustela putorius furo | 50.0 | 4e-44 | 155 |
| LLPS-Sus-1172 | Sus scrofa | 50.0 | 3e-44 | 155 |
| LLPS-Eqc-4768 | Equus caballus | 50.0 | 2e-44 | 156 |
| LLPS-Fec-2587 | Felis catus | 50.0 | 1e-43 | 154 |
| LLPS-Drm-1633 | Drosophila melanogaster | 49.68 | 2e-43 | 153 |
| LLPS-Sem-2433 | Selaginella moellendorffii | 49.67 | 1e-40 | 146 |
| LLPS-Hov-1189 | Hordeum vulgare | 49.57 | 1e-26 | 109 |
| LLPS-Scp-1252 | Schizosaccharomyces pombe | 49.51 | 7e-104 | 313 |
| LLPS-Hea-1598 | Helianthus annuus | 49.4 | 6e-42 | 152 |
| LLPS-Art-2822 | Arabidopsis thaliana | 49.38 | 2e-41 | 150 |
| LLPS-Sac-1224 | Saccharomyces cerevisiae | 49.31 | 6e-35 | 135 |
| LLPS-Thc-0130 | Theobroma cacao | 49.01 | 2e-40 | 147 |
| LLPS-Viv-0682 | Vitis vinifera | 48.78 | 1e-41 | 150 |
| LLPS-Glm-0871 | Glycine max | 48.77 | 5e-42 | 151 |
| LLPS-Phv-0837 | Phaseolus vulgaris | 48.77 | 1e-42 | 153 |
| LLPS-Gaa-3828 | Gasterosteus aculeatus | 48.67 | 4e-42 | 150 |
| LLPS-Ten-1745 | Tetraodon nigroviridis | 48.67 | 4e-42 | 150 |
| LLPS-Leo-2641 | Lepisosteus oculatus | 48.37 | 5e-43 | 152 |
| LLPS-Met-0621 | Medicago truncatula | 48.15 | 1e-41 | 150 |
| LLPS-Miv-1391 | Microbotryum violaceum | 48.05 | 6e-36 | 133 |
| LLPS-Tar-3284 | Takifugu rubripes | 48.0 | 6e-42 | 149 |
| LLPS-Orl-1531 | Oryzias latipes | 48.0 | 6e-40 | 144 |
| LLPS-Asm-2928 | Astyanax mexicanus | 48.0 | 7e-42 | 149 |
| LLPS-Icp-1545 | Ictalurus punctatus | 48.0 | 2e-42 | 150 |
| LLPS-Dar-1004 | Danio rerio | 48.0 | 6e-42 | 149 |
| LLPS-Scm-2017 | Scophthalmus maximus | 48.0 | 3e-42 | 152 |
| LLPS-Orn-4121 | Oreochromis niloticus | 48.0 | 2e-41 | 148 |
| LLPS-Pug-1137 | Puccinia graminis | 47.97 | 5e-42 | 152 |
| LLPS-Scf-1933 | Scleropages formosus | 47.33 | 2e-41 | 148 |
| LLPS-Pof-4166 | Poecilia formosa | 47.33 | 2e-41 | 149 |
| LLPS-Put-0843 | Puccinia triticina | 47.22 | 4e-36 | 134 |
| LLPS-Xim-4081 | Xiphophorus maculatus | 46.67 | 3e-41 | 147 |
| LLPS-Amt-0077 | Amborella trichopoda | 46.67 | 8e-29 | 116 |
| LLPS-Urm-2102 | Ursus maritimus | 45.52 | 2e-31 | 123 |
| LLPS-Via-1074 | Vigna angularis | 45.45 | 6e-27 | 111 |
| LLPS-Cii-1894 | Ciona intestinalis | 45.33 | 4e-37 | 137 |
| LLPS-Cym-0914 | Cyanidioschyzon merolae | 44.3 | 5e-37 | 137 |
| LLPS-Xet-3197 | Xenopus tropicalis | 44.08 | 4e-30 | 118 |
| LLPS-Rhb-3539 | Rhinopithecus bieti | 43.75 | 2e-31 | 120 |
| LLPS-Asg-0377 | Ashbya gossypii | 43.45 | 1e-80 | 254 |
| LLPS-Kop-1117 | Komagataella pastoris | 40.26 | 6e-23 | 100 |
| LLPS-Gas-0869 | Galdieria sulphuraria | 39.07 | 5e-25 | 107 |
| LLPS-Vir-0363 | Vigna radiata | 36.3 | 1e-15 | 77.8 |
| LLPS-Chc-0755 | Chondrus crispus | 35.81 | 1e-21 | 99.0 |
| LLPS-Osl-1135 | Ostreococcus lucimarinus | 28.47 | 1e-11 | 65.9 |
| LLPS-Dac-0240 | Daucus carota | 28.25 | 1e-26 | 111 |